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UniProtKB - P59817 (Z280A_HUMAN)

Entry version 139 (16 Oct 2019)
Sequence version 3 (30 Nov 2010)
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Protein

Zinc finger protein 280A

Gene

ZNF280A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a transcription factor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri334 – 357C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri364 – 387C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri423 – 445C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 474C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 280A
Alternative name(s):
3'OY11.1
Suppressor of hairy wing homolog 1
Zinc finger protein 636
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF280A
Synonyms:SUHW1, ZNF280, ZNF636
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18597 ZNF280A

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P59817

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38358

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P59817

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF280A

Domain mapping of disease mutations (DMDM)

More...DMDMi		313104252

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000470551 – 542Zinc finger protein 280AAdd BLAST542

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P59817

MaxQB - The MaxQuant DataBase

More...MaxQBi		P59817

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P59817

PeptideAtlas

More...PeptideAtlasi		P59817

PRoteomics IDEntifications database

More...PRIDEi		P59817

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57161

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000169548 Expressed in 17 organ(s), highest expression level in left adrenal gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P59817 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA044475

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		126180, 6 interactors

Protein interaction database and analysis system

More...IntActi		P59817, 10 interactors

Molecular INTeraction database

More...MINTi		P59817

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000302855

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P59817

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri334 – 357C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri364 – 387C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri423 – 445C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 474C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721 Eukaryota
COG5048 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000013047

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P59817

Database of Orthologous Groups

More...OrthoDBi		105829at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P59817

TreeFam database of animal gene trees

More...TreeFami		TF331707

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR025243 DUF4195
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13836 DUF4195, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355 ZnF_C2H2, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667 SSF57667, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P59817-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDIFLCKKV ESPKKNLRES KQREEDDEDP DLIYVGVEHV HRDAEVLFVG 
        60         70         80         90        100
MISNSKPVVS NILNRVTPGS KSRRKKGHFR QYPAHVSQPA NHVTSMAKAI 
       110        120        130        140        150
MPVSLSEGRS TDSPVTMKSS SEPGYKMSSP QVVSPNYSDS LPPGTQCLVG 
       160        170        180        190        200
AMVSGGGRNE SSPDSKRLST SDINSRDSKR VKLRDGIPGV PSLAVVPSDM 
       210        220        230        240        250
SSTISTNTPS QGICNSSNHV QNGVTFPWPD ANGKAHFNLT DPERANESGL 
       260        270        280        290        300
AMTDISSLAS QNKTFDPKKE NPIVLLSNFY YGQHKGDGQP EQKTHTTFKC 
       310        320        330        340        350
LSCVKVLKNI KFMNHMKHHL EFEKQRNDSW EDHTTCQHCH RQFPTPFQLQ 
       360        370        380        390        400
CHIDSVHIAM GPSAVCKICE LSFETDQVLL QHMKDHHKPG EMPYVCQVCH 
       410        420        430        440        450
YRSSVFADVE THFRTCHENT KNLLCLFCLK LFKTAIPYMN HCWRHSRRRV 
       460        470        480        490        500
LQCSKCRLQF LTLKEEIEHK TKDHQTFKKP EQLQGFPRET KVIIQTSVQP 
       510        520        530        540 
GSSGMASVIV SNTDPQSSPV KTKKKTAMNT RDSRLPCSKD SS
Length:542
Mass (Da):60,816
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1FFAB419D32C6433
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JN84A0A0G2JN84_HUMAN
Suppressor of hairy wing homolog 1 ...
ZNF280A SUHW1, hCG_1783619
542Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02821871K → N2 PublicationsCorresponds to variant dbSNP:rs361959Ensembl.1
Natural variantiVAR_028219136N → S2 PublicationsCorresponds to variant dbSNP:rs362011Ensembl.1
Natural variantiVAR_028220137Y → S2 PublicationsCorresponds to variant dbSNP:rs361580Ensembl.1
Natural variantiVAR_028221246N → S2 PublicationsCorresponds to variant dbSNP:rs362132Ensembl.1
Natural variantiVAR_028222249G → A2 PublicationsCorresponds to variant dbSNP:rs362124Ensembl.1
Natural variantiVAR_028223276L → F2 PublicationsCorresponds to variant dbSNP:rs16989015Ensembl.1
Natural variantiVAR_028224278N → D2 PublicationsCorresponds to variant dbSNP:rs362003Ensembl.1
Natural variantiVAR_028225486F → L2 PublicationsCorresponds to variant dbSNP:rs361762Ensembl.1
Natural variantiVAR_028226488R → S2 PublicationsCorresponds to variant dbSNP:rs361666Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D87009 Genomic DNA Translation: BAA20006.1
D87011 Genomic DNA Translation: BAA20008.1
BC053901 mRNA Translation: AAH53901.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13800.1

NCBI Reference Sequences

More...RefSeqi		NP_542778.2, NM_080740.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000302097; ENSP00000302855; ENSG00000169548

Database of genes from NCBI RefSeq genomes

More...GeneIDi		129025

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:129025

UCSC genome browser

More...UCSCi		uc032qhw.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87009 Genomic DNA Translation: BAA20006.1
D87011 Genomic DNA Translation: BAA20008.1
BC053901 mRNA Translation: AAH53901.1
CCDSiCCDS13800.1
RefSeqiNP_542778.2, NM_080740.4

3D structure databases

SMRiP59817
ModBaseiSearch...

Protein-protein interaction databases

BioGridi126180, 6 interactors
IntActiP59817, 10 interactors
MINTiP59817
STRINGi9606.ENSP00000302855

Polymorphism and mutation databases

BioMutaiZNF280A
DMDMi313104252

Proteomic databases

MassIVEiP59817
MaxQBiP59817
PaxDbiP59817
PeptideAtlasiP59817
PRIDEiP59817
ProteomicsDBi57161

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		129025

Genome annotation databases

EnsembliENST00000302097; ENSP00000302855; ENSG00000169548
GeneIDi129025
KEGGihsa:129025
UCSCiuc032qhw.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		129025

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF280A
HGNCiHGNC:18597 ZNF280A
HPAiHPA044475
neXtProtiNX_P59817
PharmGKBiPA38358

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000013047
InParanoidiP59817
OrthoDBi105829at2759
PhylomeDBiP59817
TreeFamiTF331707

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF280A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		129025
PharosiP59817

Protein Ontology

More...PROi		PR:P59817

Gene expression databases

BgeeiENSG00000169548 Expressed in 17 organ(s), highest expression level in left adrenal gland
GenevisibleiP59817 HS

Family and domain databases

InterProiView protein in InterPro
IPR025243 DUF4195
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF13836 DUF4195, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZ280A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P59817
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: November 30, 2010
Last modified: October 16, 2019
This is version 139 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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