UniProtKB - P59862 (CAD26_MOUSE)
Protein
Cadherin-like protein 26
Gene
Cdh26
Organism
Mus musculus (Mouse)
Status
Functioni
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Ligand for integrins alpha-E/beta-7, ITGAE:ITGAB7, alpha-4/beta-7, ITGA4:ITGAB7 and alpha-4/beta-1, ITGA4:ITGAB1 through which modulates CD4+ T cells activation.By similarity
GO - Molecular functioni
- alpha-catenin binding Source: UniProtKB
- beta-catenin binding Source: UniProtKB
- cadherin binding Source: GO_Central
- calcium ion binding Source: GO_Central
- delta-catenin binding Source: UniProtKB
- integrin binding Source: UniProtKB
GO - Biological processi
- CD4-positive, alpha-beta T cell activation Source: UniProtKB
- cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Cadherin-like protein 26 |
Gene namesi | Name:Cdh26 Synonyms:Gm1010 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2685856, Cdh26 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Cytoskeleton
- microtubule cytoskeleton Source: MGI
Plasma Membrane
- catenin complex Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 590 | ExtracellularSequence analysisAdd BLAST | 570 | |
Transmembranei | 591 – 611 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 612 – 763 | CytoplasmicSequence analysisAdd BLAST | 152 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000003830 | 21 – 763 | Cadherin-like protein 26Add BLAST | 743 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 56 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 60 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 146 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 394 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 440 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.By similarity
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | P59862 |
PRIDEi | P59862 |
ProteomicsDBi | 273578 |
PTM databases
GlyGeni | P59862, 5 sites |
PhosphoSitePlusi | P59862 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000039155, Expressed in olfactory epithelium and 63 other tissues |
ExpressionAtlasi | P59862, baseline and differential |
Genevisiblei | P59862, MM |
Interactioni
Subunit structurei
Homodimer.
Component of a cadherin:catenin adhesion complex composed of at least of CDH26, beta-catenin/CTNNB1, alpha-catenin/CTNNA1 and p120 catenin/CTNND1.
By similarityGO - Molecular functioni
- alpha-catenin binding Source: UniProtKB
- beta-catenin binding Source: UniProtKB
- cadherin binding Source: GO_Central
- delta-catenin binding Source: UniProtKB
- integrin binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000048829 |
Miscellaneous databases
RNActi | P59862, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 140 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 120 | |
Domaini | 141 – 250 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 110 | |
Domaini | 251 – 371 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 121 | |
Domaini | 370 – 478 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 109 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 329 – 332 | Poly-Val | 4 |
Domaini
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000161589 |
InParanoidi | P59862 |
OrthoDBi | 158870at2759 |
PhylomeDBi | P59862 |
TreeFami | TF316817 |
Family and domain databases
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS |
PANTHERi | PTHR24027, PTHR24027, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 3 hits |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 4 hits |
SUPFAMi | SSF49313, SSF49313, 5 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 2 hits PS50268, CADHERIN_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P59862-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDTRGCAWLL LLLSLPQGQS HQPLHRSKRR WVLTTLELQE EDPGPFPKLV
60 70 80 90 100
GELFNNMSNN VSLIYLIRGP GVDEFPEIGL FSIEDHQSGK IYVHRPVDRE
110 120 130 140 150
VTPSFMVHFD AVDRSTGKVV DESLIFNIRI RDVNDHAPQF PEKEFNISVK
160 170 180 190 200
ESQAAGQPIF QLLTVDLDQE NTPNSQVLYF LVSQTPLLRE SGFRIDLISG
210 220 230 240 250
EVRLSGCLHY ETAPLFTLIV RASDCGEPSL TSTATIHVSV EDSNNHMPTF
260 270 280 290 300
MEDRYEIRIS EGQVEQGVLY LPVQDGDSPF TPAWRTQFNI WDGNEEGHFD
310 320 330 340 350
IVTDPETNQG LLSIIKPLDY ESQVAHSLVV VVENQEQLFV CTEGQLQPLR
360 370 380 390 400
KAMASTMVSV QVLDTNDPPA FHPQSFIVSE EDGAWPAIQL GYFNATDPDR
410 420 430 440 450
ADSQIRYKLV HDPENWVTVD EKSGVVTTKK QIDRESPHVN DSFYTIIVHA
460 470 480 490 500
VDNGLPPLTG TGTLMLFLSD VNDNAPTLRP HSRHLEVCES AGSQPLLIEA
510 520 530 540 550
EDADLDPYAD PFTFDLDNAQ GDVEETWMLR TKQGEGHSAE LTMLRSVPPG
560 570 580 590 600
DYLVPLFIAD RQGLAQKQTV HVRICSCRSG SECEEPSDTW LLWWALSPVG
610 620 630 640 650
AALMVLSAAL LCLLRCSCTF GPKRLRGFIP SDSGHQTLIV YNEESKVPSA
660 670 680 690 700
QGCDTFFEPR GVKTLLSSTP VYLDRMVPRQ QPLQLLEGRV VEAWSQKLQS
710 720 730 740 750
IDVLEGDTGY LPHVYREEGE CEGAETLSSL TFLEQDLSPK LLGCSGSKST
760
PSEAMCFTSR VPS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ3V1P3 | Q3V1P3_MOUSE | Cadherin-like protein 26 | Cdh26 | 744 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC053928 mRNA Translation: AAH53928.1 |
CCDSi | CCDS17162.1 |
RefSeqi | NP_001278118.1, NM_001291189.1 NP_941058.1, NM_198656.2 |
Genome annotation databases
Ensembli | ENSMUST00000042092; ENSMUSP00000048829; ENSMUSG00000039155 |
GeneIDi | 381409 |
KEGGi | mmu:381409 |
UCSCi | uc008ohr.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC053928 mRNA Translation: AAH53928.1 |
CCDSi | CCDS17162.1 |
RefSeqi | NP_001278118.1, NM_001291189.1 NP_941058.1, NM_198656.2 |
3D structure databases
SMRi | P59862 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000048829 |
PTM databases
GlyGeni | P59862, 5 sites |
PhosphoSitePlusi | P59862 |
Proteomic databases
PaxDbi | P59862 |
PRIDEi | P59862 |
ProteomicsDBi | 273578 |
Protocols and materials databases
Antibodypediai | 2400, 148 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000042092; ENSMUSP00000048829; ENSMUSG00000039155 |
GeneIDi | 381409 |
KEGGi | mmu:381409 |
UCSCi | uc008ohr.2, mouse |
Organism-specific databases
CTDi | 60437 |
MGIi | MGI:2685856, Cdh26 |
Phylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000161589 |
InParanoidi | P59862 |
OrthoDBi | 158870at2759 |
PhylomeDBi | P59862 |
TreeFami | TF316817 |
Miscellaneous databases
BioGRID-ORCSi | 381409, 0 hits in 52 CRISPR screens |
ChiTaRSi | Cdh26, mouse |
PROi | PR:P59862 |
RNActi | P59862, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039155, Expressed in olfactory epithelium and 63 other tissues |
ExpressionAtlasi | P59862, baseline and differential |
Genevisiblei | P59862, MM |
Family and domain databases
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS |
PANTHERi | PTHR24027, PTHR24027, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 3 hits |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 4 hits |
SUPFAMi | SSF49313, SSF49313, 5 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 2 hits PS50268, CADHERIN_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAD26_MOUSE | |
Accessioni | P59862Primary (citable) accession number: P59862 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2003 |
Last sequence update: | September 26, 2003 | |
Last modified: | April 7, 2021 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot