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Protein

Probable G-protein coupled receptor 34

Gene

GPR34

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Orphan receptor.

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 34
Gene namesi
Name:GPR34
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 61ExtracellularSequence analysisAdd BLAST61
Transmembranei62 – 82Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini83 – 88CytoplasmicSequence analysis6
Transmembranei89 – 109Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini110 – 128ExtracellularSequence analysisAdd BLAST19
Transmembranei129 – 149Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini150 – 171CytoplasmicSequence analysisAdd BLAST22
Transmembranei172 – 192Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini193 – 216ExtracellularSequence analysisAdd BLAST24
Transmembranei217 – 237Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini238 – 269CytoplasmicSequence analysisAdd BLAST32
Transmembranei270 – 290Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini291 – 310ExtracellularSequence analysisAdd BLAST20
Transmembranei311 – 331Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini332 – 381CytoplasmicSequence analysisAdd BLAST50

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695621 – 381Probable G-protein coupled receptor 34Add BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi127 ↔ 204PROSITE-ProRule annotation
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP60019

Expressioni

Gene expression databases

BgeeiENSPTRG00000021813 Expressed in 5 organ(s), highest expression level in heart

Structurei

3D structure databases

ProteinModelPortaliP60019
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH53 Eukaryota
ENOG410ZHRR LUCA
HOGENOMiHOG000039982
HOVERGENiHBG063715
InParanoidiP60019
KOiK08383
OMAiNEIMLVF
OrthoDBiEOG091G0DKA
TreeFamiTF330969

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P60019-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSHTITMTT TSVSSWPYSS HRMRFITNHS DQPPQNFSAT PNVTTCPMDE
60 70 80 90 100
KLLSTVLTTS YSVIFIVGLV GNIIALYVFL GIHRKRNSIQ IYLLNVAIAD
110 120 130 140 150
LLLIFCLPFR IMYHINQNKW TLGVILCKVV GTLFYMNMYI SIILLGFISL
160 170 180 190 200
DRYIKINRSI QQRKAITTKQ SIYVCCIVWM LALGGFLTMI ILTLKKGGHN
210 220 230 240 250
STMCFHYRDK HNAKGEAIFN FILVVMFWLI FLLIILSYIK IGKNLLRISK
260 270 280 290 300
RRSKFPNSGK YATTARNSFI VLIIFTICFV PYHAFRFIYI SSQLNVSSCY
310 320 330 340 350
WKEIVHKTNE IMLVLSSFNS CLDPVMYFLM SSNIRKIMCQ LLFRRFQGEP
360 370 380
SRSESTSEFK PGYSLHDTSV AVKIQSSSKS T
Length:381
Mass (Da):43,860
Last modified:November 21, 2003 - v1
Checksum:i491FC016E5624379
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY241084 Genomic DNA Translation: AAP04293.1
RefSeqiNP_001009135.1, NM_001009135.3
XP_009437233.1, XM_009438958.2
XP_009437234.1, XM_009438959.2
XP_009437235.1, XM_009438960.2
XP_009437236.1, XM_009438961.2
XP_016798134.1, XM_016942645.1
UniGeneiPtr.6306

Genome annotation databases

GeneIDi473572
KEGGiptr:473572

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY241084 Genomic DNA Translation: AAP04293.1
RefSeqiNP_001009135.1, NM_001009135.3
XP_009437233.1, XM_009438958.2
XP_009437234.1, XM_009438959.2
XP_009437235.1, XM_009438960.2
XP_009437236.1, XM_009438961.2
XP_016798134.1, XM_016942645.1
UniGeneiPtr.6306

3D structure databases

ProteinModelPortaliP60019
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP60019

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi473572
KEGGiptr:473572

Organism-specific databases

CTDi2857

Phylogenomic databases

eggNOGiENOG410IH53 Eukaryota
ENOG410ZHRR LUCA
HOGENOMiHOG000039982
HOVERGENiHBG063715
InParanoidiP60019
KOiK08383
OMAiNEIMLVF
OrthoDBiEOG091G0DKA
TreeFamiTF330969

Gene expression databases

BgeeiENSPTRG00000021813 Expressed in 5 organ(s), highest expression level in heart

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPR34_PANTR
AccessioniPrimary (citable) accession number: P60019
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: November 21, 2003
Last modified: September 12, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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