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UniProtKB - P59633 (NS3B_SARS)

Entry version 80 (23 Feb 2022)
Sequence version 1 (23 Apr 2003)
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Protein

ORF3b protein

Gene

3b

Organism
Severe acute respiratory syndrome coronavirus (SARS-CoV)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Induces host cell G0/G1 arrest and apoptosis.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, G0/G1 host cell cycle checkpoint dysregulation by virus, Host-virus interaction, Modulation of host cell apoptosis by virus, Modulation of host cell cycle by virus

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...SIGNORi		P59633

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ORF3b protein
Alternative name(s):
Accessory protein 3b
Non-structural protein 3b
Short name:
ns3b
Protein X2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:3b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSevere acute respiratory syndrome coronavirus (SARS-CoV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri694009 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Sarbecovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
Paguma larvata (Masked palm civet) [TaxID: 9675]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Host mitochondrion, Host nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001061321 – 154ORF3b proteinAdd BLAST154

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		P59633

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with host RUNX1 isoform b.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4383918, 121 interactors

Protein interaction database and analysis system

More...IntActi		P59633, 115 interactors

Molecular INTeraction database

More...MINTi		P59633

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P59633

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni80 – 138Mitochondrial targeting signalAdd BLAST59
Regioni134 – 154Nucleolar targetingAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi135 – 153Bipartite nuclear localization signalSequence analysisAdd BLAST19

Family and domain databases

Conserved Domains Database

More...CDDi		cd21649, SARS-CoV_ORF3b, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR022117, SARS_3b

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12383, SARS_3b, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P59633-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMPTTLFAGT HITMTTVYHI TVSQIQLSLL KVTAFQHQNS KKTTKLVVIL 
        60         70         80         90        100
RIGTQVLKTM SLYMAISPKF TTSLSLHKLL QTLVLKMLHS SSLTSLLKTH 
       110        120        130        140        150
RMCKYTQSTA LQELLIQQWI QFMMSRRRLL ACLCKHKKVS TNLCTHSFRK 

KQVR
Length:154
Mass (Da):17,750
Last modified:April 23, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82AB0B68F11060A8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti31K → Q in strain: Isolate GD01. 1
Natural varianti99T → I in strain: Isolate BJ02. 1
Natural varianti115L → Q in strain: Isolate GD01. 1
Natural varianti121Q → P in strain: Isolate BJ01 and Isolate BJ04. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY278741 Genomic RNA Translation: AAP13447.1
AY274119 Genomic RNA Translation: AAP41039.1
AY282752 Genomic RNA No translation available.
AY278554 Genomic RNA Translation: AAP13569.1
AY278491 Genomic RNA No translation available.
AY278487 Genomic RNA No translation available.
AY278488 Genomic RNA Translation: AAP30032.1
AY278489 Genomic RNA Translation: AAP51229.1
AY278490 Genomic RNA No translation available.
AY279354 Genomic RNA No translation available.
AY291451 Genomic RNA Translation: AAP37019.1
AY310120 Genomic RNA Translation: AAP50487.1
AY291315 Genomic RNA Translation: AAP33699.1
AY463059 Genomic RNA Translation: AAR86789.1
AY338174 Genomic RNA Translation: AAQ01599.1
AY338175 Genomic RNA Translation: AAQ01611.1
AY348314 Genomic RNA Translation: AAP97884.1
AP006557 Genomic RNA Translation: BAC81350.1
AP006558 Genomic RNA Translation: BAC81364.1
AP006559 Genomic RNA Translation: BAC81378.1
AP006560 Genomic RNA Translation: BAC81392.1
AP006561 Genomic RNA Translation: BAC81406.1
AY323977 Genomic RNA Translation: AAP72976.1
AY427439 Genomic RNA Translation: AAQ94062.1

NCBI Reference Sequences

More...RefSeqi		NP_828853.1, NC_004718.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1489670

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278741 Genomic RNA Translation: AAP13447.1
AY274119 Genomic RNA Translation: AAP41039.1
AY282752 Genomic RNA No translation available.
AY278554 Genomic RNA Translation: AAP13569.1
AY278491 Genomic RNA No translation available.
AY278487 Genomic RNA No translation available.
AY278488 Genomic RNA Translation: AAP30032.1
AY278489 Genomic RNA Translation: AAP51229.1
AY278490 Genomic RNA No translation available.
AY279354 Genomic RNA No translation available.
AY291451 Genomic RNA Translation: AAP37019.1
AY310120 Genomic RNA Translation: AAP50487.1
AY291315 Genomic RNA Translation: AAP33699.1
AY463059 Genomic RNA Translation: AAR86789.1
AY338174 Genomic RNA Translation: AAQ01599.1
AY338175 Genomic RNA Translation: AAQ01611.1
AY348314 Genomic RNA Translation: AAP97884.1
AP006557 Genomic RNA Translation: BAC81350.1
AP006558 Genomic RNA Translation: BAC81364.1
AP006559 Genomic RNA Translation: BAC81378.1
AP006560 Genomic RNA Translation: BAC81392.1
AP006561 Genomic RNA Translation: BAC81406.1
AY323977 Genomic RNA Translation: AAP72976.1
AY427439 Genomic RNA Translation: AAQ94062.1
RefSeqiNP_828853.1, NC_004718.3

3D structure databases

SMRiP59633
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4383918, 121 interactors
IntActiP59633, 115 interactors
MINTiP59633

Proteomic databases

PRIDEiP59633

Genome annotation databases

GeneIDi1489670

Enzyme and pathway databases

SIGNORiP59633

Family and domain databases

CDDicd21649, SARS-CoV_ORF3b, 1 hit
InterProiView protein in InterPro
IPR022117, SARS_3b
PfamiView protein in Pfam
PF12383, SARS_3b, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNS3B_SARS
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P59633
Secondary accession number(s): Q7TFA9, Q80BV4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: February 23, 2022
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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