UniProtKB - P59279 (RAB2B_MOUSE)
Protein
Ras-related protein Rab-2B
Gene
Rab2b
Organism
Mus musculus (Mouse)
Status
Functioni
Required for protein transport from the endoplasmic reticulum to the Golgi complex.Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 13 – 21 | GTPBy similarity | 9 | |
Nucleotide bindingi | 61 – 65 | GTPBy similarity | 5 | |
Nucleotide bindingi | 119 – 122 | GTPBy similarity | 4 | |
Nucleotide bindingi | 149 – 151 | GTPBy similarity | 3 |
GO - Molecular functioni
- GTPase activity Source: InterPro
- GTP binding Source: UniProtKB-KW
GO - Biological processi
- positive regulation of exocytosis Source: MGI
- protein transport Source: UniProtKB-KW
- vesicle-mediated transport Source: UniProtKB-KW
Keywordsi
Biological process | ER-Golgi transport, Protein transport, Transport |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-8873719, RAB geranylgeranylation |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein Rab-2B |
Gene namesi | Name:Rab2b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1923588, Rab2b |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated
Golgi apparatus
- Golgi apparatus membrane Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: GO_Central
- Golgi membrane Source: GO_Central
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- presynapse Source: MGI
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000121072 | 1 – 216 | Ras-related protein Rab-2BAdd BLAST | 216 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 215 | S-geranylgeranyl cysteineBy similarity | 1 | |
Lipidationi | 216 | S-geranylgeranyl cysteineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, PrenylationProteomic databases
EPDi | P59279 |
jPOSTi | P59279 |
PaxDbi | P59279 |
PeptideAtlasi | P59279 |
PRIDEi | P59279 |
PTM databases
iPTMneti | P59279 |
PhosphoSitePlusi | P59279 |
SwissPalmi | P59279 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000022159, Expressed in substantia nigra and 276 other tissues |
ExpressionAtlasi | P59279, baseline and differential |
Genevisiblei | P59279, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 218074, 2 interactors |
IntActi | P59279, 6 interactors |
STRINGi | 10090.ENSMUSP00000022765 |
Miscellaneous databases
RNActi | P59279, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 35 – 43 | Effector regionBy similarity | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0098, Eukaryota |
GeneTreei | ENSGT00940000153886 |
InParanoidi | P59279 |
OMAi | VEEAFMI |
OrthoDBi | 1271975at2759 |
PhylomeDBi | P59279 |
TreeFami | TF300032 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
P59279-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMVNI
60 70 80 90 100
DGKQIKLQIW DTAGQESFRS ITRSYYRGAA GALLVYDITR RETFNHLTSW
110 120 130 140 150
LEDARQHSSS NMVIMLIGNK SDLESRRDVK REEGEAFARE HGLIFMETSA
160 170 180 190 200
KTACNVEEAY INTAKEIYRK IQQGLFDVHN EANGIKIGPQ QSITSSVGPC
210
SPQQNVSDIG PDSGCC
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ3TEG7 | Q3TEG7_MOUSE | Ras-related protein Rab-2B | Rab2b | 193 | Annotation score: | ||
G3UXQ7 | G3UXQ7_MOUSE | Ras-related protein Rab-2B | Rab2b | 62 | Annotation score: | ||
G3V022 | G3V022_MOUSE | Ras-related protein Rab-2B | Rab2b | 71 | Annotation score: | ||
G3UZ24 | G3UZ24_MOUSE | Ras-related protein Rab-2B | Rab2b | 45 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK038393 mRNA Translation: BAC29983.1 AK044202 mRNA Translation: BAC31814.1 AK160249 mRNA Translation: BAE35713.1 AK160351 mRNA Translation: BAE35753.1 BC046334 mRNA Translation: AAH46334.1 |
CCDSi | CCDS27052.1 |
RefSeqi | NP_766189.1, NM_172601.3 |
Genome annotation databases
Ensembli | ENSMUST00000022765; ENSMUSP00000022765; ENSMUSG00000022159 ENSMUST00000167116; ENSMUSP00000131145; ENSMUSG00000022159 |
GeneIDi | 76338 |
KEGGi | mmu:76338 |
UCSCi | uc007tox.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK038393 mRNA Translation: BAC29983.1 AK044202 mRNA Translation: BAC31814.1 AK160249 mRNA Translation: BAE35713.1 AK160351 mRNA Translation: BAE35753.1 BC046334 mRNA Translation: AAH46334.1 |
CCDSi | CCDS27052.1 |
RefSeqi | NP_766189.1, NM_172601.3 |
3D structure databases
SMRi | P59279 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 218074, 2 interactors |
IntActi | P59279, 6 interactors |
STRINGi | 10090.ENSMUSP00000022765 |
PTM databases
iPTMneti | P59279 |
PhosphoSitePlusi | P59279 |
SwissPalmi | P59279 |
Proteomic databases
EPDi | P59279 |
jPOSTi | P59279 |
PaxDbi | P59279 |
PeptideAtlasi | P59279 |
PRIDEi | P59279 |
Protocols and materials databases
Antibodypediai | 22150, 199 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000022765; ENSMUSP00000022765; ENSMUSG00000022159 ENSMUST00000167116; ENSMUSP00000131145; ENSMUSG00000022159 |
GeneIDi | 76338 |
KEGGi | mmu:76338 |
UCSCi | uc007tox.2, mouse |
Organism-specific databases
CTDi | 84932 |
MGIi | MGI:1923588, Rab2b |
Phylogenomic databases
eggNOGi | KOG0098, Eukaryota |
GeneTreei | ENSGT00940000153886 |
InParanoidi | P59279 |
OMAi | VEEAFMI |
OrthoDBi | 1271975at2759 |
PhylomeDBi | P59279 |
TreeFami | TF300032 |
Enzyme and pathway databases
Reactomei | R-MMU-8873719, RAB geranylgeranylation |
Miscellaneous databases
BioGRID-ORCSi | 76338, 1 hit in 17 CRISPR screens |
ChiTaRSi | Rab2b, mouse |
PROi | PR:P59279 |
RNActi | P59279, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022159, Expressed in substantia nigra and 276 other tissues |
ExpressionAtlasi | P59279, baseline and differential |
Genevisiblei | P59279, MM |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RAB2B_MOUSE | |
Accessioni | P59279Primary (citable) accession number: P59279 Secondary accession number(s): Q3TV67 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 12, 2003 |
Last sequence update: | February 12, 2003 | |
Last modified: | February 10, 2021 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families