UniProtKB - P59268 (ZDHC9_MOUSE)
Protein
Palmitoyltransferase ZDHHC9
Gene
Zdhhc9
Organism
Mus musculus (Mouse)
Status
Functioni
Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling.By similarity
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 169 | S-palmitoyl cysteine intermediateBy similarity | 1 |
GO - Molecular functioni
- palmitoyltransferase activity Source: MGI
- protein-cysteine S-palmitoyltransferase activity Source: GO_Central
- Ras palmitoyltransferase activity Source: UniProtKB
GO - Biological processi
- peptidyl-L-cysteine S-palmitoylation Source: UniProtKB
- protein palmitoylation Source: MGI
- protein targeting to membrane Source: GO_Central
Keywordsi
Molecular function | Acyltransferase, Transferase |
Enzyme and pathway databases
Reactomei | R-MMU-9648002, RAS processing |
Names & Taxonomyi
Protein namesi | Recommended name: Palmitoyltransferase ZDHHC9 (EC:2.3.1.225By similarity)Alternative name(s): Zinc finger DHHC domain-containing protein 9 Short name: DHHC-9 Short name: DHHC9 |
Gene namesi | Name:Zdhhc9 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2444393, Zdhhc9 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein Sequence analysis
Golgi apparatus
- Golgi apparatus membrane By similarity; Multi-pass membrane protein Sequence analysis
Cytosol
- cytosol Source: MGI
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- intrinsic component of Golgi membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- palmitoyltransferase complex Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 35 | CytoplasmicSequence analysisAdd BLAST | 35 | |
Transmembranei | 36 – 56 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 57 – 63 | LumenalSequence analysis | 7 | |
Transmembranei | 64 – 84 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 85 – 183 | CytoplasmicSequence analysisAdd BLAST | 99 | |
Transmembranei | 184 – 204 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 205 – 228 | LumenalSequence analysisAdd BLAST | 24 | |
Transmembranei | 229 – 249 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 250 – 364 | CytoplasmicSequence analysisAdd BLAST | 115 |
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212881 | 1 – 364 | Palmitoyltransferase ZDHHC9Add BLAST | 364 |
Keywords - PTMi
Lipoprotein, PalmitateProteomic databases
MaxQBi | P59268 |
PaxDbi | P59268 |
PRIDEi | P59268 |
PTM databases
iPTMneti | P59268 |
PhosphoSitePlusi | P59268 |
SwissPalmi | P59268 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000036985, Expressed in esophagus and 287 other tissues |
Genevisiblei | P59268, MM |
Interactioni
Subunit structurei
Interacts with GOLGA7.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000044734 |
Miscellaneous databases
RNActi | P59268, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 139 – 189 | DHHCPROSITE-ProRule annotationAdd BLAST | 51 |
Domaini
The DHHC domain is required for palmitoyltransferase activity.By similarity
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1311, Eukaryota |
GeneTreei | ENSGT00940000159999 |
HOGENOMi | CLU_018741_3_1_1 |
InParanoidi | P59268 |
OMAi | MRLPRVK |
OrthoDBi | 1264614at2759 |
PhylomeDBi | P59268 |
TreeFami | TF312923 |
Family and domain databases
InterProi | View protein in InterPro IPR001594, Palmitoyltrfase_DHHC |
Pfami | View protein in Pfam PF01529, DHHC, 1 hit |
PROSITEi | View protein in PROSITE PS50216, DHHC, 1 hit |
i Sequence
Sequence statusi: Complete.
P59268-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVMVVRKKV TRKWEKLPGR NTFCCDGRVM MARQKGIFYL TLFLILGTCT
60 70 80 90 100
LFFAFECRYL AVQLSPAIPV FAAMLFLFSM ATLLRTSFSD PGVIPRALPD
110 120 130 140 150
EAAFIEMEIE ATNGAVPQGQ RPPPRIKNFQ INNQIVKLKY CYTCKIFRPP
160 170 180 190 200
RASHCSICDN CVERFDHHCP WVGNCVGKRN YRYFYLFILS LSLLTIYVFA
210 220 230 240 250
FNIVYVALKS LKIGFLETLK ETPGTVLEVL ICFFTLWSVV GLTGFHTFLV
260 270 280 290 300
ALNQTTNEDI KGSWTGKNRV QNPYSHGNIV KNCCEVLCGP LPPSVLDRRG
310 320 330 340 350
ILPLEESGSR PPSTQETSSS LLPQSPASTE HMNSNEMAED TSIPEEMPPP
360
EPPEPPQEAS EAEK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK032233 mRNA Translation: BAC27774.1 BC042618 mRNA Translation: AAH42618.1 BC090832 mRNA Translation: AAH90832.1 |
CCDSi | CCDS40960.1 |
RefSeqi | NP_766053.1, NM_172465.4 XP_006541517.1, XM_006541454.3 |
Genome annotation databases
Ensembli | ENSMUST00000037960; ENSMUSP00000044734; ENSMUSG00000036985 ENSMUST00000088935; ENSMUSP00000086325; ENSMUSG00000036985 |
GeneIDi | 208884 |
KEGGi | mmu:208884 |
UCSCi | uc009tbx.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK032233 mRNA Translation: BAC27774.1 BC042618 mRNA Translation: AAH42618.1 BC090832 mRNA Translation: AAH90832.1 |
CCDSi | CCDS40960.1 |
RefSeqi | NP_766053.1, NM_172465.4 XP_006541517.1, XM_006541454.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000044734 |
PTM databases
iPTMneti | P59268 |
PhosphoSitePlusi | P59268 |
SwissPalmi | P59268 |
Proteomic databases
MaxQBi | P59268 |
PaxDbi | P59268 |
PRIDEi | P59268 |
Protocols and materials databases
Antibodypediai | 30107, 195 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000037960; ENSMUSP00000044734; ENSMUSG00000036985 ENSMUST00000088935; ENSMUSP00000086325; ENSMUSG00000036985 |
GeneIDi | 208884 |
KEGGi | mmu:208884 |
UCSCi | uc009tbx.2, mouse |
Organism-specific databases
CTDi | 51114 |
MGIi | MGI:2444393, Zdhhc9 |
Phylogenomic databases
eggNOGi | KOG1311, Eukaryota |
GeneTreei | ENSGT00940000159999 |
HOGENOMi | CLU_018741_3_1_1 |
InParanoidi | P59268 |
OMAi | MRLPRVK |
OrthoDBi | 1264614at2759 |
PhylomeDBi | P59268 |
TreeFami | TF312923 |
Enzyme and pathway databases
Reactomei | R-MMU-9648002, RAS processing |
Miscellaneous databases
BioGRID-ORCSi | 208884, 1 hit in 17 CRISPR screens |
PROi | PR:P59268 |
RNActi | P59268, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000036985, Expressed in esophagus and 287 other tissues |
Genevisiblei | P59268, MM |
Family and domain databases
InterProi | View protein in InterPro IPR001594, Palmitoyltrfase_DHHC |
Pfami | View protein in Pfam PF01529, DHHC, 1 hit |
PROSITEi | View protein in PROSITE PS50216, DHHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZDHC9_MOUSE | |
Accessioni | P59268Primary (citable) accession number: P59268 Secondary accession number(s): Q5BL19 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2003 |
Last sequence update: | February 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families