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Protein

Myocardin-related transcription factor B

Gene

Mrtfb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein
Biological processDifferentiation, Myogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Myocardin-related transcription factor BCurated
Short name:
MRTF-BCurated
Alternative name(s):
MKL/myocardin-like protein 2
Gene namesi
Name:Mrtfb
Synonyms:Mkl2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3050795 Mkl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001266291 – 1080Myocardin-related transcription factor BAdd BLAST1080

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei66PhosphoserineCombined sources1
Modified residuei531PhosphoserineCombined sources1
Modified residuei535PhosphoserineBy similarity1
Modified residuei537PhosphoserineBy similarity1
Cross-linki622Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei913PhosphoserineBy similarity1

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP59759
MaxQBiP59759
PaxDbiP59759
PRIDEiP59759

PTM databases

iPTMnetiP59759
PhosphoSitePlusiP59759

Expressioni

Tissue specificityi

Widely expressed. High expression in heart, brain and testis. Lower expression in lung, liver and kidney.1 Publication

Developmental stagei

Detected throughout the embryo at 10.5 dpc. High expression in epithelial cells of the lung, kidney, bladder, colon, testis, in the smooth muscle of the colon and small intestines, and in the mesenchymal cells adjacent to the olfactory epithelium at 15.5 dpc.1 Publication

Gene expression databases

CleanExiMM_MKL2

Interactioni

Subunit structurei

Interacts with MRTFA and SRF.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi232120, 2 interactors
DIPiDIP-60885N
IntActiP59759, 2 interactors
STRINGi10090.ENSMUSP00000009713

Structurei

3D structure databases

ProteinModelPortaliP59759
SMRiP59759
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati40 – 65RPEL 1Add BLAST26
Repeati84 – 109RPEL 2Add BLAST26
Repeati128 – 153RPEL 3Add BLAST26
Domaini383 – 417SAPPROSITE-ProRule annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni557 – 585Required for interaction with itself and with MRTFABy similarityAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili539 – 594Sequence analysisAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi320 – 346Gln-richAdd BLAST27
Compositional biasi665 – 806Gln-richAdd BLAST142

Domaini

The N-terminal region is required for nuclear localization and the C-terminal region mediates transcriptional activity.By similarity

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IFJX Eukaryota
ENOG41101AM LUCA
HOGENOMiHOG000038001
HOVERGENiHBG036493
InParanoidiP59759
KOiK22525
PhylomeDBiP59759

Family and domain databases

Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR004018 RPEL_repeat
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
PfamiView protein in Pfam
PF02755 RPEL, 2 hits
PF02037 SAP, 1 hit
SMARTiView protein in SMART
SM00707 RPEL, 3 hits
SM00513 SAP, 1 hit
SUPFAMiSSF68906 SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS51073 RPEL, 3 hits
PS50800 SAP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P59759-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIDSSKKQPQ GFPEILTAED FEPFKEKECL EGSNQKSLKE VLQLRLQQRR
60 70 80 90 100
TREQLVDQGI MPPLKSPAAF HEQIKSLERA RTENFLKHKI RSRPDRSELV
110 120 130 140 150
RMHILEETFA EPSLQATQMK LKRARLADDL NEKIAQRPGP MELVEKNILP
160 170 180 190 200
VDSSVKEAII GVVKEDYPHT HGEFSFDEDS SDALSPDQPA SQESQGSAAS
210 220 230 240 250
PSEPKVSASP PPVTASTPAQ FTSVSPAVPE FLKTPLTADQ PPTRSTAPVL
260 270 280 290 300
PTNTVSSAKS GPMLVKQSHP KNPNDKHRSK KCKDPKPRVK KLKYHQYIPP
310 320 330 340 350
NQKGEKSEPQ MDSNYARLLQ QQQLFLQLQI LSQQQQQQQQ QHYNYQTILP
360 370 380 390 400
APIKTDKNSS SGSNSGSSSS MPARRPGPLP SSLDDLKVSE LKTELKLRGL
410 420 430 440 450
PVSGTKPDLI ERLKPYQEVT SSNLATGSIV AVSSATIVTS NPEVTVALPV
460 470 480 490 500
TTLHNAVTSS VSTFKADLAL PATSSVPHVE NAHSPLPISP SPSEQSSLST
510 520 530 540 550
DDTNMTDTFT EIMTMMSPSQ LLCSSPLRVV SHDDSLSPSS STLSTLELDA
560 570 580 590 600
AEKDRKLQEK EKQIEELKRK LEQEQKLVEV LKMQLEVEKR GQQRPPDPQP
610 620 630 640 650
SDPPHPFNTS DPKHGSVGSS IKDEASLPDC SSPQQPITVP GHSVGQPIST
660 670 680 690 700
GSQTLVAKKT VVVKQEVPMA QAEQQNVVSQ FYLSSQGQPP ALVAQPQALL
710 720 730 740 750
TTQTTQLLLP VSIQGSNVTS VQLPVGSLQL QTPAQGRVQA QPHVAAATQV
760 770 780 790 800
PAAALPSALT SALPQKQEAF PQHVLGQPQP VRKVFTNSAP NTVLQYQRQP
810 820 830 840 850
GPTNQQPFVS KTSNPALQSR TAPLAPLQNG PSLASKPSSP PPPQQFVVQH
860 870 880 890 900
SLFATPITKT KDPPRYEEAI KQTRSTQPAL PEVSSVHSQQ MDDLFDILIK
910 920 930 940 950
SGEISFPIKE EPSPISKMKP VTASITTMPV NTVVSRPPPQ VQIAPPVSLE
960 970 980 990 1000
PVNSLSASLE NQLEAFLDGT LPSATDTGPL QNSSEDRESF SLIEDLQNDL
1010 1020 1030 1040 1050
LSHSSMLYQS HSPMETSEAQ LVSGTPCLSL DLSDSNLDNM EWLDITMPTT
1060 1070 1080
SSGLTPLSTT APSMFSADFL DPQDLPLPWD
Length:1,080
Mass (Da):117,547
Last modified:June 27, 2003 - v1
Checksum:i1781D8EF34517DAC
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X8R8G3X8R8_MOUSE
MCG123888
Mkl2 mCG_123888
1,091Annotation score:
Q5DTZ3Q5DTZ3_MOUSE
MKIAA1243 protein
Mkl2 mKIAA1243
1,080Annotation score:
Q8R2L3Q8R2L3_MOUSE
MKL/myocardin-like 2
Mkl2
102Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF532598 mRNA Translation: AAN33042.1
CCDSiCCDS37258.1
RefSeqiNP_705816.2, NM_153588.3
UniGeneiMm.270643

Genome annotation databases

GeneIDi239719
KEGGimmu:239719

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF532598 mRNA Translation: AAN33042.1
CCDSiCCDS37258.1
RefSeqiNP_705816.2, NM_153588.3
UniGeneiMm.270643

3D structure databases

ProteinModelPortaliP59759
SMRiP59759
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232120, 2 interactors
DIPiDIP-60885N
IntActiP59759, 2 interactors
STRINGi10090.ENSMUSP00000009713

PTM databases

iPTMnetiP59759
PhosphoSitePlusiP59759

Proteomic databases

EPDiP59759
MaxQBiP59759
PaxDbiP59759
PRIDEiP59759

Protocols and materials databases

DNASUi239719
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi239719
KEGGimmu:239719

Organism-specific databases

CTDi239719
MGIiMGI:3050795 Mkl2

Phylogenomic databases

eggNOGiENOG410IFJX Eukaryota
ENOG41101AM LUCA
HOGENOMiHOG000038001
HOVERGENiHBG036493
InParanoidiP59759
KOiK22525
PhylomeDBiP59759

Miscellaneous databases

PROiPR:P59759
SOURCEiSearch...

Gene expression databases

CleanExiMM_MKL2

Family and domain databases

Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR004018 RPEL_repeat
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
PfamiView protein in Pfam
PF02755 RPEL, 2 hits
PF02037 SAP, 1 hit
SMARTiView protein in SMART
SM00707 RPEL, 3 hits
SM00513 SAP, 1 hit
SUPFAMiSSF68906 SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS51073 RPEL, 3 hits
PS50800 SAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMRTFB_MOUSE
AccessioniPrimary (citable) accession number: P59759
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: June 27, 2003
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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