Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc transporter ZIP1

Gene

slc39a1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates zinc uptake.1 Publication

GO - Molecular functioni

  • zinc ion binding Source: ZFIN
  • zinc ion transmembrane transporter activity Source: ZFIN

GO - Biological processi

  • zinc ion transmembrane transport Source: UniProtKB
  • zinc ion transport Source: ZFIN

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Enzyme and pathway databases

ReactomeiR-DRE-442380 Zinc influx into cells by the SLC39 gene family

Protein family/group databases

TCDBi2.A.5.3.5 the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP1
Alternative name(s):
DrZIP1
Solute carrier family 39 member 1
Zrt- and Irt-like protein 1
Short name:
ZIP-1
Gene namesi
Name:slc39a1
Synonyms:zip1
ORF Names:sb:cb629, zgc:111852
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-030131-9917 slc39a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6ExtracellularSequence analysis6
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 44CytoplasmicSequence analysisAdd BLAST17
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Topological domaini66 – 86ExtracellularSequence analysisAdd BLAST21
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 158CytoplasmicSequence analysisAdd BLAST51
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 185ExtracellularSequence analysis6
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Topological domaini207 – 219CytoplasmicSequence analysisAdd BLAST13
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Topological domaini241 – 247ExtracellularSequence analysis7
Transmembranei248 – 268HelicalSequence analysisAdd BLAST21
Topological domaini269 – 281CytoplasmicSequence analysisAdd BLAST13
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000687651 – 302Zinc transporter ZIP1Add BLAST302

Proteomic databases

PaxDbiP59889

Expressioni

Tissue specificityi

Ubiquitous. Highest levels in ovary, high levels in heart, eye, kidney and brain, moderate levels in intestine and low levels in gill and skin.1 Publication

Gene expression databases

BgeeiENSDARG00000058257
ExpressionAtlasiP59889 baseline

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000062256

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni169 – 170Heavy metals bindingBy similarity2

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1558 Eukaryota
ENOG4111GP2 LUCA
GeneTreeiENSGT00530000063242
HOGENOMiHOG000236331
HOVERGENiHBG015174
InParanoidiP59889
KOiK14709
OMAiSGHHVHV
OrthoDBiEOG091G0HMY
PhylomeDBiP59889
TreeFamiTF317098

Family and domain databases

InterProiView protein in InterPro
IPR003689 ZIP
PfamiView protein in Pfam
PF02535 Zip, 1 hit

Sequencei

Sequence statusi: Complete.

P59889-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYLLQVKVG ALVGLLLLTL FFGFIPARMK WFHVTGGTEL HKAVLSFVSC
60 70 80 90 100
FAGGVFLSAC LLDIIPDYLS DIHGELQKRD LDDGFPLPEF IMACGFFTVL
110 120 130 140 150
ILEKMVLSCT EGHRNEETAP LLAPAAPNGH AHGHPSVNDL EGSGHHVHVD
160 170 180 190 200
FHAHSSFRSF MLFLSLSLHS VFEGLAIGLQ TTNAKVLEIC IAILVHKSII
210 220 230 240 250
VFSLSVKLVQ SAVKPLWVVL YVTVFAIMSP LGIGIGIVVI ETERQAGGLI
260 270 280 290 300
QAVLEGLAAG TFIYITFLEI LPHELNSSER PLLKVLFLLC GFSIMAALCF

LG
Length:302
Mass (Da):32,822
Last modified:September 26, 2003 - v1
Checksum:i96B8863752C5CF70
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8K → R in AAH96852 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY314992 mRNA Translation: AAP83180.1
BC096852 mRNA Translation: AAH96852.1
RefSeqiNP_997748.2, NM_212583.2
UniGeneiDr.30340

Genome annotation databases

EnsembliENSDART00000062257; ENSDARP00000062256; ENSDARG00000058257
ENSDART00000191509; ENSDARP00000153420; ENSDARG00000112079
GeneIDi321324
KEGGidre:321324

Similar proteinsi

Entry informationi

Entry nameiS39A1_DANRE
AccessioniPrimary (citable) accession number: P59889
Secondary accession number(s): Q4V9K6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: September 26, 2003
Last modified: June 20, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health