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Protein

Protein 7a

Gene

7a

Organism
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non-structural protein which is dispensable for virus replication in cell culture.1 Publication

GO - Biological processi

Keywordsi

Biological processG0/G1 host cell cycle checkpoint dysregulation by virus, Host-virus interaction, Modulation of host cell cycle by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Protein 7a
Alternative name(s):
Accessory protein 7a
Protein U122
Protein X4
Gene namesi
ORF Names:7a
OrganismiHuman SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
Taxonomic identifieri227859 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Paguma larvata (Masked palm civet) [TaxID: 9675]
Proteomesi

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini16 – 96Virion surfaceSequence analysisAdd BLAST81
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Topological domaini118 – 122IntravirionSequence analysis5

GO - Cellular componenti

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi14 – 18SCELY → LLLLL: Complete loss of signal sequence cleavage. 1 Publication5
Mutagenesisi118 – 120KRK → ERE: Induces rapid exit from the endoplasmic reticulum. 1 Publication3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Add BLAST15
ChainiPRO_000003743516 – 122Protein 7aAdd BLAST107

Proteomic databases

PRIDEiP59635

Interactioni

Subunit structurei

Interacts with the spike glycoprotein, M protein, E protein and the accessory protein 3a. Interacts with human SGT.3 Publications

Protein-protein interaction databases

ELMiP59635

Structurei

Secondary structure

1122
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP59635
SMRiP59635
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP59635

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi118 – 122Di-lysine motif5

Domaini

The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.By similarity

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090001AR

Family and domain databases

Gene3Di2.60.40.1550, 1 hit
InterProiView protein in InterPro
IPR014888 SARS_X4
IPR036495 SARS_X4_sf
PfamiView protein in Pfam
PF08779 SARS_X4, 1 hit
SUPFAMiSSF117066 SSF117066, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59635-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIILFLTLI VFTSCELYHY QECVRGTTVL LKEPCPSGTY EGNSPFHPLA
60 70 80 90 100
DNKFALTCTS THFAFACADG TRHTYQLRAR SVSPKLFIRQ EEVQQELYSP
110 120
LFLIVAALVF LILCFTIKRK TE
Length:122
Mass (Da):13,941
Last modified:April 23, 2003 - v1
Checksum:i6D8D8D949B0DB4B5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti38G → A in strain: Isolate Shanghai LY. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278741 Genomic RNA Translation: AAP13449.1
AY274119 Genomic RNA Translation: AAP41043.1
AY282752 Genomic RNA No translation available.
AY278554 Genomic RNA Translation: AAP13573.1
AY278491 Genomic RNA No translation available.
AY278487 Genomic RNA No translation available.
AY278488 Genomic RNA Translation: AAP30036.1
AY278489 Genomic RNA Translation: AAP51233.1
AY278490 Genomic RNA No translation available.
AY279354 Genomic RNA No translation available.
AY291451 Genomic RNA Translation: AAP37023.1
AY310120 Genomic RNA Translation: AAP50491.1
AY291315 Genomic RNA Translation: AAP33703.1
AY338174 Genomic RNA Translation: AAQ01603.1
AY338175 Genomic RNA Translation: AAQ01615.1
AY348314 Genomic RNA Translation: AAP97888.1
AP006557 Genomic RNA Translation: BAC81354.1
AP006558 Genomic RNA Translation: BAC81368.1
AP006559 Genomic RNA Translation: BAC81382.1
AP006560 Genomic RNA Translation: BAC81396.1
AP006561 Genomic RNA Translation: BAC81410.1
AY323977 Genomic RNA Translation: AAP72980.1
AY427439 Genomic RNA Translation: AAQ94066.1
AY463059 Genomic RNA Translation: AAP82982.2
AY322208 Genomic RNA Translation: AAP82970.1
RefSeqiNP_828857.1, NC_004718.3

Genome annotation databases

GeneIDi1489674
KEGGivg:1489674

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278741 Genomic RNA Translation: AAP13449.1
AY274119 Genomic RNA Translation: AAP41043.1
AY282752 Genomic RNA No translation available.
AY278554 Genomic RNA Translation: AAP13573.1
AY278491 Genomic RNA No translation available.
AY278487 Genomic RNA No translation available.
AY278488 Genomic RNA Translation: AAP30036.1
AY278489 Genomic RNA Translation: AAP51233.1
AY278490 Genomic RNA No translation available.
AY279354 Genomic RNA No translation available.
AY291451 Genomic RNA Translation: AAP37023.1
AY310120 Genomic RNA Translation: AAP50491.1
AY291315 Genomic RNA Translation: AAP33703.1
AY338174 Genomic RNA Translation: AAQ01603.1
AY338175 Genomic RNA Translation: AAQ01615.1
AY348314 Genomic RNA Translation: AAP97888.1
AP006557 Genomic RNA Translation: BAC81354.1
AP006558 Genomic RNA Translation: BAC81368.1
AP006559 Genomic RNA Translation: BAC81382.1
AP006560 Genomic RNA Translation: BAC81396.1
AP006561 Genomic RNA Translation: BAC81410.1
AY323977 Genomic RNA Translation: AAP72980.1
AY427439 Genomic RNA Translation: AAQ94066.1
AY463059 Genomic RNA Translation: AAP82982.2
AY322208 Genomic RNA Translation: AAP82970.1
RefSeqiNP_828857.1, NC_004718.3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XAKX-ray1.80A14-96[»]
1YO4NMR-A16-99[»]
ProteinModelPortaliP59635
SMRiP59635
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiP59635

Proteomic databases

PRIDEiP59635

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1489674
KEGGivg:1489674

Phylogenomic databases

OrthoDBiVOG090001AR

Miscellaneous databases

EvolutionaryTraceiP59635

Family and domain databases

Gene3Di2.60.40.1550, 1 hit
InterProiView protein in InterPro
IPR014888 SARS_X4
IPR036495 SARS_X4_sf
PfamiView protein in Pfam
PF08779 SARS_X4, 1 hit
SUPFAMiSSF117066 SSF117066, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNS7A_CVHSA
AccessioniPrimary (citable) accession number: P59635
Secondary accession number(s): Q7TA11, Q7TA17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: October 25, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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