Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative Polycomb group protein ASXL1

Gene

Asxl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as a coactivator of RARA and RXRA through association with NCOA1. Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1).2 Publications

Caution

Was reported to act as a corepressor through recruitment of KDM1A and CBX; this publication has been retracted.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1476 – 1513PHD-type; atypicalAdd BLAST38

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processTranscription, Transcription regulation, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-5689603 UCH proteinases

Names & Taxonomyi

Protein namesi
Recommended name:
Putative Polycomb group protein ASXL1
Alternative name(s):
Additional sex combs-like protein 1
Gene namesi
Name:Asxl1
Synonyms:Kiaa0978
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2684063 Asxl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000593221 – 1514Putative Polycomb group protein ASXL1Add BLAST1514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei498PhosphoserineBy similarity1
Modified residuei500PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP59598
PaxDbiP59598
PeptideAtlasiP59598
PRIDEiP59598

PTM databases

iPTMnetiP59598
PhosphoSitePlusiP59598

Expressioni

Gene expression databases

BgeeiENSMUSG00000042548 Expressed in 292 organ(s), highest expression level in primary oocyte
CleanExiMM_ASXL1
ExpressionAtlasiP59598 baseline and differential
GenevisibleiP59598 MM

Interactioni

Subunit structurei

Component of the PR-DUB complex, at least composed of BAP1 and ASXL1 (By similarity). Interacts with RARA, RXRA (PubMed:16606617). Interacts with NCOA1 (By similarity). Interacts with PPARA and PPARG (PubMed:21047783).By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230772, 1 interactor
ComplexPortaliCPX-423 PR-DUB complex
IntActiP59598, 8 interactors
STRINGi10090.ENSMUSP00000105413

Structurei

3D structure databases

ProteinModelPortaliP59598
SMRiP59598
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni300 – 655Interaction with NCOA1By similarityAdd BLAST356
Regioni1082 – 1087Required for interaction with RARABy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi284 – 288LXXLL motif 15
Motifi409 – 413Nuclear localization signalSequence analysis5
Motifi808 – 812LXXLL motif 25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi199 – 209Poly-SerAdd BLAST11
Compositional biasi284 – 288Poly-Leu5
Compositional biasi639 – 670Gly-richAdd BLAST32
Compositional biasi1430 – 1433Poly-Ser4

Domaini

Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which may be required for an association with nuclear receptors.By similarity

Sequence similaritiesi

Belongs to the Asx family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1476 – 1513PHD-type; atypicalAdd BLAST38

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGAP Eukaryota
ENOG410YF2J LUCA
GeneTreeiENSGT00520000055578
HOGENOMiHOG000293301
HOVERGENiHBG050598
InParanoidiP59598
KOiK11471
OMAiKQAFYGK
OrthoDBiEOG091G0C66
PhylomeDBiP59598
TreeFamiTF328464

Family and domain databases

InterProiView protein in InterPro
IPR026905 ASX-like_PHD
IPR024811 ASX/ASX-like
IPR028020 ASXH
IPR024815 ASXL1
IPR007759 HB1/Asxl_HTH
PANTHERiPTHR13578 PTHR13578, 1 hit
PTHR13578:SF19 PTHR13578:SF19, 1 hit
PfamiView protein in Pfam
PF13919 ASXH, 1 hit
PF05066 HARE-HTH, 1 hit
PF13922 PHD_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

P59598-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDKQKRKKE RTWAEAARLV LENYSDAPMT PKQILQVIEA EGLKEMRSGT
60 70 80 90 100
SPLACLNAML HSNSRGGEGL FYKLPGRISL FTLKKDAVQW SRNAATVDGD
110 120 130 140 150
EPEDSADVES CGSNEASTVS GENDVSLDET SSNASCSTES QSRPLSNPRD
160 170 180 190 200
SHRASSQANK QKKRTGVMLP RVVLTPLKVN GAHVEPASGF SGRHADGESG
210 220 230 240 250
SPSSSSSGSL ALGNSAIRGQ AEVTRDPAPL LRGFRKPATG QMKRNRGEEV
260 270 280 290 300
DFETPGSILV NTNLRALINS RTFHALPLHF QQQLLLLLPE VDRQVGTDGL
310 320 330 340 350
LRLSGSALNN EFFTHAAQSW RERLADGEFT HEMQVRLRQE MEKEKKVEQW
360 370 380 390 400
KEKFFEDYYG QKLGLTKEES LQQKEVQEEA KVKSGLCVSG ESVRPQRGPN
410 420 430 440 450
TRQRDGHFKK RSRPDLRTRS RRNIYKKQEP EQAGVAKDAS AAPDVSLSKD
460 470 480 490 500
TKTDLAGVNS TPGPDVSSAT SGQEGPKCPS EPVASQIQAE RDNLACASAS
510 520 530 540 550
PDRIPTLPQD TVDQETKDQK RKSFEQEASA SFPEKKPRLE DRQSFRNTIE
560 570 580 590 600
SVHTEKPQPT KEEPKVPPIR IQLSRIKPPW VAKGRPTYQI CPRIVPITES
610 620 630 640 650
SCRGWTGART LADIKARALQ ARGARGYHCN RETATTAIGG GGGPGGGGSG
660 670 680 690 700
AIDEGGGRDS SSGDGSEACG HPEPRGAPST SGESASDLQR TQLLPPCPLN
710 720 730 740 750
GEHTPAEAAM PRARREDSAS LRKEESCLLK RVPGVLTSGL EDASQPPIAP
760 770 780 790 800
TGDQPCQALP PLSSQTPVAE MLTEQPKLLL DDRTECESSR EDQGPTIPSE
810 820 830 840 850
SSSGRFPLGD LLGGGSDQAF DNMKEPVSMT PTFISELSLA NYLQDRPDDD
860 870 880 890 900
GLGLGATGLL IRESSRQEAL TEAFASGSPT SWVPILSNYE VIKTSDPESR
910 920 930 940 950
ENIPCPEPQD EKEWERAVPL IAATESVPQP ESCISHWTPP PAAVGSTGSD
960 970 980 990 1000
SEQVDLERLE MNGISEAPSP HSESTDTASD SEGHLSEDSS EVDASEVTVV
1010 1020 1030 1040 1050
KGSLGGDEKQ DWDPSASLSK VNNDLSVLTR TGGVAASQSW VSRVCSVPHK
1060 1070 1080 1090 1100
IPDSLLLSST ECQPRSVCPL RPGSSVEVTN PLVMHLLHGN LPLEKVLPPG
1110 1120 1130 1140 1150
HRSSRLESSQ LPLREQSQDR GTLQGTGENN RLAARINPGS AQTLKESILA
1160 1170 1180 1190 1200
QSYGASAGLV RAMASKAPAM SQKIAKMVTS LDSQHPETEL TPSSGNLEEI
1210 1220 1230 1240 1250
DSKEHLSSFL CEEQKEGHSL SQGSDPGAAP GQCLGDHTTS KVPCFSSTNV
1260 1270 1280 1290 1300
SLSFGSEQTD GTLSDQNNAG GHEKKLFGPG NTVTTLQCPR SEEQTPLPAE
1310 1320 1330 1340 1350
VPPVFPSRKI EPSKNSVSGG VQTTRENRMP KPPPVSADSI KTEQTFLRDP
1360 1370 1380 1390 1400
IKADAENRKA AGYSSLELVG HLQGMPFVVD LPFWKLPREP GKGFSQPLEP
1410 1420 1430 1440 1450
SSIPSQLNIK QALYGKLSKL QLSPTSFNYS SSSATFPKGL AGGVVQLSHK
1460 1470 1480 1490 1500
ASFGTGHTAS LSLQMFADSS AVESISLQCA CSLKAMIMCQ GCGAFCHDDC
1510
IGPSKLCVLC LVVR
Length:1,514
Mass (Da):162,674
Last modified:April 23, 2003 - v1
Checksum:i20D9FBE9D4CF9E74
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BQW0A0A2I3BQW0_MOUSE
Putative Polycomb group protein ASX...
Asxl1
1,513Annotation score:

Sequence cautioni

The sequence BAC65695 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122413 mRNA Translation: BAC65695.1 Different initiation.
CCDSiCCDS38285.1
RefSeqiNP_001035028.1, NM_001039939.1
UniGeneiMm.330677

Genome annotation databases

EnsembliENSMUST00000109790; ENSMUSP00000105413; ENSMUSG00000042548
GeneIDi228790
KEGGimmu:228790
UCSCiuc033hqx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiASXL1_MOUSE
AccessioniPrimary (citable) accession number: P59598
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: September 12, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again