UniProtKB - P59595 (NCAP_SARS)
Nucleoprotein
N
Functioni
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication (PubMed:17210170).
May modulate transforming growth factor-beta signaling by binding host SMAD3 (PubMed:18055455).
UniRule annotation2 PublicationsGO - Molecular functioni
- identical protein binding Source: IntAct
- RNA binding Source: UniProtKB-UniRule
GO - Biological processi
- viral RNA genome packaging Source: ComplexPortal
Keywordsi
Molecular function | Ribonucleoprotein, RNA-binding, Viral nucleoprotein |
Biological process | Host-virus interaction, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-HSA-9678110, Attachment and Entry R-HSA-9679509, Virion Assembly and Release R-HSA-9682708, Transcription of SARS-CoV-1 sgRNAs R-HSA-9683610, Maturation of nucleoprotein R-HSA-9683701, Translation of Structural Proteins |
SIGNORi | P59595 |
Names & Taxonomyi
Protein namesi | Recommended name: NucleoproteinUniRule annotationAlternative name(s): Nucleocapsid proteinUniRule annotation Short name: NCUniRule annotation Short name: Protein NUniRule annotation |
Gene namesi | Name:NUniRule annotation ORF Names:9a |
Organismi | Severe acute respiratory syndrome coronavirus (SARS-CoV) |
Taxonomic identifieri | 694009 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Sarbecovirus |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] Paguma larvata (Masked palm civet) [TaxID: 9675] |
Proteomesi |
|
Subcellular locationi
- Virion UniRule annotation2 Publications
- Host endoplasmic reticulum-Golgi intermediate compartment UniRule annotation1 Publication
- Host Golgi apparatus UniRule annotation1 Publication
- host perinuclear region 1 Publication Note: Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.UniRule annotation
Keywords - Cellular componenti
Host cytoplasm, Host Golgi apparatus, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000106003 | 1 – 422 | NucleoproteinAdd BLAST | 422 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 177 | Phosphoserine; by hostUniRule annotation1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
ADP-ribosylation, PhosphoproteinProteomic databases
PRIDEi | P59595 |
PTM databases
iPTMneti | P59595 |
Interactioni
Subunit structurei
Homooligomer. Both monomeric and oligomeric forms interact with RNA.
Interacts with protein M (PubMed:15351485).
Interacts with protein E (PubMed:24766657). May bind to host HNRNPA1 (Probable).
Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection (By similarity). May interact with host SMAD3 (Probable).
Interacts with host PPIA/CYPA (PubMed:15688292).
UniRule annotation2 Publications3 PublicationsBinary interactionsi
P59595
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 4383916, 95 interactors |
ComplexPortali | CPX-5720, SARS-CoV nucleocapsid complex |
IntActi | P59595, 252 interactors |
MINTi | P59595 |
Structurei
Secondary structure
3D structure databases
BMRBi | P59595 |
SMRi | P59595 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P59595 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 49 – 176 | CoV N NTDPROSITE-ProRule annotationAdd BLAST | 128 | |
Domaini | 248 – 365 | CoV N CTDPROSITE-ProRule annotationAdd BLAST | 118 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 52 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 42 – 187 | RNA-bindingUniRule annotationAdd BLAST | 146 | |
Regioni | 45 – 181 | RNA-bindingAdd BLAST | 137 | |
Regioni | 167 – 214 | DisorderedSequence analysisAdd BLAST | 48 | |
Regioni | 234 – 287 | DisorderedSequence analysisAdd BLAST | 54 | |
Regioni | 259 – 362 | DimerizationUniRule annotationAdd BLAST | 104 | |
Regioni | 362 – 422 | DisorderedSequence analysisAdd BLAST | 61 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 35 | Polar residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 178 – 209 | Polar residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 234 – 252 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 265 – 287 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 363 – 383 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 404 – 422 | Polar residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Family and domain databases
CDDi | cd21595, CoV_N-CTD, 1 hit cd21554, CoV_N-NTD, 1 hit |
DisProti | DP00948 |
HAMAPi | MF_04096, BETA_CORONA_NCAP, 1 hit |
InterProi | View protein in InterPro IPR044344, N_prot_C_CoV IPR044345, N_prot_N_CoV IPR043505, NCAP_bCoV IPR001218, Nucleocap_CoV IPR037179, Nucleocapsid_C IPR037195, Nucleocapsid_N |
Pfami | View protein in Pfam PF00937, CoV_nucleocap, 1 hit |
PIRSFi | PIRSF003888, Corona_nucleocap, 1 hit |
SUPFAMi | SSF103068, SSF103068, 1 hit SSF110304, SSF110304, 1 hit |
PROSITEi | View protein in PROSITE PS51929, COV_N_CTD, 1 hit PS51928, COV_N_NTD, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MSDNGPQSNQ RSAPRITFGG PTDSTDNNQN GGRNGARPKQ RRPQGLPNNT
60 70 80 90 100
ASWFTALTQH GKEELRFPRG QGVPINTNSG PDDQIGYYRR ATRRVRGGDG
110 120 130 140 150
KMKELSPRWY FYYLGTGPEA SLPYGANKEG IVWVATEGAL NTPKDHIGTR
160 170 180 190 200
NPNNNAATVL QLPQGTTLPK GFYAEGSRGG SQASSRSSSR SRGNSRNSTP
210 220 230 240 250
GSSRGNSPAR MASGGGETAL ALLLLDRLNQ LESKVSGKGQ QQQGQTVTKK
260 270 280 290 300
SAAEASKKPR QKRTATKQYN VTQAFGRRGP EQTQGNFGDQ DLIRQGTDYK
310 320 330 340 350
HWPQIAQFAP SASAFFGMSR IGMEVTPSGT WLTYHGAIKL DDKDPQFKDN
360 370 380 390 400
VILLNKHIDA YKTFPPTEPK KDKKKKTDEA QPLPQRQKKQ PTVTLLPAAD
410 420
MDDFSRQLQN SMSGASADST QA
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 50 | T → I in strain: Isolate Frankfurt 1 and Isolate FRA. | 1 | |
Natural varianti | 154 | N → Y in strain: Isolate BJ03. | 1 | |
Natural varianti | 193 | G → C in strain: Isolate CUHK-Su10. | 1 | |
Natural varianti | 325 – 326 | VT → AA in strain: Isolate Shanghai LY. | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY278741 Genomic RNA Translation: AAP13445.1 AY274119 Genomic RNA Translation: AAP41047.1 AY278554 Genomic RNA Translation: AAP13814.1 AY282752 Genomic RNA Translation: AAP30714.1 AY304492 Genomic RNA No translation available. AY304495 Genomic RNA No translation available. AY278491 Genomic RNA No translation available. AY283794 Genomic RNA No translation available. AY283795 Genomic RNA No translation available. AY283796 Genomic RNA No translation available. AY283797 Genomic RNA No translation available. AY278487 Genomic RNA No translation available. AY278488 Genomic RNA Translation: AAP30037.1 AY278489 Genomic RNA Translation: AAP51234.1 AY278490 Genomic RNA No translation available. AY279354 Genomic RNA No translation available. AY291451 Genomic RNA Translation: AAP37024.1 AY310120 Genomic RNA Translation: AAP50495.1 AY291315 Genomic RNA Translation: AAP33707.1 AY307165 Genomic RNA Translation: AAP49024.1 AY290752 Genomic RNA Translation: AAP44772.1 AY321118 Genomic RNA No translation available. AY322208 Genomic RNA Translation: AAP82974.1 AY338174 Genomic RNA Translation: AAQ01605.1 AY338175 Genomic RNA Translation: AAQ01617.1 AY348314 Genomic RNA Translation: AAP97890.1 AP006557 Genomic RNA Translation: BAC81358.1 AP006558 Genomic RNA Translation: BAC81372.1 AP006559 Genomic RNA Translation: BAC81386.1 AP006560 Genomic RNA Translation: BAC81400.1 AP006561 Genomic RNA Translation: BAC81414.1 AY323977 Genomic RNA Translation: AAP72984.1 AY362698 Genomic RNA No translation available. AY362699 Genomic RNA No translation available. AY427439 Genomic RNA Translation: AAQ94070.1 |
RefSeqi | NP_828858.1, NC_004718.3 |
Genome annotation databases
GeneIDi | 1489678 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY278741 Genomic RNA Translation: AAP13445.1 AY274119 Genomic RNA Translation: AAP41047.1 AY278554 Genomic RNA Translation: AAP13814.1 AY282752 Genomic RNA Translation: AAP30714.1 AY304492 Genomic RNA No translation available. AY304495 Genomic RNA No translation available. AY278491 Genomic RNA No translation available. AY283794 Genomic RNA No translation available. AY283795 Genomic RNA No translation available. AY283796 Genomic RNA No translation available. AY283797 Genomic RNA No translation available. AY278487 Genomic RNA No translation available. AY278488 Genomic RNA Translation: AAP30037.1 AY278489 Genomic RNA Translation: AAP51234.1 AY278490 Genomic RNA No translation available. AY279354 Genomic RNA No translation available. AY291451 Genomic RNA Translation: AAP37024.1 AY310120 Genomic RNA Translation: AAP50495.1 AY291315 Genomic RNA Translation: AAP33707.1 AY307165 Genomic RNA Translation: AAP49024.1 AY290752 Genomic RNA Translation: AAP44772.1 AY321118 Genomic RNA No translation available. AY322208 Genomic RNA Translation: AAP82974.1 AY338174 Genomic RNA Translation: AAQ01605.1 AY338175 Genomic RNA Translation: AAQ01617.1 AY348314 Genomic RNA Translation: AAP97890.1 AP006557 Genomic RNA Translation: BAC81358.1 AP006558 Genomic RNA Translation: BAC81372.1 AP006559 Genomic RNA Translation: BAC81386.1 AP006560 Genomic RNA Translation: BAC81400.1 AP006561 Genomic RNA Translation: BAC81414.1 AY323977 Genomic RNA Translation: AAP72984.1 AY362698 Genomic RNA No translation available. AY362699 Genomic RNA No translation available. AY427439 Genomic RNA Translation: AAQ94070.1 |
RefSeqi | NP_828858.1, NC_004718.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1SSK | NMR | - | A | 45-181 | [»] | |
1X7Q | X-ray | 1.45 | C | 362-370 | [»] | |
2CJR | X-ray | 2.50 | A/B/C/D/E/F/G/H | 248-365 | [»] | |
2GIB | X-ray | 1.75 | A/B | 270-370 | [»] | |
2JW8 | NMR | - | A/B | 248-365 | [»] | |
2OFZ | X-ray | 1.17 | A | 49-174 | [»] | |
2OG3 | X-ray | 1.85 | A | 49-174 | [»] | |
3I6L | X-ray | 2.40 | F | 346-354 | [»] | |
6IEX | X-ray | 2.31 | C | 216-225 | [»] | |
7LG0 | X-ray | 2.30 | C | 106-114 | [»] | |
BMRBi | P59595 | |||||
SMRi | P59595 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4383916, 95 interactors |
ComplexPortali | CPX-5720, SARS-CoV nucleocapsid complex |
IntActi | P59595, 252 interactors |
MINTi | P59595 |
PTM databases
iPTMneti | P59595 |
Proteomic databases
PRIDEi | P59595 |
Protocols and materials databases
ABCDi | P59595, 13 sequenced antibodies |
DNASUi | 1489678 |
Genome annotation databases
GeneIDi | 1489678 |
Enzyme and pathway databases
Reactomei | R-HSA-9678110, Attachment and Entry R-HSA-9679509, Virion Assembly and Release R-HSA-9682708, Transcription of SARS-CoV-1 sgRNAs R-HSA-9683610, Maturation of nucleoprotein R-HSA-9683701, Translation of Structural Proteins |
SIGNORi | P59595 |
Miscellaneous databases
EvolutionaryTracei | P59595 |
Family and domain databases
CDDi | cd21595, CoV_N-CTD, 1 hit cd21554, CoV_N-NTD, 1 hit |
DisProti | DP00948 |
HAMAPi | MF_04096, BETA_CORONA_NCAP, 1 hit |
InterProi | View protein in InterPro IPR044344, N_prot_C_CoV IPR044345, N_prot_N_CoV IPR043505, NCAP_bCoV IPR001218, Nucleocap_CoV IPR037179, Nucleocapsid_C IPR037195, Nucleocapsid_N |
Pfami | View protein in Pfam PF00937, CoV_nucleocap, 1 hit |
PIRSFi | PIRSF003888, Corona_nucleocap, 1 hit |
SUPFAMi | SSF103068, SSF103068, 1 hit SSF110304, SSF110304, 1 hit |
PROSITEi | View protein in PROSITE PS51929, COV_N_CTD, 1 hit PS51928, COV_N_NTD, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NCAP_SARS | |
Accessioni | P59595Primary (citable) accession number: P59595 Secondary accession number(s): Q7T3Z4 Q80E50 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 23, 2003 |
Last sequence update: | April 23, 2003 | |
Last modified: | May 25, 2022 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families