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Entry version 128 (02 Jun 2021)
Sequence version 2 (27 Jul 2011)
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Protein

Nephrocystin-4

Gene

Nphp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis (By similarity).

Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity).

In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (By similarity).

Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2028269, Signaling by Hippo
R-MMU-5620912, Anchoring of the basal body to the plasma membrane

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nephrocystin-4
Alternative name(s):
Nephroretinin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nphp4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2384210, Nphp4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Tight junction

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001597701 – 1425Nephrocystin-4Add BLAST1425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei145PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P59240

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P59240

PeptideAtlas

More...
PeptideAtlasi
P59240

PRoteomics IDEntifications database

More...
PRIDEi
P59240

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
293954

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P59240

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P59240

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the retina (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000039577, Expressed in oocyte and 160 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P59240, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NPHP1 and RPGRIP1L/NPHP8; NPHP1, NPHP4 and RPGRIP1L are proposed to form a functional NPHP1-4-8 module localized to cell-cell contacts and the ciliary transition zone; NPHP4 mediates the interaction between NPHP1 and RPGRIP1L.

Interacts with IQCB1/NPHP5; the interaction likely requires additional interactors (PubMed:21565611).

Interacts with RPGRIP1, CEP164, JADE1, PALS1, INADL, PARD6A, INVS, DVL2.

Interacts with INTU; INTU mediates the interaction between NPHP4 and DAAM1.

Interacts with JADE1 (By similarity).

Interacts with SPATA7 (PubMed:29899041).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
234431, 215 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P59240

Protein interaction database and analysis system

More...
IntActi
P59240, 70 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000080128

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P59240, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P59240

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni448 – 554DisorderedSequence analysisAdd BLAST107
Regioni822 – 1425Sufficient for basal bodies localizationBy similarityAdd BLAST604

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi495 – 541Polar residuesSequence analysisAdd BLAST47

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NPHP4 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QUNP, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000048827

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004882_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P59240

Identification of Orthologs from Complete Genome Data

More...
OMAi
RYPTISH

Database of Orthologous Groups

More...
OrthoDBi
53958at2759

TreeFam database of animal gene trees

More...
TreeFami
TF351573

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029775, NPHP4

The PANTHER Classification System

More...
PANTHERi
PTHR31043, PTHR31043, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P59240-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDWHRAFTQ NTLVPPHPQR ARQLGKESTA FQCILKWLDG PLIKQGILDM
60 70 80 90 100
LSELECHLRV TLFDVTYKHF FGRTWKTTVK PTNQPSKQPP RITFNEPLYF
110 120 130 140 150
HTTLSHPSIV AVVEVVTEGR KRDGTLQLLS CGFGILRIFG NKPESPTSAA
160 170 180 190 200
QDKRLRLYHG TPRALLHPLL QDPIEQNKFM RLMENCSLQY TLKPHPPLEP
210 220 230 240 250
AFHLLPENLL VSGFQQIPGL LPPHGDTGDA LRKPRFQKPT TWHLDDLFFT
260 270 280 290 300
LYPSLEKFEE ELVQLLISDR EGVGLLDSGT LEVLERRLHV CVHNGLGFVQ
310 320 330 340 350
RPQVVVLVPE MDVALTRSAS FSRKISASSK NSSGNQALVL RSHLRLPEMV
360 370 380 390 400
SHPAFAIVFQ LEYVFNSPSG ADGGASSPTS ISSVACMHMV RWAVWNPDLE
410 420 430 440 450
VGPGKVTLPL QGGVQQNPSR CLVYKVPSAS MSSEEVKQVE SGTIQFQFSL
460 470 480 490 500
SSDGPTEHAN GPRVGRRSSR KMPASPSGTP APAARDLAAT QDSPVGPGLS
510 520 530 540 550
LSQLTASPLS PALQSSSKPP LQPPDSSQSP EGPQLQAESV LESRVSHLEA
560 570 580 590 600
DLSQPASLQG TPAVEHLQEL PFTPLHAPIV VGAQTRSSRS QLSRAAMVLL
610 620 630 640 650
QSSGFPEILD ASQQPVEAVN PIDPVRFNPQ KEESDCLRGN EIVLQFLAFS
660 670 680 690 700
RAAQDCPGTP WPQTVYFTFQ FYRFPPETTP RLQLVKLDGT GKSGSGSLSH
710 720 730 740 750
ILVPINKDGS FDAGSPGLQL RYMVDPGFLK PGEQRWFAHY LAAQTLQVDV
760 770 780 790 800
WDGDSLLLIG SAGVQMKHLL RQGRPAVQVS HELEVVATEY EQEMMAVSGD
810 820 830 840 850
VAGFGSVKPI GVHTVVKGRL HLTLANVGHA CEPRARGSNL LPPSRSRVIS
860 870 880 890 900
NDGASFFSGG SLLIPGGPKR KRVVQAQRLA DVDSELAAML LTHTRAGQGP
910 920 930 940 950
QAAGQEADAV HKRKLERMRL VRLQEAGGDS DSRRISLLAQ HSVRAQHSRD
960 970 980 990 1000
LQVIDAYRER TKAESIAGVL SQAITTHHTL YATLGTAEFF EFALKNPHNT
1010 1020 1030 1040 1050
QHTVAIEIDS PELSIILDSQ EWRYFKEATG LHTPLEEDMF HLRGSLAPQL
1060 1070 1080 1090 1100
YLRPRETAHI PLKFQSFSVG PLAPTQAPAE VITEKDAESG PLWKCSAMPT
1110 1120 1130 1140 1150
KHAKVLFRVE TGQLIAVLCL TVEPQPHVVD QVFRFYHPEL TFLKKAIRLP
1160 1170 1180 1190 1200
PWHTLPGAPV GMPGEDPPVH VRCSDPNVIC EAQNVGPGEP RDVFLKVASG
1210 1220 1230 1240 1250
PSPEIKDFFV VIYADRWLAV PVQTWQVCLH SLQRVDVSCV AGQLTRLSLV
1260 1270 1280 1290 1300
LRGTQTVRKV RAFTSHPQEL KTDPAGVFVL PPHGVQDLHV GVRPRRAGSR
1310 1320 1330 1340 1350
FVHLNLVDID YHQLVASWLV CLSCRQPLIS KAFEITMAAG DEKGTNKRIT
1360 1370 1380 1390 1400
YTNPYPSRRT YRLHSDRPEL LRFKEDSFQV AGGETYTIGL RFLPSGSAGQ
1410 1420
EEILIYINDH EDKNEETFCV KVLYQ
Length:1,425
Mass (Da):157,269
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDDB9739850AEA5C4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY118229 mRNA Translation: AAM78559.1
AL607109 Genomic DNA No translation available.
AL611970 Genomic DNA No translation available.
CH466594 Genomic DNA Translation: EDL14939.1
CH466594 Genomic DNA Translation: EDL14940.1
BC138370 mRNA Translation: AAI38371.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38985.1

NCBI Reference Sequences

More...
RefSeqi
NP_700473.2, NM_153424.2
XP_006538935.1, XM_006538872.3
XP_006538936.1, XM_006538873.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000056567; ENSMUSP00000049920; ENSMUSG00000039577
ENSMUST00000081393; ENSMUSP00000080128; ENSMUSG00000039577

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
260305

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:260305

UCSC genome browser

More...
UCSCi
uc008wap.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY118229 mRNA Translation: AAM78559.1
AL607109 Genomic DNA No translation available.
AL611970 Genomic DNA No translation available.
CH466594 Genomic DNA Translation: EDL14939.1
CH466594 Genomic DNA Translation: EDL14940.1
BC138370 mRNA Translation: AAI38371.1
CCDSiCCDS38985.1
RefSeqiNP_700473.2, NM_153424.2
XP_006538935.1, XM_006538872.3
XP_006538936.1, XM_006538873.3

3D structure databases

SMRiP59240
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi234431, 215 interactors
CORUMiP59240
IntActiP59240, 70 interactors
STRINGi10090.ENSMUSP00000080128

PTM databases

iPTMnetiP59240
PhosphoSitePlusiP59240

Proteomic databases

MaxQBiP59240
PaxDbiP59240
PeptideAtlasiP59240
PRIDEiP59240
ProteomicsDBi293954

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
27030, 114 antibodies

The DNASU plasmid repository

More...
DNASUi
260305

Genome annotation databases

EnsembliENSMUST00000056567; ENSMUSP00000049920; ENSMUSG00000039577
ENSMUST00000081393; ENSMUSP00000080128; ENSMUSG00000039577
GeneIDi260305
KEGGimmu:260305
UCSCiuc008wap.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
261734
MGIiMGI:2384210, Nphp4

Phylogenomic databases

eggNOGiENOG502QUNP, Eukaryota
GeneTreeiENSGT00510000048827
HOGENOMiCLU_004882_0_0_1
InParanoidiP59240
OMAiRYPTISH
OrthoDBi53958at2759
TreeFamiTF351573

Enzyme and pathway databases

ReactomeiR-MMU-2028269, Signaling by Hippo
R-MMU-5620912, Anchoring of the basal body to the plasma membrane

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
260305, 0 hits in 52 CRISPR screens

Protein Ontology

More...
PROi
PR:P59240
RNActiP59240, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000039577, Expressed in oocyte and 160 other tissues
GenevisibleiP59240, MM

Family and domain databases

InterProiView protein in InterPro
IPR029775, NPHP4
PANTHERiPTHR31043, PTHR31043, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNPHP4_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P59240
Secondary accession number(s): B1AS30
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: July 27, 2011
Last modified: June 2, 2021
This is version 128 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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