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Protein

Fermitin family homolog 1

Gene

Fermt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites (By similarity).By similarity

GO - Molecular functioni

  • actin filament binding Source: MGI

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Fermitin family homolog 1
Alternative name(s):
Kindlin-1
Unc-112-related protein 1
Gene namesi
Name:Fermt1
Synonyms:Kind1, Urp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2443583 Fermt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are born with the expected Mendelian distribution and appear normal at birth, but fail to thrive, become dehydrated and die after three to five days. They develop skin atrophy and die due to a lethal intestinal epithelial dysfunction. The colon is shortened and swollen and presents signs of acute inflammation. At the time of death, about 80% of the colonic epithelium is detached.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194531 – 677Fermitin family homolog 1Add BLAST677

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei170PhosphoserineBy similarity1
Modified residuei179PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP59113
PaxDbiP59113
PeptideAtlasiP59113
PRIDEiP59113

PTM databases

iPTMnetiP59113
PhosphoSitePlusiP59113

Expressioni

Gene expression databases

BgeeiENSMUSG00000027356 Expressed in 28 organ(s), highest expression level in colon

Interactioni

Subunit structurei

Interacts with the cytoplasmic domain of integrins ITGB1 and ITGB3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP59113, 1 interactor
MINTiP59113
STRINGi10090.ENSMUSP00000047616

Structurei

Secondary structure

1677
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00655
ProteinModelPortaliP59113
SMRiP59113
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP59113

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 653FERMAdd BLAST558
Domaini377 – 473PHPROSITE-ProRule annotationAdd BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi147 – 154Poly-Lys8

Domaini

The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain. The FERM domain contains the subdomains F1, F2 and F3. It is preceded by a F0 domain with a ubiquitin-like fold. The F0 domain is required for integrin activation and for localization at focal adhesions (By similarity).By similarity

Sequence similaritiesi

Belongs to the kindlin family.Curated

Phylogenomic databases

eggNOGiKOG3727 Eukaryota
ENOG410XS1B LUCA
GeneTreeiENSGT00390000013444
HOGENOMiHOG000231715
HOVERGENiHBG020688
InParanoidiP59113
KOiK17082
OMAiFLRMKNR
OrthoDBiEOG091G03SD
TreeFamiTF314677

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
cd01237 PH_fermitin, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR035963 FERM_2
IPR019748 FERM_central
IPR037843 Kindlin/fermitin
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037837 PH_Kindlin/fermitin
PANTHERiPTHR16160 PTHR16160, 1 hit
PfamiView protein in Pfam
PF00373 FERM_M, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
PROSITEiView protein in PROSITE
PS00661 FERM_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

P59113-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSSGDLTSA SWELVVRVDH ANGEQQTEIT LRVSGDLHIG GVMLKLVEQM
60 70 80 90 100
NIAQDWSDYA LWWEQKRCWL LKTHWTLDKC GVQADANLLF TPQHKMLRLR
110 120 130 140 150
LPNAKTVRLR VSFSAVVFKA VADICKVLNI RRPEELSLLK PSSDYCKKKK
160 170 180 190 200
KKEKNSKEPV IEDILNLESS STSSGSPVSP GLYSKTMTPT YDPINGTPAL
210 220 230 240 250
STMTWFGDSP LTEQNCSVLA FSQPPPSPDV LADMFQPRSL VDKAKMNAGW
260 270 280 290 300
LDSSRSLMEQ SIQEDEQLQL RFKYYTFFDL NPKYDAVRIN QLYEQARWAV
310 320 330 340 350
LLEEIDCTEE EMLIFAALQY HISKLSQCAE IQDFATKSEV DEVEAALSSL
360 370 380 390 400
EVTLEGGKAD NTLEDITDIP KLADYLKLFR PKKLMLKACK QYWFVFKDTS
410 420 430 440 450
IAYFKNKELE QGEPIEKLNL RGCEIVPDVN VSGRKFGIKL LIPVADGMNE
460 470 480 490 500
VYLRCDHEDQ YARWMAACIL ASKGKTMADS SYQPEVISIL SFLKMKNRNS
510 520 530 540 550
SPLVASSLEN MDMNPECLVS PCCAKKHKSK QLAARILEAH HNVAQMPLVE
560 570 580 590 600
AKLQFIQAWQ SLPEFGLTYY LVRFKGSKKD DILGVAYNRL IRIDAVTGIP
610 620 630 640 650
VTTWRFANMK QWNVNWEIRQ VAIEFDQNVS IAFTCLSADC KIVHEYIGGY
660 670
IFLSTRSKDQ NETLDEDLFH KLTGGQD
Length:677
Mass (Da):76,941
Last modified:July 27, 2011 - v4
Checksum:i9B8B1876FA7621EE
GO

Sequence cautioni

The sequence AAH29093 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti522C → R in AAH29093 (PubMed:15489334).Curated1
Sequence conflicti586A → S in AAH29093 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL831763 Genomic DNA No translation available.
BC029093 mRNA Translation: AAH29093.1 Different initiation.
BC042792 mRNA No translation available.
AK050804 mRNA Translation: BAC34417.1
CCDSiCCDS38248.1
RefSeqiNP_932146.2, NM_198029.2
XP_017173695.1, XM_017318206.1
XP_017173696.1, XM_017318207.1
XP_017173699.1, XM_017318210.1
UniGeneiMm.209784

Genome annotation databases

EnsembliENSMUST00000038280; ENSMUSP00000047616; ENSMUSG00000027356
GeneIDi241639
KEGGimmu:241639
UCSCiuc008mno.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL831763 Genomic DNA No translation available.
BC029093 mRNA Translation: AAH29093.1 Different initiation.
BC042792 mRNA No translation available.
AK050804 mRNA Translation: BAC34417.1
CCDSiCCDS38248.1
RefSeqiNP_932146.2, NM_198029.2
XP_017173695.1, XM_017318206.1
XP_017173696.1, XM_017318207.1
XP_017173699.1, XM_017318210.1
UniGeneiMm.209784

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KMCNMR-A1-96[»]
4BBKX-ray2.10A364-509[»]
DisProtiDP00655
ProteinModelPortaliP59113
SMRiP59113
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP59113, 1 interactor
MINTiP59113
STRINGi10090.ENSMUSP00000047616

PTM databases

iPTMnetiP59113
PhosphoSitePlusiP59113

Proteomic databases

MaxQBiP59113
PaxDbiP59113
PeptideAtlasiP59113
PRIDEiP59113

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038280; ENSMUSP00000047616; ENSMUSG00000027356
GeneIDi241639
KEGGimmu:241639
UCSCiuc008mno.1 mouse

Organism-specific databases

CTDi55612
MGIiMGI:2443583 Fermt1

Phylogenomic databases

eggNOGiKOG3727 Eukaryota
ENOG410XS1B LUCA
GeneTreeiENSGT00390000013444
HOGENOMiHOG000231715
HOVERGENiHBG020688
InParanoidiP59113
KOiK17082
OMAiFLRMKNR
OrthoDBiEOG091G03SD
TreeFamiTF314677

Miscellaneous databases

EvolutionaryTraceiP59113
PROiPR:P59113
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027356 Expressed in 28 organ(s), highest expression level in colon

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
cd01237 PH_fermitin, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR035963 FERM_2
IPR019748 FERM_central
IPR037843 Kindlin/fermitin
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037837 PH_Kindlin/fermitin
PANTHERiPTHR16160 PTHR16160, 1 hit
PfamiView protein in Pfam
PF00373 FERM_M, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
PROSITEiView protein in PROSITE
PS00661 FERM_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFERM1_MOUSE
AccessioniPrimary (citable) accession number: P59113
Secondary accession number(s): A2ANX1, Q8BQG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 136 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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