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Protein

Ras-related protein Rab-15

Gene

RAB15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22GTPBy similarity8
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi121 – 124GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-15
Gene namesi
Name:RAB15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000139998.14
HGNCiHGNC:20150 RAB15
neXtProtiNX_P59190

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi376267
OpenTargetsiENSG00000139998
PharmGKBiPA134901572

Polymorphism and mutation databases

BioMutaiRAB15
DMDMi27734452

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211881 – 212Ras-related protein Rab-15Add BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi210S-geranylgeranyl cysteineBy similarity1
Modified residuei212Cysteine methyl esterBy similarity1
Lipidationi212S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP59190
MaxQBiP59190
PeptideAtlasiP59190
PRIDEiP59190
ProteomicsDBi57135
57136 [P59190-2]

PTM databases

iPTMnetiP59190
PhosphoSitePlusiP59190
SwissPalmiP59190

Expressioni

Gene expression databases

BgeeiENSG00000139998 Expressed in 192 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_RAB15
ExpressionAtlasiP59190 baseline and differential
GenevisibleiP59190 HS

Organism-specific databases

HPAiHPA041177

Interactioni

Subunit structurei

The GTP bound form of RAB15 interacts with REP15. Interacts (GTP-bound form) with MICAL1, MICAL3, MICALCL, EHBP1 and EHBP1L1.2 Publications

Protein-protein interaction databases

BioGridi132005, 5 interactors
IntActiP59190, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliP59190
SMRiP59190
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

GeneTreeiENSGT00890000139330
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP59190
KOiK07908
OMAiFHPSHIS
OrthoDBiEOG091G0J9F
PhylomeDBiP59190
TreeFamiTF314097

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P59190-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKQYDVLFR LLLIGDSGVG KTCLLCRFTD NEFHSSHIST IGVDFKMKTI
60 70 80 90 100
EVDGIKVRIQ IWDTAGQERY QTITKQYYRR AQGIFLVYDI SSERSYQHIM
110 120 130 140 150
KWVSDVDEYA PEGVQKILIG NKADEEQKRQ VGREQGQQLA KEYGMDFYET
160 170 180 190 200
SACTNLNIKE SFTRLTELVL QAHRKELEGL RMRASNELAL AELEEEEGKP
210
EGPANSSKTC WC
Length:212
Mass (Da):24,391
Last modified:January 10, 2003 - v1
Checksum:iD16A0C71797ED782
GO
Isoform 2 (identifier: P59190-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-212: YAPEGVQKIL...PANSSKTCWC → VGDATSLPGC...TSTLKSHSRV

Show »
Length:208
Mass (Da):23,518
Checksum:i58D700ECA3174682
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V196G3V196_HUMAN
Ras-related protein Rab-15
RAB15
237Annotation score:
A0A2R8YFB8A0A2R8YFB8_HUMAN
Ras-related protein Rab-15
RAB15
246Annotation score:
G3V562G3V562_HUMAN
Ras-related protein Rab-15
RAB15
166Annotation score:
J3QSF4J3QSF4_HUMAN
Ras-related protein Rab-15
RAB15
140Annotation score:
A0A2R8Y7G7A0A2R8Y7G7_HUMAN
Ras-related protein Rab-15
RAB15
162Annotation score:
A0A2R8YDI9A0A2R8YDI9_HUMAN
Ras-related protein Rab-15
RAB15
44Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010420109 – 212YAPEG…KTCWC → VGDATSLPGCGEGASPGKAR RGPDGKANASRKLCLPQPWM KTSGTHQKASRRSLLGIRLM RSRNGRWEESKGSSWRRSMA WTSMKQVPAPTSTLKSHSRV in isoform 2. 3 PublicationsAdd BLAST104

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB678452 mRNA Translation: BAL14289.1
AL139022 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW80893.1
BC040679 mRNA Translation: AAH40679.2
BX248046 mRNA Translation: CAD62353.1
CCDSiCCDS76691.1 [P59190-1]
CCDS9768.1 [P59190-2]
RefSeqiNP_001295083.1, NM_001308154.1 [P59190-1]
NP_941959.1, NM_198686.2 [P59190-2]
UniGeneiHs.512492

Genome annotation databases

EnsembliENST00000267512; ENSP00000267512; ENSG00000139998 [P59190-2]
ENST00000533601; ENSP00000434103; ENSG00000139998 [P59190-1]
GeneIDi376267
KEGGihsa:376267
UCSCiuc001xhz.2 human [P59190-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB678452 mRNA Translation: BAL14289.1
AL139022 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW80893.1
BC040679 mRNA Translation: AAH40679.2
BX248046 mRNA Translation: CAD62353.1
CCDSiCCDS76691.1 [P59190-1]
CCDS9768.1 [P59190-2]
RefSeqiNP_001295083.1, NM_001308154.1 [P59190-1]
NP_941959.1, NM_198686.2 [P59190-2]
UniGeneiHs.512492

3D structure databases

ProteinModelPortaliP59190
SMRiP59190
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132005, 5 interactors
IntActiP59190, 1 interactor

PTM databases

iPTMnetiP59190
PhosphoSitePlusiP59190
SwissPalmiP59190

Polymorphism and mutation databases

BioMutaiRAB15
DMDMi27734452

Proteomic databases

EPDiP59190
MaxQBiP59190
PeptideAtlasiP59190
PRIDEiP59190
ProteomicsDBi57135
57136 [P59190-2]

Protocols and materials databases

DNASUi376267
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267512; ENSP00000267512; ENSG00000139998 [P59190-2]
ENST00000533601; ENSP00000434103; ENSG00000139998 [P59190-1]
GeneIDi376267
KEGGihsa:376267
UCSCiuc001xhz.2 human [P59190-1]

Organism-specific databases

CTDi376267
DisGeNETi376267
EuPathDBiHostDB:ENSG00000139998.14
GeneCardsiRAB15
HGNCiHGNC:20150 RAB15
HPAiHPA041177
neXtProtiNX_P59190
OpenTargetsiENSG00000139998
PharmGKBiPA134901572
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00890000139330
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP59190
KOiK07908
OMAiFHPSHIS
OrthoDBiEOG091G0J9F
PhylomeDBiP59190
TreeFamiTF314097

Enzyme and pathway databases

ReactomeiR-HSA-8873719 RAB geranylgeranylation

Miscellaneous databases

GeneWikiiRAB15
GenomeRNAii376267
PROiPR:P59190

Gene expression databases

BgeeiENSG00000139998 Expressed in 192 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_RAB15
ExpressionAtlasiP59190 baseline and differential
GenevisibleiP59190 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB15_HUMAN
AccessioniPrimary (citable) accession number: P59190
Secondary accession number(s): G5EMR7, Q86TX7, Q8IW89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: November 7, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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