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Entry version 139 (29 Sep 2021)
Sequence version 1 (03 Jul 2003)
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Protein

Dedicator of cytokinesis protein 4

Gene

Dock4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form. Involved in regulation of adherens junction between cells. Plays a role in cell migration.

By similarity

Has a higher guanine nucleotide exchange factor activity compared to other isoforms.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-9013149, RAC1 GTPase cycle
R-MMU-9013404, RAC2 GTPase cycle
R-MMU-9013408, RHOG GTPase cycle
R-MMU-983231, Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dedicator of cytokinesis protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dock4
Synonyms:Kiaa0716
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918006, Dock4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000035954

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001899911 – 1978Dedicator of cytokinesis protein 4Add BLAST1978

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei167PhosphotyrosineCombined sources1
Modified residuei193PhosphothreonineCombined sources1
Modified residuei1608PhosphoserineCombined sources1
Modified residuei1616PhosphoserineCombined sources1
Modified residuei1623PhosphoserineBy similarity1
Modified residuei1627PhosphoserineBy similarity1
Modified residuei1629PhosphoserineBy similarity1
Modified residuei1640PhosphoserineCombined sources1
Modified residuei1778PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P59764

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P59764

PRoteomics IDEntifications database

More...
PRIDEi
P59764

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
279798 [P59764-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P59764

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P59764

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P59764

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in inner ear (at protein level).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the utricular hair bundles at 14.5 dpc (at protein level) (PubMed:16464467). At P1 expressed in cochlear hair bundles of the sensory cells extending to the apical surface of the greater epithelial ridge and in the vestibule where it is restricted to hair bundles (at protein level) (PubMed:16464467).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000035954, Expressed in Ammon's horn and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P59764, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P59764, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with nucleotide-free Rap1; functions as a guanine nucleotide exchange factor (GEF) for Rap1.

Interacts (via DOCKER domain) with RAC1; functions as a guanine nucleotide exchange factor (GEF) for RAC1.

Interacts with the SH3 domain of CRK.

Interacts with FASLG.

Interacts with ELMO2 and EPHA2; mediates activation of RAC1 by EPHA2.

Interacts with USH1C (via PDZ 1 domain).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
231952, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000047387

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P59764, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 67SH3PROSITE-ProRule annotationAdd BLAST62
Domaini401 – 574C2 DOCK-typePROSITE-ProRule annotationAdd BLAST174
Domaini1199 – 1605DOCKERPROSITE-ProRule annotationAdd BLAST407

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1657 – 1738DisorderedSequence analysisAdd BLAST82
Regioni1751 – 1978DisorderedSequence analysisAdd BLAST228

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1797 – 1803SH3-bindingSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1657 – 1708Polar residuesSequence analysisAdd BLAST52
Compositional biasi1711 – 1725Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1766 – 1785Polar residuesSequence analysisAdd BLAST20
Compositional biasi1806 – 1883Polar residuesSequence analysisAdd BLAST78

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DOCKER domain mediates interaction with small GTPases like RAC1 and is required for their activation.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain, SH3-binding

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1998, Eukaryota
KOG3166, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155659

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000595_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P59764

Identification of Orthologs from Complete Genome Data

More...
OMAi
MRDFGHS

Database of Orthologous Groups

More...
OrthoDBi
102580at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P59764

TreeFam database of animal gene trees

More...
TreeFami
TF300423

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08695, C2_Dock-B, 1 hit
cd12049, SH3_DOCK4_B, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1270.350, 1 hit
1.20.58.740, 1 hit
1.25.40.410, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037811, C2_Dock-B
IPR027007, C2_DOCK-type_domain
IPR027357, C2_DOCKER_dom
IPR035892, C2_domain_sf
IPR026791, DOCK
IPR037014, DOCK4
IPR035769, DOCK4_SH3
IPR010703, DOCK_C
IPR043161, DOCK_C_lobe_A
IPR043162, DOCK_C_lobe_C
IPR032376, DOCK_N
IPR042455, DOCK_N_sub1
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR45653, PTHR45653, 1 hit
PTHR45653:SF7, PTHR45653:SF7, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06920, DHR-2, 1 hit
PF14429, DOCK-C2, 1 hit
PF16172, DOCK_N, 1 hit
PF07653, SH3_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51650, C2_DOCK, 1 hit
PS51651, DOCKER, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P59764-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWIPTEHEKY GVVIASFRGT VPYGLSLEIG DTVQILEKCD GWYRGFALKN
60 70 80 90 100
PNIKGIFPSS YVHLKNACVK NKGQFEMVIP TEDSVITEMT STLRDWGTMW
110 120 130 140 150
KQLYVRNEGD LFHRLWHIMN EILDLRRQVL VGHLTHDRMK DVKRHITARL
160 170 180 190 200
DWGNEQLGLD LVPRKEYAMV DPEDISITEL YRLMEHRHRK KDTPVQASSH
210 220 230 240 250
HLFVQMKSLM CSNLGEELEV IFSLFDSKEN RPISERFFLR LNRNGLPKAP
260 270 280 290 300
DKPERHCSLF VDLGSSELRK DIYITVHIIR IGRMGAGEKK NACSVQYRRP
310 320 330 340 350
FGCAVLSIAD LLTGETKDDL VLKVYMCNTE SEWYQIHENI IKKLNARYNL
360 370 380 390 400
TGSNAGLAVS LQLLHGDIEQ IRREYSSVFS HGVSITRKLG FSDIIMPGEM
410 420 430 440 450
RNDLYITVER GEFEKGGKSV ARNVEVTMFI VDSNGQPLKD FISFGSGEPP
460 470 480 490 500
ASEYHSFVLY HNNSPRWSEL LKLPIPVDKF RGSHIRFEFR HCSTKEKGEK
510 520 530 540 550
KLFGFSFVPL MQEDGRTLPD GTHELIVHKC EENTNLQDTT RYLKLPFSKV
560 570 580 590 600
IFLGNNNQTM KATKESFWIT SFLCSTKLTQ NGDMLDLLKW RTHPDKITGC
610 620 630 640 650
LSKLKEIDGS EIVKFLQDTL DTLFGILDEN SQKYGSKVFD SLVHIINLLQ
660 670 680 690 700
DSKFHHFKPV MDTYIESHFA GALAYRDLIK VLKWYVDRIT EAERQEHIQE
710 720 730 740 750
VLKAQEYIFK YIVQSRRLFS LATGGQNEEE FRCCIQELLM SVRFFLSQES
760 770 780 790 800
KGTGALSQSQ AVFLSSFPAV YSELLKLFDV REVANLVQDT LGSLPTIMHV
810 820 830 840 850
DDSLQAIKLQ CIGKTVESQL YTNPDSRYIL LPVVLHHLHI HLQEQKDLIM
860 870 880 890 900
CARILSNVFC LIKKNSSEKS VLEEIDVIVA SLLDILLRTI LEITSRPQAS
910 920 930 940 950
SSAMRLQFQD VTGEFVACLL SLLRQMTDRH YQQLLNSFST KEELRDFLLQ
960 970 980 990 1000
IFTVFRILIR PEMFPKDWTV MRLVANNVII TTVLYLSDAL RKNFLNENFD
1010 1020 1030 1040 1050
YKIWDSYFYL AVIFINQLCL QLEMFTPSKK KKVLEKYGDM RVTMGCEIFS
1060 1070 1080 1090 1100
MWQNLGEHKL HFIPALIGPF LEVTLIPQPD LRNVMIPIFH DMMDWEQRRS
1110 1120 1130 1140 1150
GNFKQVEAKL IDKLDSLMSE GKGDETYREL FNSIIPLFGP YPSLLKKIER
1160 1170 1180 1190 1200
ETWRESGVSL IATVTRLMER LLDYRDCMKI GEVDGKKIGC TVSLLNFYKT
1210 1220 1230 1240 1250
ELNKEEMYIR YIHKLYDLHL KAQNFTEAAY TLLLYDELLE WSDRPLREFL
1260 1270 1280 1290 1300
TYPMQTEWQR KEHLHLTIIQ NFDRGKCWEN GIILCRKIAE QYESYYDYRN
1310 1320 1330 1340 1350
LSKMRMMEAS LYDKIMDQQR LEPEFFRVGF YGKKFPFFLR NKEFVCRGHD
1360 1370 1380 1390 1400
YERLEAFQQR MLNEFPHAIA MQHANQPDET IFQAEAQYLQ IYAVTPIPES
1410 1420 1430 1440 1450
QEVLQREGVP DNIKSFYKVN HIWKFRYDRP FHKGAKDKEN EFKSLWVERT
1460 1470 1480 1490 1500
SLYLVQSLPG ISRWFEVEKR EVVEMSPLEN AIEVLENKNQ QLKTLISQCQ
1510 1520 1530 1540 1550
TRQMQNINPL TMCLNGVIDA AVNGGVSRYQ EAFFVKDYIL SHPEDGEKIA
1560 1570 1580 1590 1600
RLRELMLEQA QILEFGLAVH EKFVPQDMRP LHKKLVDQFF VMKSSFGIQE
1610 1620 1630 1640 1650
FPACIQASPV HFPNGSPRVC RNSAPASMSP DGTRVIPRRS PLSYPAVNRY
1660 1670 1680 1690 1700
SSSSLSSQAS AEVSNITGQS ESSDEVFNMQ PSPSTSSLSS THSASPNVTS
1710 1720 1730 1740 1750
SAPSSARASP LLSDKHKHSR ENSCLSPRDR PCSAIYPTPV EPSQRMLFNH
1760 1770 1780 1790 1800
IGDGALPRSD PNLSAPEKAV NPTPSSWSLD SGKEAKNMSD SGKLISPPVP
1810 1820 1830 1840 1850
PRPTQTASPA RHTTSVSPSP AGRSPLKGSV QSFTPSPVEY NSPGLSSNSP
1860 1870 1880 1890 1900
VLSGSYSSGI SSLSRCSTSE TSGFENQANE QSVPVPVPVP VPVPVPSFSG
1910 1920 1930 1940 1950
SEEPVRKESK TPPPYSVYER TLRRPVPLPH SLSIPVTSEP PALPPKPLAA
1960 1970
RSSHLENGTR RTEPGPRPRP LPRKVSQL
Length:1,978
Mass (Da):226,550
Last modified:July 3, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4A1FC9C71C5A5719
GO
Isoform 2 (identifier: P59764-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1769-1806: Missing.
     1883-1886: Missing.

Show »
Length:1,936
Mass (Da):222,197
Checksum:i8DAE09283FA3F6F7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VLY2A0A1Y7VLY2_MOUSE
Dedicator of cytokinesis protein 4
Dock4
1,940Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0605561769 – 1806Missing in isoform 2. Add BLAST38
Alternative sequenceiVSP_0605571883 – 1886Missing in isoform 2. 4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK122353 mRNA Translation: BAC65635.1
BC141138 mRNA Translation: AAI41139.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS25895.1 [P59764-1]

NCBI Reference Sequences

More...
RefSeqi
NP_766391.2, NM_172803.2 [P59764-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000037488; ENSMUSP00000047387; ENSMUSG00000035954 [P59764-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
238130

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:238130

UCSC genome browser

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UCSCi
uc007nlh.1, mouse [P59764-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122353 mRNA Translation: BAC65635.1
BC141138 mRNA Translation: AAI41139.1
CCDSiCCDS25895.1 [P59764-1]
RefSeqiNP_766391.2, NM_172803.2 [P59764-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi231952, 2 interactors
STRINGi10090.ENSMUSP00000047387

PTM databases

iPTMnetiP59764
PhosphoSitePlusiP59764
SwissPalmiP59764

Proteomic databases

MaxQBiP59764
PaxDbiP59764
PRIDEiP59764
ProteomicsDBi279798 [P59764-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
31488, 130 antibodies

The DNASU plasmid repository

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DNASUi
238130

Genome annotation databases

EnsembliENSMUST00000037488; ENSMUSP00000047387; ENSMUSG00000035954 [P59764-1]
GeneIDi238130
KEGGimmu:238130
UCSCiuc007nlh.1, mouse [P59764-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9732
MGIiMGI:1918006, Dock4
VEuPathDBiHostDB:ENSMUSG00000035954

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG1998, Eukaryota
KOG3166, Eukaryota
GeneTreeiENSGT00940000155659
HOGENOMiCLU_000595_2_0_1
InParanoidiP59764
OMAiMRDFGHS
OrthoDBi102580at2759
PhylomeDBiP59764
TreeFamiTF300423

Enzyme and pathway databases

ReactomeiR-MMU-9013149, RAC1 GTPase cycle
R-MMU-9013404, RAC2 GTPase cycle
R-MMU-9013408, RHOG GTPase cycle
R-MMU-983231, Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
238130, 2 hits in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Dock4, mouse

Protein Ontology

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PROi
PR:P59764
RNActiP59764, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000035954, Expressed in Ammon's horn and 239 other tissues
ExpressionAtlasiP59764, baseline and differential
GenevisibleiP59764, MM

Family and domain databases

CDDicd08695, C2_Dock-B, 1 hit
cd12049, SH3_DOCK4_B, 1 hit
Gene3Di1.20.1270.350, 1 hit
1.20.58.740, 1 hit
1.25.40.410, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR037811, C2_Dock-B
IPR027007, C2_DOCK-type_domain
IPR027357, C2_DOCKER_dom
IPR035892, C2_domain_sf
IPR026791, DOCK
IPR037014, DOCK4
IPR035769, DOCK4_SH3
IPR010703, DOCK_C
IPR043161, DOCK_C_lobe_A
IPR043162, DOCK_C_lobe_C
IPR032376, DOCK_N
IPR042455, DOCK_N_sub1
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR45653, PTHR45653, 1 hit
PTHR45653:SF7, PTHR45653:SF7, 1 hit
PfamiView protein in Pfam
PF06920, DHR-2, 1 hit
PF14429, DOCK-C2, 1 hit
PF16172, DOCK_N, 1 hit
PF07653, SH3_2, 1 hit
SMARTiView protein in SMART
SM00326, SH3, 1 hit
SUPFAMiSSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51650, C2_DOCK, 1 hit
PS51651, DOCKER, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDOCK4_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P59764
Secondary accession number(s): B2RUG6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: July 3, 2003
Last modified: September 29, 2021
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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