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Protein

Keratin-associated protein 10-10

Gene

KRTAP10-10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 10-10
Alternative name(s):
High sulfur keratin-associated protein 10.10
Keratin-associated protein 10.10
Keratin-associated protein 18-10
Keratin-associated protein 18.10
Gene namesi
Name:KRTAP10-10
Synonyms:KAP10.10, KAP18-10, KRTAP10.10, KRTAP18-1, KRTAP18.10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000221859.2
HGNCiHGNC:22972 KRTAP10-10
neXtProtiNX_P60014

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000221859
PharmGKBiPA134906562

Polymorphism and mutation databases

BioMutaiKRTAP10-10
DMDMi38372286

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001852181 – 251Keratin-associated protein 10-10Add BLAST251

Proteomic databases

PaxDbiP60014
PeptideAtlasiP60014
PRIDEiP60014
ProteomicsDBi57180

PTM databases

iPTMnetiP60014
PhosphoSitePlusiP60014

Expressioni

Tissue specificityi

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

Gene expression databases

BgeeiENSG00000221859
CleanExiHS_KRTAP10-10

Interactioni

Subunit structurei

Interacts with hair keratins.

Protein-protein interaction databases

IntActiP60014, 21 interactors
STRINGi9606.ENSP00000369438

Structurei

3D structure databases

ProteinModelPortaliP60014
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati26 – 3015
Repeati31 – 3525
Repeati52 – 5635
Repeati84 – 8845
Repeati94 – 9855
Repeati99 – 10365
Repeati104 – 10976
Repeati126 – 13085
Repeati136 – 14095
Repeati146 – 150105
Repeati168 – 172115
Repeati178 – 182125
Repeati183 – 187135
Repeati202 – 206145
Repeati220 – 224155

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 22415 X 5 AA repeats of C-C-X(3)Add BLAST199

Sequence similaritiesi

Belongs to the KRTAP type 10 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4726 Eukaryota
ENOG410XY8D LUCA
GeneTreeiENSGT00880000137966
HOGENOMiHOG000234031
HOVERGENiHBG108072
InParanoidiP60014
OMAiSECAGNC
OrthoDBiEOG091G17RC
PhylomeDBiP60014
TreeFamiTF351356

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
PANTHERiPTHR23262 PTHR23262, 3 hits
PfamiView protein in Pfam
PF13885 Keratin_B2_2, 1 hit

Sequencei

Sequence statusi: Complete.

P60014-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASTMSICS SACTDSWRVV DCPESCCEPC CCAPAPSLTL VCTPVSCVSS
60 70 80 90 100
PCCQTACEPS ACQSGYTSSC TTPCYQQSSC QPDCCTSSPC QQACCVPVCC
110 120 130 140 150
VPVCCVPVCN KPVCFVPTCS ESSPSCCQQS SCQPTCCTSS PCQQACCVPV
160 170 180 190 200
CSKSVCYVPV CSGASTSCCQ QSSCQPACCT ASCCRPSSSV SLLCHPVCKS
210 220 230 240 250
TCCVPVPSCG ASASSCQPSC CRTASCVSLL CRPVCSRPAC YSLCSGQKSS

C
Length:251
Mass (Da):25,571
Last modified:November 14, 2003 - v1
Checksum:iA128CDBB45B74962
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05346320V → D. Corresponds to variant dbSNP:rs2838602Ensembl.1
Natural variantiVAR_01775572T → P1 PublicationCorresponds to variant dbSNP:rs4818947Ensembl.1
Natural variantiVAR_06005386T → S. Corresponds to variant dbSNP:rs9306109Ensembl.1
Natural variantiVAR_062114116V → M. Corresponds to variant dbSNP:rs60500206Ensembl.1
Natural variantiVAR_060054126C → S. Corresponds to variant dbSNP:rs4818948Ensembl.1
Natural variantiVAR_060055129Q → P. Corresponds to variant dbSNP:rs4818949Ensembl.1
Natural variantiVAR_053464158V → M. Corresponds to variant dbSNP:rs4818950Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076358 mRNA Translation: BAD01545.1
AJ566387 mRNA Translation: CAD97467.1
AL773602 Genomic DNA No translation available.
CCDSiCCDS33585.1
RefSeqiNP_859016.1, NM_181688.2
UniGeneiHs.474001

Genome annotation databases

EnsembliENST00000380095; ENSP00000369438; ENSG00000221859
GeneIDi353333
KEGGihsa:353333
UCSCiuc002zfq.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKR10A_HUMAN
AccessioniPrimary (citable) accession number: P60014
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: November 14, 2003
Last modified: July 18, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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