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UniProtKB - P60033 (CD81_HUMAN)

Entry version 157 (10 Apr 2019)
Sequence version 1 (21 Nov 2003)
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Protein

CD81 antigen

Gene

CD81

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells (PubMed:20237408, PubMed:27881302, PubMed:16449649). Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production (PubMed:15161911, PubMed:20237408). In T cells, facilitates the localization of CD247/CD3 zeta at antigen-induced synapses with B cells, providing for costimulation and polarization toward T helper type 2 phenotype (PubMed:22307619, PubMed:23858057, PubMed:8766544). Present in MHC class II compartments, may also play a role in antigen presentation (PubMed:8409388, PubMed:8766544). Can act both as positive and negative regulator of homotypic or heterotypic cell-cell fusion processes. Positively regulates sperm-egg fusion and may be involved in acrosome reaction (By similarity). In myoblasts, associates with CD9 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (PubMed:12796480). Also prevents the fusion of mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). May regulate the compartmentalization of enzymatic activities. In T cells, defines the subcellular localization of dNTPase SAMHD1 and permits its degradation by the proteasome, thereby controlling intracellular dNTP levels (PubMed:28871089). Also involved in cell adhesion and motility. Positively regulates integrin-mediated adhesion of macrophages, particularly relevant for the inflammatory response in the lung (By similarity).By similarity10 Publications
(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Association with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell.3 Publications
(Microbial infection) Involved in SAMHD1-dependent restriction of HIV-1 replication. May support early replication of both R5- and X4-tropic HIV-1 viruses in T cells, likely via proteasome-dependent degradation of SAMHD1.1 Publication
(Microbial infection) Specifically required for Plasmodium falciparum infectivity of hepatocytes, controlling sporozoite entry into hepatocytes via the parasitophorous vacuole and subsequent parasite differentiation to exoerythrocytic forms.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei116Important for interaction with integrin1 Publication1
Sitei144Important for interaction with integrin1 Publication1
Sitei148Important for interaction with integrin1 Publication1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei219CholesterolCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processAdaptive immunity, Host-virus interaction, Immunity
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-977606 Regulation of Complement cascade

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P60033

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.40.1.1 the tetraspanin (tetraspanin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CD81 antigen
Alternative name(s):
26 kDa cell surface protein TAPA-11 Publication
Target of the antiproliferative antibody 11 Publication
Tetraspanin-28
Short name:
Tspan-28
CD_antigen: CD811 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD811 PublicationImported
Synonyms:TAPA11 Publication, TSPAN28
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000110651.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:1701 CD81

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		186845 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P60033

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 12Cytoplasmic1 Publication1 PublicationAdd BLAST12
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 33Helical1 PublicationAdd BLAST21
Topological domaini34 – 63Extracellular1 PublicationAdd BLAST30
Transmembranei64 – 84Helical1 PublicationAdd BLAST21
Topological domaini85 – 89Cytoplasmic1 Publication5
Transmembranei90 – 112Helical1 PublicationAdd BLAST23
Topological domaini113 – 201Extracellular1 PublicationAdd BLAST89
Transmembranei202 – 224Helical1 PublicationAdd BLAST23
Topological domaini225 – 236Cytoplasmic1 Publication1 PublicationAdd BLAST12

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Immunodeficiency, common variable, 6 (CVID6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
See also OMIM:613496

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi116K → E: Reduces binding to integrin. 1 Publication1
Mutagenesisi119I → A: No effect on integrin binding. 1 Publication1
Mutagenesisi121K → E: No effect on integrin binding. 1 Publication1
Mutagenesisi124K → E: No effect on integrin binding. 1 Publication1
Mutagenesisi126F → A: No effect on integrin binding. 1 Publication1
Mutagenesisi144K → E: Reduces binding to integrin; when associated with E-148. 1 Publication1
Mutagenesisi148K → E: Reduces binding to integrin; when associated with E-144. 1 Publication1
Mutagenesisi186F → A: No effect on integrin binding. 1 Publication1
Mutagenesisi187K → E: No effect on integrin binding. 1 Publication1
Mutagenesisi188E → K or Q: Strongly reduced affinity for HCV protein E2; when associated with E-196. 1 Publication1
Mutagenesisi188E → K: Mildly reduced affinity for HCV protein E2. 1 Publication1
Mutagenesisi196D → E: Strongly reduced affinity for HCV protein E2; when associated with K-188 or Q-188. 1 Publication1
Mutagenesisi196D → K, Q or R: Strongly reduced affinity for HCV protein E2. 1 Publication1
Mutagenesisi219E → A or Q: Reduced affinity for cholesterol binding. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		975

MalaCards human disease database

More...MalaCardsi		CD81
MIMi613496 phenotype

Open Targets

More...OpenTargetsi		ENSG00000110651

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		1572 Common variable immunodeficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26240

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1075180

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CD81

Domain mapping of disease mutations (DMDM)

More...DMDMi		38503376

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002192211 – 236CD81 antigenAdd BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi156 ↔ 190Combined sources5 Publications
Disulfide bondi157 ↔ 175Combined sources5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Not glycosylated.Curated
Likely constitutively palmitoylated at low levels. Protein palmitoylation is up-regulated upon coligation of BCR and CD9-C2R-CD81 complexes in lipid rafts.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P60033

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P60033

MaxQB - The MaxQuant DataBase

More...MaxQBi		P60033

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P60033

PeptideAtlas

More...PeptideAtlasi		P60033

PRoteomics IDEntifications database

More...PRIDEi		P60033

ProteomicsDB human proteome resource

More...ProteomicsDBi		57182

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P60033

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P60033

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P60033

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed on B cells (at protein level) (PubMed:20237408). Expressed in hepatocytes (at protein level) (PubMed:12483205). Expressed in monocytes/macrophages (at protein level) (PubMed:12796480). Expressed on both naive and memory CD4-positive T cells (at protein level) (PubMed:22307619).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000110651 Expressed in 231 organ(s), highest expression level in myometrium

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P60033 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P60033 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB002507
HPA007234

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:20375010). Part of a complex composed of CD19, CR2/CD21, CD81 and IFITM1/CD225 in the membrane of mature B cells. Interacts (via the second extracellular domain) with CD19; this interaction is initiated early during biosynthesis in the ER and enables trafficking of only properly folded CD19 (PubMed:16449649, PubMed:1383329). Part of a complex that includes MHC class II/HLA-DR molecules and IFITM1 (PubMed:8409388). Interacts with IFITM1 (PubMed:2398277). Interacts with IFITM2 and IFITM3 (By similarity). Part of integrin-tetraspanin complex composed of CD9, CD81, beta-1 and beta-2 integrins in the membrane of monocyte/macrophages (PubMed:12796480). Interacts (via the second extracellular domain) with integrin ITGAV:ITGB3 (PubMed:27993971). Interacts with CD247/CD3 zeta, ICAM1 and CD9 at the immune synapse on T cell membrane (PubMed:23858057). Part of a GPCR-tetraspanin complex consisting at least of ADGRG1, CD81, possibly CD9, and GNA11 in which CD81 enhances the association of ADGRG1 with GNA11 (PubMed:15004227). Part of a complex composed of CD9, CD81, PTGFRN and IGSF8 (By similarity). Interacts directly with IGSF8 (PubMed:11504738). Interacts with CD53 and SCIMP (PubMed:21930792). Interacts with SAMHD1 (via its C-terminus) (PubMed:28871089). Interacts with glypican GPC3 and with the transcriptional repressor HHEX; binding to GPC3 decreases the availability of free CD81 for binding to HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Interacts with CLDN1 (PubMed:20375010, PubMed:21516087). Interacts with CLDN6 and CLDN9 (PubMed:20375010).By similarity8 Publications
(Microbial infection) Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		107413, 202 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P60033

Protein interaction database and analysis system

More...IntActi		P60033, 105 interactors

Molecular INTeraction database

More...MINTi		P60033

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000263645

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P60033

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1236
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G8QX-ray1.60A/B113-201[»]
1IV5X-ray2.60A/B113-201[»]
2AVZmodel-A1-236[»]
3X0EX-ray1.84A/B113-202[»]
5DFVX-ray2.80A/B112-201[»]
5DFWX-ray2.33A112-201[»]
5M2CX-ray1.96A/B112-201[»]
5M33X-ray1.28A/B113-201[»]
5M3DX-ray2.38A/B/C/D112-201[»]
5M3TX-ray2.02A/B112-201[»]
5M4RX-ray3.10A/B/C/D/E112-201[»]
5TCXX-ray2.96A2-236[»]
6EJGX-ray2.82A/B112-202[»]
6EJMX-ray2.15A/B112-202[»]
6EK2X-ray2.65A/B112-201[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P60033

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P60033

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P60033

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Binds cholesterol in a cavity lined by the transmembrane spans.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3882 Eukaryota
ENOG4111IRY LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158805

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000230651

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG002324

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P60033

KEGG Orthology (KO)

More...KOi		K06508

Database of Orthologous Groups

More...OrthoDBi		702827at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P60033

TreeFam database of animal gene trees

More...TreeFami		TF352895

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1450.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00335 Tetraspanin, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002419 Tetraspanin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00259 TMFOUR

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48652 SSF48652, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00421 TM4_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

P60033-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVEGCTKCI KYLLFVFNFV FWLAGGVILG VALWLRHDPQ TTNLLYLELG 
        60         70         80         90        100
DKPAPNTFYV GIYILIAVGA VMMFVGFLGC YGAIQESQCL LGTFFTCLVI 
       110        120        130        140        150
LFACEVAAGI WGFVNKDQIA KDVKQFYDQA LQQAVVDDDA NNAKAVVKTF 
       160        170        180        190        200
HETLDCCGSS TLTALTTSVL KNNLCPSGSN IISNLFKEDC HQKIDDLFSG 
       210        220        230 
KLYLIGIAAI VVAVIMIFEM ILSMVLCCGI RNSSVY
Length:236
Mass (Da):25,809
Last modified:November 21, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB9BD7671AC91B4A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NMH8A6NMH8_HUMAN
Tetraspanin
CD81
274Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJK1E9PJK1_HUMAN
Tetraspanin
CD81
165Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRJ8E9PRJ8_HUMAN
Tetraspanin
CD81
209Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIF1E9PIF1_HUMAN
Tetraspanin
CD81
242Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEE2H0YEE2_HUMAN
Tetraspanin
CD81
148Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDJ9H0YDJ9_HUMAN
Tetraspanin
CD81
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDL9H0YDL9_HUMAN
Tetraspanin
CD81
221Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQV4E9PQV4_HUMAN
CD81 antigen
CD81
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PM31E9PM31_HUMAN
CD81 antigen
CD81
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPF5E9PPF5_HUMAN
CD81 antigen
CD81
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M33680 mRNA Translation: AAA36663.1
BT019507 mRNA Translation: AAV38314.1
BT019508 mRNA Translation: AAV38315.1
EF064749 Genomic DNA Translation: ABK41932.1
AC129929 Genomic DNA No translation available.
AC124057 Genomic DNA No translation available.
BC002978 mRNA Translation: AAH02978.1
BC093047 mRNA Translation: AAH93047.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7734.1

Protein sequence database of the Protein Information Resource

More...PIRi		A35649

NCBI Reference Sequences

More...RefSeqi		NP_001284578.1, NM_001297649.1
NP_004347.1, NM_004356.3

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.54457

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263645; ENSP00000263645; ENSG00000110651

Database of genes from NCBI RefSeq genomes

More...GeneIDi		975

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:975

UCSC genome browser

More...UCSCi		uc001lwf.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33680 mRNA Translation: AAA36663.1
BT019507 mRNA Translation: AAV38314.1
BT019508 mRNA Translation: AAV38315.1
EF064749 Genomic DNA Translation: ABK41932.1
AC129929 Genomic DNA No translation available.
AC124057 Genomic DNA No translation available.
BC002978 mRNA Translation: AAH02978.1
BC093047 mRNA Translation: AAH93047.1
CCDSiCCDS7734.1
PIRiA35649
RefSeqiNP_001284578.1, NM_001297649.1
NP_004347.1, NM_004356.3
UniGeneiHs.54457

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G8QX-ray1.60A/B113-201[»]
1IV5X-ray2.60A/B113-201[»]
2AVZmodel-A1-236[»]
3X0EX-ray1.84A/B113-202[»]
5DFVX-ray2.80A/B112-201[»]
5DFWX-ray2.33A112-201[»]
5M2CX-ray1.96A/B112-201[»]
5M33X-ray1.28A/B113-201[»]
5M3DX-ray2.38A/B/C/D112-201[»]
5M3TX-ray2.02A/B112-201[»]
5M4RX-ray3.10A/B/C/D/E112-201[»]
5TCXX-ray2.96A2-236[»]
6EJGX-ray2.82A/B112-202[»]
6EJMX-ray2.15A/B112-202[»]
6EK2X-ray2.65A/B112-201[»]
ProteinModelPortaliP60033
SMRiP60033
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107413, 202 interactors
CORUMiP60033
IntActiP60033, 105 interactors
MINTiP60033
STRINGi9606.ENSP00000263645

Chemistry databases

BindingDBiP60033
ChEMBLiCHEMBL1075180

Protein family/group databases

TCDBi8.A.40.1.1 the tetraspanin (tetraspanin) family

PTM databases

iPTMnetiP60033
PhosphoSitePlusiP60033
SwissPalmiP60033

Polymorphism and mutation databases

BioMutaiCD81
DMDMi38503376

Proteomic databases

EPDiP60033
jPOSTiP60033
MaxQBiP60033
PaxDbiP60033
PeptideAtlasiP60033
PRIDEiP60033
ProteomicsDBi57182

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		975
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263645; ENSP00000263645; ENSG00000110651
GeneIDi975
KEGGihsa:975
UCSCiuc001lwf.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		975
DisGeNETi975
EuPathDBiHostDB:ENSG00000110651.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		CD81
HGNCiHGNC:1701 CD81
HPAiCAB002507
HPA007234
MalaCardsiCD81
MIMi186845 gene
613496 phenotype
neXtProtiNX_P60033
OpenTargetsiENSG00000110651
Orphaneti1572 Common variable immunodeficiency
PharmGKBiPA26240

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00940000158805
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiP60033
KOiK06508
OrthoDBi702827at2759
PhylomeDBiP60033
TreeFamiTF352895

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-977606 Regulation of Complement cascade
SignaLinkiP60033

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CD81 human
EvolutionaryTraceiP60033

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CD81

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		975

Protein Ontology

More...PROi		PR:P60033

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000110651 Expressed in 231 organ(s), highest expression level in myometrium
ExpressionAtlasiP60033 baseline and differential
GenevisibleiP60033 HS

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspanin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD81_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60033
Secondary accession number(s): P18582, Q5U0J6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: November 21, 2003
Last modified: April 10, 2019
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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