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Entry version 151 (18 Sep 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Histone H3.3

Gene

HTR4

more
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Caution

To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H3K4me1/2/3 = mono-, di- and trimethylated Lys-5; H3K9me1/2/3 = mono-, di- and trimethylated Lys-10; H3K9ac = acetylated Lys-10; H3S10ph = phosphorylated Ser-11; H3T11ph = phosphorylated Thr-12; H3K14ac = acetylated Lys-15; H3K18ac = acetylated Lys-19; H3K18me1 = monomethylated Lys-19; H3K23ac = acetylated Lys-24; H3K23me1 = monomethylated Lys-24; H3K27me1/2/3 = mono-, di- and trimethylated Lys-28; H3S28ph = phosphorylated Ser-29; H3K36me1/2/3 = mono-, di- and trimethylated Lys-37.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei32Impaired recognition by ATXR5 and ATXR61 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone H3.3
Alternative name(s):
Histone H3.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HTR4
Ordered Locus Names:At4g40030
ORF Names:T5J17.200
AND
Name:HTR5
Ordered Locus Names:At4g40040
ORF Names:T5J17.210
AND
Name:HTR8
Ordered Locus Names:At5g10980
ORF Names:T30N20_250, T5K6.6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 4, Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

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Araporti
AT4G40030
AT4G40040
AT5G10980

The Arabidopsis Information Resource

More...
TAIRi
locus:2140025 AT4G40040
locus:2183795 AT5G10980

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi32T → A: H3K27me1 methylation by ATXR5/6 restored. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002212681 – 136Histone H3.3Add BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei5N6,N6,N6-trimethyllysine; alternate4 Publications1
Modified residuei5N6,N6-dimethyllysine; alternate4 Publications1
Modified residuei5N6-methyllysine; alternate4 Publications1
Modified residuei10N6,N6,N6-trimethyllysine; alternate5 Publications1
Modified residuei10N6,N6-dimethyllysine; alternate5 Publications1
Modified residuei10N6-acetyllysine; alternate2 Publications1
Modified residuei10N6-methyllysine; alternate5 Publications1
Modified residuei11Phosphoserine2 Publications1
Modified residuei12Phosphothreonine1 Publication1
Modified residuei15N6-acetyllysine3 Publications1
Modified residuei19N6-acetyllysine; alternate2 Publications1
Modified residuei19N6-methyllysine; alternate1 Publication1
Modified residuei24N6-acetyllysine; alternate1 Publication1
Modified residuei24N6-methyllysine; alternate1 Publication1
Modified residuei28N6,N6,N6-trimethyllysine; alternateBy similarity1
Modified residuei28N6,N6-dimethyllysine; alternate5 Publications1
Modified residuei28N6-methyllysine; alternate5 Publications1
Modified residuei29Phosphoserine2 Publications1
Modified residuei37N6,N6,N6-trimethyllysine; alternate2 Publications1
Modified residuei37N6,N6-dimethyllysine; alternate2 Publications1
Modified residuei37N6-methyllysine; alternate2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Can be acetylated to form H3K9ac, H3K14ac, H3K18ac and H3K23ac. H3K9ac could compete with H3K9me and prevent gene silencing. H3K9acK14ac molecules are 30-fold less abundant than H3K9ac or H3K14ac. Very low level of H3K9meK14ac. H3K14 is specifically acetylated by HAG1 and deacetylated by HDA6. H3K9ac is deacetylated by HDT1. H3K9ac is restricted to euchromatin. H3K18ac, but not H3K9ac, is cell-cycle dependent and linked to replication. Reduced H4R3me2s increases H3K14ac in the FLC chromatin and activates or maintains its transcription. Vernalization decreases H3K9/14ac in the promoter region of FLC.5 Publications
Mono-, di- or trimethylated to form mainly H3K4me1/2/3, H3K9me1/2/3 and H3K36me1/2/3. Very low monomethylation at H3K18me1 or H3K23me1. H3K4me1/2/3, H3K9me3, H3K27me3 and H3K36me1/2/3 are typical marks for euchromatin, whereas heterochromatic chromocenters are enriched in H3K9me1/2 and H3K27me1/2. H3K27me3 is largely restricted to the transcribed regions of single genes and not associated with low-nucleosome density regions. SUVR1 to SUVR5, ASHH1 to ASHH3 and ASHR1 to ASHR3 methylate H3, with ASHH2 methylating specifically H3K4 and H3K36. Monomethylation at H3K27me1 by ATXR5/6 is inhibited by the presence of Thr-32. The Su(var)3-9 homolog proteins (SUVH1 to SUVH10) are H3K9-specific methyltransferases. Among them, KRYPTONITE (SUVH4) is only involved in di- or trimethylation. Regarding H3K9, the major forms are H3K9me1 (20%) and H3K9me2 (10%), while H3K9me3 is rare (0.2%). H3K9me is controlled by DNA methylation and is not required for the formation of constitutive heterochromatin, but double methylation H3K9meK27me is required for the recruitment of CMT3 to methylate heterochromatin and silence euchromatic loci. Very low level of H3K9meK14ac. 36% of H3K27 is found under the form of H3K27me1 and 6% of H3K27me2, with no detectable H3K27me3. 6% of H3K36 is found under the form of H3K36me1, 15% of H3K36me2 and 3% of H3K36me3. H3K27me2K36me1 is found in 15% of the proteins while H3k27me1K36me2 is not detected. H2BK143ub1 is probably prerequisite for H3K4me. Elevated H3K4me3 and H3K36me2 formed by ASHH2 are required for high FLC expression. Vernalization increases H3K9me2 and H3K27me2/3 and decreases H3K4me2 at the FLC locus, resulting in the epigenetic silencing of this floral repressor.10 Publications
In meta- and anaphase, H3T11ph is found on the entire length of the condensed chromosomes, whereas H3S10ph and H3S28ph are confined to the pericentromeric regions. During the first meiotic division, H3S10ph and H3S28ph are found on the entire length of the chromosome. Both sites may be involved in sister chromatid cohesion. No phosphorylation detected during interphase. AUR1 and AUR2 phosphorylate only H3S10, while AUR3 phosphorylates both H3S10 and H3S28.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei15Not N6-methylated1 Publication1
Sitei28Not N6-acetylated1 Publication1
Sitei37Not N6-acetylated1 Publication1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P59169

PRoteomics IDEntifications database

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PRIDEi
P59169

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P59169

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in a replication-independent manner. Strong expression in the generative cell of early bicellular pollen, but not detected in late bicellular and tricellular pollen.2 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P59169 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P59169 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. The H3K9meK27me dimethylated N-terminal tail of histone H3 can directly interact with the chromodomains of CMT3 and/or LHP1.

Interacts with AHL27. Binds to HIRA (PubMed:25086063).

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
15444, 9 interactors
15445, 1 interactor
16243, 2 interactors

STRING: functional protein association networks

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STRINGi
3702.AT5G10980.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P59169

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the histone H3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1745 Eukaryota
COG2036 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000155290

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P59169

KEGG Orthology (KO)

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KOi
K11253

Identification of Orthologs from Complete Genome Data

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OMAi
PNTMART

Database of Orthologous Groups

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OrthoDBi
1564596at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P59169

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009072 Histone-fold
IPR007125 Histone_H2A/H2B/H3
IPR000164 Histone_H3/CENP-A

The PANTHER Classification System

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PANTHERi
PTHR11426 PTHR11426, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00125 Histone, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00622 HISTONEH3

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00428 H3, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47113 SSF47113, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00322 HISTONE_H3_1, 1 hit
PS00959 HISTONE_H3_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 1 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoform i produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced. According to EST sequences.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P59169-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARTKQTARK STGGKAPRKQ LATKAARKSA PTTGGVKKPH RYRPGTVALR
60 70 80 90 100
EIRKYQKSTE LLIRKLPFQR LVREIAQDFK TDLRFQSHAV LALQEAAEAY
110 120 130
LVGLFEDTNL CAIHAKRVTI MPKDIQLARR IRGERA
Length:136
Mass (Da):15,406
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D72383BF2E9EBE6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MRL0A8MRL0_ARATH
Histone superfamily protein
H3.3 histone 3.3, At4g40030, T5J17.200, T5J17_200
164Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X60429 Genomic DNA Translation: CAA42958.1
X60429 Genomic DNA Translation: CAA42957.1
AL161596 Genomic DNA Translation: CAB80666.1
AL161596 Genomic DNA Translation: CAB80667.1
AL035708 Genomic DNA Translation: CAB38916.1
AL035708 Genomic DNA Translation: CAB38917.1
AL365234 Genomic DNA Translation: CAB96853.1
AL391222 Genomic DNA No translation available.
CP002687 Genomic DNA Translation: AEE87155.1
CP002687 Genomic DNA Translation: AEE87157.1
CP002687 Genomic DNA Translation: AEE87158.1
CP002687 Genomic DNA Translation: AEE87159.1
CP002687 Genomic DNA Translation: ANM66215.1
CP002687 Genomic DNA Translation: ANM67333.1
CP002688 Genomic DNA Translation: AED91617.1
AF385735 mRNA Translation: AAK60325.1
AY078027 mRNA Translation: AAL77728.1
AY070749 mRNA Translation: AAL50088.1
AY097375 mRNA Translation: AAM19891.1
BT002391 mRNA Translation: AAO00751.1
BT003326 mRNA Translation: AAO29945.1
AY086668 mRNA Translation: AAM63725.1
BT025499 mRNA Translation: ABF58917.1

Protein sequence database of the Protein Information Resource

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PIRi
S24346

NCBI Reference Sequences

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RefSeqi
NP_001031816.1, NM_001036739.1 [P59169-1]
NP_001078517.1, NM_001085048.2 [P59169-1]
NP_001328124.1, NM_001342564.1 [P59169-1]
NP_001329167.1, NM_001342565.1 [P59169-1]
NP_195713.1, NM_120167.4 [P59169-1]
NP_196659.1, NM_121136.6 [P59169-1]
NP_849529.1, NM_179198.2 [P59169-1]

Genome annotation databases

Ensembl plant genome annotation project

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EnsemblPlantsi
AT4G40030.1; AT4G40030.1; AT4G40030 [P59169-1]
AT4G40030.3; AT4G40030.3; AT4G40030 [P59169-1]
AT4G40030.4; AT4G40030.4; AT4G40030 [P59169-1]
AT4G40040.1; AT4G40040.1; AT4G40040 [P59169-1]
AT4G40040.2; AT4G40040.2; AT4G40040 [P59169-1]
AT4G40040.3; AT4G40040.3; AT4G40040 [P59169-1]
AT5G10980.1; AT5G10980.1; AT5G10980 [P59169-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
830164
830165
830965

Gramene; a comparative resource for plants

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Gramenei
AT4G40030.1; AT4G40030.1; AT4G40030 [P59169-1]
AT4G40030.3; AT4G40030.3; AT4G40030 [P59169-1]
AT4G40030.4; AT4G40030.4; AT4G40030 [P59169-1]
AT4G40040.1; AT4G40040.1; AT4G40040 [P59169-1]
AT4G40040.2; AT4G40040.2; AT4G40040 [P59169-1]
AT4G40040.3; AT4G40040.3; AT4G40040 [P59169-1]
AT5G10980.1; AT5G10980.1; AT5G10980 [P59169-1]

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT4G40030
ath:AT4G40040
ath:AT5G10980

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60429 Genomic DNA Translation: CAA42958.1
X60429 Genomic DNA Translation: CAA42957.1
AL161596 Genomic DNA Translation: CAB80666.1
AL161596 Genomic DNA Translation: CAB80667.1
AL035708 Genomic DNA Translation: CAB38916.1
AL035708 Genomic DNA Translation: CAB38917.1
AL365234 Genomic DNA Translation: CAB96853.1
AL391222 Genomic DNA No translation available.
CP002687 Genomic DNA Translation: AEE87155.1
CP002687 Genomic DNA Translation: AEE87157.1
CP002687 Genomic DNA Translation: AEE87158.1
CP002687 Genomic DNA Translation: AEE87159.1
CP002687 Genomic DNA Translation: ANM66215.1
CP002687 Genomic DNA Translation: ANM67333.1
CP002688 Genomic DNA Translation: AED91617.1
AF385735 mRNA Translation: AAK60325.1
AY078027 mRNA Translation: AAL77728.1
AY070749 mRNA Translation: AAL50088.1
AY097375 mRNA Translation: AAM19891.1
BT002391 mRNA Translation: AAO00751.1
BT003326 mRNA Translation: AAO29945.1
AY086668 mRNA Translation: AAM63725.1
BT025499 mRNA Translation: ABF58917.1
PIRiS24346
RefSeqiNP_001031816.1, NM_001036739.1 [P59169-1]
NP_001078517.1, NM_001085048.2 [P59169-1]
NP_001328124.1, NM_001342564.1 [P59169-1]
NP_001329167.1, NM_001342565.1 [P59169-1]
NP_195713.1, NM_120167.4 [P59169-1]
NP_196659.1, NM_121136.6 [P59169-1]
NP_849529.1, NM_179198.2 [P59169-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4PL6X-ray1.68C/D2-12[»]
4PLIX-ray1.65C/D33-42[»]
4PLLX-ray2.60C/D33-42[»]
SMRiP59169
ModBaseiSearch...

Protein-protein interaction databases

BioGridi15444, 9 interactors
15445, 1 interactor
16243, 2 interactors
STRINGi3702.AT5G10980.1

PTM databases

iPTMnetiP59169

Proteomic databases

PaxDbiP59169
PRIDEiP59169

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G40030.1; AT4G40030.1; AT4G40030 [P59169-1]
AT4G40030.3; AT4G40030.3; AT4G40030 [P59169-1]
AT4G40030.4; AT4G40030.4; AT4G40030 [P59169-1]
AT4G40040.1; AT4G40040.1; AT4G40040 [P59169-1]
AT4G40040.2; AT4G40040.2; AT4G40040 [P59169-1]
AT4G40040.3; AT4G40040.3; AT4G40040 [P59169-1]
AT5G10980.1; AT5G10980.1; AT5G10980 [P59169-1]
GeneIDi830164
830165
830965
GrameneiAT4G40030.1; AT4G40030.1; AT4G40030 [P59169-1]
AT4G40030.3; AT4G40030.3; AT4G40030 [P59169-1]
AT4G40030.4; AT4G40030.4; AT4G40030 [P59169-1]
AT4G40040.1; AT4G40040.1; AT4G40040 [P59169-1]
AT4G40040.2; AT4G40040.2; AT4G40040 [P59169-1]
AT4G40040.3; AT4G40040.3; AT4G40040 [P59169-1]
AT5G10980.1; AT5G10980.1; AT5G10980 [P59169-1]
KEGGiath:AT4G40030
ath:AT4G40040
ath:AT5G10980

Organism-specific databases

AraportiAT4G40030
AT4G40040
AT5G10980
TAIRilocus:2140025 AT4G40040
locus:2183795 AT5G10980

Phylogenomic databases

eggNOGiKOG1745 Eukaryota
COG2036 LUCA
HOGENOMiHOG000155290
InParanoidiP59169
KOiK11253
OMAiPNTMART
OrthoDBi1564596at2759
PhylomeDBiP59169

Miscellaneous databases

Protein Ontology

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PROi
PR:P59169

Gene expression databases

ExpressionAtlasiP59169 baseline and differential
GenevisibleiP59169 AT

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR007125 Histone_H2A/H2B/H3
IPR000164 Histone_H3/CENP-A
PANTHERiPTHR11426 PTHR11426, 1 hit
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PRINTSiPR00622 HISTONEH3
SMARTiView protein in SMART
SM00428 H3, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00322 HISTONE_H3_1, 1 hit
PS00959 HISTONE_H3_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH33_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P59169
Secondary accession number(s): Q6NR95
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 23, 2007
Last modified: September 18, 2019
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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