Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acidic phospholipase A2 3

Gene
N/A
Organism
Naja sagittifera (Andaman cobra)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

Cofactori

Ca2+1 PublicationNote: Binds 1 Ca2+ ion.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi34Calcium; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi36Calcium; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi38Calcium; via carbonyl oxygenCombined sources1 Publication1
Active sitei541 Publication1
Metal bindingi55CalciumCombined sources1 Publication1
Active sitei1001 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic phospholipase A2 3 (EC:3.1.1.4)
Short name:
svPLA2
Alternative name(s):
Phosphatidylcholine 2-acylhydrolase
OrganismiNaja sagittifera (Andaman cobra)
Taxonomic identifieri195058 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeNaja

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_0000022928‹1 – 7›7
ChainiPRO_00000229298 – 126Acidic phospholipase A2 3Add BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi18 ↔ 78Combined sources1 Publication
Disulfide bondi33 ↔ 125Combined sources1 Publication
Disulfide bondi35 ↔ 51Combined sources1 Publication
Disulfide bondi50 ↔ 106Combined sources1 Publication
Disulfide bondi57 ↔ 99Combined sources1 Publication
Disulfide bondi67 ↔ 92Combined sources1 Publication
Disulfide bondi85 ↔ 97Combined sources1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

TopDownProteomicsiP60045

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

1126
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP60045
SMRiP60045
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60045

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG008137

Family and domain databases

CDDicd00125 PLA2c, 1 hit
Gene3Di1.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001211 PLipase_A2
IPR033112 PLipase_A2_Asp_AS
IPR016090 PLipase_A2_dom
IPR036444 PLipase_A2_dom_sf
IPR033113 PLipase_A2_His_AS
PANTHERiPTHR11716 PTHR11716, 1 hit
PfamiView protein in Pfam
PF00068 Phospholip_A2_1, 1 hit
PRINTSiPR00389 PHPHLIPASEA2
SMARTiView protein in SMART
SM00085 PA2c, 1 hit
SUPFAMiSSF48619 SSF48619, 1 hit
PROSITEiView protein in PROSITE
PS00119 PA2_ASP, 1 hit
PS00118 PA2_HIS, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60045-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SNRPMPLNLY QFKNMIQCTV PSRSWQDFAD YGCYCGKGGS GTPVDDLDRC
60 70 80 90 100
CQVHDNCYNE AENISGCRPY FKTYSYECTQ GTLTCKGDNN ACAASVCDCD
110 120
RLAAICFAGA PYNDANYNID LKARCN
Length:126
Mass (Da):13,969
Last modified:November 21, 2003 - v1
Checksum:iDA6CA9CB6A447EF3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY433936 mRNA Translation: AAR08048.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY433936 mRNA Translation: AAR08048.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LN8X-ray1.65A8-126[»]
1MF4X-ray1.90A8-126[»]
1OXRX-ray1.93A8-125[»]
1SZ8X-ray1.50A8-126[»]
1T37X-ray2.60A8-125[»]
1TD7X-ray2.50A8-126[»]
1YXLX-ray1.48A8-125[»]
1ZM6X-ray2.60A8-125[»]
3GCIX-ray2.04A8-126[»]
3JQ5X-ray2.03A8-126[»]
3JQLX-ray1.20A8-126[»]
3JTIX-ray1.80A8-126[»]
3NJUX-ray1.40A8-126[»]
3OSHX-ray1.50A8-126[»]
3Q4YX-ray2.30A8-126[»]
ProteinModelPortaliP60045
SMRiP60045
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

TopDownProteomicsiP60045

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG008137

Miscellaneous databases

EvolutionaryTraceiP60045

Family and domain databases

CDDicd00125 PLA2c, 1 hit
Gene3Di1.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001211 PLipase_A2
IPR033112 PLipase_A2_Asp_AS
IPR016090 PLipase_A2_dom
IPR036444 PLipase_A2_dom_sf
IPR033113 PLipase_A2_His_AS
PANTHERiPTHR11716 PTHR11716, 1 hit
PfamiView protein in Pfam
PF00068 Phospholip_A2_1, 1 hit
PRINTSiPR00389 PHPHLIPASEA2
SMARTiView protein in SMART
SM00085 PA2c, 1 hit
SUPFAMiSSF48619 SSF48619, 1 hit
PROSITEiView protein in PROSITE
PS00119 PA2_ASP, 1 hit
PS00118 PA2_HIS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPA2A3_NAJSG
AccessioniPrimary (citable) accession number: P60045
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: November 21, 2003
Last modified: October 25, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again