UniProtKB - P60008 (HILS1_HUMAN)
Protein
Putative spermatid-specific linker histone H1-like protein
Gene
H1-9P
Organism
Homo sapiens (Human)
Status
Functioni
DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa.By similarity
Caution
Could be the product of a pseudogene. However, mouse (AC Q9QYL0) and rat (AC D3ZZW6) orthologs encode functional proteins.1 Publication
GO - Molecular functioni
- double-stranded DNA binding Source: GO_Central
- histone binding Source: UniProtKB
- nucleic acid binding Source: UniProtKB
- nucleosomal DNA binding Source: GO_Central
GO - Biological processi
- chromatin remodeling Source: UniProtKB
- chromatin silencing Source: UniProtKB
- chromosome condensation Source: UniProtKB
- germ cell development Source: UniProtKB
- multicellular organism development Source: UniProtKB-KW
- negative regulation of chromatin silencing Source: GO_Central
- negative regulation of DNA recombination Source: GO_Central
- nucleosome assembly Source: InterPro
- nucleosome positioning Source: GO_Central
- regulation of transcription, DNA-templated Source: GO_Central
- spermatogenesis Source: UniProtKB
Keywordsi
Molecular function | Chromatin regulator, Developmental protein, DNA-binding |
Biological process | Differentiation, Spermatogenesis, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P60008 |
Names & Taxonomyi
Protein namesi | Recommended name: Putative spermatid-specific linker histone H1-like proteinCuratedAlternative name(s): H1.9 linker histone pseudogeneImported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30616, H1-9P |
MIMi | 608101, gene |
neXtProti | NX_P60008 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Other locations
- Chromosome PROSITE-ProRule annotation
Nucleus
- male germ cell nucleus Source: UniProtKB
- nucleus Source: GO_Central
Other locations
- nucleosome Source: UniProtKB
Keywords - Cellular componenti
Chromosome, NucleusPathology & Biotechi
Miscellaneous databases
Pharosi | P60008, Tbio |
Genetic variation databases
BioMutai | HGNC:30616 |
DMDMi | 38372285 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000196014 | 1 – 231 | Putative spermatid-specific linker histone H1-like proteinAdd BLAST | 231 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 135 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | P60008 |
PRIDEi | P60008 |
ProteomicsDBi | 57179 |
PTM databases
iPTMneti | P60008 |
PhosphoSitePlusi | P60008 |
Expressioni
Tissue specificityi
Expressed exclusively in the testis.1 Publication
Interactioni
GO - Molecular functioni
- histone binding Source: UniProtKB
Protein-protein interaction databases
IntActi | P60008, 1 interactor |
Miscellaneous databases
RNActi | P60008, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 113 – 177 | H15PROSITE-ProRule annotationAdd BLAST | 65 |
Sequence similaritiesi
Belongs to the histone H1/H5 family.PROSITE-ProRule annotation
Phylogenomic databases
InParanoidi | P60008 |
PhylomeDBi | P60008 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR005818, Histone_H1/H5_H15 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00538, Linker_histone, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS51504, H15, 1 hit |
i Sequence
Sequence statusi: Complete.
P60008-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLHASTIWHL RSTPPRRKQW GHCDPHRILV ASEVTTEITS PTPAPRAQVC
60 70 80 90 100
GGQPWVTVLD PLSGHTGREA ERHFATVSIS AVELKYCHGW RPAGQRVPSK
110 120 130 140 150
TATGQRTCAK PCQKPSTSKV ILRAVADKGT CKYVSLATLK KAVSTTGYDM
160 170 180 190 200
ARNAYHFKRV LKGLVDKGSA GSFTLGKKQA SKSKLKVKRQ RQQRWRSGQR
210 220 230
PFGQHRSLLG SKQGHKRLIK GVRRVAKCHC N
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY286318 mRNA Translation: AAQ23050.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY286318 mRNA Translation: AAQ23050.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | P60008, 1 interactor |
PTM databases
iPTMneti | P60008 |
PhosphoSitePlusi | P60008 |
Genetic variation databases
BioMutai | HGNC:30616 |
DMDMi | 38372285 |
Proteomic databases
MassIVEi | P60008 |
PRIDEi | P60008 |
ProteomicsDBi | 57179 |
Organism-specific databases
GeneCardsi | H1-9P |
HGNCi | HGNC:30616, H1-9P |
MIMi | 608101, gene |
neXtProti | NX_P60008 |
GenAtlasi | Search... |
Phylogenomic databases
InParanoidi | P60008 |
PhylomeDBi | P60008 |
Enzyme and pathway databases
PathwayCommonsi | P60008 |
Miscellaneous databases
Pharosi | P60008, Tbio |
PROi | PR:P60008 |
RNActi | P60008, protein |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR005818, Histone_H1/H5_H15 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00538, Linker_histone, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS51504, H15, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HILS1_HUMAN | |
Accessioni | P60008Primary (citable) accession number: P60008 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 14, 2003 |
Last sequence update: | November 14, 2003 | |
Last modified: | December 2, 2020 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families