UniProtKB - P59636 (ORF9B_SARS)
Protein
ORF9b protein
Gene
9b
Organism
Severe acute respiratory syndrome coronavirus (SARS-CoV)
Status
Functioni
Plays a role in the inhibition of host innate immune response by targeting the mitochondrial-associated adapter MAVS. Mechanistically, usurps the E3 ligase ITCH to trigger the degradation of MAVS, TRAF3, and TRAF6. In addition, causes mitochondrial elongation by triggering ubiquitination and proteasomal degradation of dynamin-like protein 1/DNM1L.1 Publication
Miscellaneous
The gene encoding this protein is included within the N gene (alternative ORF).
GO - Molecular functioni
- identical protein binding Source: IntAct
GO - Biological processi
- suppression by virus of host MAVS activity Source: UniProtKB
Keywordsi
Biological process | Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host MAVS by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion |
Enzyme and pathway databases
Reactomei | R-HSA-9679504, Translation of Replicase and Assembly of the Replication Transcription Complex |
SIGNORi | P59636 |
Names & Taxonomyi
Protein namesi | Recommended name: ORF9b proteinAlternative name(s): Accessory protein 9b ORF-9b Protein 9b |
Gene namesi | ORF Names:9b |
Organismi | Severe acute respiratory syndrome coronavirus (SARS-CoV) |
Taxonomic identifieri | 694009 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Sarbecovirus |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] Paguma larvata (Masked palm civet) [TaxID: 9675] |
Proteomesi |
|
Subcellular locationi
- Virion 1 Publication
- Host cytoplasmic vesicle membrane 1 Publication; Peripheral membrane protein 1 Publication
- Host cytoplasm 3 Publications
- Host endoplasmic reticulum 1 Publication
- Host nucleus 1 Publication
- Host mitochondrion 1 Publication Note: Binds non-covalently to intracellular lipid bilayers.
GO - Cellular componenti
- host cell cytoplasmic vesicle membrane Source: UniProtKB-SubCell
- host cell endoplasmic reticulum Source: UniProtKB
- host cell mitochondrion Source: UniProtKB
- host cell nucleus Source: UniProtKB-SubCell
- membrane Source: UniProtKB-KW
- virion Source: UniProtKB
Keywords - Cellular componenti
Host cytoplasm, Host cytoplasmic vesicle, Host endoplasmic reticulum, Host membrane, Host mitochondrion, Host nucleus, Membrane, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000106137 | 1 – 98 | ORF9b proteinAdd BLAST | 98 |
Proteomic databases
PRIDEi | P59636 |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsP59636
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 4383924, 58 interactors |
ComplexPortali | CPX-6101, SARS-CoV 9b complex |
IntActi | P59636, 28 interactors |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P59636 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P59636 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 98 | 9bPROSITE-ProRule annotationAdd BLAST | 90 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 46 – 54 | Nuclear export signal1 Publication | 9 |
Sequence similaritiesi
Belongs to the coronavirus group 2 protein 9b family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR018542, Protein_9b_Betacoronavirus IPR037223, Protein_9b_SARS |
Pfami | View protein in Pfam PF09399, bCoV_lipid_BD, 1 hit |
SUPFAMi | SSF141666, SSF141666, 1 hit |
PROSITEi | View protein in PROSITE PS51920, SARS_9B, 1 hit |
i Sequence
Sequence statusi: Complete.
P59636-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPNQTNVVP PALHLVDPQI QLTITRMEDA MGQGQNSADP KVYPIILRLG
60 70 80 90
SQLSLSMARR NLDSLEARAF QSTPIVVQMT KLATTEELPD EFVVVTAK
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 58 | A → V in strain: Isolate TWK. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY278741 Genomic RNA No translation available. AY274119 Genomic RNA Translation: AAP41048.1 AY282752 Genomic RNA No translation available. AY278554 Genomic RNA Translation: AAP13574.1 AY278491 Genomic RNA No translation available. AY278487 Genomic RNA No translation available. AY278488 Genomic RNA Translation: AAP30038.1 AY278489 Genomic RNA Translation: AAP51235.1 AY278490 Genomic RNA No translation available. AY279354 Genomic RNA No translation available. AY291451 Genomic RNA Translation: AAP37025.1 AY310120 Genomic RNA Translation: AAP50496.1 AY291315 Genomic RNA Translation: AAP33708.1 AY290752 Genomic RNA Translation: AAP69659.1 AP006557 Genomic RNA Translation: BAC81359.1 AP006558 Genomic RNA Translation: BAC81373.1 AP006559 Genomic RNA Translation: BAC81387.1 AP006560 Genomic RNA Translation: BAC81401.1 AP006561 Genomic RNA Translation: BAC81415.1 AY323977 Genomic RNA Translation: AAP72985.1 AY427439 Genomic RNA Translation: AAQ94071.1 |
RefSeqi | NP_828859.1, NC_004718.3 |
Genome annotation databases
GeneIDi | 1489679 |
KEGGi | vg:1489679 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY278741 Genomic RNA No translation available. AY274119 Genomic RNA Translation: AAP41048.1 AY282752 Genomic RNA No translation available. AY278554 Genomic RNA Translation: AAP13574.1 AY278491 Genomic RNA No translation available. AY278487 Genomic RNA No translation available. AY278488 Genomic RNA Translation: AAP30038.1 AY278489 Genomic RNA Translation: AAP51235.1 AY278490 Genomic RNA No translation available. AY279354 Genomic RNA No translation available. AY291451 Genomic RNA Translation: AAP37025.1 AY310120 Genomic RNA Translation: AAP50496.1 AY291315 Genomic RNA Translation: AAP33708.1 AY290752 Genomic RNA Translation: AAP69659.1 AP006557 Genomic RNA Translation: BAC81359.1 AP006558 Genomic RNA Translation: BAC81373.1 AP006559 Genomic RNA Translation: BAC81387.1 AP006560 Genomic RNA Translation: BAC81401.1 AP006561 Genomic RNA Translation: BAC81415.1 AY323977 Genomic RNA Translation: AAP72985.1 AY427439 Genomic RNA Translation: AAQ94071.1 |
RefSeqi | NP_828859.1, NC_004718.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CME | X-ray | 2.80 | A/B | 9-98 | [»] | |
E/G | 9-98 | [»] | ||||
C/D/F/H | 10-98 | [»] | ||||
SMRi | P59636 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4383924, 58 interactors |
ComplexPortali | CPX-6101, SARS-CoV 9b complex |
IntActi | P59636, 28 interactors |
Proteomic databases
PRIDEi | P59636 |
Genome annotation databases
GeneIDi | 1489679 |
KEGGi | vg:1489679 |
Enzyme and pathway databases
Reactomei | R-HSA-9679504, Translation of Replicase and Assembly of the Replication Transcription Complex |
SIGNORi | P59636 |
Miscellaneous databases
EvolutionaryTracei | P59636 |
Family and domain databases
InterProi | View protein in InterPro IPR018542, Protein_9b_Betacoronavirus IPR037223, Protein_9b_SARS |
Pfami | View protein in Pfam PF09399, bCoV_lipid_BD, 1 hit |
SUPFAMi | SSF141666, SSF141666, 1 hit |
PROSITEi | View protein in PROSITE PS51920, SARS_9B, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ORF9B_SARS | |
Accessioni | P59636Primary (citable) accession number: P59636 Secondary accession number(s): Q7T6R2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 23, 2003 |
Last sequence update: | April 23, 2003 | |
Last modified: | February 10, 2021 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families