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UniProtKB - P59199 (DPO1_STRPN)

Entry version 116 (25 May 2022)
Sequence version 1 (10 Jan 2003)
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Protein

DNA polymerase I

Gene

polA

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA replication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase I (EC:2.7.7.7)
Short name:
POL I
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:polA
Ordered Locus Names:SP_0032
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri170187 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000585 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001012531 – 877DNA polymerase IAdd BLAST877

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Single-chain monomer with multiple functions.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		170187.SP_0032

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P59199

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P59199

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini177 – 2705'-3' exonucleaseSequence analysisAdd BLAST94
Domaini302 – 4653'-5' exonucleaseSequence analysisAdd BLAST164

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0258, Bacteria
COG0749, Bacteria

Identification of Orthologs from Complete Genome Data

More...OMAi		NRPPMPD

Database for complete collections of gene phylogenies

More...PhylomeDBi		P59199

Family and domain databases

Conserved Domains Database

More...CDDi		cd09898, H3TH_53EXO, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002562, 3'-5'_exonuclease_dom
IPR020046, 5-3_exonucl_a-hlix_arch_N
IPR002421, 5-3_exonuclease
IPR036279, 5-3_exonuclease_C_sf
IPR019760, DNA-dir_DNA_pol_A_CS
IPR001098, DNA-dir_DNA_pol_A_palm_dom
IPR043502, DNA/RNA_pol_sf
IPR020045, DNA_polI_H3TH
IPR018320, DNA_polymerase_1
IPR002298, DNA_polymerase_A
IPR008918, HhH2
IPR029060, PIN-like_dom_sf
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf

The PANTHER Classification System

More...PANTHERi		PTHR10133, PTHR10133, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01367, 5_3_exonuc, 1 hit
PF02739, 5_3_exonuc_N, 1 hit
PF00476, DNA_pol_A, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00868, DNAPOLI

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00474, 35EXOc, 1 hit
SM00475, 53EXOc, 1 hit
SM00279, HhH2, 1 hit
SM00482, POLAc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47807, SSF47807, 1 hit
SSF53098, SSF53098, 1 hit
SSF56672, SSF56672, 1 hit
SSF88723, SSF88723, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00593, pola, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00447, DNA_POLYMERASE_A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P59199-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKKKLLLID GSSVAFRAFF ALYQQLDRFK NVAGLHTNAI YGFQLMLSHL 
        60         70         80         90        100
LERVEPSHIL VAFDAGKTTF RTEMYADYKG GRAKTPDEFR EQFPFIRELL 
       110        120        130        140        150
DHMGIRHYDL AQYEADDIIG TLDKLAEQDG FDITIVSGDK DLIQLTDEHT 
       160        170        180        190        200
VVEISKKGVA EFEAFTPDYL MEEMGLTPAQ FIDLKALMGD KSDNIPGVTK 
       210        220        230        240        250
VGEKTGIKLL LEHGSLEGIY ENIDGMKTSK MKENLINDKE QAFLSKTLAT 
       260        270        280        290        300
IDTKAPIAIG LEDLVYSGPD VENLGKFYDE MGFKQLKQAL NVSSADVSES 
       310        320        330        340        350
LDFTIVDQIS QDMLSEESIF HFELFGENYH TDNLVGFVWS CGDKLYATDK 
       360        370        380        390        400
LELLQDPIFK DFLEKTSLRV YDFKKVKVLL QRFGVDLQAP AFDIRLAKYL 
       410        420        430        440        450
LSTVEDNEIA TIASLYGQTY LVDDETFYGK GVKKAIPERE KFLEHLACKL 
       460        470        480        490        500
AVLVETEPIL LEKLSENGQL ELLYDMEQPL AFVLAKMEIA GIMVKKETLL 
       510        520        530        540        550
EMQAENELVI EKLTQEIYEL AGEEFNVNSP KQLGVLLFEK LGLPLEYTKK 
       560        570        580        590        600
TKTGYSTAVD VLERLAPIAP IVKKILDYRQ IAKIQSTYVI GLQDWILADG 
       610        620        630        640        650
KIHTRYVQDL TQTGRLSSVD PNLQNIPARL EQGRLIRKAF VPEWEDSVLL 
       660        670        680        690        700
SSDYSQIELR VLAHISKDEH LIKAFQEGAD IHTSTAMRVF GIERPDDVTA 
       710        720        730        740        750
NDRRNAKAVN FGVVYGISDF GLSNNLGISR KEAKAYIDTY FERFPGIKNY 
       760        770        780        790        800
MDEVVREARD KGYVETLFKR RRELPDINSR NFNIRGFAER TAINSPIQGS 
       810        820        830        840        850
AADILKIAMI QLDKALVAGG YQTKMLLQVH DEIVLEVPKS ELVEMKKLVK 
       860        870 
QTMEEAIQLS VPLIADENEG ATWYEAK
Length:877
Mass (Da):99,253
Last modified:January 10, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2621865B94586913
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE005672 Genomic DNA Translation: AAK74222.1

Protein sequence database of the Protein Information Resource

More...PIRi		E95003

NCBI Reference Sequences

More...RefSeqi		WP_001808750.1, NZ_AKVY01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAK74222; AAK74222; SP_0032

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		spn:SP_0032

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA Translation: AAK74222.1
PIRiE95003
RefSeqiWP_001808750.1, NZ_AKVY01000001.1

3D structure databases

AlphaFoldDBiP59199
SMRiP59199
ModBaseiSearch...

Protein-protein interaction databases

STRINGi170187.SP_0032

Genome annotation databases

EnsemblBacteriaiAAK74222; AAK74222; SP_0032
KEGGispn:SP_0032

Phylogenomic databases

eggNOGiCOG0258, Bacteria
COG0749, Bacteria
OMAiNRPPMPD
PhylomeDBiP59199

Family and domain databases

CDDicd09898, H3TH_53EXO, 1 hit
Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR002562, 3'-5'_exonuclease_dom
IPR020046, 5-3_exonucl_a-hlix_arch_N
IPR002421, 5-3_exonuclease
IPR036279, 5-3_exonuclease_C_sf
IPR019760, DNA-dir_DNA_pol_A_CS
IPR001098, DNA-dir_DNA_pol_A_palm_dom
IPR043502, DNA/RNA_pol_sf
IPR020045, DNA_polI_H3TH
IPR018320, DNA_polymerase_1
IPR002298, DNA_polymerase_A
IPR008918, HhH2
IPR029060, PIN-like_dom_sf
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
PANTHERiPTHR10133, PTHR10133, 2 hits
PfamiView protein in Pfam
PF01367, 5_3_exonuc, 1 hit
PF02739, 5_3_exonuc_N, 1 hit
PF00476, DNA_pol_A, 1 hit
PRINTSiPR00868, DNAPOLI
SMARTiView protein in SMART
SM00474, 35EXOc, 1 hit
SM00475, 53EXOc, 1 hit
SM00279, HhH2, 1 hit
SM00482, POLAc, 1 hit
SUPFAMiSSF47807, SSF47807, 1 hit
SSF53098, SSF53098, 1 hit
SSF56672, SSF56672, 1 hit
SSF88723, SSF88723, 1 hit
TIGRFAMsiTIGR00593, pola, 1 hit
PROSITEiView protein in PROSITE
PS00447, DNA_POLYMERASE_A, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPO1_STRPN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P59199
Secondary accession number(s): P13252
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: May 25, 2022
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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