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Protein

Somatostatin

Gene

Sst

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Somatostatin inhibits the release of somatotropin.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin
Cleaved into the following 3 chains:
Gene namesi
Name:Sst
Synonyms:Smst
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:98326 Sst

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3309058

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
PeptideiPRO_000003309225 – 34Antrin10
PropeptideiPRO_000003309335 – 88By similarityAdd BLAST54
PeptideiPRO_000003309489 – 116Somatostatin-28Add BLAST28
PeptideiPRO_0000033095103 – 116Somatostatin-14Add BLAST14

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi105 ↔ 116By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP60041
PeptideAtlasiP60041
PRIDEiP60041

PTM databases

iPTMnetiP60041
PhosphoSitePlusiP60041

Expressioni

Gene expression databases

BgeeiENSMUSG00000004366 Expressed in 148 organ(s), highest expression level in islet of Langerhans
CleanExiMM_SST
ExpressionAtlasiP60041 baseline and differential
GenevisibleiP60041 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004480

Structurei

3D structure databases

ProteinModelPortaliP60041
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatostatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXQ5 Eukaryota
ENOG4111WUI LUCA
GeneTreeiENSGT00510000047914
HOGENOMiHOG000036630
HOVERGENiHBG017816
InParanoidiP60041
KOiK05237
OMAiGEPEDIR
OrthoDBiEOG091G157X
PhylomeDBiP60041
TreeFamiTF333185

Family and domain databases

InterProiView protein in InterPro
IPR004250 Somatostatin
IPR018142 Somatostatin/Cortistatin_C
PANTHERiPTHR10558 PTHR10558, 1 hit
PfamiView protein in Pfam
PF03002 Somatostatin, 1 hit
PIRSFiPIRSF001814 Somatostatin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60041-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSCRLQCAL AALCIVLALG GVTGAPSDPR LRQFLQKSLA AATGKQELAK
60 70 80 90 100
YFLAELLSEP NQTENDALEP EDLPQAAEQD EMRLELQRSA NSNPAMAPRE
110
RKAGCKNFFW KTFTSC
Length:116
Mass (Da):12,746
Last modified:July 21, 1986 - v1
Checksum:iD48B5454C4490375
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51468 Genomic DNA Translation: CAA35831.1
BC010770 mRNA Translation: AAH10770.1
CCDSiCCDS28080.1
PIRiS08416 RIMSS1
RefSeqiNP_033241.1, NM_009215.1
UniGeneiMm.2453

Genome annotation databases

EnsembliENSMUST00000004480; ENSMUSP00000004480; ENSMUSG00000004366
GeneIDi20604
KEGGimmu:20604
UCSCiuc007ytx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51468 Genomic DNA Translation: CAA35831.1
BC010770 mRNA Translation: AAH10770.1
CCDSiCCDS28080.1
PIRiS08416 RIMSS1
RefSeqiNP_033241.1, NM_009215.1
UniGeneiMm.2453

3D structure databases

ProteinModelPortaliP60041
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004480

Chemistry databases

ChEMBLiCHEMBL3309058

PTM databases

iPTMnetiP60041
PhosphoSitePlusiP60041

Proteomic databases

PaxDbiP60041
PeptideAtlasiP60041
PRIDEiP60041

Protocols and materials databases

DNASUi20604
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004480; ENSMUSP00000004480; ENSMUSG00000004366
GeneIDi20604
KEGGimmu:20604
UCSCiuc007ytx.1 mouse

Organism-specific databases

CTDi6750
MGIiMGI:98326 Sst

Phylogenomic databases

eggNOGiENOG410IXQ5 Eukaryota
ENOG4111WUI LUCA
GeneTreeiENSGT00510000047914
HOGENOMiHOG000036630
HOVERGENiHBG017816
InParanoidiP60041
KOiK05237
OMAiGEPEDIR
OrthoDBiEOG091G157X
PhylomeDBiP60041
TreeFamiTF333185

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-418594 G alpha (i) signalling events

Miscellaneous databases

PROiPR:P60041
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004366 Expressed in 148 organ(s), highest expression level in islet of Langerhans
CleanExiMM_SST
ExpressionAtlasiP60041 baseline and differential
GenevisibleiP60041 MM

Family and domain databases

InterProiView protein in InterPro
IPR004250 Somatostatin
IPR018142 Somatostatin/Cortistatin_C
PANTHERiPTHR10558 PTHR10558, 1 hit
PfamiView protein in Pfam
PF03002 Somatostatin, 1 hit
PIRSFiPIRSF001814 Somatostatin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSMS_MOUSE
AccessioniPrimary (citable) accession number: P60041
Secondary accession number(s): P01167
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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