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Protein

Membrane protein

Gene

M

Organism
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane proteinUniRule annotation
Short name:
M proteinUniRule annotation
Alternative name(s):
E1 glycoproteinUniRule annotation
Matrix glycoproteinUniRule annotation
Membrane glycoproteinUniRule annotation
Gene namesi
Name:MUniRule annotation
ORF Names:5
OrganismiHuman SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
Taxonomic identifieri227859 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Paguma larvata (Masked palm civet) [TaxID: 9675]
Proteomesi

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18Virion surfaceUniRule annotationAdd BLAST18
Transmembranei19 – 39HelicalUniRule annotationAdd BLAST21
Topological domaini40 – 49IntravirionUniRule annotation10
Transmembranei50 – 70HelicalUniRule annotationAdd BLAST21
Topological domaini71 – 78Virion surfaceUniRule annotation8
Transmembranei79 – 99HelicalUniRule annotationAdd BLAST21
Topological domaini100 – 221IntravirionUniRule annotationAdd BLAST122

GO - Cellular componenti

Keywords - Cellular componenti

Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Viral matrix protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001060351 – 221Membrane proteinAdd BLAST221

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP59596

Interactioni

Subunit structurei

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus (By similarity). Interacts with the accessory proteins 3a and 7a.UniRule annotation3 Publications

Protein-protein interaction databases

ELMiP59596

Structurei

3D structure databases

SMRiP59596
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP59596

Family & Domainsi

Sequence similaritiesi

Belongs to the betacoronaviruses M protein family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000NM

Family and domain databases

HAMAPiMF_04202 BETA_CORONA_M, 1 hit
InterProiView protein in InterPro
IPR002574 Corona_M
PfamiView protein in Pfam
PF01635 Corona_M, 1 hit

Sequencei

Sequence statusi: Complete.

P59596-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADNGTITVE ELKQLLEQWN LVIGFLFLAW IMLLQFAYSN RNRFLYIIKL
60 70 80 90 100
VFLWLLWPVT LACFVLAAVY RINWVTGGIA IAMACIVGLM WLSYFVASFR
110 120 130 140 150
LFARTRSMWS FNPETNILLN VPLRGTIVTR PLMESELVIG AVIIRGHLRM
160 170 180 190 200
AGHSLGRCDI KDLPKEITVA TSRTLSYYKL GASQRVGTDS GFAAYNRYRI
210 220
GNYKLNTDHA GSNDNIALLV Q
Length:221
Mass (Da):25,061
Last modified:April 23, 2003 - v1
Checksum:i275C37085A0215A8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti11E → K in strain: Isolate Sin2500. 1
Natural varianti27F → C in strain: Isolate CUHK-Su10, Isolate TWC2, Isolate TWC3, Isolate TWH, Isolate TWJ, Isolate TWK, Isolate TWS, Isolate TWY, Isolate Taiwan TC1, Isolate Taiwan TC2 and Isolate Taiwan TC3. 1
Natural varianti68A → V in strain: Isolate HKU-39849, Isolate FRA and Isolate Frankfurt 1. 1
Natural varianti73N → T in strain: Isolate TC3. 1
Natural varianti119L → P in strain: Isolate Shanghai QXC1. 1
Natural varianti154S → P in strain: Isolate Urbani. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278741 Genomic RNA Translation: AAP13444.1
AY274119 Genomic RNA Translation: AAP41041.1
AY278554 Genomic RNA Translation: AAP13571.1
AY282752 Genomic RNA No translation available.
AY304492 Genomic RNA No translation available.
AY304495 Genomic RNA No translation available.
AY278491 Genomic RNA No translation available.
AY283794 Genomic RNA No translation available.
AY283795 Genomic RNA No translation available.
AY283796 Genomic RNA No translation available.
AY283797 Genomic RNA No translation available.
AY283798 Genomic RNA No translation available.
AY278487 Genomic RNA No translation available.
AY278488 Genomic RNA Translation: AAP30034.1
AY278489 Genomic RNA Translation: AAP51231.1
AY278490 Genomic RNA No translation available.
AY279354 Genomic RNA No translation available.
AY291451 Genomic RNA Translation: AAP37021.1
AY310120 Genomic RNA Translation: AAP50489.1
AY291315 Genomic RNA Translation: AAP33701.1
AY463059 Genomic RNA Translation: AAR86790.1
AY323974 mRNA Translation: AAP73415.1
AY321118 Genomic RNA No translation available.
AY338174 Genomic RNA Translation: AAQ01601.1
AY338175 Genomic RNA Translation: AAQ01613.1
AY348314 Genomic RNA Translation: AAP97886.1
AP006557 Genomic RNA Translation: BAC81352.1
AP006558 Genomic RNA Translation: BAC81366.1
AP006559 Genomic RNA Translation: BAC81380.1
AP006560 Genomic RNA Translation: BAC81394.1
AP006561 Genomic RNA Translation: BAC81408.1
AY323977 Genomic RNA Translation: AAP72978.1
AY362698 Genomic RNA No translation available.
AY362699 Genomic RNA No translation available.
AY427439 Genomic RNA Translation: AAQ94064.1
RefSeqiNP_828855.1, NC_004718.3

Genome annotation databases

GeneIDi1489672
KEGGivg:1489672

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278741 Genomic RNA Translation: AAP13444.1
AY274119 Genomic RNA Translation: AAP41041.1
AY278554 Genomic RNA Translation: AAP13571.1
AY282752 Genomic RNA No translation available.
AY304492 Genomic RNA No translation available.
AY304495 Genomic RNA No translation available.
AY278491 Genomic RNA No translation available.
AY283794 Genomic RNA No translation available.
AY283795 Genomic RNA No translation available.
AY283796 Genomic RNA No translation available.
AY283797 Genomic RNA No translation available.
AY283798 Genomic RNA No translation available.
AY278487 Genomic RNA No translation available.
AY278488 Genomic RNA Translation: AAP30034.1
AY278489 Genomic RNA Translation: AAP51231.1
AY278490 Genomic RNA No translation available.
AY279354 Genomic RNA No translation available.
AY291451 Genomic RNA Translation: AAP37021.1
AY310120 Genomic RNA Translation: AAP50489.1
AY291315 Genomic RNA Translation: AAP33701.1
AY463059 Genomic RNA Translation: AAR86790.1
AY323974 mRNA Translation: AAP73415.1
AY321118 Genomic RNA No translation available.
AY338174 Genomic RNA Translation: AAQ01601.1
AY338175 Genomic RNA Translation: AAQ01613.1
AY348314 Genomic RNA Translation: AAP97886.1
AP006557 Genomic RNA Translation: BAC81352.1
AP006558 Genomic RNA Translation: BAC81366.1
AP006559 Genomic RNA Translation: BAC81380.1
AP006560 Genomic RNA Translation: BAC81394.1
AP006561 Genomic RNA Translation: BAC81408.1
AY323977 Genomic RNA Translation: AAP72978.1
AY362698 Genomic RNA No translation available.
AY362699 Genomic RNA No translation available.
AY427439 Genomic RNA Translation: AAQ94064.1
RefSeqiNP_828855.1, NC_004718.3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3I6GX-ray2.20C/F88-96[»]
SMRiP59596
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiP59596

Proteomic databases

PRIDEiP59596

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1489672
KEGGivg:1489672

Phylogenomic databases

OrthoDBiVOG090000NM

Miscellaneous databases

EvolutionaryTraceiP59596

Family and domain databases

HAMAPiMF_04202 BETA_CORONA_M, 1 hit
InterProiView protein in InterPro
IPR002574 Corona_M
PfamiView protein in Pfam
PF01635 Corona_M, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVME1_CVHSA
AccessioniPrimary (citable) accession number: P59596
Secondary accession number(s): Q6S8E5
, Q7T6Q8, Q7T6R1, Q7T6R5, Q7T6S0, Q7T6S3, Q7T726, Q7T7P6, Q7T7S6, Q7TA12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: June 20, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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