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Protein

Non-structural protein V

Gene

P/V

Organism
Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. Blocks the type I interferon signaling pathway by interacting with host TYK2 and thereby inhibiting downstream STAT1 and STAT2 phosphorylation. Moderately affects the type II interferon signaling (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi232Zinc 1By similarity1
Metal bindingi251Zinc 1By similarity1
Metal bindingi255Zinc 2By similarity1
Metal bindingi267Zinc 2By similarity1
Metal bindingi269Zinc 2By similarity1
Metal bindingi272Zinc 2By similarity1
Metal bindingi276Zinc 1By similarity1
Metal bindingi279Zinc 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host IRF7 by virus, Inhibition of host MDA5 by virus, Inhibition of host RLR pathway by virus, Inhibition of host STAT2 by virus, Interferon antiviral system evasion, Viral immunoevasion
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein V
Gene namesi
Name:P/V
OrganismiMeasles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)
Taxonomic identifieri11239 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeMorbillivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001428121 – 299Non-structural protein VAdd BLAST299

Interactioni

Subunit structurei

Interacts with host IFIH1/MDA5 and DHX58/LGP2. Interacts with host TYK2; this interaction inhibits the type I interferon signaling pathway whithout affecting the type II pathway. Interacts with host IRF7; this interaction inhibits IRF7 translocation to the nucleus. Interacts with host CHUK and RELA. Interacts (via C-terminus) with host STAT2 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP60168
SMRiP60168
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paramyxoviruses V protein family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR024279 Paramyx_V_Zn-bd
IPR028243 Paramyxo_P/V_N
PfamiView protein in Pfam
PF13825 Paramyxo_PNT, 1 hit
PF13008 zf-Paramyx-P, 1 hit

Sequencei

Sequence statusi: Complete.

P60168-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEEQARHVK NGLECIRALK AEPIGSLAIG EAMAAWSEIS DNPGQERATY
60 70 80 90 100
KEEKAGGSGL SKPCLSAIGS TEGGAPRIRG QGSGESDDDT ETLGIPSRNL
110 120 130 140 150
QASSTGLQCH YVYDHSGEAV KGIQDADSIM VQSGLDGDST LSEGDNESEN
160 170 180 190 200
SDVDIGEPDT EGYAITDRGS APISMGFRAS DVETAEGGEI HELLRLQSRG
210 220 230 240 250
NNFPKLGKTL NVPPPPDPGR ASTSETPIKK GHRREISLIW DGDRVFIDRW
260 270 280 290
CNPMCSKVTL GTIRARCTCG ECPRVCEQCR TDTGVDTRIW YHNLPEIPE
Length:299
Mass (Da):32,132
Last modified:December 15, 2003 - v1
Checksum:iBB3913613CB6BD3A
GO

RNA editingi

Edited at position 231.1 Publication
Partially edited. RNA editing at this position consists of an insertion of one guanine nucleotide. The sequence displayed here is the V protein, derived from the edited RNA. The unedited RNA gives rise to the P protein (AC Q00793).

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10635 mRNA No translation available.

Keywords - Coding sequence diversityi

RNA editing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10635 mRNA No translation available.

3D structure databases

ProteinModelPortaliP60168
SMRiP60168
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR024279 Paramyx_V_Zn-bd
IPR028243 Paramyxo_P/V_N
PfamiView protein in Pfam
PF13825 Paramyxo_PNT, 1 hit
PF13008 zf-Paramyx-P, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiV_MEASY
AccessioniPrimary (citable) accession number: P60168
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: February 15, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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