UniProtKB - P59867 (KAX63_HETSP)
Protein
Potassium channel toxin alpha-KTx 6.3
Gene
N/A
Organism
Heterometrus spinifer (Asia giant forest scorpion) (Malaysian black scorpion)
Status
Functioni
Potently blocks voltage-gated potassium channels Kv1.1/KCNA1 and Kv1.3/KCNA3. Mildly blocks intermediate (IK) conductance calcium-activated potassium channels (KCa3.1/KCNN4) and ERG1/Kv11.1/KCNH2.3 Publications
Miscellaneous
Does not block Kv1.2/KCNA2 potassium channels.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 21 | Important for activity | 1 | |
Sitei | 23 | Critical for activity | 1 | |
Sitei | 25 | Important for activity | 1 | |
Sitei | 26 | Important for activity | 1 | |
Sitei | 33 | Important for activity | 1 |
GO - Molecular functioni
- ion channel inhibitor activity Source: InterPro
- toxin activity Source: UniProtKB-KW
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Potassium channel toxin alpha-KTx 6.3Alternative name(s): Neurotoxin HsTX11 Publication |
Organismi | Heterometrus spinifer (Asia giant forest scorpion) (Malaysian black scorpion) |
Taxonomic identifieri | 118530 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Iurida › Scorpionoidea › Scorpionidae › Scorpioninae › Heterometrus |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000044908 | 1 – 34 | Potassium channel toxin alpha-KTx 6.31 PublicationAdd BLAST | 34 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 3 ↔ 24 | 3 Publications | ||
Disulfide bondi | 9 ↔ 29 | 3 Publications | ||
Disulfide bondi | 13 ↔ 31 | 3 Publications | ||
Disulfide bondi | 19 ↔ 34 | 3 Publications | ||
Modified residuei | 34 | Cysteine amide1 Publication | 1 |
Keywords - PTMi
Amidation, Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.Curated
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1QUZ | NMR | - | A | 1-34 | [»] | |
1WPD | NMR | - | A | 7-34 | [»] | |
1Y2P | NMR | - | A | 1-34 | [»] | |
ProteinModelPortali | P59867 | |||||
SMRi | P59867 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P59867 |
Family & Domainsi
Domaini
Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).2 Publications
Sequence similaritiesi
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 06 subfamily.Curated
Family and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf IPR001947 Scorpion_toxinS_K_inh |
Pfami | View protein in Pfam PF00451 Toxin_2, 1 hit |
PRINTSi | PR00286 CHARYBDTOXIN |
ProDomi | View protein in ProDom or Entries sharing at least one domain PD003586 Scorpion_toxinS, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS01138 SCORP_SHORT_TOXIN, 1 hit |
i Sequence
Sequence statusi: Complete.
Mass spectrometryi
Similar proteinsi
Cross-referencesi
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1QUZ | NMR | - | A | 1-34 | [»] | |
1WPD | NMR | - | A | 7-34 | [»] | |
1Y2P | NMR | - | A | 1-34 | [»] | |
ProteinModelPortali | P59867 | |||||
SMRi | P59867 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Miscellaneous databases
EvolutionaryTracei | P59867 |
Family and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf IPR001947 Scorpion_toxinS_K_inh |
Pfami | View protein in Pfam PF00451 Toxin_2, 1 hit |
PRINTSi | PR00286 CHARYBDTOXIN |
ProDomi | View protein in ProDom or Entries sharing at least one domain PD003586 Scorpion_toxinS, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS01138 SCORP_SHORT_TOXIN, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | KAX63_HETSP | |
Accessioni | P59867Primary (citable) accession number: P59867 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2003 |
Last sequence update: | September 26, 2003 | |
Last modified: | November 22, 2017 | |
This is version 73 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries - SIMILARITY comments
Index of protein domains and families - PDB cross-references
Index of Protein Data Bank (PDB) cross-references