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Protein

Transcription elongation factor 1 homolog

Gene

ELOF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi26ZincBy similarity1
Metal bindingi29ZincBy similarity1
Metal bindingi50ZincBy similarity1
Metal bindingi53ZincBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II complex binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor 1 homolog
Gene namesi
Name:ELOF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130165.10
HGNCiHGNC:28691 ELOF1
neXtProtiNX_P60002

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84337
OpenTargetsiENSG00000130165
PharmGKBiPA142671911

Polymorphism and mutation databases

BioMutaiELOF1
DMDMi38372864

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001209411 – 83Transcription elongation factor 1 homologAdd BLAST83

Proteomic databases

EPDiP60002
MaxQBiP60002
PaxDbiP60002
PeptideAtlasiP60002
PRIDEiP60002
ProteomicsDBi57177

PTM databases

iPTMnetiP60002
PhosphoSitePlusiP60002

Expressioni

Gene expression databases

BgeeiENSG00000130165 Expressed in 199 organ(s), highest expression level in left testis
CleanExiHS_ELOF1
ExpressionAtlasiP60002 baseline and differential
GenevisibleiP60002 HS

Organism-specific databases

HPAiHPA045606

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
C5orf22Q49AR23EBI-714648,EBI-746224

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124061, 9 interactors
IntActiP60002, 7 interactors
MINTiP60002
STRINGi9606.ENSP00000252445

Structurei

3D structure databases

ProteinModelPortaliP60002
SMRiP60002
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ELOF1 family.Curated

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3214 Eukaryota
COG4888 LUCA
GeneTreeiENSGT00390000000053
HOVERGENiHBG024628
InParanoidiP60002
PhylomeDBiP60002
TreeFamiTF313731

Family and domain databases

Gene3Di2.20.25.190, 1 hit
InterProiView protein in InterPro
IPR007808 Elf1
IPR038567 T_Elf1_sf
PANTHERiPTHR20934 PTHR20934, 1 hit
PfamiView protein in Pfam
PF05129 Elf1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P60002-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRRKSKRKP PPKKKMTGTL ETQFTCPFCN HEKSCDVKMD RARNTGVISC
60 70 80
TVCLEEFQTP ITYLSEPVDV YSDWIDACEA ANQ
Length:83
Mass (Da):9,462
Last modified:November 14, 2003 - v1
Checksum:i77F11EFBEC72AC6F
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A024R7E8A0A024R7E8_HUMAN
Transcription elongation factor 1 h...
ELOF1 hCG_29982
104Annotation score:
K7EPC8K7EPC8_HUMAN
Transcription elongation factor 1 h...
ELOF1
90Annotation score:
K7EN05K7EN05_HUMAN
Transcription elongation factor 1 h...
ELOF1
76Annotation score:
K7EMV4K7EMV4_HUMAN
Transcription elongation factor 1 h...
ELOF1
120Annotation score:
K7EQ44K7EQ44_HUMAN
Transcription elongation factor 1 h...
ELOF1
114Annotation score:
K7EL94K7EL94_HUMAN
Transcription elongation factor 1 h...
ELOF1
14Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007516 mRNA Translation: AAH07516.1
CCDSiCCDS12264.1
RefSeqiNP_115753.1, NM_032377.3
XP_016882847.1, XM_017027358.1
XP_016882848.1, XM_017027359.1
UniGeneiHs.631633

Genome annotation databases

EnsembliENST00000252445; ENSP00000252445; ENSG00000130165
ENST00000586120; ENSP00000467914; ENSG00000130165
ENST00000590700; ENSP00000467264; ENSG00000130165
GeneIDi84337
KEGGihsa:84337
UCSCiuc002mse.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007516 mRNA Translation: AAH07516.1
CCDSiCCDS12264.1
RefSeqiNP_115753.1, NM_032377.3
XP_016882847.1, XM_017027358.1
XP_016882848.1, XM_017027359.1
UniGeneiHs.631633

3D structure databases

ProteinModelPortaliP60002
SMRiP60002
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124061, 9 interactors
IntActiP60002, 7 interactors
MINTiP60002
STRINGi9606.ENSP00000252445

PTM databases

iPTMnetiP60002
PhosphoSitePlusiP60002

Polymorphism and mutation databases

BioMutaiELOF1
DMDMi38372864

Proteomic databases

EPDiP60002
MaxQBiP60002
PaxDbiP60002
PeptideAtlasiP60002
PRIDEiP60002
ProteomicsDBi57177

Protocols and materials databases

DNASUi84337
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252445; ENSP00000252445; ENSG00000130165
ENST00000586120; ENSP00000467914; ENSG00000130165
ENST00000590700; ENSP00000467264; ENSG00000130165
GeneIDi84337
KEGGihsa:84337
UCSCiuc002mse.1 human

Organism-specific databases

CTDi84337
DisGeNETi84337
EuPathDBiHostDB:ENSG00000130165.10
GeneCardsiELOF1
HGNCiHGNC:28691 ELOF1
HPAiHPA045606
neXtProtiNX_P60002
OpenTargetsiENSG00000130165
PharmGKBiPA142671911
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3214 Eukaryota
COG4888 LUCA
GeneTreeiENSGT00390000000053
HOVERGENiHBG024628
InParanoidiP60002
PhylomeDBiP60002
TreeFamiTF313731

Miscellaneous databases

ChiTaRSiELOF1 human
GenomeRNAii84337
PROiPR:P60002

Gene expression databases

BgeeiENSG00000130165 Expressed in 199 organ(s), highest expression level in left testis
CleanExiHS_ELOF1
ExpressionAtlasiP60002 baseline and differential
GenevisibleiP60002 HS

Family and domain databases

Gene3Di2.20.25.190, 1 hit
InterProiView protein in InterPro
IPR007808 Elf1
IPR038567 T_Elf1_sf
PANTHERiPTHR20934 PTHR20934, 1 hit
PfamiView protein in Pfam
PF05129 Elf1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiELOF1_HUMAN
AccessioniPrimary (citable) accession number: P60002
Secondary accession number(s): Q8R1J7, Q96II4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: November 14, 2003
Last modified: October 10, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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