Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 146 (29 Sep 2021)
Sequence version 2 (10 Jan 2006)
Previous versions | rss
Add a publicationFeedback
Protein

WD repeat and HMG-box DNA-binding protein 1

Gene

Wdhd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication.

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1004 – 1073HMG boxPROSITE-ProRule annotationAdd BLAST70

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat and HMG-box DNA-binding protein 1
Alternative name(s):
Acidic nucleoplasmic DNA-binding protein 1
Short name:
And-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Wdhd1
Synonyms:And1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443514, Wdhd1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000037572

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000513391 – 1117WD repeat and HMG-box DNA-binding protein 1Add BLAST1117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei333PhosphoserineBy similarity1
Modified residuei377PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki390Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei664N6-acetyllysineCombined sources1
Modified residuei819PhosphothreonineCombined sources1
Modified residuei821PhosphoserineCombined sources1
Modified residuei910PhosphoserineBy similarity1
Modified residuei923PhosphoserineBy similarity1
Modified residuei953N6-acetyllysineBy similarity1
Modified residuei1030PhosphoserineBy similarity1
Cross-linki1116Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki1116Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P59328

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P59328

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P59328

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P59328

PeptideAtlas

More...
PeptideAtlasi
P59328

PRoteomics IDEntifications database

More...
PRIDEi
P59328

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
297935 [P59328-1]
297936 [P59328-2]
297937 [P59328-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P59328

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P59328

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000037572, Expressed in ear vesicle and 228 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P59328, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P59328, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the polymerase alpha catalytic subunit POLA1.

Interacts with MCM10.

Interacts with DNA2 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
230088, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000107421

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P59328, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P59328

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati11 – 50WD 1Add BLAST40
Repeati52 – 91WD 2Add BLAST40
Repeati93 – 131WD 3Add BLAST39
Repeati134 – 173WD 4Add BLAST40
Repeati184 – 223WD 5Add BLAST40
Repeati228 – 267WD 6Add BLAST40
Repeati271 – 310WD 7Add BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni816 – 885DisorderedSequence analysisAdd BLAST70
Regioni911 – 1005DisorderedSequence analysisAdd BLAST95
Regioni1054 – 1074DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi816 – 834Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi848 – 872Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi913 – 946Polar residuesSequence analysisAdd BLAST34
Compositional biasi989 – 1005Polar residuesSequence analysisAdd BLAST17

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1274, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002030

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004219_6_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P59328

Identification of Orthologs from Complete Genome Data

More...
OMAi
RYAHTNG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P59328

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.30.10, 1 hit
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024977, Apc4_WD40_dom
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
IPR022100, Mcl1_mid
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12894, ANAPC4_WD40, 1 hit
PF00505, HMG_box, 1 hit
PF12341, Mcl1_mid, 1 hit
PF00400, WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00398, HMG, 1 hit
SM00320, WD40, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47095, SSF47095, 1 hit
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50118, HMG_BOX_2, 1 hit
PS00678, WD_REPEATS_1, 2 hits
PS50082, WD_REPEATS_2, 3 hits
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P59328-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPATQKPMRY GHTEGHTEVC FDDSGSYIVT CGSDGDVRMW EDLDDDDPKS
60 70 80 90 100
VNVGEKAFSC ALKNGKLVTA VSNNTVQVYT FPEGVPDGIL TRFTTNANHV
110 120 130 140 150
VFNGAGNKIA AGSSDFLVKV VDVMDNSQQQ TFRGHDAPVL SLSFDPKDIF
160 170 180 190 200
LASASCDGTV RVWNISDQTC AVSWPVLQKS NDVVNAKSIC RLAWQPKAGK
210 220 230 240 250
LLAVPVEKSV KLYRRETWSN PFDLSDSSIS QTLNIVTWSP CGQYLAAGAI
260 270 280 290 300
NGLIVVWNVE TKDCMERVKH EKGYAICGLA WHPTCSRICY TDVEGNLGVL
310 320 330 340 350
ENVCDLSGKV SSNKVSSRVE KDYNDLFDGD DTSSAGDFLN DNAVEIPSFS
360 370 380 390 400
KGIINEDDDN DDIMLAADHD LGDDENSVDV TMLKADLSHK EEGDDDQARS
410 420 430 440 450
IHNLPLIRPQ RPFYDGPMPT PRQKPFQSSS TPLHLSHRFM VWNSVGIIRC
460 470 480 490 500
YNDDQDSAID VEFHDTSIHH ATHLLNAFNY TMGTLSHEAI LLACESADEL
510 520 530 540 550
ASKLHCLHFS SWDSSKEWMV DMPQNEDIEA ICLGLGWAAA ATTALLLRLF
560 570 580 590 600
TIGGVQKEVF CLPGPVVSMA GHGEQLCIVY HRGTGFDGDQ CLGVQLLELG
610 620 630 640 650
RKKNQVLHGD PLPLTRKSYL TWLGFSAEGT PCYVDSEGCV RMLNRGLGNT
660 670 680 690 700
WTPVCNIREH CKGKSDHYWV VGIHENPQQL RCIPCKGSRF PPTLPRPAVA
710 720 730 740 750
ILSFKLPYCQ TSTEKGQMEE QFWHSVLFHN YLDYLAKNGY DYEESIKNQA
760 770 780 790 800
VKEQQELLMK MLALSCKLER EFRCVELADL MTQNAVHLAI KYASRSRKLI
810 820 830 840 850
LAQKLSELAA EKAAELAETQ SEEEKEEDFR EKLNAGYSHT TTEWSRPRVR
860 870 880 890 900
SQVEDAEDRE DTVSEEKPES HNHGQNLFQS ANSSDTPALK SGAVFSSSQG
910 920 930 940 950
WVNPFKVVVS SKEPAVSANS TRSANILDSM NKSSRKSTSL NRMENNEKSP
960 970 980 990 1000
VIKPLTPKPR SKQASAASYF QKRTPQADKT EEVKENPKSS SSDAPAVCLQ
1010 1020 1030 1040 1050
NSENQRPKTG FQMWLEENRS QILSDNPDIS DETDIIKEGM IRFRVLSAEE
1060 1070 1080 1090 1100
RKAWTNKAKG ETASDGAEAK KRKRVVSEIC ETENQEETVK ENLDLSKKQK
1110
ALNLPANQKL SAFAFKQ
Length:1,117
Mass (Da):124,254
Last modified:January 10, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i01F80C3012B39EA7
GO
Isoform 2 (identifier: P59328-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     630-641: TPCYVDSEGCVR → KIIFFLYIKDIF
     642-1117: Missing.

Show »
Length:641
Mass (Da):70,637
Checksum:iC39755D52BE86DF0
GO
Isoform 3 (identifier: P59328-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     314-350: Missing.

Show »
Length:1,080
Mass (Da):120,217
Checksum:i07C387828084F8ED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J1F8A0A0R4J1F8_MOUSE
WD repeat and HMG-box DNA-binding p...
Wdhd1
1,081Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K6EDP7A0A2K6EDP7_MOUSE
WD repeat and HMG-box DNA-binding p...
Wdhd1
1,118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BQ38A0A2I3BQ38_MOUSE
WD repeat and HMG-box DNA-binding p...
Wdhd1
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti54G → V in BAC29408 (PubMed:16141072).Curated1
Sequence conflicti350S → P in BAC29408 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016898314 – 350Missing in isoform 3. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_006757630 – 641TPCYV…EGCVR → KIIFFLYIKDIF in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_006758642 – 1117Missing in isoform 2. 1 PublicationAdd BLAST476

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC063740 mRNA Translation: AAH63740.1
AK036390 mRNA Translation: BAC29408.1
AK052690 mRNA Translation: BAC35097.1

NCBI Reference Sequences

More...
RefSeqi
NP_766186.2, NM_172598.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000111790; ENSMUSP00000107420; ENSMUSG00000037572 [P59328-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
218973

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:218973

UCSC genome browser

More...
UCSCi
uc007thu.2, mouse [P59328-3]
uc007thv.2, mouse [P59328-1]
uc007thw.2, mouse [P59328-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063740 mRNA Translation: AAH63740.1
AK036390 mRNA Translation: BAC29408.1
AK052690 mRNA Translation: BAC35097.1
RefSeqiNP_766186.2, NM_172598.3

3D structure databases

SMRiP59328
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi230088, 2 interactors
STRINGi10090.ENSMUSP00000107421

PTM databases

iPTMnetiP59328
PhosphoSitePlusiP59328

Proteomic databases

EPDiP59328
jPOSTiP59328
MaxQBiP59328
PaxDbiP59328
PeptideAtlasiP59328
PRIDEiP59328
ProteomicsDBi297935 [P59328-1]
297936 [P59328-2]
297937 [P59328-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
44, 169 antibodies

The DNASU plasmid repository

More...
DNASUi
218973

Genome annotation databases

EnsembliENSMUST00000111790; ENSMUSP00000107420; ENSMUSG00000037572 [P59328-2]
GeneIDi218973
KEGGimmu:218973
UCSCiuc007thu.2, mouse [P59328-3]
uc007thv.2, mouse [P59328-1]
uc007thw.2, mouse [P59328-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11169
MGIiMGI:2443514, Wdhd1
VEuPathDBiHostDB:ENSMUSG00000037572

Phylogenomic databases

eggNOGiKOG1274, Eukaryota
GeneTreeiENSGT00390000002030
HOGENOMiCLU_004219_6_0_1
InParanoidiP59328
OMAiRYAHTNG
PhylomeDBiP59328

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
218973, 5 hits in 11 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Wdhd1, mouse

Protein Ontology

More...
PROi
PR:P59328
RNActiP59328, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000037572, Expressed in ear vesicle and 228 other tissues
ExpressionAtlasiP59328, baseline and differential
GenevisibleiP59328, MM

Family and domain databases

Gene3Di1.10.30.10, 1 hit
2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR024977, Apc4_WD40_dom
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
IPR022100, Mcl1_mid
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12894, ANAPC4_WD40, 1 hit
PF00505, HMG_box, 1 hit
PF12341, Mcl1_mid, 1 hit
PF00400, WD40, 2 hits
SMARTiView protein in SMART
SM00398, HMG, 1 hit
SM00320, WD40, 5 hits
SUPFAMiSSF47095, SSF47095, 1 hit
SSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50118, HMG_BOX_2, 1 hit
PS00678, WD_REPEATS_1, 2 hits
PS50082, WD_REPEATS_2, 3 hits
PS50294, WD_REPEATS_REGION, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDHD1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P59328
Secondary accession number(s): Q6P408
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2003
Last sequence update: January 10, 2006
Last modified: September 29, 2021
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again