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UniProtKB - P59199 (DPO1_STRPN)
Protein
DNA polymerase I
Gene
polA
Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Functioni
In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.
By similarityCatalytic activityi
- EC:2.7.7.7
GO - Molecular functioni
- 3'-5' exonuclease activity Source: InterPro
- DNA binding Source: UniProtKB-KW
- DNA-directed DNA polymerase activity Source: UniProtKB-KW
GO - Biological processi
- DNA-dependent DNA replication Source: InterPro
- DNA repair Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding, DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase |
Biological process | DNA damage, DNA repair, DNA replication |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:polA Ordered Locus Names:SP_0032 |
Organismi | Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) |
Taxonomic identifieri | 170187 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000101253 | 1 – 877 | DNA polymerase IAdd BLAST | 877 |
Interactioni
Subunit structurei
Single-chain monomer with multiple functions.
By similarityProtein-protein interaction databases
STRINGi | 170187.SP_0032 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 177 – 270 | 5'-3' exonucleaseSequence analysisAdd BLAST | 94 | |
Domaini | 302 – 465 | 3'-5' exonucleaseSequence analysisAdd BLAST | 164 |
Sequence similaritiesi
Belongs to the DNA polymerase type-A family.Curated
Phylogenomic databases
eggNOGi | COG0258, Bacteria COG0749, Bacteria |
OMAi | NRPPMPD |
PhylomeDBi | P59199 |
Family and domain databases
CDDi | cd09898, H3TH_53EXO, 1 hit |
Gene3Di | 3.30.420.10, 1 hit |
InterProi | View protein in InterPro IPR002562, 3'-5'_exonuclease_dom IPR020046, 5-3_exonucl_a-hlix_arch_N IPR002421, 5-3_exonuclease IPR036279, 5-3_exonuclease_C_sf IPR019760, DNA-dir_DNA_pol_A_CS IPR001098, DNA-dir_DNA_pol_A_palm_dom IPR043502, DNA/RNA_pol_sf IPR020045, DNA_polI_H3TH IPR018320, DNA_polymerase_1 IPR002298, DNA_polymerase_A IPR008918, HhH2 IPR029060, PIN-like_dom_sf IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf |
PANTHERi | PTHR10133, PTHR10133, 2 hits |
Pfami | View protein in Pfam PF01367, 5_3_exonuc, 1 hit PF02739, 5_3_exonuc_N, 1 hit PF00476, DNA_pol_A, 1 hit |
PRINTSi | PR00868, DNAPOLI |
SMARTi | View protein in SMART SM00474, 35EXOc, 1 hit SM00475, 53EXOc, 1 hit SM00279, HhH2, 1 hit SM00482, POLAc, 1 hit |
SUPFAMi | SSF47807, SSF47807, 1 hit SSF53098, SSF53098, 1 hit SSF56672, SSF56672, 1 hit SSF88723, SSF88723, 1 hit |
TIGRFAMsi | TIGR00593, pola, 1 hit |
PROSITEi | View protein in PROSITE PS00447, DNA_POLYMERASE_A, 1 hit |
i Sequence
Sequence statusi: Complete.
P59199-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDKKKLLLID GSSVAFRAFF ALYQQLDRFK NVAGLHTNAI YGFQLMLSHL
60 70 80 90 100
LERVEPSHIL VAFDAGKTTF RTEMYADYKG GRAKTPDEFR EQFPFIRELL
110 120 130 140 150
DHMGIRHYDL AQYEADDIIG TLDKLAEQDG FDITIVSGDK DLIQLTDEHT
160 170 180 190 200
VVEISKKGVA EFEAFTPDYL MEEMGLTPAQ FIDLKALMGD KSDNIPGVTK
210 220 230 240 250
VGEKTGIKLL LEHGSLEGIY ENIDGMKTSK MKENLINDKE QAFLSKTLAT
260 270 280 290 300
IDTKAPIAIG LEDLVYSGPD VENLGKFYDE MGFKQLKQAL NVSSADVSES
310 320 330 340 350
LDFTIVDQIS QDMLSEESIF HFELFGENYH TDNLVGFVWS CGDKLYATDK
360 370 380 390 400
LELLQDPIFK DFLEKTSLRV YDFKKVKVLL QRFGVDLQAP AFDIRLAKYL
410 420 430 440 450
LSTVEDNEIA TIASLYGQTY LVDDETFYGK GVKKAIPERE KFLEHLACKL
460 470 480 490 500
AVLVETEPIL LEKLSENGQL ELLYDMEQPL AFVLAKMEIA GIMVKKETLL
510 520 530 540 550
EMQAENELVI EKLTQEIYEL AGEEFNVNSP KQLGVLLFEK LGLPLEYTKK
560 570 580 590 600
TKTGYSTAVD VLERLAPIAP IVKKILDYRQ IAKIQSTYVI GLQDWILADG
610 620 630 640 650
KIHTRYVQDL TQTGRLSSVD PNLQNIPARL EQGRLIRKAF VPEWEDSVLL
660 670 680 690 700
SSDYSQIELR VLAHISKDEH LIKAFQEGAD IHTSTAMRVF GIERPDDVTA
710 720 730 740 750
NDRRNAKAVN FGVVYGISDF GLSNNLGISR KEAKAYIDTY FERFPGIKNY
760 770 780 790 800
MDEVVREARD KGYVETLFKR RRELPDINSR NFNIRGFAER TAINSPIQGS
810 820 830 840 850
AADILKIAMI QLDKALVAGG YQTKMLLQVH DEIVLEVPKS ELVEMKKLVK
860 870
QTMEEAIQLS VPLIADENEG ATWYEAK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005672 Genomic DNA Translation: AAK74222.1 |
PIRi | E95003 |
RefSeqi | WP_001808750.1, NZ_AKVY01000001.1 |
Genome annotation databases
EnsemblBacteriai | AAK74222; AAK74222; SP_0032 |
KEGGi | spn:SP_0032 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005672 Genomic DNA Translation: AAK74222.1 |
PIRi | E95003 |
RefSeqi | WP_001808750.1, NZ_AKVY01000001.1 |
3D structure databases
AlphaFoldDBi | P59199 |
SMRi | P59199 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 170187.SP_0032 |
Genome annotation databases
EnsemblBacteriai | AAK74222; AAK74222; SP_0032 |
KEGGi | spn:SP_0032 |
Phylogenomic databases
eggNOGi | COG0258, Bacteria COG0749, Bacteria |
OMAi | NRPPMPD |
PhylomeDBi | P59199 |
Family and domain databases
CDDi | cd09898, H3TH_53EXO, 1 hit |
Gene3Di | 3.30.420.10, 1 hit |
InterProi | View protein in InterPro IPR002562, 3'-5'_exonuclease_dom IPR020046, 5-3_exonucl_a-hlix_arch_N IPR002421, 5-3_exonuclease IPR036279, 5-3_exonuclease_C_sf IPR019760, DNA-dir_DNA_pol_A_CS IPR001098, DNA-dir_DNA_pol_A_palm_dom IPR043502, DNA/RNA_pol_sf IPR020045, DNA_polI_H3TH IPR018320, DNA_polymerase_1 IPR002298, DNA_polymerase_A IPR008918, HhH2 IPR029060, PIN-like_dom_sf IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf |
PANTHERi | PTHR10133, PTHR10133, 2 hits |
Pfami | View protein in Pfam PF01367, 5_3_exonuc, 1 hit PF02739, 5_3_exonuc_N, 1 hit PF00476, DNA_pol_A, 1 hit |
PRINTSi | PR00868, DNAPOLI |
SMARTi | View protein in SMART SM00474, 35EXOc, 1 hit SM00475, 53EXOc, 1 hit SM00279, HhH2, 1 hit SM00482, POLAc, 1 hit |
SUPFAMi | SSF47807, SSF47807, 1 hit SSF53098, SSF53098, 1 hit SSF56672, SSF56672, 1 hit SSF88723, SSF88723, 1 hit |
TIGRFAMsi | TIGR00593, pola, 1 hit |
PROSITEi | View protein in PROSITE PS00447, DNA_POLYMERASE_A, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DPO1_STRPN | |
Accessioni | P59199Primary (citable) accession number: P59199 Secondary accession number(s): P13252 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2003 |
Last sequence update: | January 10, 2003 | |
Last modified: | May 25, 2022 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |