Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

YTH domain-containing family protein 1

Gene

Ythdf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and promotes mRNA translation efficiency. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei401N6-methyladenosineBy similarity1
Binding sitei441N6-methyladenosineBy similarity1
Binding sitei465N6-methyladenosineBy similarity1
Binding sitei470N6-methyladenosineBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
YTH domain-containing family protein 1Curated
Alternative name(s):
Dermatomyositis associated with cancer putative autoantigen 1 homologBy similarity
Short name:
DACA-1 homologBy similarity
Gene namesi
Name:Ythdf1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1917431 Ythdf1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002230742 – 559YTH domain-containing family protein 1Add BLAST558

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei182PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP59326
MaxQBiP59326
PaxDbiP59326
PRIDEiP59326

PTM databases

iPTMnetiP59326
PhosphoSitePlusiP59326

Expressioni

Gene expression databases

BgeeiENSMUSG00000038848 Expressed in 290 organ(s), highest expression level in urinary bladder
CleanExiMM_YTHDF1
ExpressionAtlasiP59326 baseline and differential
GenevisibleiP59326 MM

Interactioni

Subunit structurei

Interacts with ribosomes. Interacts with eIF3 (EIF3A or EIF3B). Interacts with YTHDF3.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037808

Structurei

3D structure databases

ProteinModelPortaliP59326
SMRiP59326
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini389 – 523YTHPROSITE-ProRule annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni395 – 397N6-methyladenosine bindingBy similarity3
Regioni411 – 412N6-methyladenosine bindingBy similarity2

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi241 – 334Gln/Pro-richAdd BLAST94

Phylogenomic databases

eggNOGiKOG1901 Eukaryota
ENOG410YABQ LUCA
GeneTreeiENSGT00390000017549
HOGENOMiHOG000232058
HOVERGENiHBG060315
InParanoidiP59326
KOiK20102
OMAiQPKMKAK
PhylomeDBiP59326
TreeFamiTF323736

Family and domain databases

InterProiView protein in InterPro
IPR007275 YTH_domain
PfamiView protein in Pfam
PF04146 YTH, 1 hit
PROSITEiView protein in PROSITE
PS50882 YTH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P59326-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSATSVDPQR TKGQDNKVQN GSLHQKDAVH DNDFEPYLSG QSNPSNSYPS
60 70 80 90 100
MSDPYLSSYY PPSIGFPYSL SEAPWSTAGD PPIPYLTTYG QLSNGDHHFM
110 120 130 140 150
HDAVFGQPGG LGNNIYQHRF NFFPENPAFS AWGTSGSQGQ QTQSSAYGSS
160 170 180 190 200
YTYPPSSLGG TVVDGQTGFH SDSLNKAPGM NSLEQGMVGL KIGDVTTSAV
210 220 230 240 250
KTVGSVVNSV ALTGVLSGNG GTNVNMPVSK PTSWAAIASK PAKPQPKMKT
260 270 280 290 300
KSGPIVGGAL PPPPIKHNMD IGTWDNKGPA PKASAPQQTP SPQAAPQPQQ
310 320 330 340 350
VAQPLPVQPP PLVQPQYQSP QQPLQPRWVA PRNRNAAFGQ SGGANSDSNS
360 370 380 390 400
VGNAQPTSAP SVESHPVLEK LKAAHSYNPK EFDWNLKSGR VFIIKSYSED
410 420 430 440 450
DIHRSIKYSI WCSTEHGNKR LDGAFRSMSS KGPVYLLFSV NGSGHFCGVA
460 470 480 490 500
EMKSPVDYGT SAGVWSQDKW KGKFDVKWIF VKDVPNNQLR HIRLENNDNK
510 520 530 540 550
PVTNSRDTQE VPLEKAKQVL KIIASYKHTT SIFDDFSHYE KRQEEEEVVR

KERQNRNKQ
Length:559
Mass (Da):60,879
Last modified:February 12, 2003 - v1
Checksum:i2DFA0E2D8751FA24
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AWN8A2AWN8_MOUSE
YTH domain family 1, isoform CRA_a
Ythdf1 mCG_6742
586Annotation score:
A2AWN7A2AWN7_MOUSE
YTH domain-containing family protei...
Ythdf1
183Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046768 mRNA Translation: BAC32861.1
AK172582 mRNA Translation: BAE43080.1
BC061479 mRNA Translation: AAH61479.1
BC065050 mRNA Translation: AAH65050.1
CCDSiCCDS17188.1
RefSeqiNP_776122.1, NM_173761.3
UniGeneiMm.30205

Genome annotation databases

EnsembliENSMUST00000037299; ENSMUSP00000037808; ENSMUSG00000038848
GeneIDi228994
KEGGimmu:228994
UCSCiuc008okd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046768 mRNA Translation: BAC32861.1
AK172582 mRNA Translation: BAE43080.1
BC061479 mRNA Translation: AAH61479.1
BC065050 mRNA Translation: AAH65050.1
CCDSiCCDS17188.1
RefSeqiNP_776122.1, NM_173761.3
UniGeneiMm.30205

3D structure databases

ProteinModelPortaliP59326
SMRiP59326
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037808

PTM databases

iPTMnetiP59326
PhosphoSitePlusiP59326

Proteomic databases

EPDiP59326
MaxQBiP59326
PaxDbiP59326
PRIDEiP59326

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037299; ENSMUSP00000037808; ENSMUSG00000038848
GeneIDi228994
KEGGimmu:228994
UCSCiuc008okd.1 mouse

Organism-specific databases

CTDi54915
MGIiMGI:1917431 Ythdf1

Phylogenomic databases

eggNOGiKOG1901 Eukaryota
ENOG410YABQ LUCA
GeneTreeiENSGT00390000017549
HOGENOMiHOG000232058
HOVERGENiHBG060315
InParanoidiP59326
KOiK20102
OMAiQPKMKAK
PhylomeDBiP59326
TreeFamiTF323736

Miscellaneous databases

PROiPR:P59326
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038848 Expressed in 290 organ(s), highest expression level in urinary bladder
CleanExiMM_YTHDF1
ExpressionAtlasiP59326 baseline and differential
GenevisibleiP59326 MM

Family and domain databases

InterProiView protein in InterPro
IPR007275 YTH_domain
PfamiView protein in Pfam
PF04146 YTH, 1 hit
PROSITEiView protein in PROSITE
PS50882 YTH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiYTHD1_MOUSE
AccessioniPrimary (citable) accession number: P59326
Secondary accession number(s): Q3T9E2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: February 12, 2003
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again