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Protein

Lethal(3)malignant brain tumor-like protein 2

Gene

L3mbtl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri81 – 116FCS-typePROSITE-ProRule annotationAdd BLAST36

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-8953750 Transcriptional Regulation by E2F6

Names & Taxonomyi

Protein namesi
Recommended name:
Lethal(3)malignant brain tumor-like protein 2
Short name:
L(3)mbt-like protein 2
Gene namesi
Name:L3mbtl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2443584 L3mbtl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844491 – 703Lethal(3)malignant brain tumor-like protein 2Add BLAST703

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineBy similarity1
Modified residuei67PhosphoserineBy similarity1
Modified residuei338PhosphoserineBy similarity1
Cross-linki405Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki647Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki673Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei681PhosphoserineBy similarity1
Modified residuei685PhosphoserineBy similarity1
Modified residuei687PhosphoserineBy similarity1
Cross-linki698Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki698Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP59178
PaxDbiP59178
PeptideAtlasiP59178
PRIDEiP59178

PTM databases

iPTMnetiP59178
PhosphoSitePlusiP59178

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSMUSG00000022394 Expressed in 230 organ(s), highest expression level in brain
CleanExiMM_L3MBTL2
ExpressionAtlasiP59178 baseline and differential
GenevisibleiP59178 MM

Interactioni

Subunit structurei

Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229554, 51 interactors
IntActiP59178, 14 interactors
MINTiP59178
STRINGi10090.ENSMUSP00000023029

Structurei

3D structure databases

ProteinModelPortaliP59178
SMRiP59178
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati179 – 283MBT 1Add BLAST105
Repeati291 – 391MBT 2Add BLAST101
Repeati397 – 500MBT 3Add BLAST104
Repeati508 – 604MBT 4Add BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 21Poly-Glu5
Compositional biasi620 – 624Poly-Lys5

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri81 – 116FCS-typePROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410KCPG Eukaryota
ENOG410ZYE4 LUCA
GeneTreeiENSGT00760000119024
HOVERGENiHBG057974
InParanoidiP59178
OMAiPQTIHAK
TreeFamiTF316498

Family and domain databases

Gene3Di3.30.60.160, 1 hit
InterProiView protein in InterPro
IPR038038 L3MBTL2
IPR004092 Mbt
IPR012313 Znf_FCS
IPR038603 Znf_FCS_sf
PANTHERiPTHR12247:SF64 PTHR12247:SF64, 1 hit
PfamiView protein in Pfam
PF02820 MBT, 4 hits
SMARTiView protein in SMART
SM00561 MBT, 4 hits
PROSITEiView protein in PROSITE
PS51079 MBT, 4 hits
PS51024 ZF_FCS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P59178-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKPRGTEEA PSSEPMEEEE EDDLDLFGGY DSFRSYNSSA GSESSSYLEE
60 70 80 90 100
SSEAENEDRE AGELPTSPLH LFSSANNRSL DGSGSEPAVC EMCGIVGTRE
110 120 130 140 150
AFFSKTKRFC SVSCSRSYSS NSKKASILAR LQGKPPTKKA KVLHKAAWSA
160 170 180 190 200
KIGAFLHAQG TGQLADGTPT GQDALVLGFD WGKFLKDHSY KAAPVSCFKH
210 220 230 240 250
VPLYDQWEDV MKGMKVEVLN SDAVLPSRVY WIATVIQAAG YRVLLRYEGF
260 270 280 290 300
ENDASHDFWC NLGTVDVHPI GWCAINSKIL VPPRTIHAKF TDWKSYLMKR
310 320 330 340 350
LVGSRTLPAD FHIKMVESMK YPFRQGMRLE VVDKTQVSRT RMAVVDTVIG
360 370 380 390 400
GRLRLLYEDG DSDDDFWCHM WSPLIHPVGW SRRVGHGIKM SDRRCDMSHH
410 420 430 440 450
PTFRKIYCDA VPYLFKKVRA VYTEGGWFEE GMKLEAIDPL NLGSICVATI
460 470 480 490 500
CKVLLDGYLM ICVDGGPSTD GSDWFCYHAS SHAIFPATFC QKNDIELTPP
510 520 530 540 550
KGYETQPFAW ETYLEKTKSK AAPARLFNMD CPNHGFKVGM KLEAVDLMEP
560 570 580 590 600
RLICVATVKR VVHRLLSIHF DGWDNEYDQW VDCESPDIYP VGWCELTGYQ
610 620 630 640 650
LQPPVSAEPN TPQKGKDTTK KKKKQFGKKR KRIPSAKTRP LRQGSKKPLL
660 670 680 690 700
EDNLEALGVS EPVPDDIIAV CVKEEHQDIS SLDRSPSPQL PLPIESIKQE

RNN
Length:703
Mass (Da):78,971
Last modified:July 27, 2011 - v2
Checksum:i2E9B5DF5BFCEAFF9
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80XB1Q80XB1_MOUSE
Lethal(3)malignant brain tumor-like...
L3mbtl2 M4mbt
713Annotation score:
Q80XB0Q80XB0_MOUSE
Lethal(3)malignant brain tumor-like...
L3mbtl2 M4mbt
393Annotation score:
G3UY70G3UY70_MOUSE
Lethal(3)malignant brain tumor-like...
L3mbtl2
739Annotation score:
G3UX47G3UX47_MOUSE
Lethal(3)malignant brain tumor-like...
L3mbtl2
138Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti682L → P in AAH23933 (PubMed:15489334).Curated1
Sequence conflicti682L → P in AAH30864 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237000 mRNA Translation: AAP44771.1
AK029115 mRNA Translation: BAC26305.1
AK036510 mRNA Translation: BAC29456.1
CH466550 Genomic DNA Translation: EDL04569.1
BC023933 mRNA Translation: AAH23933.1
BC030864 mRNA Translation: AAH30864.1
CCDSiCCDS27669.1
RefSeqiNP_666105.2, NM_145993.5
UniGeneiMm.280768
Mm.486476
Mm.491152

Genome annotation databases

EnsembliENSMUST00000023029; ENSMUSP00000023029; ENSMUSG00000022394
GeneIDi214669
KEGGimmu:214669
UCSCiuc007wwu.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237000 mRNA Translation: AAP44771.1
AK029115 mRNA Translation: BAC26305.1
AK036510 mRNA Translation: BAC29456.1
CH466550 Genomic DNA Translation: EDL04569.1
BC023933 mRNA Translation: AAH23933.1
BC030864 mRNA Translation: AAH30864.1
CCDSiCCDS27669.1
RefSeqiNP_666105.2, NM_145993.5
UniGeneiMm.280768
Mm.486476
Mm.491152

3D structure databases

ProteinModelPortaliP59178
SMRiP59178
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229554, 51 interactors
IntActiP59178, 14 interactors
MINTiP59178
STRINGi10090.ENSMUSP00000023029

PTM databases

iPTMnetiP59178
PhosphoSitePlusiP59178

Proteomic databases

MaxQBiP59178
PaxDbiP59178
PeptideAtlasiP59178
PRIDEiP59178

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023029; ENSMUSP00000023029; ENSMUSG00000022394
GeneIDi214669
KEGGimmu:214669
UCSCiuc007wwu.2 mouse

Organism-specific databases

CTDi83746
MGIiMGI:2443584 L3mbtl2

Phylogenomic databases

eggNOGiENOG410KCPG Eukaryota
ENOG410ZYE4 LUCA
GeneTreeiENSGT00760000119024
HOVERGENiHBG057974
InParanoidiP59178
OMAiPQTIHAK
TreeFamiTF316498

Enzyme and pathway databases

ReactomeiR-MMU-8953750 Transcriptional Regulation by E2F6

Miscellaneous databases

ChiTaRSiL3mbtl2 mouse
PROiPR:P59178
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022394 Expressed in 230 organ(s), highest expression level in brain
CleanExiMM_L3MBTL2
ExpressionAtlasiP59178 baseline and differential
GenevisibleiP59178 MM

Family and domain databases

Gene3Di3.30.60.160, 1 hit
InterProiView protein in InterPro
IPR038038 L3MBTL2
IPR004092 Mbt
IPR012313 Znf_FCS
IPR038603 Znf_FCS_sf
PANTHERiPTHR12247:SF64 PTHR12247:SF64, 1 hit
PfamiView protein in Pfam
PF02820 MBT, 4 hits
SMARTiView protein in SMART
SM00561 MBT, 4 hits
PROSITEiView protein in PROSITE
PS51079 MBT, 4 hits
PS51024 ZF_FCS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLMBL2_MOUSE
AccessioniPrimary (citable) accession number: P59178
Secondary accession number(s): Q8BHD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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