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UniProtKB - P59633 (NS3B_SARS)
Protein
ORF3b protein
Gene
3b
Organism
Severe acute respiratory syndrome coronavirus (SARS-CoV)
Status
Functioni
Induces host cell G0/G1 arrest and apoptosis.
2 PublicationsGO - Biological processi
- modulation by virus of host apoptotic process Source: UniProtKB-KW
- modulation by virus of host G0/G1 transition checkpoint Source: UniProtKB-KW
- regulation of cytokine production Source: CACAO
Keywordsi
Biological process | Apoptosis, G0/G1 host cell cycle checkpoint dysregulation by virus, Host-virus interaction, Modulation of host cell apoptosis by virus, Modulation of host cell cycle by virus |
Enzyme and pathway databases
SIGNORi | P59633 |
Names & Taxonomyi
Protein namesi | Recommended name: ORF3b proteinAlternative name(s): Accessory protein 3b Non-structural protein 3b Short name: ns3b Protein X2 |
Gene namesi | ORF Names:3b |
Organismi | Severe acute respiratory syndrome coronavirus (SARS-CoV) |
Taxonomic identifieri | 694009 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Sarbecovirus |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] Paguma larvata (Masked palm civet) [TaxID: 9675] |
Proteomesi |
|
Subcellular locationi
- host nucleolus 1 Publication
- Host mitochondrion 1 Publication
Keywords - Cellular componenti
Host mitochondrion, Host nucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000106132 | 1 – 154 | ORF3b proteinAdd BLAST | 154 |
Proteomic databases
PRIDEi | P59633 |
Interactioni
Subunit structurei
Interacts with host RUNX1 isoform b.
1 PublicationBinary interactionsi
P59633
With | #Exp. | IntAct |
---|---|---|
RUNX1 - isoform AML-1B [Q01196-1] from Homo sapiens. | 6 | EBI-25489004,EBI-925940 |
Protein-protein interaction databases
BioGRIDi | 4383918, 121 interactors |
IntActi | P59633, 115 interactors |
MINTi | P59633 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 80 – 138 | Mitochondrial targeting signalAdd BLAST | 59 | |
Regioni | 134 – 154 | Nucleolar targetingAdd BLAST | 21 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 135 – 153 | Bipartite nuclear localization signalSequence analysisAdd BLAST | 19 |
Family and domain databases
CDDi | cd21649, SARS-CoV_ORF3b, 1 hit |
InterProi | View protein in InterPro IPR022117, SARS_3b |
Pfami | View protein in Pfam PF12383, SARS_3b, 1 hit |
i Sequence
Sequence statusi: Complete.
P59633-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMPTTLFAGT HITMTTVYHI TVSQIQLSLL KVTAFQHQNS KKTTKLVVIL
60 70 80 90 100
RIGTQVLKTM SLYMAISPKF TTSLSLHKLL QTLVLKMLHS SSLTSLLKTH
110 120 130 140 150
RMCKYTQSTA LQELLIQQWI QFMMSRRRLL ACLCKHKKVS TNLCTHSFRK
KQVR
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 31 | K → Q in strain: Isolate GD01. | 1 | |
Natural varianti | 99 | T → I in strain: Isolate BJ02. | 1 | |
Natural varianti | 115 | L → Q in strain: Isolate GD01. | 1 | |
Natural varianti | 121 | Q → P in strain: Isolate BJ01 and Isolate BJ04. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY278741 Genomic RNA Translation: AAP13447.1 AY274119 Genomic RNA Translation: AAP41039.1 AY282752 Genomic RNA No translation available. AY278554 Genomic RNA Translation: AAP13569.1 AY278491 Genomic RNA No translation available. AY278487 Genomic RNA No translation available. AY278488 Genomic RNA Translation: AAP30032.1 AY278489 Genomic RNA Translation: AAP51229.1 AY278490 Genomic RNA No translation available. AY279354 Genomic RNA No translation available. AY291451 Genomic RNA Translation: AAP37019.1 AY310120 Genomic RNA Translation: AAP50487.1 AY291315 Genomic RNA Translation: AAP33699.1 AY463059 Genomic RNA Translation: AAR86789.1 AY338174 Genomic RNA Translation: AAQ01599.1 AY338175 Genomic RNA Translation: AAQ01611.1 AY348314 Genomic RNA Translation: AAP97884.1 AP006557 Genomic RNA Translation: BAC81350.1 AP006558 Genomic RNA Translation: BAC81364.1 AP006559 Genomic RNA Translation: BAC81378.1 AP006560 Genomic RNA Translation: BAC81392.1 AP006561 Genomic RNA Translation: BAC81406.1 AY323977 Genomic RNA Translation: AAP72976.1 AY427439 Genomic RNA Translation: AAQ94062.1 |
RefSeqi | NP_828853.1, NC_004718.3 |
Genome annotation databases
GeneIDi | 1489670 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY278741 Genomic RNA Translation: AAP13447.1 AY274119 Genomic RNA Translation: AAP41039.1 AY282752 Genomic RNA No translation available. AY278554 Genomic RNA Translation: AAP13569.1 AY278491 Genomic RNA No translation available. AY278487 Genomic RNA No translation available. AY278488 Genomic RNA Translation: AAP30032.1 AY278489 Genomic RNA Translation: AAP51229.1 AY278490 Genomic RNA No translation available. AY279354 Genomic RNA No translation available. AY291451 Genomic RNA Translation: AAP37019.1 AY310120 Genomic RNA Translation: AAP50487.1 AY291315 Genomic RNA Translation: AAP33699.1 AY463059 Genomic RNA Translation: AAR86789.1 AY338174 Genomic RNA Translation: AAQ01599.1 AY338175 Genomic RNA Translation: AAQ01611.1 AY348314 Genomic RNA Translation: AAP97884.1 AP006557 Genomic RNA Translation: BAC81350.1 AP006558 Genomic RNA Translation: BAC81364.1 AP006559 Genomic RNA Translation: BAC81378.1 AP006560 Genomic RNA Translation: BAC81392.1 AP006561 Genomic RNA Translation: BAC81406.1 AY323977 Genomic RNA Translation: AAP72976.1 AY427439 Genomic RNA Translation: AAQ94062.1 |
RefSeqi | NP_828853.1, NC_004718.3 |
3D structure databases
SMRi | P59633 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4383918, 121 interactors |
IntActi | P59633, 115 interactors |
MINTi | P59633 |
Proteomic databases
PRIDEi | P59633 |
Genome annotation databases
GeneIDi | 1489670 |
Enzyme and pathway databases
SIGNORi | P59633 |
Family and domain databases
CDDi | cd21649, SARS-CoV_ORF3b, 1 hit |
InterProi | View protein in InterPro IPR022117, SARS_3b |
Pfami | View protein in Pfam PF12383, SARS_3b, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NS3B_SARS | |
Accessioni | P59633Primary (citable) accession number: P59633 Secondary accession number(s): Q7TFA9, Q80BV4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 23, 2003 |
Last sequence update: | April 23, 2003 | |
Last modified: | February 23, 2022 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |