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Protein

Bifunctional protein PyrR 2

Gene

pyrR2

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes (By similarity).By similarity
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.By similarity

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei133SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, RNA-binding, Transferase
Biological processTranscription, Transcription regulation, Transcription termination

Enzyme and pathway databases

BioCyciLPLA220668:G1GW0-1532-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PyrR 2
Including the following 2 domains:
Pyrimidine operon regulatory protein 2
Uracil phosphoribosyltransferase 2 (EC:2.4.2.9)
Short name:
UPRTase 2
Gene namesi
Name:pyrR2
Ordered Locus Names:lp_1782
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000000432 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001830421 – 174Bifunctional protein PyrR 2Add BLAST174

Interactioni

Subunit structurei

Homodimer and homohexamer; in equilibrium.By similarity

Protein-protein interaction databases

STRINGi220668.lp_1782

Structurei

3D structure databases

ProteinModelPortaliP59389
SMRiP59389
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni39 – 40Substrate-bindingBy similarity2
Regioni100 – 108Substrate bindingBy similarity9

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi96 – 108PRPP-bindingBy similarityAdd BLAST13

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108UK1 Bacteria
COG2065 LUCA
HOGENOMiHOG000245770
KOiK02825
OMAiVRITYEI

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01219 PyrR, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR023050 PyrR
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit

Sequencei

Sequence statusi: Complete.

P59389-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKEVVDSMA MKRALTRITY EIIEQNKGIK NVVLVGVKTR GVYIAQRIAA
60 70 80 90 100
QLQQLEGTAI PVGELDITAF RDDQPLDQAR LSTDYQLTFS VADKRVILVD
110 120 130 140 150
DVLFTGRTIR AALDALMGGG RPQSIALAVL VDRGHRELPI RADFIGRNIP
160 170
TARQERIKVT VNEIDGHDGI EIIN
Length:174
Mass (Da):19,303
Last modified:March 25, 2003 - v1
Checksum:i0547E7286C395B41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935263 Genomic DNA Translation: CCC79069.1
RefSeqiWP_003644388.1, NC_004567.2
YP_004889583.1, NC_004567.2

Genome annotation databases

EnsemblBacteriaiCCC79069; CCC79069; lp_1782
GeneIDi1063520
KEGGilpl:lp_1782
PATRICifig|220668.9.peg.1503

Similar proteinsi

Entry informationi

Entry nameiPYRR2_LACPL
AccessioniPrimary (citable) accession number: P59389
Secondary accession number(s): F9UPD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 25, 2003
Last modified: February 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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