UniProtKB - P59901 (LIRA4_HUMAN)
Protein
Leukocyte immunoglobulin-like receptor subfamily A member 4
Gene
LILRA4
Organism
Homo sapiens (Human)
Status
Functioni
Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca2+ (PubMed:16735691, PubMed:19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760).4 Publications
GO - Molecular functioni
- coreceptor activity Source: UniProtKB
- signaling receptor binding Source: UniProtKB
GO - Biological processi
- Fc-epsilon receptor signaling pathway Source: UniProtKB
- innate immune response Source: UniProtKB-KW
- negative regulation of interferon-alpha production Source: UniProtKB
- negative regulation of toll-like receptor 7 signaling pathway Source: UniProtKB
- negative regulation of toll-like receptor 9 signaling pathway Source: UniProtKB
- negative regulation of tumor necrosis factor production Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Biological process | Immunity, Innate immunity |
Enzyme and pathway databases
PathwayCommonsi | P59901 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Names & Taxonomyi
Protein namesi | Recommended name: Leukocyte immunoglobulin-like receptor subfamily A member 4Alternative name(s): CD85 antigen-like family member G Immunoglobulin-like transcript 72 Publications Short name: ILT-72 Publications CD_antigen: CD85g |
Gene namesi | Name:LILRA4 Synonyms:ILT73 Publications |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15503, LILRA4 |
MIMi | 607517, gene |
neXtProti | NX_P59901 |
VEuPathDBi | HostDB:ENSG00000239961.2 |
Subcellular locationi
Plasma membrane
- Cell membrane 4 Publications; Single-pass type I membrane protein 4 Publications
Plasma Membrane
- Fc-epsilon receptor I complex Source: UniProtKB
- integral component of plasma membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 446 | ExtracellularSequence analysisAdd BLAST | 423 | |
Transmembranei | 447 – 467 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 468 – 499 | CytoplasmicSequence analysisAdd BLAST | 32 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 23547 |
PharmGKBi | PA142671546 |
Miscellaneous databases
Pharosi | P59901, Tbio |
Genetic variation databases
BioMutai | LILRA4 |
DMDMi | 288558815 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000014819 | 24 – 499 | Leukocyte immunoglobulin-like receptor subfamily A member 4Add BLAST | 476 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 49 ↔ 98 | PROSITE-ProRule annotation | ||
Glycosylationi | 138 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 143 ↔ 195 | PROSITE-ProRule annotation | ||
Glycosylationi | 239 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 244 ↔ 295 | PROSITE-ProRule annotation | ||
Glycosylationi | 279 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 300 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 344 ↔ 395 | PROSITE-ProRule annotation | ||
Modified residuei | 404 | 3'-nitrotyrosineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, NitrationProteomic databases
jPOSTi | P59901 |
MassIVEi | P59901 |
PaxDbi | P59901 |
PeptideAtlasi | P59901 |
PRIDEi | P59901 |
ProteomicsDBi | 57167 [P59901-1] 57168 [P59901-2] |
TopDownProteomicsi | P59901-1 [P59901-1] |
PTM databases
GlyGeni | P59901, 4 sites |
iPTMneti | P59901 |
PhosphoSitePlusi | P59901 |
Expressioni
Tissue specificityi
Detected on plasmacytoid dendritic cells (at protein level). Detected on plasmacytoid dendritic cells, but not on monocytes or B cells.1 Publication
Gene expression databases
Bgeei | ENSG00000239961, Expressed in cingulate cortex and 226 other tissues |
ExpressionAtlasi | P59901, baseline and differential |
Genevisiblei | P59901, HS |
Organism-specific databases
HPAi | ENSG00000239961, Group enriched (blood, brain, lymphoid tissue) |
Interactioni
Subunit structurei
Binary interactionsi
P59901
With | #Exp. | IntAct |
---|---|---|
BST2 [Q10589] | 2 | EBI-2841591,EBI-2476339 |
GO - Molecular functioni
- signaling receptor binding Source: UniProtKB
Protein-protein interaction databases
IntActi | P59901, 2 interactors |
STRINGi | 9606.ENSP00000291759 |
Miscellaneous databases
RNActi | P59901, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 118 | Ig-like C2-type 1Add BLAST | 95 | |
Domaini | 123 – 213 | Ig-like C2-type 2Add BLAST | 91 | |
Domaini | 224 – 313 | Ig-like C2-type 3Add BLAST | 90 | |
Domaini | 324 – 413 | Ig-like C2-type 4Add BLAST | 90 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RYEX, Eukaryota |
HOGENOMi | CLU_021100_2_0_1 |
InParanoidi | P59901 |
OrthoDBi | 1000446at2759 |
PhylomeDBi | P59901 |
TreeFami | TF336644 |
Family and domain databases
Gene3Di | 2.60.40.10, 4 hits |
InterProi | View protein in InterPro IPR016332, A1B_glyco/leuk_Ig-like_rcpt IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF00047, ig, 1 hit PF13895, Ig_2, 2 hits |
PIRSFi | PIRSF001979, Alpha_1B_glycoprot_prd, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 4 hits SM00408, IGc2, 3 hits |
SUPFAMi | SSF48726, SSF48726, 4 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P59901-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTLILTSLLF FGLSLGPRTR VQAENLPKPI LWAEPGPVIT WHNPVTIWCQ
60 70 80 90 100
GTLEAQGYRL DKEGNSMSRH ILKTLESENK VKLSIPSMMW EHAGRYHCYY
110 120 130 140 150
QSPAGWSEPS DPLELVVTAY SRPTLSALPS PVVTSGVNVT LRCASRLGLG
160 170 180 190 200
RFTLIEEGDH RLSWTLNSHQ HNHGKFQALF PMGPLTFSNR GTFRCYGYEN
210 220 230 240 250
NTPYVWSEPS DPLQLLVSGV SRKPSLLTLQ GPVVTPGENL TLQCGSDVGY
260 270 280 290 300
IRYTLYKEGA DGLPQRPGRQ PQAGLSQANF TLSPVSRSYG GQYRCYGAHN
310 320 330 340 350
VSSEWSAPSD PLDILIAGQI SDRPSLSVQP GPTVTSGEKV TLLCQSWDPM
360 370 380 390 400
FTFLLTKEGA AHPPLRLRSM YGAHKYQAEF PMSPVTSAHA GTYRCYGSRS
410 420 430 440 450
SNPYLLSHPS EPLELVVSGA TETLNPAQKK SDSKTAPHLQ DYTVENLIRM
460 470 480 490
GVAGLVLLFL GILLFEAQHS QRSPPRCSQE ANSRKDNAPF RVVEPWEQI
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JNG2 | A0A0G2JNG2_HUMAN | Leukocyte immunoglobulin-like recep... | LILRA4 | 400 | Annotation score: | ||
A0A075B7A5 | A0A075B7A5_HUMAN | Leukocyte immunoglobulin-like recep... | LILRA4 | 140 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | L → P in AAD02203 (Ref. 1) Curated | 1 | |
Sequence conflicti | 7 | S → V in AAD02203 (Ref. 1) Curated | 1 | |
Sequence conflicti | 9 – 11 | LFF → ICL in AAD02203 (Ref. 1) Curated | 3 | |
Sequence conflicti | 235 | T → N in BI834924 (Ref. 4) Curated | 1 | |
Sequence conflicti | 398 | S → T in AAD02203 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_056054 | 27 | P → L. Corresponds to variant dbSNP:rs2241384Ensembl. | 1 | |
Natural variantiVAR_056055 | 155 | I → V. Corresponds to variant dbSNP:rs10419832Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038694 | 1 – 66 | Missing in isoform 2. 1 PublicationAdd BLAST | 66 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF041261 mRNA Translation: AAD02203.1 AC008746 Genomic DNA No translation available. AC008984 Genomic DNA No translation available. BC109198 mRNA Translation: AAI09199.1 BI834924 mRNA No translation available. AF283989 mRNA Translation: AAL36993.1 |
CCDSi | CCDS12890.1 [P59901-1] |
RefSeqi | NP_036408.4, NM_012276.4 |
Genome annotation databases
Ensembli | ENST00000291759; ENSP00000291759; ENSG00000239961 ENST00000613813; ENSP00000479979; ENSG00000277092 [P59901-1] ENST00000616790; ENSP00000483846; ENSG00000274185 [P59901-1] ENST00000619832; ENSP00000481073; ENSG00000276798 [P59901-1] |
GeneIDi | 23547 |
KEGGi | hsa:23547 |
UCSCi | uc002qfj.4, human [P59901-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF041261 mRNA Translation: AAD02203.1 AC008746 Genomic DNA No translation available. AC008984 Genomic DNA No translation available. BC109198 mRNA Translation: AAI09199.1 BI834924 mRNA No translation available. AF283989 mRNA Translation: AAL36993.1 |
CCDSi | CCDS12890.1 [P59901-1] |
RefSeqi | NP_036408.4, NM_012276.4 |
3D structure databases
SMRi | P59901 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P59901, 2 interactors |
STRINGi | 9606.ENSP00000291759 |
PTM databases
GlyGeni | P59901, 4 sites |
iPTMneti | P59901 |
PhosphoSitePlusi | P59901 |
Genetic variation databases
BioMutai | LILRA4 |
DMDMi | 288558815 |
Proteomic databases
jPOSTi | P59901 |
MassIVEi | P59901 |
PaxDbi | P59901 |
PeptideAtlasi | P59901 |
PRIDEi | P59901 |
ProteomicsDBi | 57167 [P59901-1] 57168 [P59901-2] |
TopDownProteomicsi | P59901-1 [P59901-1] |
Protocols and materials databases
ABCDi | P59901, 3 sequenced antibodies |
Antibodypediai | 32892, 280 antibodies |
Genome annotation databases
Ensembli | ENST00000291759; ENSP00000291759; ENSG00000239961 ENST00000613813; ENSP00000479979; ENSG00000277092 [P59901-1] ENST00000616790; ENSP00000483846; ENSG00000274185 [P59901-1] ENST00000619832; ENSP00000481073; ENSG00000276798 [P59901-1] |
GeneIDi | 23547 |
KEGGi | hsa:23547 |
UCSCi | uc002qfj.4, human [P59901-1] |
Organism-specific databases
CTDi | 23547 |
DisGeNETi | 23547 |
GeneCardsi | LILRA4 |
HGNCi | HGNC:15503, LILRA4 |
HPAi | ENSG00000239961, Group enriched (blood, brain, lymphoid tissue) |
MIMi | 607517, gene |
neXtProti | NX_P59901 |
PharmGKBi | PA142671546 |
VEuPathDBi | HostDB:ENSG00000239961.2 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RYEX, Eukaryota |
HOGENOMi | CLU_021100_2_0_1 |
InParanoidi | P59901 |
OrthoDBi | 1000446at2759 |
PhylomeDBi | P59901 |
TreeFami | TF336644 |
Enzyme and pathway databases
PathwayCommonsi | P59901 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Miscellaneous databases
BioGRID-ORCSi | 23547, 8 hits in 865 CRISPR screens |
GeneWikii | LILRA4 |
GenomeRNAii | 23547 |
Pharosi | P59901, Tbio |
PROi | PR:P59901 |
RNActi | P59901, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000239961, Expressed in cingulate cortex and 226 other tissues |
ExpressionAtlasi | P59901, baseline and differential |
Genevisiblei | P59901, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 4 hits |
InterProi | View protein in InterPro IPR016332, A1B_glyco/leuk_Ig-like_rcpt IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF00047, ig, 1 hit PF13895, Ig_2, 2 hits |
PIRSFi | PIRSF001979, Alpha_1B_glycoprot_prd, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 4 hits SM00408, IGc2, 3 hits |
SUPFAMi | SSF48726, SSF48726, 4 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LIRA4_HUMAN | |
Accessioni | P59901Primary (citable) accession number: P59901 Secondary accession number(s): Q32MC4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2003 |
Last sequence update: | February 9, 2010 | |
Last modified: | February 10, 2021 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot