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Entry version 90 (17 Jun 2020)
Sequence version 1 (10 Oct 2003)
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Protein

Hemagglutinin A

Gene

hagA

Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Agglutinates erythrocytes.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHemagglutinin, Hydrolase, Protease, Thiol protease
Biological processVirulence

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PGIN242619:G1G02-1715-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hemagglutinin A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hagA
Ordered Locus Names:PG_1837
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri242619 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000588 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002653726 – 2164Hemagglutinin AAdd BLAST2139

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P59915

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
242619.PG_1837

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12164
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P59915

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P59915

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni26 – 539Peptidase C25-like 1Add BLAST514
Regioni540 – 991Peptidase C25-like 2Add BLAST452
Regioni992 – 1443Peptidase C25-like 3Add BLAST452

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C25 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG41061HS Bacteria
ENOG4112AJT LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_232326_0_0_10

KEGG Orthology (KO)

More...
KOi
K20276

Identification of Orthologs from Complete Genome Data

More...
OMAi
AFRHFGC

Database of Orthologous Groups

More...
OrthoDBi
1063831at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011628 Cleaved_adhesin
IPR003961 FN3_dom
IPR013783 Ig-like_fold
IPR018832 Pept_C25_gingipain_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07675 Cleaved_Adhesin, 8 hits
PF10365 DUF2436, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P59915-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKLNSLFSL AVLLSLLCWG QTAAAQGGPK TAPSVTHQAV QKGIRTSKAK
60 70 80 90 100
DLRDPIPAGM ARIILEAHDV WEDGTGYQML WDADHNQYGA SIPEESFWFA
110 120 130 140 150
NGTIPAGLYD PFEYKVPVNA DASFSPTNFV LDGTASADIP AGTYDYVIIN
160 170 180 190 200
PNPGIIYIVG EGVSKGNDYV VEAGKTYHFT VQRQGPGDAA SVVVTGEGGN
210 220 230 240 250
EFAPVQNLQW SVSGQTVTLT WQAPASDKRT YVLNESFDTQ TLPNGWTMID
260 270 280 290 300
ADGDGHNWLS TINVYNTATH TGDGAMFSKS WTASSGAKID LSPDNYLVTP
310 320 330 340 350
KFTVPENGKL SYWVSSQEPW TNEHYGVFLS TTGNEAANFT IKLLEETLGS
360 370 380 390 400
GKPAPMNLVK SEGVKAPAPY QERTIDLSAY AGQQVYLAFR HFGCTGIFRL
410 420 430 440 450
YLDDVAVSGE GSSNDYTYTV YRDNVVIAQN LTATTFNQEN VAPGQYNYCV
460 470 480 490 500
EVKYTAGVSP KVCKDVTVEG SNEFAPVQNL TGSAVGQKVT LKWDAPNGTP
510 520 530 540 550
NPNPGTTTLS ESFENGIPAS WKTIDADGDG NNWTTTPPPG GSSFAGHNSA
560 570 580 590 600
ICVSSASYIN FEGPQNPDNY LVTPELSLPN GGTLTFWVCA QDANYASEHY
610 620 630 640 650
AVYASSTGND ASNFANALLE EVLTAKTVVT APEAIRGTRV QGTWYQKTVQ
660 670 680 690 700
LPAGTKYVAF RHFGCTDFFW INLDDVEIKA NGKRADFTET FESSTHGEAP
710 720 730 740 750
AEWTTIDADG DGQGWLCLSS GQLGWLTAHG GTNVVASFSW NGMALNPDNY
760 770 780 790 800
LISKDVTGAT KVKYYYAVND GFPGDHYAVM ISKTGTNAGD FTVVFEETPN
810 820 830 840 850
GINKGGARFG LSTEANGAKP QSVWIERTVD LPAGTKYVAF RHYNCSDLNY
860 870 880 890 900
ILLDDIQFTM GGSPTPTDYT YTVYRDGTKI KEGLTETTFE EDGVATGNHE
910 920 930 940 950
YCVEVKYTAG VSPKECVNVT VDPVQFNPVQ NLTGSAVGQK VTLKWDAPNG
960 970 980 990 1000
TPNPNPGTTT LSESFENGIP ASWKTIDADG DGNNWTTTPP PGGTSFAGHN
1010 1020 1030 1040 1050
SAICVSSASY INFEGPQNPD NYLVTPELSL PNGGTLTFWV CAQDANYASE
1060 1070 1080 1090 1100
HYAVYASSTG NDASNFANAL LEEVLTAKTV VTAPEAIRGT RVQGTWYQKT
1110 1120 1130 1140 1150
VQLPAGTKYV AFRHFGCTDF FWINLDDVEI KANGKRADFT ETFESSTHGE
1160 1170 1180 1190 1200
APAEWTTIDA DGDGQGWLCL SSGQLDWLTA HGGTNVVASF SWNGMALNPD
1210 1220 1230 1240 1250
NYLISKDVTG ATKVKYYYAV NDGFPGDHYA VMISKTGTNA GDFTVVFEET
1260 1270 1280 1290 1300
PNGINKGGAR FGLSTEANGA KPQSVWIERT VDLPAGTKYV AFRHYNCSDL
1310 1320 1330 1340 1350
NYILLDDIQF TMGGSPTPTD YTYTVYRDGT KIKEGLTETT FEEDGVATGN
1360 1370 1380 1390 1400
HEYCVEVKYT AGVSPKECVN VTVDPVQFNP VQNLTGSAVG QKVTLKWDAP
1410 1420 1430 1440 1450
NGTPNPNPGT TTLSESFENG IPASWKTIDA DGDGNNWTTT PPPGGTSFAG
1460 1470 1480 1490 1500
HNSAICVSSA SYINFEGPQN PDNYLVTPEL SLPNGGTLTF WVCAQDANYA
1510 1520 1530 1540 1550
SEHYAVYASS TGNDASNFAN ALLEEVLTAK TVVTAPEAIR GTRVQGTWYQ
1560 1570 1580 1590 1600
KTVQLPAGTK YVAFRHFGCT DFFWINLDDV EIKANGKRAD FTETFESSTH
1610 1620 1630 1640 1650
GEAPAEWTTI DADGDGQGWL CLSSGQLGWL TAHGGTNVVA SFSWNGMALN
1660 1670 1680 1690 1700
PDNYLISKDV TGATKVKYYY AVNDGFPGDH YAVMISKTGT NAGDFTVVFE
1710 1720 1730 1740 1750
ETPNGINKGG ARFGLSTEAN GAKPQSVWIE RTVDLPAGTK YVAFRHYNCS
1760 1770 1780 1790 1800
DLNYILLDDI QFTMGGSPTP TDYTYTVYRD GTKIKEGLTE TTFEEDGVAT
1810 1820 1830 1840 1850
GNHEYCVEVK YTAGVSPKEC VNVTINPTQF NPVQNLTAEQ APNSMDAILK
1860 1870 1880 1890 1900
WNAPASKRAE VLNEDFENGI PASWKTIDAD GDGNNWTTTP PPGGSSFAGH
1910 1920 1930 1940 1950
NSAICVSSAS YINFEGPQNP DNYLVTPELS LPGGGTLTFW VCAQDANYAS
1960 1970 1980 1990 2000
EHYAVYASST GNDASNFANA LLEEVLTAKT VVTAPEAIRG TRVQGTWYQK
2010 2020 2030 2040 2050
TVQLPAGTKY VAFRHFGCTD FFWINLDDVV ITSGNAPSYT YTIYRNNTQI
2060 2070 2080 2090 2100
ASGVTETTYR DPDLATGFYT YGVKVVYPNG ESAIETATLN ITSLADVTAQ
2110 2120 2130 2140 2150
KPYTLTVVGK TITVTCQGEA MIYDMNGRRL AAGRNTVVYT AQGGHYAVMV
2160
VVDGKSYVEK LAVK
Length:2,164
Mass (Da):233,389
Last modified:October 10, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6DFAB22832586C63
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ66831 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE015924 Genomic DNA Translation: AAQ66831.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
WP_043876452.1, NC_002950.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAQ66831; AAQ66831; PG_1837

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pgi:PG_1837

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|242619.8.peg.1698

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015924 Genomic DNA Translation: AAQ66831.1 Different initiation.
RefSeqiWP_043876452.1, NC_002950.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KM5X-ray1.40A/B1137-1314[»]
SMRiP59915
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi242619.PG_1837

Proteomic databases

PRIDEiP59915

Genome annotation databases

EnsemblBacteriaiAAQ66831; AAQ66831; PG_1837
KEGGipgi:PG_1837
PATRICifig|242619.8.peg.1698

Phylogenomic databases

eggNOGiENOG41061HS Bacteria
ENOG4112AJT LUCA
HOGENOMiCLU_232326_0_0_10
KOiK20276
OMAiAFRHFGC
OrthoDBi1063831at2

Enzyme and pathway databases

BioCyciPGIN242619:G1G02-1715-MONOMER

Miscellaneous databases

EvolutionaryTraceiP59915

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR011628 Cleaved_adhesin
IPR003961 FN3_dom
IPR013783 Ig-like_fold
IPR018832 Pept_C25_gingipain_C
PfamiView protein in Pfam
PF07675 Cleaved_Adhesin, 8 hits
PF10365 DUF2436, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHAGA1_PORGI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P59915
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: June 17, 2020
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Peptidase families
    Classification of peptidase families and list of entries
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