Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

FXYD domain-containing ion transport regulator 4

Gene

FXYD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-5578775 Ion homeostasis
R-HSA-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
FXYD domain-containing ion transport regulator 4
Gene namesi
Name:FXYD4
ORF Names:UNQ526/PRO1069
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000150201.14
HGNCiHGNC:4028 FXYD4
neXtProtiNX_P59646

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 38ExtracellularSequence analysisAdd BLAST18
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 89CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi53828
OpenTargetsiENSG00000150201
PharmGKBiPA28444

Polymorphism and mutation databases

BioMutaiFXYD4
DMDMi114152806

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001036621 – 89FXYD domain-containing ion transport regulator 4Add BLAST69

Proteomic databases

PaxDbiP59646
PeptideAtlasiP59646
PRIDEiP59646
ProteomicsDBi57153

PTM databases

PhosphoSitePlusiP59646

Expressioni

Gene expression databases

BgeeiENSG00000150201
CleanExiHS_FXYD4
GenevisibleiP59646 HS

Organism-specific databases

HPAiHPA058421

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000363575

Structurei

3D structure databases

ProteinModelPortaliP59646
SMRiP59646
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J4PQ Eukaryota
ENOG4111AWX LUCA
GeneTreeiENSGT00530000063998
HOGENOMiHOG000234469
InParanoidiP59646
KOiK13359
OMAiPFYYDWE
PhylomeDBiP59646
TreeFamiTF333443

Family and domain databases

InterProiView protein in InterPro
IPR000272 Ion-transport_regulator_FXYD
PfamiView protein in Pfam
PF02038 ATP1G1_PLM_MAT8, 1 hit
PROSITEiView protein in PROSITE
PS01310 FXYD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERVTLALLL LAGLTALEAN DPFANKDDPF YYDWKNLQLS GLICGGLLAI
60 70 80
AGIAAVLSGK CKCKSSQKQH SPVPEKAIPL ITPGSATTC
Length:89
Mass (Da):9,373
Last modified:September 5, 2006 - v2
Checksum:iC5935929A22449B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63C → Y in AAQ88947 (PubMed:12975309).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358584 mRNA Translation: AAQ88947.1
AL512654 Genomic DNA No translation available.
BC054876 mRNA Translation: AAH54876.1
CCDSiCCDS7203.1
RefSeqiNP_001171892.1, NM_001184963.1
NP_775183.1, NM_173160.2
UniGeneiHs.130497

Genome annotation databases

EnsembliENST00000476166; ENSP00000473361; ENSG00000150201
ENST00000616495; ENSP00000483791; ENSG00000150201
GeneIDi53828
KEGGihsa:53828
UCSCiuc001jaq.2 human

Similar proteinsi

Entry informationi

Entry nameiFXYD4_HUMAN
AccessioniPrimary (citable) accession number: P59646
Secondary accession number(s): Q6UWZ1, Q7Z4M5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: September 5, 2006
Last modified: June 20, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health