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Protein

Taste receptor type 2 member 31

Gene

TAS2R31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Activated by the sulfonyl amide sweeteners saccharin and acesulfame K.By similarity

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

GO - Molecular functioni

  • bitter taste receptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 31
Short name:
T2R31
Alternative name(s):
Taste receptor type 2 member 44
Short name:
T2R44
Taste receptor type 2 member 53
Short name:
T2R53
Gene namesi
Name:TAS2R31
Synonyms:TAS2R44
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000256436.1
HGNCiHGNC:19113 TAS2R31
MIMi612669 gene
neXtProtiNX_P59538

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2ExtracellularSequence analysis2
Transmembranei3 – 23Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini24 – 55CytoplasmicSequence analysisAdd BLAST32
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 100ExtracellularSequence analysisAdd BLAST24
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 126CytoplasmicSequence analysis5
Transmembranei127 – 147Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini148 – 181ExtracellularSequence analysisAdd BLAST34
Transmembranei182 – 202Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini203 – 229CytoplasmicSequence analysisAdd BLAST27
Transmembranei230 – 250Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini251 – 259ExtracellularSequence analysis9
Transmembranei260 – 280Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini281 – 309CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000256436

Chemistry databases

ChEMBLiCHEMBL2034804
GuidetoPHARMACOLOGYi674

Polymorphism and mutation databases

BioMutaiTAS2R31
DMDMi338817946

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000823091 – 309Taste receptor type 2 member 31Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP59538
PeptideAtlasiP59538
PRIDEiP59538
ProteomicsDBi57145

PTM databases

iPTMnetiP59538
PhosphoSitePlusiP59538

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Gene expression databases

BgeeiENSG00000256436
CleanExiHS_TAS2R44

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000375093

Chemistry databases

BindingDBiP59538

Structurei

3D structure databases

ProteinModelPortaliP59538
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9F7 Eukaryota
ENOG4111BEG LUCA
GeneTreeiENSGT00760000119096
InParanoidiP59538
KOiK08474
OMAiVINMKEI
OrthoDBiEOG091G0HMB
PhylomeDBiP59538
TreeFamiTF335891

Family and domain databases

InterProiView protein in InterPro
IPR007960 T2R
PANTHERiPTHR11394 PTHR11394, 1 hit
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit

Sequencei

Sequence statusi: Complete.

P59538-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTFIPIIFS SVVVVLFVIG NFANGFIALV NSIERVKRQK ISFADQILTA
60 70 80 90 100
LAVSRVGLLW VLLLNWYSTV FNPAFYSVEV RTTAYNVWAV TGHFSNWLAT
110 120 130 140 150
SLSIFYLLKI ANFSNLIFLH LKRRVKSVIL VMLLGPLLFL ACQLFVINMK
160 170 180 190 200
EIVRTKEYEG NLTWKIKLRS AVYLSDATVT TLGNLVPFTL TLLCFLLLIC
210 220 230 240 250
SLCKHLKKMQ LHGKGSQDPS TKVHIKALQT VIFFLLLCAV YFLSIMISVW
260 270 280 290 300
SFGSLENKPV FMFCKAIRFS YPSIHPFILI WGNKKLKQTF LSVLRQVRYW

VKGEKPSSP
Length:309
Mass (Da):35,278
Last modified:June 28, 2011 - v2
Checksum:i56926C025E4C6358
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03068435R → W. Corresponds to variant dbSNP:rs10845295Ensembl.1
Natural variantiVAR_030685162L → M2 PublicationsCorresponds to variant dbSNP:rs10743938Ensembl.1
Natural variantiVAR_030686217Q → E. Corresponds to variant dbSNP:rs10845294Ensembl.1
Natural variantiVAR_030687227A → V1 PublicationCorresponds to variant dbSNP:rs10845293Ensembl.1
Natural variantiVAR_030688240V → I1 PublicationCorresponds to variant dbSNP:rs10772423Ensembl.1
Natural variantiVAR_062090276P → R. Corresponds to variant dbSNP:rs12318612Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494228 Genomic DNA Translation: AAM19319.1
AY114090 Genomic DNA Translation: AAM63540.1
AY724942 Genomic DNA Translation: AAU21144.1
AC018630 Genomic DNA No translation available.
BC117421 mRNA Translation: AAI17422.1
CCDSiCCDS53747.1
RefSeqiNP_795366.2, NM_176885.2
UniGeneiHs.688197

Genome annotation databases

EnsembliENST00000390675; ENSP00000375093; ENSG00000256436
ENST00000572376; ENSP00000459810; ENSG00000263097
GeneIDi259290
KEGGihsa:259290
UCSCiuc001qzo.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiT2R31_HUMAN
AccessioniPrimary (citable) accession number: P59538
Secondary accession number(s): P59547, Q17R84, Q645X5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: June 28, 2011
Last modified: June 20, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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