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Protein

Beta-defensin 1

Gene

DEFB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • CCR6 chemokine receptor binding Source: UniProtKB
  • identical protein binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.C.85.1.1 the pore-forming -defensin (-defensin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-defensin 1
Short name:
BD-1
Short name:
hBD-1
Alternative name(s):
Defensin, beta 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DEFB1
Synonyms:BD1, HBD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000164825.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2766 DEFB1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602056 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P60022

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1672

Open Targets

More...
OpenTargetsi
ENSG00000164825

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27243

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DEFB1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
38503374

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisCombined sourcesAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000689922 – 321 PublicationAdd BLAST11
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000000690033 – 68Beta-defensin 1Add BLAST36

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi37 ↔ 66
Disulfide bondi44 ↔ 59
Disulfide bondi49 ↔ 67

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P60022

PeptideAtlas

More...
PeptideAtlasi
P60022

PRoteomics IDEntifications database

More...
PRIDEi
P60022

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57181

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P60022

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Blood plasma. Sperm. Highly expressed in the lower head and midpiece of sperm. Significantly reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164825 Expressed in 160 organ(s), highest expression level in adult mammalian kidney

CleanEx database of gene expression profiles

More...
CleanExi
HS_DEFB1

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P60022 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (PubMed:23938203). Homodimer (PubMed:23938203).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108036, 9 interactors

Protein interaction database and analysis system

More...
IntActi
P60022, 3 interactors

Molecular INTeraction database

More...
MINTi
P60022

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000297439

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P60022

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

168
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E4SNMR-A33-68[»]
1IJUX-ray1.40A/B/C/D33-68[»]
1IJVX-ray1.20A/B33-68[»]
1KJ5NMR-A33-68[»]
2NLBX-ray1.85A/B/C/D33-68[»]
2NLCX-ray1.65A/B/C/D33-68[»]
2NLDX-ray1.49A/B33-68[»]
2NLEX-ray1.35A/B33-68[»]
2NLFX-ray1.45A/B33-68[»]
2NLGX-ray1.65A/B/C/D33-68[»]
2NLHX-ray1.85A/B/C/D33-68[»]
2NLPX-ray1.85A/B/C/D33-68[»]
2NLQX-ray1.80A/B/C/D33-68[»]
2NLSX-ray0.98A33-68[»]
2PLZX-ray1.36A33-68[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P60022

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P60022

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P60022

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J7H1 Eukaryota
ENOG41119QC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017014

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112188

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG084156

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P60022

Identification of Orthologs from Complete Genome Data

More...
OMAi
NRIEGTC

Database of Orthologous Groups

More...
OrthoDBi
1584343at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P60022

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001855 Defensin_beta-typ

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00711 Defensin_beta, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P60022-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTSYLLLFT LCLLLSEMAS GGNFLTGLGH RSDHYNCVSS GGQCLYSACP
60
IFTKIQGTCY RGKAKCCK
Length:68
Mass (Da):7,420
Last modified:November 21, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB0AB76DEC3B14F94
GO

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 3928±0.5 Da from positions 33 - 68. Determined by ESI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01840538V → I. Corresponds to variant dbSNP:rs2738047Ensembl.1
Natural variantiVAR_01492548A → V. Corresponds to variant dbSNP:rs1800967Ensembl.1
Natural variantiVAR_01492667C → S. Corresponds to variant dbSNP:rs1800968Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U50931, U50930 Genomic DNA Translation: AAC51728.1
X92744 mRNA Translation: CAA63405.1
U73945 mRNA Translation: AAB49758.1
BC033298 mRNA Translation: AAH33298.1
BC047677 mRNA Translation: AAH47677.1
Z50788 mRNA Translation: CAA90650.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5959.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S66282

NCBI Reference Sequences

More...
RefSeqi
NP_005209.1, NM_005218.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.32949

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000297439; ENSP00000297439; ENSG00000164825
ENST00000642865; ENSP00000494448; ENSG00000284881

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1672

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1672

UCSC genome browser

More...
UCSCi
uc003wqs.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50931, U50930 Genomic DNA Translation: AAC51728.1
X92744 mRNA Translation: CAA63405.1
U73945 mRNA Translation: AAB49758.1
BC033298 mRNA Translation: AAH33298.1
BC047677 mRNA Translation: AAH47677.1
Z50788 mRNA Translation: CAA90650.1
CCDSiCCDS5959.1
PIRiS66282
RefSeqiNP_005209.1, NM_005218.3
UniGeneiHs.32949

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E4SNMR-A33-68[»]
1IJUX-ray1.40A/B/C/D33-68[»]
1IJVX-ray1.20A/B33-68[»]
1KJ5NMR-A33-68[»]
2NLBX-ray1.85A/B/C/D33-68[»]
2NLCX-ray1.65A/B/C/D33-68[»]
2NLDX-ray1.49A/B33-68[»]
2NLEX-ray1.35A/B33-68[»]
2NLFX-ray1.45A/B33-68[»]
2NLGX-ray1.65A/B/C/D33-68[»]
2NLHX-ray1.85A/B/C/D33-68[»]
2NLPX-ray1.85A/B/C/D33-68[»]
2NLQX-ray1.80A/B/C/D33-68[»]
2NLSX-ray0.98A33-68[»]
2PLZX-ray1.36A33-68[»]
ProteinModelPortaliP60022
SMRiP60022
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108036, 9 interactors
IntActiP60022, 3 interactors
MINTiP60022
STRINGi9606.ENSP00000297439

Chemistry databases

BindingDBiP60022

Protein family/group databases

TCDBi1.C.85.1.1 the pore-forming -defensin (-defensin) family

Polymorphism and mutation databases

BioMutaiDEFB1
DMDMi38503374

Proteomic databases

PaxDbiP60022
PeptideAtlasiP60022
PRIDEiP60022
ProteomicsDBi57181

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1672
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297439; ENSP00000297439; ENSG00000164825
ENST00000642865; ENSP00000494448; ENSG00000284881
GeneIDi1672
KEGGihsa:1672
UCSCiuc003wqs.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1672
DisGeNETi1672
EuPathDBiHostDB:ENSG00000164825.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DEFB1
HGNCiHGNC:2766 DEFB1
MIMi602056 gene
neXtProtiNX_P60022
OpenTargetsiENSG00000164825
PharmGKBiPA27243

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J7H1 Eukaryota
ENOG41119QC LUCA
GeneTreeiENSGT00390000017014
HOGENOMiHOG000112188
HOVERGENiHBG084156
InParanoidiP60022
OMAiNRIEGTC
OrthoDBi1584343at2759
PhylomeDBiP60022

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Miscellaneous databases

EvolutionaryTraceiP60022

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Defensin,_beta_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1672
PMAP-CutDBiP60022

Protein Ontology

More...
PROi
PR:P60022

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164825 Expressed in 160 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_DEFB1
GenevisibleiP60022 HS

Family and domain databases

InterProiView protein in InterPro
IPR001855 Defensin_beta-typ
PfamiView protein in Pfam
PF00711 Defensin_beta, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDEFB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60022
Secondary accession number(s): Q09753
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: November 21, 2003
Last modified: January 16, 2019
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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