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Entry version 128 (31 Jul 2019)
Sequence version 1 (14 Nov 2003)
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Protein

Anaphase-promoting complex subunit 15

Gene

ANAPC15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-HSA-176412 Phosphorylation of the APC/C
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anaphase-promoting complex subunit 15
Short name:
APC15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANAPC15
Synonyms:C11orf51
ORF Names:HSPC020
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24531 ANAPC15

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614717 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P60006

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
25906

Open Targets

More...
OpenTargetsi
ENSG00000110200

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485346

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANAPC15

Domain mapping of disease mutations (DMDM)

More...
DMDMi
38372627

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000840721 – 121Anaphase-promoting complex subunit 15Add BLAST121

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P60006

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P60006

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P60006

PeptideAtlas

More...
PeptideAtlasi
P60006

PRoteomics IDEntifications database

More...
PRIDEi
P60006

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57178 [P60006-1]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110200 Expressed in 216 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P60006 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P60006 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036596

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5.

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117412, 50 interactors

Database of interacting proteins

More...
DIPi
DIP-61021N

Protein interaction database and analysis system

More...
IntActi
P60006, 45 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000439403

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1121
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P60006

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi63 – 117Asp-richAdd BLAST55

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the APC15 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J0F5 Eukaryota
ENOG410Y01T LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000938

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000026787

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P60006

Database of Orthologous Groups

More...
OrthoDBi
1412795at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P60006

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026182 ANAPC15

The PANTHER Classification System

More...
PANTHERi
PTHR22526 PTHR22526, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15243 ANAPC15, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P60006-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTLFPSLFP RVTETLWFNL DRPCVEETEL QQQEQQHQAW LQSIAEKDNN
60 70 80 90 100
LVPIGKPASE HYDDEEEEDD EDDEDSEEDS EDDEDMQDMD EMNDYNESPD
110 120
DGEVNEVDME GNEQDQDQWM I
Length:121
Mass (Da):14,281
Last modified:November 14, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C889607C3013A82
GO
Isoform 2 (identifier: P60006-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-106: E → EPPLQ

Note: No experimental confimation available.
Show »
Length:125
Mass (Da):14,716
Checksum:iBCDB1E98984878D3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WDQ6F8WDQ6_HUMAN
Anaphase-promoting complex subunit ...
ANAPC15
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H6E4F5H6E4_HUMAN
Anaphase-promoting complex subunit ...
ANAPC15
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5EA39G5EA39_HUMAN
Anaphase-promoting complex subunit ...
ANAPC15 C11orf51, hCG_23235
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H3R3F5H3R3_HUMAN
Anaphase-promoting complex subunit ...
ANAPC15
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H2T3F5H2T3_HUMAN
Anaphase-promoting complex subunit ...
ANAPC15
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GXB9F5GXB9_HUMAN
Anaphase-promoting complex subunit ...
ANAPC15
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GWM6F5GWM6_HUMAN
Anaphase-promoting complex subunit ...
ANAPC15
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence EAW74842 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti73D → G in AK222622 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055048106E → EPPLQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF077206 mRNA Translation: AAD27001.1
AL080071 mRNA Translation: CAB45698.1
AK222622 mRNA No translation available.
AP000812 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74842.1 Sequence problems.
BC005156 mRNA Translation: AAH05156.1
BC005393 mRNA Translation: AAH05393.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS60880.1 [P60006-2]
CCDS8210.1 [P60006-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T12467

NCBI Reference Sequences

More...
RefSeqi
NP_001265414.1, NM_001278485.1 [P60006-2]
NP_001265415.1, NM_001278486.1 [P60006-2]
NP_001265416.1, NM_001278487.1 [P60006-1]
NP_001265417.1, NM_001278488.1 [P60006-1]
NP_001265418.1, NM_001278489.1 [P60006-1]
NP_001265419.1, NM_001278490.1 [P60006-1]
NP_001265420.1, NM_001278491.1 [P60006-1]
NP_001265421.1, NM_001278492.1 [P60006-1]
NP_001265422.1, NM_001278493.1 [P60006-1]
NP_001265423.1, NM_001278494.1 [P60006-1]
NP_054761.1, NM_014042.2 [P60006-1]
XP_016872985.1, XM_017017496.1 [P60006-1]
XP_016872986.1, XM_017017497.1 [P60006-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000227618; ENSP00000227618; ENSG00000110200 [P60006-1]
ENST00000535234; ENSP00000446412; ENSG00000110200 [P60006-1]
ENST00000535503; ENSP00000443383; ENSG00000110200 [P60006-1]
ENST00000538393; ENSP00000440002; ENSG00000110200 [P60006-1]
ENST00000538919; ENSP00000440983; ENSG00000110200 [P60006-1]
ENST00000542531; ENSP00000443911; ENSG00000110200 [P60006-1]
ENST00000543587; ENSP00000439403; ENSG00000110200 [P60006-2]
ENST00000545680; ENSP00000443645; ENSG00000110200 [P60006-2]
ENST00000545944; ENSP00000446383; ENSG00000110200 [P60006-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25906

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25906

UCSC genome browser

More...
UCSCi
uc001orv.5 human [P60006-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077206 mRNA Translation: AAD27001.1
AL080071 mRNA Translation: CAB45698.1
AK222622 mRNA No translation available.
AP000812 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74842.1 Sequence problems.
BC005156 mRNA Translation: AAH05156.1
BC005393 mRNA Translation: AAH05393.1
CCDSiCCDS60880.1 [P60006-2]
CCDS8210.1 [P60006-1]
PIRiT12467
RefSeqiNP_001265414.1, NM_001278485.1 [P60006-2]
NP_001265415.1, NM_001278486.1 [P60006-2]
NP_001265416.1, NM_001278487.1 [P60006-1]
NP_001265417.1, NM_001278488.1 [P60006-1]
NP_001265418.1, NM_001278489.1 [P60006-1]
NP_001265419.1, NM_001278490.1 [P60006-1]
NP_001265420.1, NM_001278491.1 [P60006-1]
NP_001265421.1, NM_001278492.1 [P60006-1]
NP_001265422.1, NM_001278493.1 [P60006-1]
NP_001265423.1, NM_001278494.1 [P60006-1]
NP_054761.1, NM_014042.2 [P60006-1]
XP_016872985.1, XM_017017496.1 [P60006-1]
XP_016872986.1, XM_017017497.1 [P60006-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UI9electron microscopy3.60D1-121[»]
5A31electron microscopy4.30D6-121[»]
5G04electron microscopy4.00D1-121[»]
5G05electron microscopy3.40D1-121[»]
5L9Telectron microscopy6.40D1-121[»]
5L9Uelectron microscopy6.40D1-121[»]
5LCWelectron microscopy4.00D1-121[»]
SMRiP60006
ModBaseiSearch...

Protein-protein interaction databases

BioGridi117412, 50 interactors
DIPiDIP-61021N
IntActiP60006, 45 interactors
STRINGi9606.ENSP00000439403

Polymorphism and mutation databases

BioMutaiANAPC15
DMDMi38372627

Proteomic databases

EPDiP60006
MaxQBiP60006
PaxDbiP60006
PeptideAtlasiP60006
PRIDEiP60006
ProteomicsDBi57178 [P60006-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
25906
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000227618; ENSP00000227618; ENSG00000110200 [P60006-1]
ENST00000535234; ENSP00000446412; ENSG00000110200 [P60006-1]
ENST00000535503; ENSP00000443383; ENSG00000110200 [P60006-1]
ENST00000538393; ENSP00000440002; ENSG00000110200 [P60006-1]
ENST00000538919; ENSP00000440983; ENSG00000110200 [P60006-1]
ENST00000542531; ENSP00000443911; ENSG00000110200 [P60006-1]
ENST00000543587; ENSP00000439403; ENSG00000110200 [P60006-2]
ENST00000545680; ENSP00000443645; ENSG00000110200 [P60006-2]
ENST00000545944; ENSP00000446383; ENSG00000110200 [P60006-1]
GeneIDi25906
KEGGihsa:25906
UCSCiuc001orv.5 human [P60006-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
25906
DisGeNETi25906

GeneCards: human genes, protein and diseases

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GeneCardsi
ANAPC15
HGNCiHGNC:24531 ANAPC15
HPAiHPA036596
MIMi614717 gene
neXtProtiNX_P60006
OpenTargetsiENSG00000110200
PharmGKBiPA143485346

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J0F5 Eukaryota
ENOG410Y01T LUCA
GeneTreeiENSGT00390000000938
HOGENOMiHOG000026787
InParanoidiP60006
OrthoDBi1412795at2759
PhylomeDBiP60006

Enzyme and pathway databases

ReactomeiR-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-HSA-176412 Phosphorylation of the APC/C
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ANAPC15 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
25906

Protein Ontology

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PROi
PR:P60006

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000110200 Expressed in 216 organ(s), highest expression level in testis
ExpressionAtlasiP60006 baseline and differential
GenevisibleiP60006 HS

Family and domain databases

InterProiView protein in InterPro
IPR026182 ANAPC15
PANTHERiPTHR22526 PTHR22526, 1 hit
PfamiView protein in Pfam
PF15243 ANAPC15, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPC15_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60006
Secondary accession number(s): G3V1Q3, Q9CXK2, Q9Y269
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: November 14, 2003
Last modified: July 31, 2019
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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