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Protein

Neutrophil defensin 3

Gene

DEFA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.4 Publications

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin, Fungicide
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-HSA-1461973 Defensins
R-HSA-1462054 Alpha-defensins

Names & Taxonomyi

Protein namesi
Recommended name:
Neutrophil defensin 3
Alternative name(s):
Defensin, alpha 3
HNP-3
Short name:
HP-3
Short name:
HP3
Cleaved into the following 2 chains:
Alternative name(s):
HNP-2
Short name:
HP-2
Short name:
HP2
Gene namesi
Name:DEFA3
Synonyms:DEF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000239839.5
HGNCiHGNC:2762 DEFA3
MIMi604522 gene
neXtProtiNX_P59666

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1668
OpenTargetsiENSG00000239839
PharmGKBiPA27239

Polymorphism and mutation databases

BioMutaiDEFA3
DMDMi30316323

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
PropeptideiPRO_000000677720 – 38Add BLAST19
ChainiPRO_000000677839 – 94HP 3-56Add BLAST56
PeptideiPRO_000000677965 – 94Neutrophil defensin 3Add BLAST30
PeptideiPRO_000000678066 – 94Neutrophil defensin 2Add BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi66 ↔ 94
Disulfide bondi68 ↔ 83
Disulfide bondi73 ↔ 93

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP59666
PeptideAtlasiP59666
PRIDEiP59666
ProteomicsDBi57155
TopDownProteomicsiP59666

PTM databases

iPTMnetiP59666
PhosphoSitePlusiP59666

Miscellaneous databases

PMAP-CutDBiP59666

Expressioni

Gene expression databases

BgeeiENSG00000239839 Expressed in 83 organ(s), highest expression level in lung
CleanExiHS_DEFA3
ExpressionAtlasiP59666 baseline and differential
GenevisibleiP59666 HS

Organism-specific databases

HPAiHPA052517

Interactioni

Subunit structurei

Dimer.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiP59666, 2 interactors
STRINGi9606.ENSP00000328359

Structurei

Secondary structure

194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP59666
SMRiP59666
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP59666

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JK0K Eukaryota
ENOG41116GP LUCA
GeneTreeiENSGT00730000111183
HOGENOMiHOG000233351
HOVERGENiHBG011703
InParanoidiP59666
KOiK05230
OMAiWRSEACH
PhylomeDBiP59666
TreeFamiTF338414

Family and domain databases

InterProiView protein in InterPro
IPR006081 Alpha-defensin
IPR016327 Alpha-defensin_pro
IPR006080 Defensin_beta/alpha
IPR002366 Defensin_propep
PANTHERiPTHR11876 PTHR11876, 1 hit
PfamiView protein in Pfam
PF00323 Defensin_1, 1 hit
PF00879 Defensin_propep, 1 hit
PIRSFiPIRSF001875 Alpha-defensin, 1 hit
SMARTiView protein in SMART
SM00048 DEFSN, 1 hit
PROSITEiView protein in PROSITE
PS00269 DEFENSIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59666-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTLAILAAI LLVALQAQAE PLQARADEVA AAPEQIAADI PEVVVSLAWD
60 70 80 90
ESLAPKHPGS RKNMDCYCRI PACIAGERRY GTCIYQGRLW AFCC
Length:94
Mass (Da):10,245
Last modified:April 30, 2003 - v1
Checksum:i0E0F8E957376C6AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21131 mRNA Translation: AAA35753.2
M23281 mRNA Translation: AAA52304.1
L12691 Genomic DNA Translation: AAB57722.1
X13621 mRNA Translation: CAA31952.1
BC027917 mRNA Translation: AAH27917.1
CCDSiCCDS5962.1
PIRiC40499
RefSeqiNP_005208.1, NM_005217.3
UniGeneiHs.654448

Genome annotation databases

EnsembliENST00000327857; ENSP00000328359; ENSG00000239839
GeneIDi1668
KEGGihsa:1668

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21131 mRNA Translation: AAA35753.2
M23281 mRNA Translation: AAA52304.1
L12691 Genomic DNA Translation: AAB57722.1
X13621 mRNA Translation: CAA31952.1
BC027917 mRNA Translation: AAH27917.1
CCDSiCCDS5962.1
PIRiC40499
RefSeqiNP_005208.1, NM_005217.3
UniGeneiHs.654448

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DFNX-ray1.90A/B65-94[»]
1ZMHX-ray1.50A/B/C/D66-94[»]
1ZMIX-ray1.15A/B/C/D66-94[»]
1ZMKX-ray1.30A/B66-94[»]
2PM4X-ray1.95A/B65-94[»]
2PM5X-ray2.40A/B65-94[»]
ProteinModelPortaliP59666
SMRiP59666
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP59666, 2 interactors
STRINGi9606.ENSP00000328359

PTM databases

iPTMnetiP59666
PhosphoSitePlusiP59666

Polymorphism and mutation databases

BioMutaiDEFA3
DMDMi30316323

Proteomic databases

PaxDbiP59666
PeptideAtlasiP59666
PRIDEiP59666
ProteomicsDBi57155
TopDownProteomicsiP59666

Protocols and materials databases

DNASUi1668
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327857; ENSP00000328359; ENSG00000239839
GeneIDi1668
KEGGihsa:1668

Organism-specific databases

CTDi1668
DisGeNETi1668
EuPathDBiHostDB:ENSG00000239839.5
GeneCardsiDEFA3
HGNCiHGNC:2762 DEFA3
HPAiHPA052517
MIMi604522 gene
neXtProtiNX_P59666
OpenTargetsiENSG00000239839
PharmGKBiPA27239
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JK0K Eukaryota
ENOG41116GP LUCA
GeneTreeiENSGT00730000111183
HOGENOMiHOG000233351
HOVERGENiHBG011703
InParanoidiP59666
KOiK05230
OMAiWRSEACH
PhylomeDBiP59666
TreeFamiTF338414

Enzyme and pathway databases

ReactomeiR-HSA-1461973 Defensins
R-HSA-1462054 Alpha-defensins

Miscellaneous databases

EvolutionaryTraceiP59666
GeneWikiiDEFA3
GenomeRNAii1668
PMAP-CutDBiP59666
PROiPR:P59666
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000239839 Expressed in 83 organ(s), highest expression level in lung
CleanExiHS_DEFA3
ExpressionAtlasiP59666 baseline and differential
GenevisibleiP59666 HS

Family and domain databases

InterProiView protein in InterPro
IPR006081 Alpha-defensin
IPR016327 Alpha-defensin_pro
IPR006080 Defensin_beta/alpha
IPR002366 Defensin_propep
PANTHERiPTHR11876 PTHR11876, 1 hit
PfamiView protein in Pfam
PF00323 Defensin_1, 1 hit
PF00879 Defensin_propep, 1 hit
PIRSFiPIRSF001875 Alpha-defensin, 1 hit
SMARTiView protein in SMART
SM00048 DEFSN, 1 hit
PROSITEiView protein in PROSITE
PS00269 DEFENSIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDEF3_HUMAN
AccessioniPrimary (citable) accession number: P59666
Secondary accession number(s): P11479, Q14125
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: April 30, 2003
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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