Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Keratin-associated protein 12-1

Gene

KRTAP12-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 12-1
Alternative name(s):
High sulfur keratin-associated protein 12.1
Keratin-associated protein 12.1
Gene namesi
Name:KRTAP12-1
Synonyms:KAP12.1, KRTAP12.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000187175.5
HGNCiHGNC:20529 KRTAP12-1
neXtProtiNX_P59990

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134971238

Polymorphism and mutation databases

BioMutaiKRTAP12-1
DMDMi38257913

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001851961 – 96Keratin-associated protein 12-1Add BLAST96

Proteomic databases

PaxDbiP59990
PeptideAtlasiP59990
PRIDEiP59990
ProteomicsDBi57174

Expressioni

Tissue specificityi

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

Gene expression databases

BgeeiENSG00000187175 Expressed in 14 organ(s), highest expression level in heart
CleanExiHS_KRTAP12-1

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

Protein-protein interaction databases

BioGridi131687, 12 interactors
IntActiP59990, 58 interactors
STRINGi9606.ENSP00000375475

Structurei

3D structure databases

ProteinModelPortaliP59990
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati10 – 1415
Repeati15 – 1925
Repeati24 – 2835
Repeati30 – 3445
Repeati35 – 3955
Repeati45 – 4965
Repeati50 – 5475
Repeati55 – 5985
Repeati60 – 6495
Repeati70 – 74105
Repeati75 – 79115
Repeati80 – 84125
Repeati85 – 89135
Repeati90 – 94145

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni10 – 9414 X 5 AA approximate repeatsAdd BLAST85

Sequence similaritiesi

Belongs to the KRTAP type 12 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4726 Eukaryota
ENOG410XY8D LUCA
GeneTreeiENSGT00720000108835
HOGENOMiHOG000234031
HOVERGENiHBG095457
InParanoidiP59990
OMAiFKPAVCV
PhylomeDBiP59990
TreeFamiTF339135

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
PANTHERiPTHR23262 PTHR23262, 1 hit
PfamiView protein in Pfam
PF13885 Keratin_B2_2, 1 hit

Sequencei

Sequence statusi: Complete.

P59990-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCHTSCSSGC QPACCAPSPC QASCYIPVGC QSSVCVPVSF KPAVCVPVRC
60 70 80 90
QSSVCVPVSC RPVVYAAPSC QSSGCCQPSC TSVLCRPISC STPSCC
Length:96
Mass (Da):9,737
Last modified:November 7, 2003 - v1
Checksum:i9360F4462E1036C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076363 mRNA Translation: BAD01550.1
AJ566388 mRNA Translation: CAD97468.1
AL773604 Genomic DNA No translation available.
BC119713 mRNA Translation: AAI19714.1
BC120942 mRNA Translation: AAI20943.1
BC127648 mRNA Translation: AAI27649.1
CCDSiCCDS42966.1
RefSeqiNP_859014.1, NM_181686.1
UniGeneiHs.688628

Genome annotation databases

EnsembliENST00000391617; ENSP00000375475; ENSG00000187175
GeneIDi353332
KEGGihsa:353332
UCSCiuc002zfv.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076363 mRNA Translation: BAD01550.1
AJ566388 mRNA Translation: CAD97468.1
AL773604 Genomic DNA No translation available.
BC119713 mRNA Translation: AAI19714.1
BC120942 mRNA Translation: AAI20943.1
BC127648 mRNA Translation: AAI27649.1
CCDSiCCDS42966.1
RefSeqiNP_859014.1, NM_181686.1
UniGeneiHs.688628

3D structure databases

ProteinModelPortaliP59990
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131687, 12 interactors
IntActiP59990, 58 interactors
STRINGi9606.ENSP00000375475

Polymorphism and mutation databases

BioMutaiKRTAP12-1
DMDMi38257913

Proteomic databases

PaxDbiP59990
PeptideAtlasiP59990
PRIDEiP59990
ProteomicsDBi57174

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391617; ENSP00000375475; ENSG00000187175
GeneIDi353332
KEGGihsa:353332
UCSCiuc002zfv.3 human

Organism-specific databases

CTDi353332
EuPathDBiHostDB:ENSG00000187175.5
GeneCardsiKRTAP12-1
HGNCiHGNC:20529 KRTAP12-1
neXtProtiNX_P59990
PharmGKBiPA134971238
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4726 Eukaryota
ENOG410XY8D LUCA
GeneTreeiENSGT00720000108835
HOGENOMiHOG000234031
HOVERGENiHBG095457
InParanoidiP59990
OMAiFKPAVCV
PhylomeDBiP59990
TreeFamiTF339135

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Miscellaneous databases

GenomeRNAii353332
PROiPR:P59990

Gene expression databases

BgeeiENSG00000187175 Expressed in 14 organ(s), highest expression level in heart
CleanExiHS_KRTAP12-1

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
PANTHERiPTHR23262 PTHR23262, 1 hit
PfamiView protein in Pfam
PF13885 Keratin_B2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKR121_HUMAN
AccessioniPrimary (citable) accession number: P59990
Secondary accession number(s): Q0VAS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 7, 2003
Last modified: September 12, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again