DNAJB13

Functionⁱ

Plays a role in the formation of the central complex of ciliary and flagellar axonemes.By similarity1 Publication

GO - Molecular functionⁱ

unfolded protein binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

axonemal central apparatus assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 27486783
protein folding Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone
Biological process	Cilium biogenesis/degradation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DnaJ homolog subfamily B member 13 Alternative name(s): Testis and spermatogenesis cell-related protein 6 Testis spermatocyte apoptosis-related gene 6 protein Testis spermatogenesis apoptosis-related gene 3 protein Testis spermatogenesis apoptosis-related gene 6 protein
Gene namesⁱ	Name:DNAJB13 Synonyms:TSARG3, TSARG6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000187726.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30718 DNAJB13
MIMⁱ	610263 gene
neXtProtⁱ	NX_P59910

Keywords - Cellular componentⁱ

Cell projection, Cilium, Flagellum

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Ciliary dyskinesia, primary, 34 (CILD34)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of primary ciliary dyskinesia, a disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. CILD34 inheritance is autosomal recessive.

Keywords - Diseaseⁱ

Ciliopathy, Disease mutation, Primary ciliary dyskinesia

Organism-specific databases

DisGeNET More...DisGeNETⁱ	374407
MalaCards human disease database More...MalaCardsⁱ	DNAJB13
MIMⁱ	617091 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000187726
PharmGKBⁱ	PA142671972

Polymorphism and mutation databases

BioMutaⁱ	DNAJB13
DMDMⁱ	41704179

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000071039	1 – 316	DnaJ homolog subfamily B member 13Add BLAST		316

Proteomic databases

PaxDbⁱ	P59910
PeptideAtlas More...PeptideAtlasⁱ	P59910
PRIDEⁱ	P59910
ProteomicsDBⁱ	57169 57170 [P59910-2]

PTM databases

iPTMnetⁱ	P59910
PhosphoSitePlusⁱ	P59910

Expressionⁱ

Tissue specificityⁱ

Specifically expressed in testis and trachea.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000187726
CleanExⁱ	HS_DNAJB13
ExpressionAtlasⁱ	P59910 baseline and differential
Genevisibleⁱ	P59910 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA052465 HPA061330

HPAⁱ

HPA052465
HPA061330

Interactionⁱ

Subunit structureⁱ

Homodimer (PubMed:27486783). Interacts with SUN5 (By similarity).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PB2	B4URF7	2	EBI-11514233,EBI-6050648	From Influenza A virus (strain A/Wilson-Smith/1933 H1N1).

With

Entry

#Exp.

IntAct

Notes

PB2

B4URF7

2

EBI-11514233,EBI-6050648

From Influenza A virus (strain A/Wilson-Smith/1933 H1N1).

GO - Molecular functionⁱ

unfolded protein binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	P59910, 14 interactors
Molecular INTeraction database More...MINTⁱ	P59910
STRINGⁱ	9606.ENSP00000344431

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P59910
SMRⁱ	P59910
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	4 – 68	JPROSITE-ProRule annotationAdd BLAST		65

Phylogenomic databases

eggNOGⁱ	KOG0714 Eukaryota COG0484 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118947
HOGENOMⁱ	HOG000226718
HOVERGENⁱ	HBG066727
InParanoidⁱ	P59910
KEGG Orthology (KO) More...KOⁱ	K09519
OMAⁱ	AMQKFRI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DLS
PhylomeDBⁱ	P59910
TreeFamⁱ	TF105141

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06257 DnaJ, 1 hit
Gene3Dⁱ	1.10.287.110, 1 hit
InterProⁱ	View protein in InterPro IPR002939 DnaJ_C IPR001623 DnaJ_domain IPR018253 DnaJ_domain_CS IPR008971 HSP40/DnaJ_pept-bd IPR036869 J_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00226 DnaJ, 1 hit PF01556 DnaJ_C, 1 hit
PRINTSⁱ	PR00625 JDOMAIN
SMARTⁱ	View protein in SMART SM00271 DnaJ, 1 hit
SUPFAMⁱ	SSF46565 SSF46565, 1 hit SSF49493 SSF49493, 2 hits
PROSITEⁱ	View protein in PROSITE PS00636 DNAJ_1, 1 hit PS50076 DNAJ_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: P59910-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQDYYSVLG ITRNSEDAQI KQAYRRLALK HHPLKSNEPS SAEIFRQIAE 
        60         70         80         90        100
AYDVLSDPMK RGIYDKFGEE GLKGGIPLEF GSQTPWTTGY VFHGKPEKVF 
       110        120        130        140        150
HEFFGGNNPF SEFFDAEGSE VDLNFGGLQG RGVKKQDPQV ERDLYLSLED 
       160        170        180        190        200
LFFGCTKKIK ISRRVLNEDG YSSTIKDKIL TIDVKPGWRQ GTRITFEKEG 
       210        220        230        240        250
DQGPNIIPAD IIFIVKEKLH PRFRRENDNL FFVNPIPLGK ALTCCTVEVR 
       260        270        280        290        300
TLDDRLLNIP INDIIHPKYF KKVPGEGMPL PEDPTKKGDL FIFFDIQFPT 
       310 
RLTPQKKQML RQALLT

Length:316

Mass (Da):36,118

Last modified:October 10, 2003 - v1

Checksum:ⁱ8251CB720724B7E5

GO

Isoform 2 (identifier: P59910-2) [UniParc]FASTA Add to basket

Also known as: TSARG5

The sequence of this isoform differs from the canonical sequence as follows:
1-175: Missing.
176-201: KDKILTIDVKPGWRQGTRITFEKEGD → METSRGRNLAKVTRPTSPCHLLASPA

« Hide

        10         20         30         40         50
METSRGRNLA KVTRPTSPCH LLASPAQGPN IIPADIIFIV KEKLHPRFRR 
        60         70         80         90        100
ENDNLFFVNP IPLGKALTCC TVEVRTLDDR LLNIPINDII HPKYFKKVPG 
       110        120        130        140 
EGMPLPEDPT KKGDLFIFFD IQFPTRLTPQ KKQMLRQALL T

Show »

Length:141

Mass (Da):16,085

Checksum:ⁱ8E9BCD598D26A1DC

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_077053	278	M → R in CILD34; loss of expression in patient cells; increased proteasome-mediated degradation; no effect on homodimerization. 1 PublicationCorresponds to variant dbSNP:rs754776389EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_008519	1 – 175	Missing in isoform 2. 1 PublicationAdd BLAST		175
Alternative sequenceⁱVSP_008520	176 – 201	KDKIL…EKEGD → METSRGRNLAKVTRPTSPCH LLASPA in isoform 2. 1 PublicationAdd BLAST		26

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF419291 mRNA Translation: AAN32702.1 Sequence problems. AF516185 mRNA Translation: AAP47195.1 AY138810 mRNA Translation: AAN15929.1 AY325766 mRNA Translation: AAQ17190.1 AP003717 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74920.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8227.1 [P59910-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_705842.2, NM_153614.3 [P59910-1]
UniGeneⁱ	Hs.567888

Genome annotation databases

Ensemblⁱ	ENST00000339764; ENSP00000344431; ENSG00000187726 [P59910-1] ENST00000537753; ENSP00000439711; ENSG00000187726 [P59910-2] ENST00000543947; ENSP00000438576; ENSG00000187726 [P59910-2]
GeneIDⁱ	374407
KEGGⁱ	hsa:374407
UCSC genome browser More...UCSCⁱ	uc001ouo.3 human [P59910-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P59910	UPI000C2A692B		Ugandan red Colobus		354
DnaJ heat shock protein family (Hsp40) member B13		PAPAN		316
DnaJ heat shock protein family (Hsp40) member B13		PANTR		316
DnaJ heat shock protein family (Hsp40) member B13		MANLE		316
UPI000274479A		PANPA		316
+13
P59910-2	DNAJB13 isoform 1		PONAB		141
Uncharacterized protein		COLAP		141
DnaJ heat shock protein family (Hsp40) member B13		PROCO		140
DnaJ heat shock protein family (Hsp40) member B13		CALJA		140

Protein	Similar proteins		Species	Score	Length
P59910	UPI000C2A692B		Ugandan red Colobus		354
DnaJ heat shock protein family (Hsp40) member B13		MACFA		316
Uncharacterized protein		MACMU		316
DnaJ heat shock protein family (Hsp40) member B13		PANTR		316
DnaJ heat shock protein family (Hsp40) member B13		MANLE		316
+159
P59910-2	DNAJB13 isoform 1		PONAB		141
Uncharacterized protein		COLAP		141
DnaJ heat shock protein family (Hsp40) member B13		PROCO		140
DnaJ heat shock protein family (Hsp40) member B13		CALJA		140
Uncharacterized protein		NOMLE		124

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF419291 mRNA Translation: AAN32702.1 Sequence problems. AF516185 mRNA Translation: AAP47195.1 AY138810 mRNA Translation: AAN15929.1 AY325766 mRNA Translation: AAQ17190.1 AP003717 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74920.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8227.1 [P59910-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_705842.2, NM_153614.3 [P59910-1]
UniGeneⁱ	Hs.567888

3D structure databases

ProteinModelPortalⁱ	P59910
SMRⁱ	P59910
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P59910, 14 interactors
Molecular INTeraction database More...MINTⁱ	P59910
STRINGⁱ	9606.ENSP00000344431

PTM databases

iPTMnetⁱ	P59910
PhosphoSitePlusⁱ	P59910

Polymorphism and mutation databases

BioMutaⁱ	DNAJB13
DMDMⁱ	41704179

Proteomic databases

PaxDbⁱ	P59910
PeptideAtlas More...PeptideAtlasⁱ	P59910
PRIDEⁱ	P59910
ProteomicsDBⁱ	57169 57170 [P59910-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	374407
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000339764; ENSP00000344431; ENSG00000187726 [P59910-1] ENST00000537753; ENSP00000439711; ENSG00000187726 [P59910-2] ENST00000543947; ENSP00000438576; ENSG00000187726 [P59910-2]
GeneIDⁱ	374407
KEGGⁱ	hsa:374407
UCSC genome browser More...UCSCⁱ	uc001ouo.3 human [P59910-1]

Organism-specific databases

CTDⁱ	374407
DisGeNET More...DisGeNETⁱ	374407
EuPathDBⁱ	HostDB:ENSG00000187726.8
GeneCardsⁱ	DNAJB13
H-InvDBⁱ	HIX0171374
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30718 DNAJB13
Human Protein Atlas More...HPAⁱ	HPA052465 HPA061330
MalaCards human disease database More...MalaCardsⁱ	DNAJB13
MIMⁱ	610263 gene 617091 phenotype
neXtProtⁱ	NX_P59910
Open Targets More...OpenTargetsⁱ	ENSG00000187726
PharmGKBⁱ	PA142671972
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0714 Eukaryota COG0484 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118947
HOGENOMⁱ	HOG000226718
HOVERGENⁱ	HBG066727
InParanoidⁱ	P59910
KEGG Orthology (KO) More...KOⁱ	K09519
OMAⁱ	AMQKFRI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DLS
PhylomeDBⁱ	P59910
TreeFamⁱ	TF105141

Miscellaneous databases

GenomeRNAiⁱ	374407
Protein Ontology More...PROⁱ	PR:P59910
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000187726
CleanExⁱ	HS_DNAJB13
ExpressionAtlasⁱ	P59910 baseline and differential
Genevisibleⁱ	P59910 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06257 DnaJ, 1 hit
Gene3Dⁱ	1.10.287.110, 1 hit
InterProⁱ	View protein in InterPro IPR002939 DnaJ_C IPR001623 DnaJ_domain IPR018253 DnaJ_domain_CS IPR008971 HSP40/DnaJ_pept-bd IPR036869 J_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00226 DnaJ, 1 hit PF01556 DnaJ_C, 1 hit
PRINTSⁱ	PR00625 JDOMAIN
SMARTⁱ	View protein in SMART SM00271 DnaJ, 1 hit
SUPFAMⁱ	SSF46565 SSF46565, 1 hit SSF49493 SSF49493, 2 hits
PROSITEⁱ	View protein in PROSITE PS00636 DNAJ_1, 1 hit PS50076 DNAJ_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DJB13_HUMAN
Accessionⁱ	P59910Primary (citable) accession number: P59910 Secondary accession number(s): B3LEP4, Q8IZW5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
	Last sequence update:	October 10, 2003
	Last modified:	July 18, 2018
	This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P59910 (DJB13_HUMAN)

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DnaJ homolog subfamily B member 13

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytoskeleton

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ