UniProtKB - P59944 (KAX1D_LEIHE)
Protein
Potassium channel toxin alpha-KTx 1.13
Gene
N/A
Organism
Leiurus hebraeus (Deathstalker scorpion) (Leiurus quinquestriatus hebraeus)
Status
Functioni
Potent selective inhibitor of high conductance (maxi-K), different medium and small conductance calcium-activated potassium channels (KCa1.1/KCNMA1 and others), as well as a voltage-dependent potassium channel (Kv1.3/KCNA3>Kv1.2/KCNA2>Kv1.6/KCNA3>>Shaker/Sh). It blocks channel activity by a simple bimolecular inhibition process.By similarity
Has a pH-specific antimicrobial activity against bacteria (B.subtilis, E.coli and S.aureus) and the fungus C.albicans.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 27 | Basic residue of the functional dyadBy similarity | 1 | |
Sitei | 36 | Aromatic residue of the functional dyadBy similarity | 1 |
GO - Molecular functioni
- ion channel inhibitor activity Source: InterPro
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- defense response to bacterium Source: UniProtKB-KW
- defense response to fungus Source: UniProtKB-KW
- killing of cells of other organism Source: UniProtKB-KW
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Potassium channel toxin alpha-KTx 1.13Alternative name(s): Charybdotoxin c1 Publication Short name: ChTx-c1 Publication |
Organismi | Leiurus hebraeus (Deathstalker scorpion) (Leiurus quinquestriatus hebraeus) |
Taxonomic identifieri | 6884 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Leiurus › |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000044892 | 1 – 37 | Potassium channel toxin alpha-KTx 1.13Add BLAST | 37 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | Pyrrolidone carboxylic acidBy similarity | 1 | |
Disulfide bondi | 7 ↔ 28 | By similarity | ||
Disulfide bondi | 13 ↔ 33 | By similarity | ||
Disulfide bondi | 17 ↔ 35 | By similarity |
Keywords - PTMi
Disulfide bond, Pyrrolidone carboxylic acidExpressioni
Tissue specificityi
Expressed by the venom gland.Curated
Structurei
3D structure databases
ProteinModelPortali | P59944 |
SMRi | P59944 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 26 – 33 | Interaction with Ca(2+)-activated K(+) channelsSequence analysis | 8 |
Domaini
Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).By similarity
Sequence similaritiesi
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 01 subfamily.Curated
Family and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf IPR001947 Scorpion_toxinS_K_inh |
Pfami | View protein in Pfam PF00451 Toxin_2, 1 hit |
PRINTSi | PR00286 CHARYBDTOXIN |
ProDomi | View protein in ProDom or Entries sharing at least one domain PD003586 Scorpion_toxinS, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS01138 SCORP_SHORT_TOXIN, 1 hit |
i Sequence
Sequence statusi: Complete.
Similar proteinsi
Cross-referencesi
3D structure databases
ProteinModelPortali | P59944 |
SMRi | P59944 |
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf IPR001947 Scorpion_toxinS_K_inh |
Pfami | View protein in Pfam PF00451 Toxin_2, 1 hit |
PRINTSi | PR00286 CHARYBDTOXIN |
ProDomi | View protein in ProDom or Entries sharing at least one domain PD003586 Scorpion_toxinS, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS01138 SCORP_SHORT_TOXIN, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | KAX1D_LEIHE | |
Accessioni | P59944Primary (citable) accession number: P59944 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2003 |
Last sequence update: | October 31, 2003 | |
Last modified: | December 5, 2018 | |
This is version 52 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries - SIMILARITY comments
Index of protein domains and families