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Protein

Membrane protein

Gene

M

Organism
Porcine epidemic diarrhea virus (strain CV777) (PEDV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane proteinUniRule annotation
Short name:
M proteinUniRule annotation
Alternative name(s):
E1 glycoproteinUniRule annotation
Matrix glycoproteinUniRule annotation
Membrane glycoproteinUniRule annotation
Gene namesi
Name:MUniRule annotation
ORF Names:5
OrganismiPorcine epidemic diarrhea virus (strain CV777) (PEDV)
Taxonomic identifieri229032 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeAlphacoronavirus
Virus hostiSus scrofa (Pig) [TaxID: 9823]
Proteomesi
  • UP000008159 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11Virion surfaceUniRule annotationAdd BLAST11
Transmembranei12 – 32HelicalUniRule annotationAdd BLAST21
Topological domaini33 – 41IntravirionUniRule annotation9
Transmembranei42 – 62HelicalUniRule annotationAdd BLAST21
Topological domaini63 – 75Virion surfaceUniRule annotationAdd BLAST13
Transmembranei76 – 96HelicalUniRule annotationAdd BLAST21
Topological domaini97 – 226IntravirionUniRule annotationAdd BLAST130

GO - Cellular componenti

Keywords - Cellular componenti

Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Viral matrix protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001060401 – 226Membrane proteinAdd BLAST226

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP59771
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni200 – 216Interaction with N proteinUniRule annotationAdd BLAST17

Sequence similaritiesi

Belongs to the alphacoronaviruses M protein family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000NM

Family and domain databases

HAMAPiMF_04201 ALPHA_CORONA_M, 1 hit
InterProiView protein in InterPro
IPR002574 Corona_M
PfamiView protein in Pfam
PF01635 Corona_M, 1 hit

Sequencei

Sequence statusi: Complete.

P59771-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNGSIPVDE VIEHLRNWNF TWNIILTILL VVLQYGHYKY SVFLYGVKMA
60 70 80 90 100
ILWILWPLVL ALSLFDAWAS FQVNWVFFAF SILMACITLM LWIMYFVNSI
110 120 130 140 150
RLWRRTHSWW SFNPETDALL TTSVMGRQVC IPVLGAPTGV TLTLLSGTLF
160 170 180 190 200
VEGYKVATGV QVSQLPNFVT VAKATTTIVY GRVGRSVNAS SGTGWAFYVR
210 220
SKHGDYSAVS NPSAVLTDSE KVLHLV
Length:226
Mass (Da):25,410
Last modified:July 11, 2003 - v1
Checksum:i46B79453DE42F67B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti150F → L. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z24733 Genomic RNA Translation: CAA80857.1
AF353511 Genomic RNA Translation: AAK38659.1
Z14976 Genomic RNA Translation: CAA78699.1
PIRiS37434
RefSeqiNP_598313.1, NC_003436.1

Genome annotation databases

GeneIDi935182
KEGGivg:935182

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z24733 Genomic RNA Translation: CAA80857.1
AF353511 Genomic RNA Translation: AAK38659.1
Z14976 Genomic RNA Translation: CAA78699.1
PIRiS37434
RefSeqiNP_598313.1, NC_003436.1

3D structure databases

ProteinModelPortaliP59771
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi935182
KEGGivg:935182

Phylogenomic databases

OrthoDBiVOG090000NM

Family and domain databases

HAMAPiMF_04201 ALPHA_CORONA_M, 1 hit
InterProiView protein in InterPro
IPR002574 Corona_M
PfamiView protein in Pfam
PF01635 Corona_M, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVME1_PEDV7
AccessioniPrimary (citable) accession number: P59771
Secondary accession number(s): Q07504, Q91AU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: July 11, 2003
Last modified: November 7, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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