9b - Protein 9b - Human SARS coronavirus (SARS-CoV)

Functionⁱ

Miscellaneous

The gene encoding this protein is included within the N gene (alternative ORF).

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein 9b Alternative name(s): Accessory protein 9b ORF-9b
Gene namesⁱ	ORF Names:9b
Organismⁱ	Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
Taxonomic identifierⁱ	227859 [NCBI]
Taxonomic lineageⁱ	Viruses › ssRNA viruses › ssRNA positive-strand viruses, no DNA stage › Nidovirales › Coronaviridae › Coronavirinae › Betacoronavirus ›
Virus hostⁱ	Homo sapiens (Human) [TaxID: 9606] Paguma larvata (Masked palm civet) [TaxID: 9675]
Proteomesⁱ	UP000160648 Componentⁱ: Genome UP000121636 Componentⁱ: Genome UP000116947 Componentⁱ: Genome UP000145651 Componentⁱ: Genome UP000146108 Componentⁱ: Genome UP000172416 Componentⁱ: Genome UP000137377 Componentⁱ: Genome UP000000354 Componentⁱ: Genome UP000103670 Componentⁱ: Genome UP000131569 Componentⁱ: Genome UP000153467 Componentⁱ: Genome UP000148194 Componentⁱ: Genome UP000138690 Componentⁱ: Genome UP000109640 Componentⁱ: Genome UP000131955 Componentⁱ: Genome

Subcellular locationⁱ

Host cytoplasmic vesicle membrane
1 Publication
Manual assertion based on experiment inⁱ
- Ref.13
  "The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus."
  Meier C., Aricescu A.R., Assenberg R., Aplin R.T., Gilbert R.J.C., Grimes J.M., Stuart D.I.
  Structure 14:1157-1165(2006) [PubMed] [Europe PMC] [Abstract]
  Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 9-98, SUBCELLULAR LOCATION.
; Peripheral membrane protein
1 Publication
Manual assertion based on experiment inⁱ
- Ref.13
  "The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus."
  Meier C., Aricescu A.R., Assenberg R., Aplin R.T., Gilbert R.J.C., Grimes J.M., Stuart D.I.
  Structure 14:1157-1165(2006) [PubMed] [Europe PMC] [Abstract]
  Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 9-98, SUBCELLULAR LOCATION.
Host cytoplasm
1 Publication
Manual assertion based on experiment inⁱ
- Ref.13
  "The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus."
  Meier C., Aricescu A.R., Assenberg R., Aplin R.T., Gilbert R.J.C., Grimes J.M., Stuart D.I.
  Structure 14:1157-1165(2006) [PubMed] [Europe PMC] [Abstract]
  Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 9-98, SUBCELLULAR LOCATION.

Note:

Binds non-covalently to intracellular lipid bilayers.

GO - Cellular componentⁱ

host cell cytoplasmic vesicle membrane Source: UniProtKB-SubCell
membrane Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Host cytoplasm, Host cytoplasmic vesicle, Host membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000106137	1 – 98	Protein 9bAdd BLAST		98

Interactionⁱ

Subunit structureⁱ

Homodimer.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	14 – 23	Combined sources	10
Beta strandⁱ	42 – 47	Combined sources	6
Beta strandⁱ	54 – 60	Combined sources	7
Beta strandⁱ	65 – 67	Combined sources	3
Beta strandⁱ	69 – 74	Combined sources	6
Helixⁱ	85 – 87	Combined sources	3
Beta strandⁱ	90 – 97	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	P59636
SMRⁱ	P59636
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P59636

EvolutionaryTraceⁱ

P59636

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the coronavirus group 2 protein 9b family.Curated

Phylogenomic databases

Database of Orthologous Groups More...OrthoDBⁱ	VOG090001JI

OrthoDBⁱ

VOG090001JI

Family and domain databases

InterProⁱ	View protein in InterPro IPR018542 SARS_lipid-bd IPR037223 SARS_ORF-9b
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09399 SARS_lipid_bind, 1 hit
SUPFAMⁱ	SSF141666 SSF141666, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P59636-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDPNQTNVVP PALHLVDPQI QLTITRMEDA MGQGQNSADP KVYPIILRLG 
        60         70         80         90 
SQLSLSMARR NLDSLEARAF QSTPIVVQMT KLATTEELPD EFVVVTAK

Length:98

Mass (Da):10,802

Last modified:April 23, 2003 - v1

Checksum:ⁱ5166F22872915FCB

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱ	58	A → V in strain: Isolate TWK.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY278741 Genomic RNA No translation available. AY274119 Genomic RNA Translation: AAP41048.1 AY282752 Genomic RNA No translation available. AY278554 Genomic RNA Translation: AAP13574.1 AY278491 Genomic RNA No translation available. AY278487 Genomic RNA No translation available. AY278488 Genomic RNA Translation: AAP30038.1 AY278489 Genomic RNA Translation: AAP51235.1 AY278490 Genomic RNA No translation available. AY279354 Genomic RNA No translation available. AY291451 Genomic RNA Translation: AAP37025.1 AY310120 Genomic RNA Translation: AAP50496.1 AY291315 Genomic RNA Translation: AAP33708.1 AY290752 Genomic RNA Translation: AAP69659.1 AP006557 Genomic RNA Translation: BAC81359.1 AP006558 Genomic RNA Translation: BAC81373.1 AP006559 Genomic RNA Translation: BAC81387.1 AP006560 Genomic RNA Translation: BAC81401.1 AP006561 Genomic RNA Translation: BAC81415.1 AY323977 Genomic RNA Translation: AAP72985.1 AY427439 Genomic RNA Translation: AAQ94071.1
NCBI Reference Sequences More...RefSeqⁱ	NP_828859.1, NC_004718.3

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AY278741 Genomic RNA No translation available.
AY274119 Genomic RNA Translation: AAP41048.1
AY282752 Genomic RNA No translation available.
AY278554 Genomic RNA Translation: AAP13574.1
AY278491 Genomic RNA No translation available.
AY278487 Genomic RNA No translation available.
AY278488 Genomic RNA Translation: AAP30038.1
AY278489 Genomic RNA Translation: AAP51235.1
AY278490 Genomic RNA No translation available.
AY279354 Genomic RNA No translation available.
AY291451 Genomic RNA Translation: AAP37025.1
AY310120 Genomic RNA Translation: AAP50496.1
AY291315 Genomic RNA Translation: AAP33708.1
AY290752 Genomic RNA Translation: AAP69659.1
AP006557 Genomic RNA Translation: BAC81359.1
AP006558 Genomic RNA Translation: BAC81373.1
AP006559 Genomic RNA Translation: BAC81387.1
AP006560 Genomic RNA Translation: BAC81401.1
AP006561 Genomic RNA Translation: BAC81415.1
AY323977 Genomic RNA Translation: AAP72985.1
AY427439 Genomic RNA Translation: AAQ94071.1

RefSeqⁱ

NP_828859.1, NC_004718.3

Genome annotation databases

GeneIDⁱ	1489679
KEGGⁱ	vg:1489679

Protein	Similar proteins		Species	Score	Length	Source
P59636	Uncharacterized protein		SARS coronavirus MA15 ExoN1		98	UniRef100_P59636
Non-structural protein 9b		SARS coronavirus wtic-MB		98
Uncharacterized protein		SARS coronavirus HKU-39849		98
Non-structural protein 9b		SARS coronavirus ExoN1		98
Uncharacterized protein		SARS coronavirus MA15		98
+24

Protein	Similar proteins		Species	Score	Length	Source
P59636	Uncharacterized protein		SARS coronavirus MA15 ExoN1		98	UniRef90_P59636
Non-structural protein 9b		SARS coronavirus wtic-MB		98
Uncharacterized protein		SARS coronavirus HKU-39849		98
Non-structural protein 9b		SARS coronavirus ExoN1		98
Uncharacterized protein		SARS coronavirus MA15		98
+43

Protein	Similar proteins		Species	Score	Length	Source
P59636	Protein 9b		BCHK3		97	UniRef50_P59636
Protein 9b		BCRP3		97
Protein 9b		BC279		97
Uncharacterized protein		SARS coronavirus MA15 ExoN1		98
Non-structural protein 9b		SARS coronavirus wtic-MB		98
+65

Entry informationⁱ

Entry nameⁱ	ORF9B_CVHSA
Accessionⁱ	P59636Primary (citable) accession number: P59636 Secondary accession number(s): Q7T6R2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
	Last sequence update:	April 23, 2003
	Last modified:	May 23, 2018
	This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Viral Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

UniProtKB - P59636 (ORF9B_CVHSA)

Your basket is currently empty. ⁱ

Protein 9b

9b

Select a section on the left to see content.

Functionⁱ

Miscellaneous

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Interactionⁱ

Subunit structureⁱ

Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Natural variant

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProt is an ELIXIR core data resource

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P59636 (ORF9B_CVHSA)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Protein 9b

9b

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ