UniProtKB - P59817 (Z280A_HUMAN)
Protein
Zinc finger protein 280A
Gene
ZNF280A
Organism
Homo sapiens (Human)
Status
Functioni
May function as a transcription factor.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 334 – 357 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 364 – 387 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 423 – 445 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 451 – 474 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P59817 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 280AAlternative name(s): 3'OY11.1 Suppressor of hairy wing homolog 1 Zinc finger protein 636 |
Gene namesi | Name:ZNF280A Synonyms:SUHW1, ZNF280, ZNF636 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000169548.3 |
HGNCi | HGNC:18597, ZNF280A |
neXtProti | NX_P59817 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nuclear chromatin Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 129025 |
PharmGKBi | PA38358 |
Miscellaneous databases
Pharosi | P59817, Tdark |
Polymorphism and mutation databases
BioMutai | ZNF280A |
DMDMi | 313104252 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047055 | 1 – 542 | Zinc finger protein 280AAdd BLAST | 542 |
Proteomic databases
jPOSTi | P59817 |
MassIVEi | P59817 |
MaxQBi | P59817 |
PaxDbi | P59817 |
PeptideAtlasi | P59817 |
PRIDEi | P59817 |
ProteomicsDBi | 57161 |
Expressioni
Gene expression databases
Bgeei | ENSG00000169548, Expressed in left adrenal gland and 22 other tissues |
Genevisiblei | P59817, HS |
Organism-specific databases
HPAi | ENSG00000169548, Tissue enhanced (adrenal gland, epididymis, retina) |
Interactioni
Binary interactionsi
Hide detailsP59817
With | #Exp. | IntAct |
---|---|---|
CABP5 [Q9NP86] | 3 | EBI-8489342,EBI-10311131 |
EIF1AD [Q8N9N8] | 3 | EBI-8489342,EBI-750700 |
ENOPH1 [Q9UHY7] | 5 | EBI-8489342,EBI-726969 |
PDE4C - isoform PDE4C2 [Q08493-2] | 3 | EBI-8489342,EBI-12169289 |
Protein-protein interaction databases
BioGRIDi | 126180, 13 interactors |
IntActi | P59817, 11 interactors |
MINTi | P59817 |
STRINGi | 9606.ENSP00000302855 |
Miscellaneous databases
RNActi | P59817, protein |
Family & Domainsi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 334 – 357 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 364 – 387 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 423 – 445 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 451 – 474 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
HOGENOMi | CLU_010097_3_2_1 |
InParanoidi | P59817 |
OrthoDBi | 105829at2759 |
PhylomeDBi | P59817 |
TreeFami | TF331707 |
Family and domain databases
InterProi | View protein in InterPro IPR025243, DUF4195 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF13836, DUF4195, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P59817-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDIFLCKKV ESPKKNLRES KQREEDDEDP DLIYVGVEHV HRDAEVLFVG
60 70 80 90 100
MISNSKPVVS NILNRVTPGS KSRRKKGHFR QYPAHVSQPA NHVTSMAKAI
110 120 130 140 150
MPVSLSEGRS TDSPVTMKSS SEPGYKMSSP QVVSPNYSDS LPPGTQCLVG
160 170 180 190 200
AMVSGGGRNE SSPDSKRLST SDINSRDSKR VKLRDGIPGV PSLAVVPSDM
210 220 230 240 250
SSTISTNTPS QGICNSSNHV QNGVTFPWPD ANGKAHFNLT DPERANESGL
260 270 280 290 300
AMTDISSLAS QNKTFDPKKE NPIVLLSNFY YGQHKGDGQP EQKTHTTFKC
310 320 330 340 350
LSCVKVLKNI KFMNHMKHHL EFEKQRNDSW EDHTTCQHCH RQFPTPFQLQ
360 370 380 390 400
CHIDSVHIAM GPSAVCKICE LSFETDQVLL QHMKDHHKPG EMPYVCQVCH
410 420 430 440 450
YRSSVFADVE THFRTCHENT KNLLCLFCLK LFKTAIPYMN HCWRHSRRRV
460 470 480 490 500
LQCSKCRLQF LTLKEEIEHK TKDHQTFKKP EQLQGFPRET KVIIQTSVQP
510 520 530 540
GSSGMASVIV SNTDPQSSPV KTKKKTAMNT RDSRLPCSKD SS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JN84 | A0A0G2JN84_HUMAN | Suppressor of hairy wing homolog 1 ... | ZNF280A SUHW1, hCG_1783619 | 542 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028218 | 71 | K → N2 PublicationsCorresponds to variant dbSNP:rs361959Ensembl. | 1 | |
Natural variantiVAR_028219 | 136 | N → S2 PublicationsCorresponds to variant dbSNP:rs362011Ensembl. | 1 | |
Natural variantiVAR_028220 | 137 | Y → S2 PublicationsCorresponds to variant dbSNP:rs361580Ensembl. | 1 | |
Natural variantiVAR_028221 | 246 | N → S2 PublicationsCorresponds to variant dbSNP:rs362132Ensembl. | 1 | |
Natural variantiVAR_028222 | 249 | G → A2 PublicationsCorresponds to variant dbSNP:rs362124Ensembl. | 1 | |
Natural variantiVAR_028223 | 276 | L → F2 PublicationsCorresponds to variant dbSNP:rs16989015Ensembl. | 1 | |
Natural variantiVAR_028224 | 278 | N → D2 PublicationsCorresponds to variant dbSNP:rs362003Ensembl. | 1 | |
Natural variantiVAR_028225 | 486 | F → L2 PublicationsCorresponds to variant dbSNP:rs361762Ensembl. | 1 | |
Natural variantiVAR_028226 | 488 | R → S2 PublicationsCorresponds to variant dbSNP:rs361666Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D87009 Genomic DNA Translation: BAA20006.1 D87011 Genomic DNA Translation: BAA20008.1 BC053901 mRNA Translation: AAH53901.1 |
CCDSi | CCDS13800.1 |
RefSeqi | NP_542778.2, NM_080740.4 |
Genome annotation databases
Ensembli | ENST00000302097; ENSP00000302855; ENSG00000169548 |
GeneIDi | 129025 |
KEGGi | hsa:129025 |
UCSCi | uc032qhw.1, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D87009 Genomic DNA Translation: BAA20006.1 D87011 Genomic DNA Translation: BAA20008.1 BC053901 mRNA Translation: AAH53901.1 |
CCDSi | CCDS13800.1 |
RefSeqi | NP_542778.2, NM_080740.4 |
3D structure databases
SMRi | P59817 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126180, 13 interactors |
IntActi | P59817, 11 interactors |
MINTi | P59817 |
STRINGi | 9606.ENSP00000302855 |
Polymorphism and mutation databases
BioMutai | ZNF280A |
DMDMi | 313104252 |
Proteomic databases
jPOSTi | P59817 |
MassIVEi | P59817 |
MaxQBi | P59817 |
PaxDbi | P59817 |
PeptideAtlasi | P59817 |
PRIDEi | P59817 |
ProteomicsDBi | 57161 |
Protocols and materials databases
Antibodypediai | 23629, 169 antibodies |
DNASUi | 129025 |
Genome annotation databases
Ensembli | ENST00000302097; ENSP00000302855; ENSG00000169548 |
GeneIDi | 129025 |
KEGGi | hsa:129025 |
UCSCi | uc032qhw.1, human |
Organism-specific databases
CTDi | 129025 |
DisGeNETi | 129025 |
EuPathDBi | HostDB:ENSG00000169548.3 |
GeneCardsi | ZNF280A |
HGNCi | HGNC:18597, ZNF280A |
HPAi | ENSG00000169548, Tissue enhanced (adrenal gland, epididymis, retina) |
neXtProti | NX_P59817 |
PharmGKBi | PA38358 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
HOGENOMi | CLU_010097_3_2_1 |
InParanoidi | P59817 |
OrthoDBi | 105829at2759 |
PhylomeDBi | P59817 |
TreeFami | TF331707 |
Enzyme and pathway databases
PathwayCommonsi | P59817 |
Miscellaneous databases
BioGRID-ORCSi | 129025, 10 hits in 848 CRISPR screens |
ChiTaRSi | ZNF280A, human |
GenomeRNAii | 129025 |
Pharosi | P59817, Tdark |
PROi | PR:P59817 |
RNActi | P59817, protein |
Gene expression databases
Bgeei | ENSG00000169548, Expressed in left adrenal gland and 22 other tissues |
Genevisiblei | P59817, HS |
Family and domain databases
InterProi | View protein in InterPro IPR025243, DUF4195 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF13836, DUF4195, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Z280A_HUMAN | |
Accessioni | P59817Primary (citable) accession number: P59817 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 15, 2003 |
Last sequence update: | November 30, 2010 | |
Last modified: | December 2, 2020 | |
This is version 146 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations