UniProtKB - P59533 (T2R38_HUMAN)
Protein
Taste receptor type 2 member 38
Gene
TAS2R38
Organism
Homo sapiens (Human)
Status
Functioni
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity
Miscellaneous
Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
GO - Molecular functioni
- bitter taste receptor activity Source: UniProtKB
- G protein-coupled receptor activity Source: UniProtKB-KW
GO - Biological processi
- detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: Reactome
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Sensory transduction, Taste |
Enzyme and pathway databases
PathwayCommonsi | P59533 |
Reactomei | R-HSA-418594, G alpha (i) signalling events R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) |
Protein family/group databases
TCDBi | 9.A.14.17.5, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Taste receptor type 2 member 38Short name: T2R38 Alternative name(s): PTC bitter taste receptor Taste receptor type 2 member 61 Short name: T2R61 |
Gene namesi | Name:TAS2R38 Synonyms:PTC |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000257138.1 |
HGNCi | HGNC:9584, TAS2R38 |
MIMi | 607751, gene |
neXtProti | NX_P59533 |
Subcellular locationi
Other locations
Plasma Membrane
- plasma membrane Source: CACAO
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 17 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 18 – 38 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 39 – 55 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 56 – 76 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 77 – 94 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 95 – 115 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 116 – 142 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 143 – 163 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 164 – 190 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 191 – 211 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 212 – 251 | CytoplasmicSequence analysisAdd BLAST | 40 | |
Transmembranei | 252 – 272 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 273 – 276 | ExtracellularSequence analysis | 4 | |
Transmembranei | 277 – 297 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 298 – 333 | CytoplasmicSequence analysisAdd BLAST | 36 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 5726 |
MalaCardsi | TAS2R38 |
MIMi | 171200, phenotype |
OpenTargetsi | ENSG00000257138 |
PharmGKBi | PA33936 |
Miscellaneous databases
Pharosi | P59533, Tbio |
Polymorphism and mutation databases
BioMutai | TAS2R38 |
DMDMi | 68068016 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000082273 | 1 – 333 | Taste receptor type 2 member 38Add BLAST | 333 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 89 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 178 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | P59533 |
PaxDbi | P59533 |
PRIDEi | P59533 |
ProteomicsDBi | 57140 |
PTM databases
GlyGeni | P59533, 2 sites |
iPTMneti | P59533 |
PhosphoSitePlusi | P59533 |
Expressioni
Tissue specificityi
Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed in testis (PubMed:16720576).1 Publication
Gene expression databases
Bgeei | ENSG00000257138, Expressed in sural nerve and 11 other tissues |
Genevisiblei | P59533, HS |
Organism-specific databases
HPAi | ENSG00000257138, Tissue enhanced (intestine) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 111698, 2 interactors |
STRINGi | 9606.ENSP00000448219 |
Miscellaneous databases
RNActi | P59533, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor T2R family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502T15G, Eukaryota |
GeneTreei | ENSGT00960000186638 |
HOGENOMi | CLU_072337_3_0_1 |
InParanoidi | P59533 |
OMAi | VRADHMA |
OrthoDBi | 1010573at2759 |
PhylomeDBi | P59533 |
TreeFami | TF335891 |
Family and domain databases
InterProi | View protein in InterPro IPR007960, TAS2R IPR030050, TAS2R38 |
PANTHERi | PTHR11394:SF52, PTHR11394:SF52, 1 hit |
Pfami | View protein in Pfam PF05296, TAS2R, 1 hit |
i Sequence
Sequence statusi: Complete.
P59533-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLTLTRIRTV SYEVRSTFLF ISVLEFAVGF LTNAFVFLVN FWDVVKRQAL
60 70 80 90 100
SNSDCVLLCL SISRLFLHGL LFLSAIQLTH FQKLSEPLNH SYQAIIMLWM
110 120 130 140 150
IANQANLWLA ACLSLLYCSK LIRFSHTFLI CLASWVSRKI SQMLLGIILC
160 170 180 190 200
SCICTVLCVW CFFSRPHFTV TTVLFMNNNT RLNWQIKDLN LFYSFLFCYL
210 220 230 240 250
WSVPPFLLFL VSSGMLTVSL GRHMRTMKVY TRNSRDPSLE AHIKALKSLV
260 270 280 290 300
SFFCFFVISS CAAFISVPLL ILWRDKIGVM VCVGIMAACP SGHAAILISG
310 320 330
NAKLRRAVMT ILLWAQSSLK VRADHKADSR TLC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 186 | I → N in AAM19322 (PubMed:12379855).Curated | 1 |
Polymorphismi
Variations in TAS2R38 are associated with the ability to taste phenylthiocarbamide (PTC tasting) [MIMi:171200]; also called thiourea tasting. The ability to taste the substance PTC and a number of related substances is genetically controlled. Genetic studies have demonstrated complex inheritance for this trait. For some people (and some chimpanzees also), the chemical PTC tastes very bitter. For others, it is tasteless. Actually, substantial variation in taste sensitivity exists in human. Five haplotypes arising from three coding SNPs in the TAS2R38 gene are associated with distinct phenotypes of PTC taste sensitivity.
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_017860 | 49 | A → P1 PublicationCorresponds to variant dbSNP:rs713598EnsemblClinVar. | 1 | |
Natural variantiVAR_017861 | 262 | A → V5 PublicationsCorresponds to variant dbSNP:rs1726866Ensembl. | 1 | |
Natural variantiVAR_017862 | 296 | I → V1 PublicationCorresponds to variant dbSNP:rs10246939EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF494231 Genomic DNA Translation: AAM19322.1 AY114095 Genomic DNA Translation: AAM63545.1 AY258598 Genomic DNA Translation: AAP14667.1 AY724960 Genomic DNA Translation: AAU21156.1 CH236950 Genomic DNA Translation: EAL24011.1 CH471070 Genomic DNA Translation: EAW83993.1 BC104933 mRNA Translation: AAI04934.1 BC104937 mRNA Translation: AAI04938.1 |
CCDSi | CCDS34765.1 |
RefSeqi | NP_789787.4, NM_176817.4 |
Genome annotation databases
Ensembli | ENST00000547270; ENSP00000448219; ENSG00000257138 |
GeneIDi | 5726 |
KEGGi | hsa:5726 |
UCSCi | uc003vwx.1, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Protein Spotlight A tail of protection - Issue 119 of July 2010 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF494231 Genomic DNA Translation: AAM19322.1 AY114095 Genomic DNA Translation: AAM63545.1 AY258598 Genomic DNA Translation: AAP14667.1 AY724960 Genomic DNA Translation: AAU21156.1 CH236950 Genomic DNA Translation: EAL24011.1 CH471070 Genomic DNA Translation: EAW83993.1 BC104933 mRNA Translation: AAI04934.1 BC104937 mRNA Translation: AAI04938.1 |
CCDSi | CCDS34765.1 |
RefSeqi | NP_789787.4, NM_176817.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 111698, 2 interactors |
STRINGi | 9606.ENSP00000448219 |
Protein family/group databases
TCDBi | 9.A.14.17.5, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | P59533, 2 sites |
iPTMneti | P59533 |
PhosphoSitePlusi | P59533 |
Polymorphism and mutation databases
BioMutai | TAS2R38 |
DMDMi | 68068016 |
Proteomic databases
MassIVEi | P59533 |
PaxDbi | P59533 |
PRIDEi | P59533 |
ProteomicsDBi | 57140 |
Protocols and materials databases
Antibodypediai | 50262, 137 antibodies |
Genome annotation databases
Ensembli | ENST00000547270; ENSP00000448219; ENSG00000257138 |
GeneIDi | 5726 |
KEGGi | hsa:5726 |
UCSCi | uc003vwx.1, human |
Organism-specific databases
CTDi | 5726 |
DisGeNETi | 5726 |
EuPathDBi | HostDB:ENSG00000257138.1 |
GeneCardsi | TAS2R38 |
HGNCi | HGNC:9584, TAS2R38 |
HPAi | ENSG00000257138, Tissue enhanced (intestine) |
MalaCardsi | TAS2R38 |
MIMi | 171200, phenotype 607751, gene |
neXtProti | NX_P59533 |
OpenTargetsi | ENSG00000257138 |
PharmGKBi | PA33936 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502T15G, Eukaryota |
GeneTreei | ENSGT00960000186638 |
HOGENOMi | CLU_072337_3_0_1 |
InParanoidi | P59533 |
OMAi | VRADHMA |
OrthoDBi | 1010573at2759 |
PhylomeDBi | P59533 |
TreeFami | TF335891 |
Enzyme and pathway databases
PathwayCommonsi | P59533 |
Reactomei | R-HSA-418594, G alpha (i) signalling events R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) |
Miscellaneous databases
BioGRID-ORCSi | 5726, 3 hits in 838 CRISPR screens |
GeneWikii | TAS2R38 |
GenomeRNAii | 5726 |
Pharosi | P59533, Tbio |
PROi | PR:P59533 |
RNActi | P59533, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000257138, Expressed in sural nerve and 11 other tissues |
Genevisiblei | P59533, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007960, TAS2R IPR030050, TAS2R38 |
PANTHERi | PTHR11394:SF52, PTHR11394:SF52, 1 hit |
Pfami | View protein in Pfam PF05296, TAS2R, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | T2R38_HUMAN | |
Accessioni | P59533Primary (citable) accession number: P59533 Secondary accession number(s): A4D1U6 Q86UK3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 11, 2003 |
Last sequence update: | June 21, 2005 | |
Last modified: | December 2, 2020 | |
This is version 153 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries