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Protein

BPI fold-containing family B member 4

Gene

BPIFB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).By similarity

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-HSA-6803157 Antimicrobial peptides

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family B member 4
Alternative name(s):
Ligand-binding protein RY2G5
Long palate, lung and nasal epithelium carcinoma-associated protein 4
Gene namesi
Name:BPIFB4
Synonyms:C20orf186, LPLUNC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000186191.7
HGNCiHGNC:16179 BPIFB4
MIMi615718 gene
neXtProtiNX_P59827

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi149954
OpenTargetsiENSG00000186191
PharmGKBiPA25728

Polymorphism and mutation databases

BioMutaiBPIFB4
DMDMi215274098

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000008915919 – 614BPI fold-containing family B member 4Add BLAST596

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi273N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi295 ↔ 332By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP59827
PeptideAtlasiP59827
PRIDEiP59827
ProteomicsDBi57163
57164 [P59827-2]

PTM databases

iPTMnetiP59827
PhosphoSitePlusiP59827

Expressioni

Tissue specificityi

Expressed in nasal tissue.1 Publication

Gene expression databases

BgeeiENSG00000186191 Expressed in 34 organ(s), highest expression level in prostate gland
CleanExiHS_C20orf186
ExpressionAtlasiP59827 baseline and differential
GenevisibleiP59827 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000364632

Structurei

3D structure databases

ProteinModelPortaliP59827
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi131 – 226Gly-richAdd BLAST96

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4160 Eukaryota
ENOG410Z88E LUCA
GeneTreeiENSGT00730000110772
HOGENOMiHOG000231741
HOVERGENiHBG108092
InParanoidiP59827
OMAiCPLIIRI
OrthoDBiEOG091G048N
PhylomeDBiP59827
TreeFamiTF315617

Family and domain databases

InterProiView protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR032942 BPI/LBP/Plunc
IPR001124 Lipid-bd_serum_glycop_C
IPR017942 Lipid-bd_serum_glycop_N
PANTHERiPTHR10504 PTHR10504, 1 hit
PfamiView protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
PF02886 LBP_BPI_CETP_C, 1 hit
SMARTiView protein in SMART
SM00328 BPI1, 1 hit
SM00329 BPI2, 1 hit
SUPFAMiSSF55394 SSF55394, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P59827-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWMAWCVAAL SVVAVCGTSH ETNTVLRVTK DVLSNAISGM LQQSDALHSA
60 70 80 90 100
LREVPLGVGD IPYNDFHVRG PPPVYTNGKK LDGIYQYGHI ETNDNTAQLG
110 120 130 140 150
GKYRYGEILE SEGSIRDLRN SGYRSAENAY GGHRGLGRYR AAPVGRLHRR
160 170 180 190 200
ELQPGEIPPG VATGAVGPGG LLGTGGMLAA DGILAGQGGL LGGGGLLGDG
210 220 230 240 250
GLLGGGGVLG VLGEGGILST VQGITGLRIV ELTLPRVSVR LLPGVGVYLS
260 270 280 290 300
LYTRVAINGK SLIGFLDIAV EVNITAKVRL TMDRTGYPRL VIERCDTLLG
310 320 330 340 350
GIKVKLLRGL LPNLVDNLVN RVLADVLPDL LCPIVDVVLG LVNDQLGLVD
360 370 380 390 400
SLIPLGILGS VQYTFSSLPL VTGEFLELDL NTLVGEAGGG LIDYPLGWPA
410 420 430 440 450
VSPKPMPELP PMGDNTKSQL AMSANFLGSV LTLLQKQHAL DLDITNGMFE
460 470 480 490 500
ELPPLTTATL GALIPKVFQQ YPESCPLIIR IQVLNPPSVM LQKDKALVKV
510 520 530 540 550
LATAEVMVSQ PKDLETTICL IDVDTEFLAS FSTEGDKLMI DAKLEKTSLN
560 570 580 590 600
LRTSNVGNFD IGLMEVLVEK IFDLAFMPAM NAVLGSGVPL PKILNIDFSN
610
ADIDVLEDLL VLSA
Length:614
Mass (Da):65,055
Last modified:November 25, 2008 - v2
Checksum:iF92C542B75CB97E1
GO
Isoform 2 (identifier: P59827-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.

Show »
Length:575
Mass (Da):60,951
Checksum:iD4B804F446EF7707
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WEG9F8WEG9_HUMAN
BPI fold-containing family B member...
BPIFB4
44Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059372167G → W. Corresponds to variant dbSNP:rs2424943Ensembl.1
Natural variantiVAR_055998199D → G. Corresponds to variant dbSNP:rs4339026Ensembl.1
Natural variantiVAR_055999206G → W. Corresponds to variant dbSNP:rs2424943Ensembl.1
Natural variantiVAR_059373229I → V. Corresponds to variant dbSNP:rs2070325Ensembl.1
Natural variantiVAR_056000268I → V. Corresponds to variant dbSNP:rs2070325Ensembl.1
Natural variantiVAR_056001320N → T. Corresponds to variant dbSNP:rs2889732Ensembl.1
Natural variantiVAR_069042527F → L. Corresponds to variant dbSNP:rs11699009Ensembl.1
Natural variantiVAR_069043533T → I. Corresponds to variant dbSNP:rs11696307Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0378281 – 39Missing in isoform 2. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF549190 mRNA Translation: AAP84990.1
AL121756 Genomic DNA No translation available.
CCDSiCCDS13213.2 [P59827-1]
RefSeqiNP_872325.2, NM_182519.2 [P59827-1]
UniGeneiHs.38961

Genome annotation databases

EnsembliENST00000375483; ENSP00000364632; ENSG00000186191 [P59827-1]
GeneIDi149954
KEGGihsa:149954
UCSCiuc010zue.3 human [P59827-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF549190 mRNA Translation: AAP84990.1
AL121756 Genomic DNA No translation available.
CCDSiCCDS13213.2 [P59827-1]
RefSeqiNP_872325.2, NM_182519.2 [P59827-1]
UniGeneiHs.38961

3D structure databases

ProteinModelPortaliP59827
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000364632

PTM databases

iPTMnetiP59827
PhosphoSitePlusiP59827

Polymorphism and mutation databases

BioMutaiBPIFB4
DMDMi215274098

Proteomic databases

PaxDbiP59827
PeptideAtlasiP59827
PRIDEiP59827
ProteomicsDBi57163
57164 [P59827-2]

Protocols and materials databases

DNASUi149954
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375483; ENSP00000364632; ENSG00000186191 [P59827-1]
GeneIDi149954
KEGGihsa:149954
UCSCiuc010zue.3 human [P59827-1]

Organism-specific databases

CTDi149954
DisGeNETi149954
EuPathDBiHostDB:ENSG00000186191.7
GeneCardsiBPIFB4
H-InvDBiHIX0040539
HGNCiHGNC:16179 BPIFB4
MIMi615718 gene
neXtProtiNX_P59827
OpenTargetsiENSG00000186191
PharmGKBiPA25728
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4160 Eukaryota
ENOG410Z88E LUCA
GeneTreeiENSGT00730000110772
HOGENOMiHOG000231741
HOVERGENiHBG108092
InParanoidiP59827
OMAiCPLIIRI
OrthoDBiEOG091G048N
PhylomeDBiP59827
TreeFamiTF315617

Enzyme and pathway databases

ReactomeiR-HSA-6803157 Antimicrobial peptides

Miscellaneous databases

GenomeRNAii149954
PROiPR:P59827
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186191 Expressed in 34 organ(s), highest expression level in prostate gland
CleanExiHS_C20orf186
ExpressionAtlasiP59827 baseline and differential
GenevisibleiP59827 HS

Family and domain databases

InterProiView protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR032942 BPI/LBP/Plunc
IPR001124 Lipid-bd_serum_glycop_C
IPR017942 Lipid-bd_serum_glycop_N
PANTHERiPTHR10504 PTHR10504, 1 hit
PfamiView protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
PF02886 LBP_BPI_CETP_C, 1 hit
SMARTiView protein in SMART
SM00328 BPI1, 1 hit
SM00329 BPI2, 1 hit
SUPFAMiSSF55394 SSF55394, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiBPIB4_HUMAN
AccessioniPrimary (citable) accession number: P59827
Secondary accession number(s): Q5TDX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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