Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 170 (07 Oct 2020)
Sequence version 1 (30 Apr 2003)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Neutrophil defensin 1

Gene

DEFA1

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin, Fungicide
Biological processAntiviral defense

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P59665

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1461973, Defensins
R-HSA-1462054, Alpha-defensins
R-HSA-6798695, Neutrophil degranulation

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.C.19.1.1, the defensin (defensin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neutrophil defensin 1
Alternative name(s):
Defensin, alpha 1
HNP-1
Short name:
HP-1
Short name:
HP1
Cleaved into the following 2 chains:
Alternative name(s):
HNP-2
Short name:
HP-2
Short name:
HP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DEFA1
Synonyms:DEF1, DEFA2, MRS
AND
Name:DEFA1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000206047.2
HostDB:ENSG00000240247.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2761, DEFA1
HGNC:33596, DEFA1B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
125220, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P59665

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1667
728358

Open Targets

More...
OpenTargetsi
ENSG00000206047
ENSG00000240247

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165585475

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P59665, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DEFA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
30316322

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 191 PublicationAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000677120 – 38Add BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000677239 – 94HP 1-56Add BLAST56
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000000677365 – 94Neutrophil defensin 1Add BLAST30
PeptideiPRO_000000677466 – 94Neutrophil defensin 2Add BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi66 ↔ 941 Publication
Disulfide bondi68 ↔ 831 Publication
Disulfide bondi73 ↔ 931 Publication
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei78ADP-ribosylarginine; by ART11 Publication1
Modified residuei85Phosphotyrosine1 Publication1
Modified residuei88ADP-ribosylarginine; by ART11 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

ADP-ribosylation drastically reduces cytotoxic and antibacterial activities, and enhances IL8 production.
Phosphorylation at Tyr-85 has been found in some cancer cell lines, and interferes with ADP-ribosylation.1 Publication

Keywords - PTMi

ADP-ribosylation, Disulfide bond, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P59665

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P59665

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P59665

PeptideAtlas

More...
PeptideAtlasi
P59665

PRoteomics IDEntifications database

More...
PRIDEi
P59665

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
57154

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P59665

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P59665

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P59665

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000206047, Expressed in bone marrow and 97 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P59665, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000206047, Tissue enriched (bone)
ENSG00000240247, Tissue enriched (bone)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Dimer (PubMed:17452329).

Interacts with RETN (PubMed:15064728).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
108031, 94 interactors
608786, 5 interactors

Protein interaction database and analysis system

More...
IntActi
P59665, 88 interactors

Molecular INTeraction database

More...
MINTi
P59665

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000372139

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P59665, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
P59665

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P59665

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P59665

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the alpha-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502T2EX, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153268

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_160803_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P59665

KEGG Orthology (KO)

More...
KOi
K05230

Identification of Orthologs from Complete Genome Data

More...
OMAi
IPACLAG

Database of Orthologous Groups

More...
OrthoDBi
1610714at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P59665

TreeFam database of animal gene trees

More...
TreeFami
TF338414

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006081, Alpha-defensin
IPR016327, Alpha-defensin_pro
IPR006080, Defensin_beta/alpha
IPR002366, Defensin_propep

The PANTHER Classification System

More...
PANTHERi
PTHR11876, PTHR11876, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00323, Defensin_1, 1 hit
PF00879, Defensin_propep, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001875, Alpha-defensin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00048, DEFSN, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00269, DEFENSIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P59665-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTLAILAAI LLVALQAQAE PLQARADEVA AAPEQIAADI PEVVVSLAWD
60 70 80 90
ESLAPKHPGS RKNMACYCRI PACIAGERRY GTCIYQGRLW AFCC
Length:94
Mass (Da):10,201
Last modified:April 30, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E0F8E95737396FA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M21130 mRNA Translation: AAA52302.1
M26602 mRNA Translation: AAA52303.1
L12690 Genomic DNA Translation: AAA36382.1
X52053 mRNA Translation: CAA36280.1
AF200455 Genomic DNA Translation: AAT68875.1
AF200455 Genomic DNA Translation: AAT68878.1
AF200455 Genomic DNA Translation: AAT68879.1
AF200455 Genomic DNA Translation: AAT68880.1
AF238378 Genomic DNA Translation: AAT68883.1
AF238378 Genomic DNA Translation: AAT68884.1
BC069423 mRNA Translation: AAH69423.1
BC093791 mRNA Translation: AAH93791.1
BC112188 mRNA Translation: AAI12189.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34797.1
CCDS43691.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S32499, A40499

NCBI Reference Sequences

More...
RefSeqi
NP_001035965.1, NM_001042500.1
NP_004075.1, NM_004084.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000382679; ENSP00000372126; ENSG00000206047
ENST00000382689; ENSP00000372136; ENSG00000240247
ENST00000382692; ENSP00000372139; ENSG00000206047
ENST00000644528; ENSP00000496578; ENSG00000284983
ENST00000644617; ENSP00000496340; ENSG00000285176
ENST00000644834; ENSP00000496058; ENSG00000284983
ENST00000645146; ENSP00000493747; ENSG00000285176

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1667
728358

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1667
hsa:728358

UCSC genome browser

More...
UCSCi
uc003wqv.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21130 mRNA Translation: AAA52302.1
M26602 mRNA Translation: AAA52303.1
L12690 Genomic DNA Translation: AAA36382.1
X52053 mRNA Translation: CAA36280.1
AF200455 Genomic DNA Translation: AAT68875.1
AF200455 Genomic DNA Translation: AAT68878.1
AF200455 Genomic DNA Translation: AAT68879.1
AF200455 Genomic DNA Translation: AAT68880.1
AF238378 Genomic DNA Translation: AAT68883.1
AF238378 Genomic DNA Translation: AAT68884.1
BC069423 mRNA Translation: AAH69423.1
BC093791 mRNA Translation: AAH93791.1
BC112188 mRNA Translation: AAI12189.1
CCDSiCCDS34797.1
CCDS43691.1
PIRiS32499, A40499
RefSeqiNP_001035965.1, NM_001042500.1
NP_004075.1, NM_004084.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KHTNMR-A65-94[»]
2PM1X-ray1.60A65-94[»]
3GNYX-ray1.56A/B65-94[»]
3H6CX-ray1.63A/B65-94[»]
3HJ2X-ray1.40A/B65-94[»]
3HJDX-ray1.65A/B65-94[»]
3LO1X-ray1.60A65-94[»]
3LO2X-ray1.56A/B65-94[»]
3LO4X-ray1.75A/B65-94[»]
3LO6X-ray1.56A/B65-94[»]
3LO9X-ray1.56A/B65-94[»]
3LOEX-ray1.56A65-94[»]
3LVXX-ray1.63A/B65-94[»]
4DU0X-ray1.90A/B/C/D65-94[»]
4LB1X-ray2.00A/B/D/E65-94[»]
4LB7X-ray1.90A/B/D/E65-94[»]
4LBBX-ray1.72A/B65-94[»]
4LBFX-ray1.70A/B/C/D/E/F/G/H65-94[»]
BMRBiP59665
SMRiP59665
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108031, 94 interactors
608786, 5 interactors
IntActiP59665, 88 interactors
MINTiP59665
STRINGi9606.ENSP00000372139

Protein family/group databases

TCDBi1.C.19.1.1, the defensin (defensin) family

PTM databases

iPTMnetiP59665
PhosphoSitePlusiP59665

Polymorphism and mutation databases

BioMutaiDEFA1
DMDMi30316322

Proteomic databases

jPOSTiP59665
MassIVEiP59665
PaxDbiP59665
PeptideAtlasiP59665
PRIDEiP59665
ProteomicsDBi57154
TopDownProteomicsiP59665

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
74056, 14 antibodies
8213, 393 antibodies

The DNASU plasmid repository

More...
DNASUi
1667

Genome annotation databases

EnsembliENST00000382679; ENSP00000372126; ENSG00000206047
ENST00000382689; ENSP00000372136; ENSG00000240247
ENST00000382692; ENSP00000372139; ENSG00000206047
ENST00000644528; ENSP00000496578; ENSG00000284983
ENST00000644617; ENSP00000496340; ENSG00000285176
ENST00000644834; ENSP00000496058; ENSG00000284983
ENST00000645146; ENSP00000493747; ENSG00000285176
GeneIDi1667
728358
KEGGihsa:1667
hsa:728358
UCSCiuc003wqv.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1667
728358
DisGeNETi1667
728358
EuPathDBiHostDB:ENSG00000206047.2
HostDB:ENSG00000240247.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DEFA1
DEFA1B
HGNCiHGNC:2761, DEFA1
HGNC:33596, DEFA1B
HPAiENSG00000206047, Tissue enriched (bone)
ENSG00000240247, Tissue enriched (bone)
MIMi125220, gene
neXtProtiNX_P59665
OpenTargetsiENSG00000206047
ENSG00000240247
PharmGKBiPA165585475

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502T2EX, Eukaryota
GeneTreeiENSGT00940000153268
HOGENOMiCLU_160803_0_0_1
InParanoidiP59665
KOiK05230
OMAiIPACLAG
OrthoDBi1610714at2759
PhylomeDBiP59665
TreeFamiTF338414

Enzyme and pathway databases

PathwayCommonsiP59665
ReactomeiR-HSA-1461973, Defensins
R-HSA-1462054, Alpha-defensins
R-HSA-6798695, Neutrophil degranulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
1667, 4 hits in 467 CRISPR screens
728358, 1 hit in 89 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DEFA1B, human
EvolutionaryTraceiP59665

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
DEFA1B
Defensin,_alpha_1
PharosiP59665, Tbio

Protein Ontology

More...
PROi
PR:P59665
RNActiP59665, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000206047, Expressed in bone marrow and 97 other tissues
GenevisibleiP59665, HS

Family and domain databases

InterProiView protein in InterPro
IPR006081, Alpha-defensin
IPR016327, Alpha-defensin_pro
IPR006080, Defensin_beta/alpha
IPR002366, Defensin_propep
PANTHERiPTHR11876, PTHR11876, 1 hit
PfamiView protein in Pfam
PF00323, Defensin_1, 1 hit
PF00879, Defensin_propep, 1 hit
PIRSFiPIRSF001875, Alpha-defensin, 1 hit
SMARTiView protein in SMART
SM00048, DEFSN, 1 hit
PROSITEiView protein in PROSITE
PS00269, DEFENSIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDEF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P59665
Secondary accession number(s): P11479, Q14125, Q6EZF6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: April 30, 2003
Last modified: October 7, 2020
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again