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Protein

Glutathione peroxidase 6

Gene

GPX6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase

Enzyme and pathway databases

BRENDAi1.11.1.9 2681
ReactomeiR-HSA-3299685 Detoxification of Reactive Oxygen Species

Protein family/group databases

PeroxiBasei3605 HsGPx06

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase 6 (EC:1.11.1.9)
Short name:
GPx-6
Short name:
GSHPx-6
Gene namesi
Name:GPX6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000198704.9
HGNCiHGNC:4558 GPX6
MIMi607913 gene
neXtProtiNX_P59796

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi257202
OpenTargetsiENSG00000198704
PharmGKBiPA28954

Chemistry databases

DrugBankiDB00143 Glutathione

Polymorphism and mutation databases

BioMutaiGPX6
DMDMi187692196

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001308120 – 221Glutathione peroxidase 6Add BLAST202

Proteomic databases

PaxDbiP59796
PeptideAtlasiP59796
PRIDEiP59796
ProteomicsDBi57159

Expressioni

Tissue specificityi

Expressed in olfactory epithelium and embryos.1 Publication

Gene expression databases

BgeeiENSG00000198704 Expressed in 9 organ(s), highest expression level in testis
CleanExiHS_GPX6
ExpressionAtlasiP59796 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354581

Structurei

3D structure databases

ProteinModelPortaliP59796
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1651 Eukaryota
COG0386 LUCA
GeneTreeiENSGT00760000119230
HOGENOMiHOG000277055
HOVERGENiHBG004333
InParanoidiP59796
KOiK00432
OMAiXGLTAQY
OrthoDBiEOG091G10LN
PhylomeDBiP59796
TreeFamiTF105318

Family and domain databases

CDDicd00340 GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR000889 Glutathione_peroxidase
IPR029759 GPX_AS
IPR029760 GPX_CS
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11592 PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255 GSHPx, 1 hit
PIRSFiPIRSF000303 Glutathion_perox, 1 hit
PRINTSiPR01011 GLUTPROXDASE
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00460 GLUTATHIONE_PEROXID_1, 1 hit
PS00763 GLUTATHIONE_PEROXID_2, 1 hit
PS51355 GLUTATHIONE_PEROXID_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P59796-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFQQFQASCL VLFFLVGFAQ QTLKPQNRKV DCNKGVTGTI YEYGALTLNG
60 70 80 90 100
EEYIQFKQFA GKHVLFVNVA AYUGLAAQYP ELNALQEELK NFGVIVLAFP
110 120 130 140 150
CNQFGKQEPG TNSEILLGLK YVCPGSGFVP SFQLFEKGDV NGEKEQKVFT
160 170 180 190 200
FLKNSCPPTS DLLGSSSQLF WEPMKVHDIR WNFEKFLVGP DGVPVMHWFH
210 220
QAPVSTVKSD ILEYLKQFNT H
Length:221
Mass (Da):24,971
Last modified:February 26, 2008 - v2
Checksum:iE9B48AF5F17C3FDD
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0K3A0A087X0K3_HUMAN
Glutathione peroxidase
GPX6
220Annotation score:
A0A182DWH6A0A182DWH6_HUMAN
Glutathione peroxidase
GPX6
181Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0252496Q → L1 PublicationCorresponds to variant dbSNP:rs35510314Ensembl.1
Natural variantiVAR_02525013F → L1 PublicationCorresponds to variant dbSNP:rs406113Ensembl.1
Natural variantiVAR_02525153Y → H1 PublicationCorresponds to variant dbSNP:rs34825130Ensembl.1
Natural variantiVAR_02525258Q → H1 PublicationCorresponds to variant dbSNP:rs6922986Ensembl.1
Natural variantiVAR_02525372Y → N1 PublicationCorresponds to variant dbSNP:rs35062161Ensembl.1
Natural variantiVAR_025254136E → D1 PublicationCorresponds to variant dbSNP:rs35394555Ensembl.1
Natural variantiVAR_025255140V → M1 PublicationCorresponds to variant dbSNP:rs36055795Ensembl.1
Natural variantiVAR_025256157P → S1 PublicationCorresponds to variant dbSNP:rs35658392Ensembl.1
Natural variantiVAR_025257161D → G1 PublicationCorresponds to variant dbSNP:rs34955392Ensembl.1
Natural variantiVAR_025258188V → A1 PublicationCorresponds to variant dbSNP:rs35701070Ensembl.1

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei73Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY324826 mRNA Translation: AAP85543.1
DQ088982 Genomic DNA Translation: AAY68223.1
AL049543 Genomic DNA No translation available.
Z98745 Genomic DNA No translation available.
CCDSiCCDS43432.1
RefSeqiNP_874360.1, NM_182701.1
UniGeneiHs.448570

Genome annotation databases

EnsembliENST00000361902; ENSP00000354581; ENSG00000198704
GeneIDi257202
KEGGihsa:257202
UCSCiuc021yrx.1 human

Keywords - Coding sequence diversityi

Polymorphism, Selenocysteine

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY324826 mRNA Translation: AAP85543.1
DQ088982 Genomic DNA Translation: AAY68223.1
AL049543 Genomic DNA No translation available.
Z98745 Genomic DNA No translation available.
CCDSiCCDS43432.1
RefSeqiNP_874360.1, NM_182701.1
UniGeneiHs.448570

3D structure databases

ProteinModelPortaliP59796
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000354581

Chemistry databases

DrugBankiDB00143 Glutathione

Protein family/group databases

PeroxiBasei3605 HsGPx06

Polymorphism and mutation databases

BioMutaiGPX6
DMDMi187692196

Proteomic databases

PaxDbiP59796
PeptideAtlasiP59796
PRIDEiP59796
ProteomicsDBi57159

Protocols and materials databases

DNASUi257202
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361902; ENSP00000354581; ENSG00000198704
GeneIDi257202
KEGGihsa:257202
UCSCiuc021yrx.1 human

Organism-specific databases

CTDi257202
DisGeNETi257202
EuPathDBiHostDB:ENSG00000198704.9
GeneCardsiGPX6
H-InvDBiHIX0032860
HGNCiHGNC:4558 GPX6
MIMi607913 gene
neXtProtiNX_P59796
OpenTargetsiENSG00000198704
PharmGKBiPA28954
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1651 Eukaryota
COG0386 LUCA
GeneTreeiENSGT00760000119230
HOGENOMiHOG000277055
HOVERGENiHBG004333
InParanoidiP59796
KOiK00432
OMAiXGLTAQY
OrthoDBiEOG091G10LN
PhylomeDBiP59796
TreeFamiTF105318

Enzyme and pathway databases

BRENDAi1.11.1.9 2681
ReactomeiR-HSA-3299685 Detoxification of Reactive Oxygen Species

Miscellaneous databases

GeneWikiiGPX6
GenomeRNAii257202
PROiPR:P59796
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198704 Expressed in 9 organ(s), highest expression level in testis
CleanExiHS_GPX6
ExpressionAtlasiP59796 baseline and differential

Family and domain databases

CDDicd00340 GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR000889 Glutathione_peroxidase
IPR029759 GPX_AS
IPR029760 GPX_CS
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11592 PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255 GSHPx, 1 hit
PIRSFiPIRSF000303 Glutathion_perox, 1 hit
PRINTSiPR01011 GLUTPROXDASE
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00460 GLUTATHIONE_PEROXID_1, 1 hit
PS00763 GLUTATHIONE_PEROXID_2, 1 hit
PS51355 GLUTATHIONE_PEROXID_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPX6_HUMAN
AccessioniPrimary (citable) accession number: P59796
Secondary accession number(s): Q4PJ17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: February 26, 2008
Last modified: November 7, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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