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Entry version 154 (31 Jul 2019)
Sequence version 2 (16 Dec 2008)
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Protein

A disintegrin and metalloproteinase with thrombospondin motifs 20

Gene

ADAMTS20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain.

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi403Zinc; catalyticBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei404PROSITE-ProRule annotation1
Metal bindingi407Zinc; catalyticBy similarity1
Metal bindingi413Zinc; catalyticBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M12.246

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 20 (EC:3.4.24.-)
Short name:
ADAM-TS 20
Short name:
ADAM-TS20
Short name:
ADAMTS-20
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17178 ADAMTS20

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611681 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P59510

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80070

Open Targets

More...
OpenTargetsi
ENSG00000173157

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134901626

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADAMTS20

Domain mapping of disease mutations (DMDM)

More...
DMDMi
218511943

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002920622 – 253By similarityAdd BLAST232
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000029207254 – 1910A disintegrin and metalloproteinase with thrombospondin motifs 20Add BLAST1657

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi334 ↔ 387By similarity
Disulfide bondi363 ↔ 369By similarity
Disulfide bondi381 ↔ 462By similarity
Disulfide bondi419 ↔ 446By similarity
Glycosylationi445N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi489 ↔ 511By similarity
Disulfide bondi500 ↔ 521By similarity
Disulfide bondi506 ↔ 540By similarity
Disulfide bondi534 ↔ 545By similarity
Disulfide bondi568 ↔ 605By similarity
Disulfide bondi572 ↔ 610By similarity
Disulfide bondi583 ↔ 595By similarity
Glycosylationi702N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi717N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi728N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi809N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi870N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1061N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1456N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1542N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1572N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1763N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1781N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1852N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.By similarity
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P59510

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P59510

PeptideAtlas

More...
PeptideAtlasi
P59510

PRoteomics IDEntifications database

More...
PRIDEi
P59510

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57138 [P59510-1]
57139 [P59510-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P59510

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P59510

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Very sparingly expressed, although is detected at low levels in testis, prostate, ovary, heart, placenta, lung and pancreas. Overexpressed in several brain, colon and breast carcinomas.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173157 Expressed in 16 organ(s), highest expression level in kidney

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P59510 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P59510 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027608
HPA027609

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
P59510, 2 interactors

Molecular INTeraction database

More...
MINTi
P59510

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000374071

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P59510

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini259 – 467Peptidase M12BPROSITE-ProRule annotationAdd BLAST209
Domaini468 – 555DisintegrinAdd BLAST88
Domaini556 – 611TSP type-1 1PROSITE-ProRule annotationAdd BLAST56
Domaini846 – 904TSP type-1 2PROSITE-ProRule annotationAdd BLAST59
Domaini905 – 961TSP type-1 3PROSITE-ProRule annotationAdd BLAST57
Domaini966 – 1023TSP type-1 4PROSITE-ProRule annotationAdd BLAST58
Domaini1024 – 1073TSP type-1 5PROSITE-ProRule annotationAdd BLAST50
Domaini1076 – 1135TSP type-1 6PROSITE-ProRule annotationAdd BLAST60
Domaini1152 – 1206TSP type-1 7PROSITE-ProRule annotationAdd BLAST55
Domaini1207 – 1264TSP type-1 8PROSITE-ProRule annotationAdd BLAST58
Domaini1304 – 1356TSP type-1 9PROSITE-ProRule annotationAdd BLAST53
Domaini1358 – 1416TSP type-1 10PROSITE-ProRule annotationAdd BLAST59
Domaini1417 – 1475TSP type-1 11PROSITE-ProRule annotationAdd BLAST59
Domaini1476 – 1531TSP type-1 12PROSITE-ProRule annotationAdd BLAST56
Domaini1535 – 1588TSP type-1 13PROSITE-ProRule annotationAdd BLAST54
Domaini1589 – 1652TSP type-1 14PROSITE-ProRule annotationAdd BLAST64
Domaini1654 – 1710TSP type-1 15PROSITE-ProRule annotationAdd BLAST57
Domaini1711 – 1910GONPROSITE-ProRule annotationAdd BLAST200

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni724 – 846SpacerAdd BLAST123

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi612 – 723Cys-richAdd BLAST112

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3538 Eukaryota
ENOG410XPKZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158636

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000004798

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P59510

KEGG Orthology (KO)

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KOi
K09609

Identification of Orthologs from Complete Genome Data

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OMAi
HCDSGPC

Database of Orthologous Groups

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OrthoDBi
125522at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P59510

TreeFam database of animal gene trees

More...
TreeFami
TF331949

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 11 hits
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR041645 ADAM_CR_2
IPR010294 ADAM_spacer1
IPR013273 ADAMTS/ADAMTS-like
IPR024079 MetalloPept_cat_dom_sf
IPR012314 Pept_M12B_GON-ADAMTSs
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17771 ADAM_CR_2, 1 hit
PF05986 ADAM_spacer1, 1 hit
PF08685 GON, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 11 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01857 ADAMTSFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00209 TSP1, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82895 SSF82895, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS51046 GON, 1 hit
PS50092 TSP1, 12 hits
PS00142 ZINC_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P59510-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWVAKWLTGL LYHLSLFITR SWEVDFHPRQ EALVRTLTSY EVVIPERVNE
60 70 80 90 100
FGEVFPQSHH FSRQKRSSEA LEPMPFRTHY RFTAYGQLFQ LNLTADASFL
110 120 130 140 150
AAGYTEVHLG TPERGAWESD AGPSDLRHCF YRGQVNSQED YKAVVSLCGG
160 170 180 190 200
LTGTFKGQNG EYFLEPIMKA DGNEYEDGHN KPHLIYRQDL NNSFLQTLKY
210 220 230 240 250
CSVSESQIKE TSLPFHTYSN MNEDLNVMKE RVLGHTSKNV PLKDERRHSR
260 270 280 290 300
KKRLISYPRY IEIMVTADAK VVSAHGSNLQ NYILTLMSIV ATIYKDPSIG
310 320 330 340 350
NLIHIVVVKL VMIHREEEGP VINFDGATTL KNFCSWQQTQ NDLDDVHPSH
360 370 380 390 400
HDTAVLITRE DICSSKEKCN MLGLSYLGTI CDPLQSCFIN EEKGLISAFT
410 420 430 440 450
IAHELGHTLG VQHDDNPRCK EMKVTKYHVM APALSFHMSP WSWSNCSRKY
460 470 480 490 500
VTEFLDTGYG ECLLDKPDEE IYNLPSELPG SRYDGNKQCE LAFGPGSQMC
510 520 530 540 550
PHINICMHLW CTSTEKLHKG CFTQHVPPAD GTDCGPGMHC RHGLCVNKET
560 570 580 590 600
ETRPVNGEWG PWEPYSSCSR TCGGGIESAT RRCNRPEPRN GGNYCVGRRM
610 620 630 640 650
KFRSCNTDSC PKGTQDFREK QCSDFNGKHL DISGIPSNVR WLPRYSGIGT
660 670 680 690 700
KDRCKLYCQV AGTNYFYLLK DMVEDGTPCG TETHDICVQG QCMAAGCDHV
710 720 730 740 750
LNSSAKIDKC GVCGGDNSSC KTITGVFNSS HYGYNVVVKI PAGATNVDIR
760 770 780 790 800
QYSYSGQPDD SYLALSDAEG NFLFNGNFLL STSKKEINVQ GTRTVIEYSG
810 820 830 840 850
SNNAVERINS TNRQEKEILI EVLCVGNLYN PDVHYSFNIP LEERSDMFTW
860 870 880 890 900
DPYGPWEGCT KMCQGLQRRN ITCIHKSDHS VVSDKECDHL PLPSFVTQSC
910 920 930 940 950
NTDCELRWHV IGKSECSSQC GQGYRTLDIH CMKYSIHEGQ TVQVDDHYCG
960 970 980 990 1000
DQLKPPTQEL CHGNCVFTRW HYSEWSQCSR SCGGGERSRE SYCMNNFGHR
1010 1020 1030 1040 1050
LADNECQELS RVTRENCNEF SCPSWAASEW SECLVTCGKG TKQRQVWCQL
1060 1070 1080 1090 1100
NVDHLSDGFC NSSTKPESLS PCELHTCASW QVGPWGPCTT TCGHGYQMRD
1110 1120 1130 1140 1150
VKCVNELASA VLEDTECHEA SRPSDRQSCV LTPCSFISKL ETALLPTVLI
1160 1170 1180 1190 1200
KKMAQWRHGS WTPCSVSCGR GTQARYVSCR DALDRIADES YCAHLPRPAE
1210 1220 1230 1240 1250
IWDCFTPCGE WQAGDWSPCS ASCGHGKTTR QVLCMNYHQP IDENYCDPEV
1260 1270 1280 1290 1300
RPLMEQECSL AACPPAHSHF PSSPVQPSYY LSTNLPLTQK LEDNENQVVH
1310 1320 1330 1340 1350
PSVRGNQWRT GPWGSCSSSC SGGLQHRAVV CQDENGQSAS YCDAASKPPE
1360 1370 1380 1390 1400
LQQCGPGPCP QWNYGNWGEC SQTCGGGIKS RLVICQFPNG QILEDHNCEI
1410 1420 1430 1440 1450
VNKPPSVIQC HMHACPADVS WHQEPWTSCS ASCGKGRKYR EVFCIDQFQR
1460 1470 1480 1490 1500
KLEDTNCSQV QKPPTHKACR SVRCPSWKAN SWNECSVTCG SGVQQRDVYC
1510 1520 1530 1540 1550
RLKGVGQVVE EMCDQSTRPC SQRRCWSQDC VQHKGMERGR LNCSTSCERK
1560 1570 1580 1590 1600
DSHQRMECTD NQIRQVNEIV YNSSTISLTS KNCRNPPCNY IVVTADSSQC
1610 1620 1630 1640 1650
ANNCGFSYRQ RITYCTEIPS TKKHKLHRLR PIVYQECPVV PSSQVYQCIN
1660 1670 1680 1690 1700
SCLHLATWKV GKWSKCSVTC GIGIMKRQVK CITKHGLSSD LCLNHLKPGA
1710 1720 1730 1740 1750
QKKCYANDCK SFTTCKEIQV KNHIRKDGDY YLNIKGRIIK IYCADMYLEN
1760 1770 1780 1790 1800
PKEYLTLVQG EENFSEVYGF RLKNPYQCPF NGSRREDCEC DNGHLAAGYT
1810 1820 1830 1840 1850
VFSKIRIDLT SMQIKTTDLL FSKTIFGNAV PFATAGDCYS AFRCPQGQFS
1860 1870 1880 1890 1900
INLSGTGMKI SSTAKWLTQG SYTSVSIRRS EDGTRFFGKC GGYCGKCLPH
1910
MTTGLPIQVI
Length:1,910
Mass (Da):214,721
Last modified:December 16, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7FFCB0D56F4B6D9
GO
Isoform 2 (identifier: P59510-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     683-693: THDICVQGQCM → SYNIDCNCVLK
     1429-1504: CSASCGKGRK...QRDVYCRLKG → EDLKVKLLPQ...GDLKYYKNSL
     1505-1910: Missing.

Show »
Length:1,504
Mass (Da):169,506
Checksum:i2F9D75248EE885DF
GO
Isoform 3 (identifier: P59510-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     818-821: ILIE → LILQ

Show »
Length:1,910
Mass (Da):214,720
Checksum:i93AA3B0AC1B9C6D9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PBD5E9PBD5_HUMAN
A disintegrin and metalloproteinase...
ADAMTS20
1,504Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V1X8G3V1X8_HUMAN
A disintegrin and metalloproteinase...
ADAMTS20 hCG_39495
1,504Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHN3H0YHN3_HUMAN
A disintegrin and metalloproteinase...
ADAMTS20
634Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti152T → V in CAD56159 (PubMed:12562771).Curated1
Sequence conflicti152T → V in CAD56160 (PubMed:12562771).Curated1
Sequence conflicti360E → Y in CAD56159 (PubMed:12562771).Curated1
Sequence conflicti360E → Y in CAD56160 (PubMed:12562771).Curated1
Sequence conflicti371M → T in AAO15766 (PubMed:12514189).Curated1
Sequence conflicti456D → E in CAD56159 (PubMed:12562771).Curated1
Sequence conflicti456D → E in CAD56160 (PubMed:12562771).Curated1
Sequence conflicti648I → V in CAD56159 (PubMed:12562771).Curated1
Sequence conflicti648I → V in CAD56160 (PubMed:12562771).Curated1
Sequence conflicti792 – 793Missing in CAD56159 (PubMed:12562771).Curated2
Sequence conflicti792 – 793Missing in CAD56160 (PubMed:12562771).Curated2
Sequence conflicti908 – 912WHVIG → GMLLAK in AAO15766 (PubMed:12514189).Curated5
Sequence conflicti1315S → Q in CAD56159 (PubMed:12562771).Curated1
Sequence conflicti1315S → Q in CAD56160 (PubMed:12562771).Curated1
Sequence conflicti1327R → T in AAO15766 (PubMed:12514189).Curated1
Sequence conflicti1816T → A in CAD56159 (PubMed:12562771).Curated1
Sequence conflicti1881E → Q in CAD56159 (PubMed:12562771).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057088876K → M. Corresponds to variant dbSNP:rs7302446Ensembl.1
Natural variantiVAR_0570891000R → H. Corresponds to variant dbSNP:rs7297737Ensembl.1
Natural variantiVAR_0570901273S → F. Corresponds to variant dbSNP:rs7310011Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007106683 – 693THDICVQGQCM → SYNIDCNCVLK in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_047084818 – 821ILIE → LILQ in isoform 3. 1 Publication4
Alternative sequenceiVSP_0071071429 – 1504CSASC…CRLKG → EDLKVKLLPQRTIILWELMK NIFCHGKHSHMYLINVVTDH LLYPRHCDPETIETYFLSLW SLQFTWGDLKYYKNSL in isoform 2. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_0071081505 – 1910Missing in isoform 2. 1 PublicationAdd BLAST406

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF488804 mRNA Translation: AAO15766.1
AJ515153 mRNA Translation: CAD56159.3
AJ515154 mRNA Translation: CAD56160.2
AC090525 Genomic DNA No translation available.
AC107018 Genomic DNA No translation available.
AC120104 Genomic DNA No translation available.
CH471111 Genomic DNA Translation: EAW57861.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31778.2 [P59510-3]

NCBI Reference Sequences

More...
RefSeqi
NP_079279.3, NM_025003.4 [P59510-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000389420; ENSP00000374071; ENSG00000173157 [P59510-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80070

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80070

UCSC genome browser

More...
UCSCi
uc010skx.3 human [P59510-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF488804 mRNA Translation: AAO15766.1
AJ515153 mRNA Translation: CAD56159.3
AJ515154 mRNA Translation: CAD56160.2
AC090525 Genomic DNA No translation available.
AC107018 Genomic DNA No translation available.
AC120104 Genomic DNA No translation available.
CH471111 Genomic DNA Translation: EAW57861.1
CCDSiCCDS31778.2 [P59510-3]
RefSeqiNP_079279.3, NM_025003.4 [P59510-3]

3D structure databases

SMRiP59510
ModBaseiSearch...

Protein-protein interaction databases

IntActiP59510, 2 interactors
MINTiP59510
STRINGi9606.ENSP00000374071

Protein family/group databases

MEROPSiM12.246

PTM databases

iPTMnetiP59510
PhosphoSitePlusiP59510

Polymorphism and mutation databases

BioMutaiADAMTS20
DMDMi218511943

Proteomic databases

jPOSTiP59510
PaxDbiP59510
PeptideAtlasiP59510
PRIDEiP59510
ProteomicsDBi57138 [P59510-1]
57139 [P59510-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389420; ENSP00000374071; ENSG00000173157 [P59510-3]
GeneIDi80070
KEGGihsa:80070
UCSCiuc010skx.3 human [P59510-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80070
DisGeNETi80070

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ADAMTS20
HGNCiHGNC:17178 ADAMTS20
HPAiHPA027608
HPA027609
MIMi611681 gene
neXtProtiNX_P59510
OpenTargetsiENSG00000173157
PharmGKBiPA134901626

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3538 Eukaryota
ENOG410XPKZ LUCA
GeneTreeiENSGT00940000158636
HOGENOMiHOG000004798
InParanoidiP59510
KOiK09609
OMAiHCDSGPC
OrthoDBi125522at2759
PhylomeDBiP59510
TreeFamiTF331949

Enzyme and pathway databases

ReactomeiR-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ADAMTS20 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80070

Protein Ontology

More...
PROi
PR:P59510

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000173157 Expressed in 16 organ(s), highest expression level in kidney
ExpressionAtlasiP59510 baseline and differential
GenevisibleiP59510 HS

Family and domain databases

Gene3Di2.20.100.10, 11 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR041645 ADAM_CR_2
IPR010294 ADAM_spacer1
IPR013273 ADAMTS/ADAMTS-like
IPR024079 MetalloPept_cat_dom_sf
IPR012314 Pept_M12B_GON-ADAMTSs
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF17771 ADAM_CR_2, 1 hit
PF05986 ADAM_spacer1, 1 hit
PF08685 GON, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 11 hits
PRINTSiPR01857 ADAMTSFAMILY
SMARTiView protein in SMART
SM00209 TSP1, 13 hits
SUPFAMiSSF82895 SSF82895, 12 hits
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS51046 GON, 1 hit
PS50092 TSP1, 12 hits
PS00142 ZINC_PROTEASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATS20_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P59510
Secondary accession number(s): A6NNC9, J3QT00
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: December 16, 2008
Last modified: July 31, 2019
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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