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Protein

VIP36-like protein

Gene

Lman2l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53 (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92CarbohydratePROSITE-ProRule annotation1
Binding sitei127CarbohydratePROSITE-ProRule annotation1
Metal bindingi158CalciumPROSITE-ProRule annotation1
Metal bindingi160Calcium; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi162CalciumPROSITE-ProRule annotation1
Binding sitei187CarbohydratePROSITE-ProRule annotation1
Metal bindingi190CalciumPROSITE-ProRule annotation1

GO - Molecular functioni

  • mannose binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

LigandLectin, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-5694530 Cargo concentration in the ER

Names & Taxonomyi

Protein namesi
Recommended name:
VIP36-like protein
Alternative name(s):
Lectin mannose-binding 2-like
Short name:
LMAN2-like protein
Gene namesi
Name:Lman2l
Synonyms:Vipl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2443010 Lman2l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini44 – 312LumenalSequence analysisAdd BLAST269
Transmembranei313 – 335HelicalSequence analysisAdd BLAST23
Topological domaini336 – 347CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 43Sequence analysisAdd BLAST43
ChainiPRO_000001766944 – 347VIP36-like proteinAdd BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi180N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi199 ↔ 236PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP59481
PaxDbiP59481
PeptideAtlasiP59481
PRIDEiP59481

PTM databases

iPTMnetiP59481
PhosphoSitePlusiP59481

Expressioni

Gene expression databases

BgeeiENSMUSG00000001143 Expressed in 242 organ(s), highest expression level in blastocyst
CleanExiMM_LMAN2L
ExpressionAtlasiP59481 baseline and differential
GenevisibleiP59481 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000117200

Structurei

3D structure databases

ProteinModelPortaliP59481
SMRiP59481
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 273L-type lectin-likePROSITE-ProRule annotationAdd BLAST226

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni160 – 162Carbohydrate bindingPROSITE-ProRule annotation3
Regioni257 – 259Carbohydrate bindingPROSITE-ProRule annotation3

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi343 – 345Endoplasmic reticulum retention signalBy similarity3

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3839 Eukaryota
ENOG410YH8V LUCA
GeneTreeiENSGT00530000062977
HOGENOMiHOG000164540
HOVERGENiHBG052334
InParanoidiP59481
KOiK10083
PhylomeDBiP59481
TreeFamiTF313311

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR005052 Lectin_leg
PfamiView protein in Pfam
PF03388 Lectin_leg-like, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51328 L_LECTIN_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P59481-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAASRPSWW QRWRRRAWAR DGAKLLLFLL LLGSGPGPRH VRAGQAVEYL
60 70 80 90 100
KREHSLSKPY QGVGTSSSSL WNLMGNAMVM TQYIRLTPDM QSKQGALWNR
110 120 130 140 150
VPCFLKDWEL QVHFKIHGQG KKNLHGDGLA IWYTKDRMQP GPVFGNMDKF
160 170 180 190 200
VGLGVFVDTY PNEEKQHERV FPYISAMVNN GSLSYDHERD GRPTELGGCT
210 220 230 240 250
AIVRNIRYDT FLVIRYVKRH LTIMMDIDGK HEWRDCIEMP GVRLPRGYYF
260 270 280 290 300
GTSSITGDLS DNHDVISLKL FELTGVRTPE EEKLHRDVFL PSVDNLKLPE
310 320 330 340
MTVPPTPLSG LALFLIVFFS LVFSVFAIVI GIILYNKWQD QSRKRFY
Length:347
Mass (Da):39,881
Last modified:April 4, 2003 - v1
Checksum:iB5DD3287F86E4C23
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z4P2D3Z4P2_MOUSE
Lectin, mannose-binding 2-like, iso...
Lman2l mCG_17749
358Annotation score:
J3QNZ7J3QNZ7_MOUSE
VIP36-like protein
Lman2l
157Annotation score:
J3QPK9J3QPK9_MOUSE
VIP36-like protein
Lman2l
75Annotation score:
F6QN75F6QN75_MOUSE
VIP36-like protein
Lman2l
124Annotation score:
A0A0A6YX25A0A0A6YX25_MOUSE
VIP36-like protein
Lman2l
205Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16R → H in BAE34318 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK158015 mRNA Translation: BAE34318.1
BC046969 mRNA Translation: AAH46969.1
CCDSiCCDS14878.1
RefSeqiNP_001013392.1, NM_001013374.2
NP_001297446.1, NM_001310517.1
UniGeneiMm.287854

Genome annotation databases

EnsembliENSMUST00000125304; ENSMUSP00000117200; ENSMUSG00000001143
GeneIDi214895
KEGGimmu:214895
UCSCiuc007aqc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK158015 mRNA Translation: BAE34318.1
BC046969 mRNA Translation: AAH46969.1
CCDSiCCDS14878.1
RefSeqiNP_001013392.1, NM_001013374.2
NP_001297446.1, NM_001310517.1
UniGeneiMm.287854

3D structure databases

ProteinModelPortaliP59481
SMRiP59481
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000117200

PTM databases

iPTMnetiP59481
PhosphoSitePlusiP59481

Proteomic databases

MaxQBiP59481
PaxDbiP59481
PeptideAtlasiP59481
PRIDEiP59481

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000125304; ENSMUSP00000117200; ENSMUSG00000001143
GeneIDi214895
KEGGimmu:214895
UCSCiuc007aqc.1 mouse

Organism-specific databases

CTDi81562
MGIiMGI:2443010 Lman2l

Phylogenomic databases

eggNOGiKOG3839 Eukaryota
ENOG410YH8V LUCA
GeneTreeiENSGT00530000062977
HOGENOMiHOG000164540
HOVERGENiHBG052334
InParanoidiP59481
KOiK10083
PhylomeDBiP59481
TreeFamiTF313311

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-5694530 Cargo concentration in the ER

Miscellaneous databases

PROiPR:P59481
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001143 Expressed in 242 organ(s), highest expression level in blastocyst
CleanExiMM_LMAN2L
ExpressionAtlasiP59481 baseline and differential
GenevisibleiP59481 MM

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR005052 Lectin_leg
PfamiView protein in Pfam
PF03388 Lectin_leg-like, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51328 L_LECTIN_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLMA2L_MOUSE
AccessioniPrimary (citable) accession number: P59481
Secondary accession number(s): Q3TZ91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: April 4, 2003
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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