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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Gene

GNG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).By similarity

GO - Molecular functioni

  • G-protein beta-subunit binding Source: UniProtKB
  • GTPase activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-202040 G-protein activation
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-418555 G alpha (s) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
SignaLinkiP59768
SIGNORiP59768

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Alternative name(s):
G gamma-I
Gene namesi
Name:GNG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000186469.8
HGNCiHGNC:4404 GNG2
MIMi606981 gene
neXtProtiNX_P59768

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54331
OpenTargetsiENSG00000186469
PharmGKBiPA28784

Chemistry databases

ChEMBLiCHEMBL3883319
DrugBankiDB01159 Halothane

Polymorphism and mutation databases

BioMutaiGNG2
DMDMi32699499

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000126112 – 68Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2Add BLAST67
PropeptideiPRO_000001261269 – 71Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei68Cysteine methyl esterBy similarity1
Lipidationi68S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP59768
MaxQBiP59768
PaxDbiP59768
PeptideAtlasiP59768
PRIDEiP59768
ProteomicsDBi57156

PTM databases

iPTMnetiP59768
PhosphoSitePlusiP59768

Expressioni

Tissue specificityi

Expressed in fetal tissues, including testis, adrenal gland, brain, white blood cells and brain.1 Publication

Gene expression databases

BgeeiENSG00000186469 Expressed in 193 organ(s), highest expression level in frontal cortex
CleanExiHS_GNG2
ExpressionAtlasiP59768 baseline and differential
GenevisibleiP59768 HS

Organism-specific databases

HPAiCAB018380
HPA003534

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (PubMed:19713215).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GNB1P628734EBI-602681,EBI-357130

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119933, 52 interactors
CORUMiP59768
DIPiDIP-33949N
IntActiP59768, 5 interactors
MINTiP59768
STRINGi9606.ENSP00000334448

Structurei

Secondary structure

171
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP59768
SMRiP59768
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP59768

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00760000119218
HOVERGENiHBG014983
InParanoidiP59768
KOiK07826
PhylomeDBiP59768
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.iShow all

P59768-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASNNTASIA QARKLVEQLK MEANIDRIKV SKAAADLMAY CEAHAKEDPL
60 70
LTPVPASENP FREKKFFCAI L
Length:71
Mass (Da):7,850
Last modified:January 23, 2007 - v2
Checksum:iEDB74E4135E7A37A
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V2N0G3V2N0_HUMAN
Guanine nucleotide-binding protein ...
GNG2
110Annotation score:
G3V3J9G3V3J9_HUMAN
Guanine nucleotide-binding protein ...
GNG2
102Annotation score:
G3V2C9G3V2C9_HUMAN
Guanine nucleotide-binding protein ...
GNG2
52Annotation score:
G3V415G3V415_HUMAN
Guanine nucleotide binding protein ...
GNG2 hCG_2013367
61Annotation score:
G3V2W5G3V2W5_HUMAN
Guanine nucleotide-binding protein ...
GNG2
37Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF493870 mRNA Translation: AAM12584.1
AL832878 mRNA Translation: CAI46198.1
CH471078 Genomic DNA Translation: EAW65663.1
BC020774 mRNA Translation: AAH20774.1
BC060856 mRNA Translation: AAH60856.1
CCDSiCCDS32082.1
PIRiJC7290 GNG2
RefSeqiNP_001230702.1, NM_001243773.1
NP_001230703.1, NM_001243774.1
NP_444292.1, NM_053064.4
XP_006720236.1, XM_006720173.2
XP_011535148.1, XM_011536846.2
XP_016876865.1, XM_017021376.1
XP_016876866.1, XM_017021377.1
UniGeneiHs.187772
Hs.709082
Hs.723399
Hs.741081

Genome annotation databases

EnsembliENST00000335281; ENSP00000334448; ENSG00000186469
ENST00000554736; ENSP00000452014; ENSG00000186469
ENST00000555472; ENSP00000451102; ENSG00000186469
ENST00000556752; ENSP00000451576; ENSG00000186469
ENST00000556766; ENSP00000451231; ENSG00000186469
ENST00000615906; ENSP00000484021; ENSG00000186469
GeneIDi54331
KEGGihsa:54331
UCSCiuc001wzi.4 human

Similar proteinsi

Entry informationi

Entry nameiGBG2_HUMAN
AccessioniPrimary (citable) accession number: P59768
Secondary accession number(s): Q5JPE2, Q6P9A9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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