The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - P59657 (SULD_STRR6)
Protein
Bifunctional folate synthesis protein
Gene
sulD
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Functioni
Catalyzes two sequential steps of tetrahydrofolate biosynthesis, the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin diphosphate.
By similarityCatalytic activityi
- EC:4.1.2.25By similarity
- 6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H+By similarityEC:2.7.6.3By similarity
: tetrahydrofolate biosynthesis Pathwayi
This protein is involved in step 3 and 4 of the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate. This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 21 | SubstrateBy similarity | 1 | |
Binding sitei | 53 | SubstrateBy similarity | 1 | |
Active sitei | 99 | Proton donor/acceptor; for DHNA activityBy similarity | 1 | |
Metal bindingi | 212 | Magnesium 1By similarity | 1 | |
Metal bindingi | 212 | Magnesium 2By similarity | 1 | |
Metal bindingi | 214 | Magnesium 1By similarity | 1 | |
Metal bindingi | 214 | Magnesium 2By similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 160 – 163 | ATPBy similarity | 4 | |
Nucleotide bindingi | 171 – 173 | ATPBy similarity | 3 | |
Nucleotide bindingi | 192 – 195 | ATPBy similarity | 4 | |
Nucleotide bindingi | 200 – 215 | ATPBy similarityAdd BLAST | 16 | |
Nucleotide bindingi | 227 – 233 | ATPBy similarity | 7 | |
Nucleotide bindingi | 238 – 240 | ATPBy similarity | 3 |
GO - Molecular functioni
- 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-KW
- dihydroneopterin aldolase activity Source: UniProtKB-EC
- kinase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- folic acid biosynthetic process Source: UniProtKB-KW
- tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Kinase, Lyase, Multifunctional enzyme, Transferase |
Biological process | Folate biosynthesis |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00077;UER00154 UPA00077;UER00155 |
Names & Taxonomyi
Protein namesi | Recommended name: Bifunctional folate synthesis proteinIncluding the following 2 domains: Alternative name(s): 7,8-dihydroneopterin aldolase 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC:2.7.6.3) Alternative name(s): 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase1 Publication Short name: PPPK 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase Short name: HPPK1 Publication |
Gene namesi | Name:sulD1 Publication Ordered Locus Names:spr0269 |
Organismi | Streptococcus pneumoniae (strain ATCC BAA-255 / R6) |
Taxonomic identifieri | 171101 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000168245 | 1 – 270 | Bifunctional folate synthesis proteinAdd BLAST | 270 |
Interactioni
Subunit structurei
Homooctamer.
1 PublicationProtein-protein interaction databases
STRINGi | 171101.spr0269 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P59657 |
SMRi | P59657 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P59657 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 119 | DHNAAdd BLAST | 119 | |
Regioni | 72 – 73 | Substrate bindingBy similarity | 2 | |
Regioni | 120 – 270 | HPPKAdd BLAST | 151 |
Sequence similaritiesi
In the N-terminal section; belongs to the DHNA family.Curated
In the C-terminal section; belongs to the HPPK family.Curated
Phylogenomic databases
eggNOGi | COG0801, Bacteria COG1539, Bacteria |
HOGENOMi | CLU_023499_0_0_9 |
OMAi | IKKPWAP |
Family and domain databases
CDDi | cd00534, DHNA_DHNTPE, 1 hit cd00483, HPPK, 1 hit |
Gene3Di | 3.30.1130.10, 1 hit 3.30.70.560, 1 hit |
InterProi | View protein in InterPro IPR006156, Dihydroneopterin_aldolase IPR006157, FolB_dom IPR043133, GTP-CH-I_C/QueF IPR000550, Hppk IPR035907, Hppk_sf |
Pfami | View protein in Pfam PF02152, FolB, 1 hit PF01288, HPPK, 1 hit |
SMARTi | View protein in SMART SM00905, FolB, 1 hit |
SUPFAMi | SSF55083, SSF55083, 1 hit |
TIGRFAMsi | TIGR00525, folB, 1 hit TIGR00526, folB_dom, 1 hit TIGR01498, folK, 1 hit |
PROSITEi | View protein in PROSITE PS00794, HPPK, 1 hit |
i Sequence
Sequence statusi: Complete.
P59657-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDQLQIKDLE MFAYHGLFPS EKELGQKFIV SAILSYDMTK AATDLDLTAS
60 70 80 90 100
VHYGELCQQW TTWFQETSED LIETVAYKLV ERTFESYPLV QEMKLELKKP
110 120 130 140 150
WAPVHLSLDT CSVTIHRRKQ RAFIALGSNM GDKQANLKQA IDKLRARGIH
160 170 180 190 200
ILKESSVLAT EPWGGVEQDS FANQVVEVET WLPAQDLLET LLAIESELGR
210 220 230 240 250
VREVHWGPRL IDLDLLFVED QILYTDDLIL PHPYIAERLF VLESLQEIAP
260 270
HFIHPILKQP IRNLYDALKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE007317 Genomic DNA Translation: AAK99073.1 |
RefSeqi | NP_357863.1, NC_003098.1 WP_000372525.1, NC_003098.1 |
Genome annotation databases
EnsemblBacteriai | AAK99073; AAK99073; spr0269 |
GeneIDi | 60233326 |
KEGGi | spr:spr0269 |
PATRICi | fig|171101.6.peg.306 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE007317 Genomic DNA Translation: AAK99073.1 |
RefSeqi | NP_357863.1, NC_003098.1 WP_000372525.1, NC_003098.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CG8 | X-ray | 2.90 | A/B/C/D | 1-270 | [»] | |
AlphaFoldDBi | P59657 | |||||
SMRi | P59657 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 171101.spr0269 |
Genome annotation databases
EnsemblBacteriai | AAK99073; AAK99073; spr0269 |
GeneIDi | 60233326 |
KEGGi | spr:spr0269 |
PATRICi | fig|171101.6.peg.306 |
Phylogenomic databases
eggNOGi | COG0801, Bacteria COG1539, Bacteria |
HOGENOMi | CLU_023499_0_0_9 |
OMAi | IKKPWAP |
Enzyme and pathway databases
UniPathwayi | UPA00077;UER00154 UPA00077;UER00155 |
Miscellaneous databases
EvolutionaryTracei | P59657 |
Family and domain databases
CDDi | cd00534, DHNA_DHNTPE, 1 hit cd00483, HPPK, 1 hit |
Gene3Di | 3.30.1130.10, 1 hit 3.30.70.560, 1 hit |
InterProi | View protein in InterPro IPR006156, Dihydroneopterin_aldolase IPR006157, FolB_dom IPR043133, GTP-CH-I_C/QueF IPR000550, Hppk IPR035907, Hppk_sf |
Pfami | View protein in Pfam PF02152, FolB, 1 hit PF01288, HPPK, 1 hit |
SMARTi | View protein in SMART SM00905, FolB, 1 hit |
SUPFAMi | SSF55083, SSF55083, 1 hit |
TIGRFAMsi | TIGR00525, folB, 1 hit TIGR00526, folB_dom, 1 hit TIGR01498, folK, 1 hit |
PROSITEi | View protein in PROSITE PS00794, HPPK, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SULD_STRR6 | |
Accessioni | P59657Primary (citable) accession number: P59657 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 30, 2003 |
Last sequence update: | April 30, 2003 | |
Last modified: | May 25, 2022 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families