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Protein

Taste receptor type 2 member 38

Gene

TAS2R38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

GO - Molecular functioni

  • bitter taste receptor activity Source: UniProtKB
  • G protein-coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Protein family/group databases

TCDBi9.A.14.17.5 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 38
Short name:
T2R38
Alternative name(s):
PTC bitter taste receptor
Taste receptor type 2 member 61
Short name:
T2R61
Gene namesi
Name:TAS2R38
Synonyms:PTC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000257138.1
HGNCiHGNC:9584 TAS2R38
MIMi607751 gene
neXtProtiNX_P59533

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17ExtracellularSequence analysisAdd BLAST17
Transmembranei18 – 38Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini39 – 55CytoplasmicSequence analysisAdd BLAST17
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 94ExtracellularSequence analysisAdd BLAST18
Transmembranei95 – 115Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini116 – 142CytoplasmicSequence analysisAdd BLAST27
Transmembranei143 – 163Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini164 – 190ExtracellularSequence analysisAdd BLAST27
Transmembranei191 – 211Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini212 – 251CytoplasmicSequence analysisAdd BLAST40
Transmembranei252 – 272Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini273 – 276ExtracellularSequence analysis4
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 333CytoplasmicSequence analysisAdd BLAST36

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5726
MalaCardsiTAS2R38
MIMi171200 phenotype
OpenTargetsiENSG00000257138
PharmGKBiPA33936

Polymorphism and mutation databases

BioMutaiTAS2R38
DMDMi68068016

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822731 – 333Taste receptor type 2 member 38Add BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP59533
PeptideAtlasiP59533
PRIDEiP59533
ProteomicsDBi57140

PTM databases

iPTMnetiP59533
PhosphoSitePlusiP59533

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed in testis (PubMed:16720576).1 Publication

Gene expression databases

BgeeiENSG00000257138 Expressed in 4 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_TAS2R38
GenevisibleiP59533 HS

Organism-specific databases

HPAiHPA043862
HPA054366

Interactioni

Protein-protein interaction databases

BioGridi111698, 2 interactors
STRINGi9606.ENSP00000448219

Structurei

3D structure databases

ProteinModelPortaliP59533
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH9N Eukaryota
ENOG410Z3YE LUCA
GeneTreeiENSGT00760000119096
HOGENOMiHOG000041379
HOVERGENiHBG098741
InParanoidiP59533
KOiK08474
OMAiKIVRFSH
OrthoDBiEOG091G0ERQ
PhylomeDBiP59533
TreeFamiTF335891

Family and domain databases

CDDicd15025 7tm_TAS2R38, 1 hit
InterProiView protein in InterPro
IPR007960 T2R
IPR030050 TAS2R38
PANTHERiPTHR11394:SF52 PTHR11394:SF52, 1 hit
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit

Sequencei

Sequence statusi: Complete.

P59533-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTLTRIRTV SYEVRSTFLF ISVLEFAVGF LTNAFVFLVN FWDVVKRQAL
60 70 80 90 100
SNSDCVLLCL SISRLFLHGL LFLSAIQLTH FQKLSEPLNH SYQAIIMLWM
110 120 130 140 150
IANQANLWLA ACLSLLYCSK LIRFSHTFLI CLASWVSRKI SQMLLGIILC
160 170 180 190 200
SCICTVLCVW CFFSRPHFTV TTVLFMNNNT RLNWQIKDLN LFYSFLFCYL
210 220 230 240 250
WSVPPFLLFL VSSGMLTVSL GRHMRTMKVY TRNSRDPSLE AHIKALKSLV
260 270 280 290 300
SFFCFFVISS CAAFISVPLL ILWRDKIGVM VCVGIMAACP SGHAAILISG
310 320 330
NAKLRRAVMT ILLWAQSSLK VRADHKADSR TLC
Length:333
Mass (Da):37,892
Last modified:June 21, 2005 - v3
Checksum:iE3B5EDD5AB99994C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti186I → N in AAM19322 (PubMed:12379855).Curated1

Polymorphismi

Variations in TAS2R38 are associated with the ability to taste phenylthiocarbamide (PTC tasting) [MIMi:171200]; also called thiourea tasting. The ability to taste the substance PTC and a number of related substances is genetically controlled. Genetic studies have demonstrated complex inheritance for this trait. For some people (and some chimpanzees also), the chemical PTC tastes very bitter. For others, it is tasteless. Actually, substantial variation in taste sensitivity exists in human. Five haplotypes arising from three coding SNPs in the TAS2R38 gene are associated with distinct phenotypes of PTC taste sensitivity.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01786049A → P1 PublicationCorresponds to variant dbSNP:rs713598EnsemblClinVar.1
Natural variantiVAR_017861262A → V5 PublicationsCorresponds to variant dbSNP:rs1726866Ensembl.1
Natural variantiVAR_017862296I → V1 PublicationCorresponds to variant dbSNP:rs10246939EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494231 Genomic DNA Translation: AAM19322.1
AY114095 Genomic DNA Translation: AAM63545.1
AY258598 Genomic DNA Translation: AAP14667.1
AY724960 Genomic DNA Translation: AAU21156.1
CH236950 Genomic DNA Translation: EAL24011.1
CH471070 Genomic DNA Translation: EAW83993.1
BC104933 mRNA Translation: AAI04934.1
BC104937 mRNA Translation: AAI04938.1
CCDSiCCDS34765.1
RefSeqiNP_789787.4, NM_176817.4
UniGeneiHs.647085

Genome annotation databases

EnsembliENST00000547270; ENSP00000448219; ENSG00000257138
GeneIDi5726
KEGGihsa:5726
UCSCiuc003vwx.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Protein Spotlight

A tail of protection - Issue 119 of July 2010

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494231 Genomic DNA Translation: AAM19322.1
AY114095 Genomic DNA Translation: AAM63545.1
AY258598 Genomic DNA Translation: AAP14667.1
AY724960 Genomic DNA Translation: AAU21156.1
CH236950 Genomic DNA Translation: EAL24011.1
CH471070 Genomic DNA Translation: EAW83993.1
BC104933 mRNA Translation: AAI04934.1
BC104937 mRNA Translation: AAI04938.1
CCDSiCCDS34765.1
RefSeqiNP_789787.4, NM_176817.4
UniGeneiHs.647085

3D structure databases

ProteinModelPortaliP59533
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111698, 2 interactors
STRINGi9606.ENSP00000448219

Protein family/group databases

TCDBi9.A.14.17.5 the g-protein-coupled receptor (gpcr) family
GPCRDBiSearch...

PTM databases

iPTMnetiP59533
PhosphoSitePlusiP59533

Polymorphism and mutation databases

BioMutaiTAS2R38
DMDMi68068016

Proteomic databases

PaxDbiP59533
PeptideAtlasiP59533
PRIDEiP59533
ProteomicsDBi57140

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000547270; ENSP00000448219; ENSG00000257138
GeneIDi5726
KEGGihsa:5726
UCSCiuc003vwx.1 human

Organism-specific databases

CTDi5726
DisGeNETi5726
EuPathDBiHostDB:ENSG00000257138.1
GeneCardsiTAS2R38
H-InvDBiHIX0033729
HGNCiHGNC:9584 TAS2R38
HPAiHPA043862
HPA054366
MalaCardsiTAS2R38
MIMi171200 phenotype
607751 gene
neXtProtiNX_P59533
OpenTargetsiENSG00000257138
PharmGKBiPA33936
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH9N Eukaryota
ENOG410Z3YE LUCA
GeneTreeiENSGT00760000119096
HOGENOMiHOG000041379
HOVERGENiHBG098741
InParanoidiP59533
KOiK08474
OMAiKIVRFSH
OrthoDBiEOG091G0ERQ
PhylomeDBiP59533
TreeFamiTF335891

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Miscellaneous databases

GeneWikiiTAS2R38
GenomeRNAii5726
PROiPR:P59533
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000257138 Expressed in 4 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_TAS2R38
GenevisibleiP59533 HS

Family and domain databases

CDDicd15025 7tm_TAS2R38, 1 hit
InterProiView protein in InterPro
IPR007960 T2R
IPR030050 TAS2R38
PANTHERiPTHR11394:SF52 PTHR11394:SF52, 1 hit
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT2R38_HUMAN
AccessioniPrimary (citable) accession number: P59533
Secondary accession number(s): A4D1U6
, P59552, Q2M3E8, Q645W3, Q86UK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: June 21, 2005
Last modified: November 7, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  7. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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