UniProtKB - P59596 (VME1_SARS)
Protein
Membrane protein
Gene
M
Organism
Severe acute respiratory syndrome coronavirus (SARS-CoV)
Status
Functioni
Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.UniRule annotation
GO - Molecular functioni
- identical protein binding Source: IntAct
- structural constituent of virion Source: UniProtKB-UniRule
GO - Biological processi
- mitigation of host immune response by virus Source: UniProtKB-KW
Keywordsi
Biological process | Host-virus interaction, Viral immunoevasion |
Enzyme and pathway databases
Reactomei | R-HSA-9678110, Attachment and Entry R-HSA-9679509, Virion Assembly and Release R-HSA-9683612, Maturation of protein M R-HSA-9683701, Translation of structural proteins |
SIGNORi | P59596 |
Names & Taxonomyi
Protein namesi | Recommended name: Membrane proteinUniRule annotationShort name: M proteinUniRule annotation Alternative name(s): E1 glycoproteinUniRule annotation Matrix glycoproteinUniRule annotation Membrane glycoproteinUniRule annotation |
Gene namesi | Name:MUniRule annotation ORF Names:5 |
Organismi | Severe acute respiratory syndrome coronavirus (SARS-CoV) |
Taxonomic identifieri | 694009 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Sarbecovirus |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] Paguma larvata (Masked palm civet) [TaxID: 9675] |
Proteomesi |
|
Subcellular locationi
- Virion membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
- Host Golgi apparatus membrane UniRule annotation; Multi-pass membrane protein UniRule annotation Note: Largely embedded in the lipid bilayer.UniRule annotation
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 18 | Virion surfaceUniRule annotationAdd BLAST | 18 | |
Transmembranei | 19 – 39 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 40 – 49 | IntravirionUniRule annotation | 10 | |
Transmembranei | 50 – 70 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 71 – 78 | Virion surfaceUniRule annotation | 8 | |
Transmembranei | 79 – 99 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 100 – 221 | IntravirionUniRule annotationAdd BLAST | 122 |
GO - Cellular componenti
- host cell Golgi membrane Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-UniRule
- viral envelope Source: UniProtKB-UniRule
- virion membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Viral matrix protein, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000106035 | 1 – 221 | Membrane proteinAdd BLAST | 221 |
Keywords - PTMi
GlycoproteinProteomic databases
PRIDEi | P59596 |
Interactioni
Subunit structurei
Homomultimer.
Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex.
Forms a complex with HE and S proteins.
Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus (By similarity).
Interacts with the accessory proteins 3a and 7a.
UniRule annotation3 PublicationsBinary interactionsi
Hide detailsP59596
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 4383913, 39 interactors |
ELMi | P59596 |
IntActi | P59596, 111 interactors |
Structurei
3D structure databases
SMRi | P59596 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P59596 |
Family & Domainsi
Sequence similaritiesi
Belongs to the betacoronaviruses M protein family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
HAMAPi | MF_04202, BETA_CORONA_M, 1 hit |
InterProi | View protein in InterPro IPR002574, M_CoV |
Pfami | View protein in Pfam PF01635, CoV_M, 1 hit |
PROSITEi | View protein in PROSITE PS51927, COV_M, 1 hit |
i Sequence
Sequence statusi: Complete.
P59596-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADNGTITVE ELKQLLEQWN LVIGFLFLAW IMLLQFAYSN RNRFLYIIKL
60 70 80 90 100
VFLWLLWPVT LACFVLAAVY RINWVTGGIA IAMACIVGLM WLSYFVASFR
110 120 130 140 150
LFARTRSMWS FNPETNILLN VPLRGTIVTR PLMESELVIG AVIIRGHLRM
160 170 180 190 200
AGHSLGRCDI KDLPKEITVA TSRTLSYYKL GASQRVGTDS GFAAYNRYRI
210 220
GNYKLNTDHA GSNDNIALLV Q
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 11 | E → K in strain: Isolate Sin2500. | 1 | |
Natural varianti | 27 | F → C in strain: Isolate CUHK-Su10, Isolate TWC2, Isolate TWC3, Isolate TWH, Isolate TWJ, Isolate TWK, Isolate TWS, Isolate TWY, Isolate Taiwan TC1, Isolate Taiwan TC2 and Isolate Taiwan TC3. | 1 | |
Natural varianti | 68 | A → V in strain: Isolate HKU-39849, Isolate FRA and Isolate Frankfurt 1. | 1 | |
Natural varianti | 73 | N → T in strain: Isolate TC3. | 1 | |
Natural varianti | 119 | L → P in strain: Isolate Shanghai QXC1. | 1 | |
Natural varianti | 154 | S → P in strain: Isolate Urbani. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY278741 Genomic RNA Translation: AAP13444.1 AY274119 Genomic RNA Translation: AAP41041.1 AY278554 Genomic RNA Translation: AAP13571.1 AY282752 Genomic RNA No translation available. AY304492 Genomic RNA No translation available. AY304495 Genomic RNA No translation available. AY278491 Genomic RNA No translation available. AY283794 Genomic RNA No translation available. AY283795 Genomic RNA No translation available. AY283796 Genomic RNA No translation available. AY283797 Genomic RNA No translation available. AY283798 Genomic RNA No translation available. AY278487 Genomic RNA No translation available. AY278488 Genomic RNA Translation: AAP30034.1 AY278489 Genomic RNA Translation: AAP51231.1 AY278490 Genomic RNA No translation available. AY279354 Genomic RNA No translation available. AY291451 Genomic RNA Translation: AAP37021.1 AY310120 Genomic RNA Translation: AAP50489.1 AY291315 Genomic RNA Translation: AAP33701.1 AY463059 Genomic RNA Translation: AAR86790.1 AY323974 mRNA Translation: AAP73415.1 AY321118 Genomic RNA No translation available. AY338174 Genomic RNA Translation: AAQ01601.1 AY338175 Genomic RNA Translation: AAQ01613.1 AY348314 Genomic RNA Translation: AAP97886.1 AP006557 Genomic RNA Translation: BAC81352.1 AP006558 Genomic RNA Translation: BAC81366.1 AP006559 Genomic RNA Translation: BAC81380.1 AP006560 Genomic RNA Translation: BAC81394.1 AP006561 Genomic RNA Translation: BAC81408.1 AY323977 Genomic RNA Translation: AAP72978.1 AY362698 Genomic RNA No translation available. AY362699 Genomic RNA No translation available. AY427439 Genomic RNA Translation: AAQ94064.1 |
RefSeqi | NP_828855.1, NC_004718.3 |
Genome annotation databases
GeneIDi | 1489672 |
KEGGi | vg:1489672 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY278741 Genomic RNA Translation: AAP13444.1 AY274119 Genomic RNA Translation: AAP41041.1 AY278554 Genomic RNA Translation: AAP13571.1 AY282752 Genomic RNA No translation available. AY304492 Genomic RNA No translation available. AY304495 Genomic RNA No translation available. AY278491 Genomic RNA No translation available. AY283794 Genomic RNA No translation available. AY283795 Genomic RNA No translation available. AY283796 Genomic RNA No translation available. AY283797 Genomic RNA No translation available. AY283798 Genomic RNA No translation available. AY278487 Genomic RNA No translation available. AY278488 Genomic RNA Translation: AAP30034.1 AY278489 Genomic RNA Translation: AAP51231.1 AY278490 Genomic RNA No translation available. AY279354 Genomic RNA No translation available. AY291451 Genomic RNA Translation: AAP37021.1 AY310120 Genomic RNA Translation: AAP50489.1 AY291315 Genomic RNA Translation: AAP33701.1 AY463059 Genomic RNA Translation: AAR86790.1 AY323974 mRNA Translation: AAP73415.1 AY321118 Genomic RNA No translation available. AY338174 Genomic RNA Translation: AAQ01601.1 AY338175 Genomic RNA Translation: AAQ01613.1 AY348314 Genomic RNA Translation: AAP97886.1 AP006557 Genomic RNA Translation: BAC81352.1 AP006558 Genomic RNA Translation: BAC81366.1 AP006559 Genomic RNA Translation: BAC81380.1 AP006560 Genomic RNA Translation: BAC81394.1 AP006561 Genomic RNA Translation: BAC81408.1 AY323977 Genomic RNA Translation: AAP72978.1 AY362698 Genomic RNA No translation available. AY362699 Genomic RNA No translation available. AY427439 Genomic RNA Translation: AAQ94064.1 |
RefSeqi | NP_828855.1, NC_004718.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3I6G | X-ray | 2.20 | C/F | 88-96 | [»] | |
3I6K | X-ray | 2.80 | C/G | 60-69 | [»] | |
3TO2 | X-ray | 2.60 | C | 61-69 | [»] | |
SMRi | P59596 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4383913, 39 interactors |
ELMi | P59596 |
IntActi | P59596, 111 interactors |
Proteomic databases
PRIDEi | P59596 |
Protocols and materials databases
ABCDi | P59596, 1 sequenced antibody |
Genome annotation databases
GeneIDi | 1489672 |
KEGGi | vg:1489672 |
Enzyme and pathway databases
Reactomei | R-HSA-9678110, Attachment and Entry R-HSA-9679509, Virion Assembly and Release R-HSA-9683612, Maturation of protein M R-HSA-9683701, Translation of structural proteins |
SIGNORi | P59596 |
Miscellaneous databases
EvolutionaryTracei | P59596 |
Family and domain databases
HAMAPi | MF_04202, BETA_CORONA_M, 1 hit |
InterProi | View protein in InterPro IPR002574, M_CoV |
Pfami | View protein in Pfam PF01635, CoV_M, 1 hit |
PROSITEi | View protein in PROSITE PS51927, COV_M, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VME1_SARS | |
Accessioni | P59596Primary (citable) accession number: P59596 Secondary accession number(s): Q6S8E5 Q7TA12 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 23, 2003 |
Last sequence update: | April 23, 2003 | |
Last modified: | February 10, 2021 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families